Effective transcutaneous immunization against hepatitis B virus by a combined approach of hydrogel patch formulation and microneedle arrays

Biomedical Microdevices

Volumn 15, Issue 6, 2013, Pages 1077-1085

  Guo, Lei ^a,b   Qiu, Yuqin ^a   Chen, Jianmin ^a,b   Zhang, Suohui ^a   Xu, Bai ^a   Gao, Yunhua ^a  

^a TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Hepatitis B surface antigen (HBsAg); Hydrogel formulation; Microneedle; Transcutaneous immunization

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; INTRAMUSCULAR INJECTIONS; LIQUID FORMULATIONS; MICRONEEDLE ARRAYS; MICRONEEDLES; TRANSCUTANEOUS IMMUNIZATIONS; TRANSDERMAL DELIVERY; VACCINATION STRATEGY;

ANTIGENS; HYDROGELS; NEEDLES; VIRUSES;

IMMUNIZATION;

CHOLERA TOXIN B SUBUNIT; HEPATITIS B SURFACE ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; DRUG ANTIGENICITY; DRUG DOSAGE FORM COMPARISON; DRUG DOSE COMPARISON; DRUG FORMULATION; FEMALE; FUNCTIONAL MICROARRAY SYSTEM; HEPATITIS B VIRUS; HYDROGEL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN CULTURE; SKIN PERMEABILITY; THERMOSTABILITY; TISSUE MICROARRAY;

HEPATITIS B VIRUS; MUS; RATTUS; SUS;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, CUTANEOUS; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHOLERA TOXIN; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HYDROGELS; IMMUNITY, HUMORAL; IMMUNIZATION; MICE; NEEDLES; PERMEABILITY; RATS; SKIN; TIME FACTORS; VIRAL VACCINES;

EID: 84890551133     PISSN: 13872176     EISSN: 15728781     Source Type: Journal    
DOI: 10.1007/s10544-013-9799-z     Document Type: Article

References (35)

