Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responses

Journal of Controlled Release

Volumn 159, Issue 2, 2012, Pages 215-221

  Fernando, Germain J P ^a   Chen, Xianfeng ^a   Primiero, Clare A ^a   Yukiko, Sally R ^a   Fairmaid, Emily J ^b   Corbett, Holly J ^a   Frazer, Ian H ^a   Brown, Lorena E ^b   Kendall, Mark A F ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Adjuvants; Dose sparing; Microneedles; Needle free vaccines; Skin immunization

Indexed keywords

ADJUVANTS; ANTIBODY RESPONSE; DELIVERY DEVICE; DOSE SPARING; IMMUNE CELLS; IMMUNE RESPONSE; IMMUNOGENICITY; INFLUENZA VACCINES; INHIBITION ASSAYS; INTRAMUSCULAR INJECTIONS; MICRONEEDLES; NANOPATCHES; TARGETED DELIVERY;

ANTIBODIES; CELL CULTURE; CELL PROLIFERATION; IMMUNOLOGY; MUSCLE; NEEDLES; SYRINGES; VACCINES;

ANTIGENS;

HEMAGGLUTININ; IMMUNOGLOBULIN G ANTIBODY; INFLUENZA VACCINE; QUIL A;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; FEMALE; IMMUNIZATION; IMMUNOCOMPETENT CELL; IMMUNOGENICITY; MOUSE; NEEDLE; NONHUMAN; PRIORITY JOURNAL; SKIN CELL; SYRINGE; TRANSDERMAL PATCH;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG SYNERGISM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOGLOBULIN G; INFLUENZA VACCINES; MICE; MICE, INBRED C57BL; MICROINJECTIONS; MICROSCOPY, ELECTRON, SCANNING; NANOSTRUCTURES; ORTHOMYXOVIRIDAE; SAPONINS; SKIN; SURFACE PROPERTIES; TRANSDERMAL PATCH;

EID: 84862776743     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.01.030     Document Type: Article

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