1. S.N. Andrews, V. Zarnitsyn, B. Bondy, M.R. Prausnitz, Optimization of microdermabrasion for controlled removal of stratum corneum. Int. J. Pharm. 407(1-2), 95-104 (2011)
2. F. Anjuère, A.G. Chandy, F. Audant, D. Rousseau, J. Holmgren, C. Czerkinsky, Transcutaneous immunization with cholera toxin B subunit adjuvant suppresses IgE antibody responses via selective induction of Th1 immune responses. J. Immunol. 170(3), 1586-1592 (2003)
3. S.M. Bal, Z. Ding, E. van Riet, W. Jiskoot, J.A. Bouwstra, Advances in transcutaneous vaccine delivery: do all ways lead to Rome? J. Control Release. 148(3), 266-282 (2010)
4. E.D. Baron, L. Harris, W.S. Redpath, H. Shapiro, F. Hetzel, G. Morley, D. Bar-Or, S.R. Stevens, Laser-assisted penetration of topical anesthetic in adults. Arch. Dermatol. 139(10), 1288-1290 (2003)
5. K. Broos, M.E. Janssens, I. Goeyse, P. Vanlandschoot, G. Leroux-Roels, D. Geysen, Y. Guisez, Comparison of serum humoral responses induced by oral immunization with hepatitis B virus core antigen and the cholera toxin B subunit. Clin. Vaccine Immunol. 15(5), 852-858 (2008)
6. R.P. Chilcott, J. Jenner, S.A. Hotchkiss, P. Rice, In vitro skin absorption and decontamination of sulphur mustard: comparison of human and pig-ear skin. J. Appl. Toxicol. 21(4), 279-283 (2001)
7. H.J. Choi, D.G. Yoo, B.J. Bondy, F.S. Quan, R.W. Compans, S.M. Kang, M.R. Prausnitz, Stability of influenza vaccine coated onto microneedles. Biomaterials 33(14), 3756-3769 (2012)
8. R.L. Coffman, D.A. Lebman, P. Rothman, Mechanism and regulation of immunoglobulin isotype switching. Adv. Immunol. 54, 229-270 (1993)
9. S.A. Coulman, A. Anstey, C. Gateley, A. Morrissey, P. McLoughlin, C. Allender, J.C. Birchall, Microneedle mediated delivery of nanoparticles into human skin. Int. J. Pharm. 366(1-2), 190-200 (2009)
10. I.P. Dick, R.C. Scott, Pig ear skin as an in-vitro model for human skin permeability. J. Pharml. 44(8), 640-645 (1992)
11. Z. Ding, F.J. Verbaan, M. Bivas-Benita, L. Bungener, A. Hukriede, D.J. van den Brtg, G. Kersten, J.A. Bouwstra, Microneedle arrays for the transcutaneous immunization of diphtheria and influenza in BALB/c mice. J. Control Release. 136(1), 71-78 (2009)
12. G.J. Fernando, X. Chen, C.A. Primiero, S.R. Yukiko, E.J. Fairmaid, H.J. Corbett, I.H. Frazer, L.E. Brown, M.A. Kendall, Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody response. J. Control Release. 159(2), 215-221 (2012)
13. D.H. Fuller, P. Loudon, C. Schmaljohn, Preclinical and clinical progress of particle-mediated DNA vaccines for infectious diseases. Methods 40(1), 86-97 (2006)
14. H.J.G.E. Gardeniers, R. Lüttge, E.J.W. Berenschot, M.J. de Boer, S.Y. Yeshurun, M. Hefetz, R. Vant' Oever, A. van den Berg, Silicon micromachined hollow microneedles for transdermal liquid transport. J. Microelectromech. Syst. 12(6), 855-862 (2003)
15. H.S. Gill, M.R. Prausnitz, Coated microneedles for transdermal delivery. J. Control Release. 117(2), 227-237 (2007)
16. H.S. Gill, S.N. Andrews, S.K. Sakthivel, A. Fedanov, I.R. Williams, D.A. Garber, F.H. Priddy, S. Yellin, M.B. Feinberg, S.I. Staprans, M.R. Prausnitz, Selective removal of stratum corneum by microdermabrasion to increase skin permeability. Eur. J. Pharm. Sci. 38(2), 95-103 (2009)
17. H.J. Hirschberg, G.G. van de Wijdeven, H. Kraan, J.P. Amorij, G.F. Kersten, Bioneedles as alternative delivery system for hepatitis B vaccine. J. Control Release. 147(2), 211-217 (2010)
18. J. Hou, Z. Liu, F. Gu, Epidemiology and prevention of Hepatitis B Virus infection. Int. J. Med. Sci. 2(1), 50-57 (2005)
19. Y. Ishii, T. Nakae, F. Sakamoto, K. Matsuo, K. Matsuo, Y.S. Quan, F. Kamiyama, T. Fujita, A. Yamamoto, S. Nakagawa, N. Okada, A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection. J. Control Release. 131(2), 113-120 (2008)
20. Y.C. Kim, F.S. Quan, R.W. Compans, S.M. Kang, M.R. Prausnitz, Formulation and vaccine stability and immunogenicity. J. Control Release. 14(19), 187-195 (2010)
21. D. Koutsonanos, M. Martin, V. Zarnitsyn, S. Sullivan, R. Compans, M. Prausnitz, I. Skountzou, Transdermal influenza immunization with vaccine-coated microneedle arrays. PLoS ONE. 4(3), 1-10 (2009)
22. T.S. Kupper, R.C. Fuhlbrigge, Immune surveillance in the skin: mechanisms and clinical consequences. Nat. Rev. Immunol. 4(3), 211-222 (2004)
23. K. Lee, C.Y. Lee, H. Jung, Dissolving microneedles for transdermal drug administration prepared by stepwise controlled drawing of maltose. Biomaterials 32(11), 3134-3140 (2011)
24. K. Matsuo, Y. Ishii, Y. Quan, F. Kamiyama, Y. Mukai, Y. Yoshioka, N. Okada, Sh. Nakagawa, Transcutaneous vaccination using a hydrogel patch induces effective immune responses to tetanus and diphtheria toxoid in hairless rat. J. Control Release 149, 15-20 (2011)
25. J.A. Mumford, H. Wilson, D. Hannant, D.M. Jessett, Antigenicity and immunogenicity of equine influenza vaccines containing a Carbomer adjuvant. Epidemiol. Infect. 112(2), 421-437 (1994)
26. S. Naito, Y. Ito, T. Kiyohara, M. Kataoka, M. Ochiai, K. Takada, Antigen-loaded dissolving microneedle array as a novel tool for percutaneous vaccination. Vaccine 30(6), 1191-1197 (2012)
27. M. Pearton, S.M. Kang, J.M. Song, Y.C. Kim, F.S. Quan, A. Anstey, M. Iyvor, M.R. Prausnitz, R.W. Compans, J.C. Birchall, Influenza virus-like particles coated onto microneedles can elicit stimulatory effects on Langerhans cells in human skin. Vaccine 28(37), 6104-6113 (2010)
28. B.E. Polat, D. Hart, R. Langer, D. Blankschtein, Ultrasound-mediated Transdermal drug delivery: mechanisms, scope, and emerging trends. J. Control Release. 152(3), 330-348 (2011)
29. M.R. Prausnitz, R. Langer, Transdermal drug delivery. Nat. Biotechnol. 26(11), 1261-1268 (2009)
30. Y. Qiu, G. Qin, S. Zhang, Y. Wu, B. Xu, Y. Gao, Novel lyophilized hydrogel patches for convenient and effective administration of microneedle-mediated insulin delivery. Int. J. Pharm. 437(1-2), 51-56 (2012)
31. G.A. Rizzuto, T. Merghoub, D. Hirschhorn-Cymerman, C. Liu, A.M. Lesokhin, D. Sahawneh, H. Zhong, K.S. Panageas, M.A. Perales, G. Altan-Bonnet, J.D. Wolchok, A.N. Houghton, Self-antigen-special CD8+ T cell precursor frequency determines the quality of the antitumor immune response. J. Exp. Med. 206(4), 849-866 (2009)
32. A. Shukla, O.P. Katare, B. Singh, S.P. Vyas, M-cell targeted delivery of recombinant epatitis B surface antigen using cholera toxin B subunit conjugated bilosomes. Int. J. Pharm. 385(1-2), 47-52 (2010)
33. R. Toll, U. Jacobi, H. Richter, J. Lademann, H. Schaefer, U. Blume-Peytavi, Penetration profile of microspheres in follicular targeting of terminal hair follicles. J. Invest Dwematol. 123(1), 168-176 (2004)
34. A. Vrdoljak, M.G. McGrath, J.B. Carey, S.J. Draper, A.V. Hill, C. O'Mahony, A.M. Crean, A.C. Moore, Coated microneedle arrays for transcutaneous delivery of live virus vaccines. J. Control Release. 159(1), 34-42 (2012)
35. S. Zhang, G. Qin, Y. Wu, Y. Gao, Y. Qiu, F. Li, B. Xu, Enhanced bioavailability of L-carnitine after painless intradermal delivery vs. oral administration in rats. Pharm. Res. 28(1), 117-123 (2011)