Enhanced bioavailability of L-carnitine after painless intradermal delivery vs. oral administration in rats

Pharmaceutical Research

Volumn 28, Issue 1, 2011, Pages 117-123

  Zhang, Suohui ^a,b   Qin, Guangjiong ^a,b   Wu, Yan ^a,b   Gao, Yunhua ^a   Qiu, Yuqin ^a   Li, Fang ^a   Xu, Bai ^a,c  

^a TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c Suzhou Natong Bionanotechnology Co Ltd   (China)

Author keywords

absolute bioavailability; functional microarray; hydrogel patch; intradermal delivery system; L carnitine; microneedles

Indexed keywords

CARBOMER; CARNITINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; HYDROGEL; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MEMBRANE TRANSPORT; MICRONEEDLE; NEEDLE; NONHUMAN; PERCUTANEOUS DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ACRYLIC RESINS; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CARNITINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; HUMANS; HYDROGELS; INJECTIONS, INTRADERMAL; MALE; MICROINJECTIONS; NEEDLES; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SKIN ABSORPTION; SWINE; TISSUE DISTRIBUTION;

EID: 78651226472     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0109-7     Document Type: Article

References (31)

1. Sharma S, Black SM. Carnitine homeostasis, mitochondrial function and cardiovascular disease. Drug Discovery Today: Disease Mechanisms in Press, corrected Proof (2009).
2. Gvozdjáková A. Carnitine. In: Gvozdjáková A, editor. Mitochondrial Medicine. Netherlands: Springer Netherlands; 2008. p. 357-66.
3. R Pons DC De Vivo 1995 Primary and secondary carnitine deficiency syndromes J Child Neurol 10 S8 S24 8576570
4. A Jusić 1992 Carnitine: physiologic role, primary and secondary deficiency Lijec Vjesn 114 166 171 1343053
5. AA Michael 1997 Carnitine and its derivatives in cardiovascular disease Prog Cardiovasc Dis 40 265 286 10.1016/S0033-0620(97)80037-0 (Pubitemid 28008762)
6. I Ilias I Manoli MR Blackman PW Gold S Alesci 2004 L-Carnitine and acetyl-L-carnitine in the treatment of complications associated with HIV infection and antiretroviral therapy Mitochondrion 4 163 168 1:CAS:528:DC%2BD2cXnvFWmu7Y%3D 10.1016/j.mito.2004.05.012 16120381 (Pubitemid 39549805)
7. EP Brass CL Hoppel WR Hiatt 1994 Effect of intravenous L-carnitine on carnitine homeostasis and fuel metabolism during exercise in humans Clin Pharmacol Ther 55 681 692 1:CAS:528:DyaK2cXmt1Wls7c%3D 10.1038/clpt.1994.85 8004884
8. KD Wutzke H Lorenz 2004 The effect of l-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects Metabolism 53 1002 1006 1:CAS:528:DC%2BD2cXmt1Cgsbs%3D 10.1016/j.metabol.2004. 03.007 15281008 (Pubitemid 38988283)
9. B Chang M Nishikawa S Nishiguchi M Inoue 2005 L-carnitine inhibits hepatocarcinogenesis via protection of mitochondria Int J Cancer 113 719 729 1:CAS:528:DC%2BD2MXnvFGisg%3D%3D 10.1002/ijc.20636 15499623 (Pubitemid 40101252)
10. S Ahmad 2001 L-carnitine in dialysis patients Semin Dialysis 14 209 217 1:STN:280:DC%2BD3MzmtlWktg%3D%3D 10.1046/j.1525-139X.2001.00055.x
11. M Costa D Canale M Filicori S D'Lddio A Lenzi 1994 L-carnitine in idiopathic asthenozoospermia: a multicenter study Andrologia 26 155 159 1:STN:280:DyaK2czmsl2gsw%3D%3D 10.1111/j.1439-0272.1994.tb00780.x 8085668
12. G Mingrone AV Greco E Capristo G Benedetti A Giancaterini A De Gaetano, et al. 1999 L-carnitine improves glucose disposal in type 2 diabetic patients J Am Coll Nutr 18 77 82 1:CAS:528:DyaK1MXhs1Cksbs%3D 10067662
13. AM Evans G Fornasini 2003 Pharmacokinetics of L-carnitine Clin Pharmacokinet 42 941 967 1:CAS:528:DC%2BD3sXnslGms74%3D 10.2165/00003088- 200342110-00002 12908852 (Pubitemid 37056103)
14. H Gudjonsson BU Li AL Shug WA Olsen 1985 Studies of carnitine metabolism in relation to intestinal absorption Am J Physiol 248 G313 G319 1:CAS:528:DyaL2MXhsVKlsbw%3D 3976890
15. CJ Rebouche DL Mack PF Edmonson 1984 L-Carnitine dissimilation in the gastrointestinal tract of the rat Biochemistry 23 6422 6426 1:CAS:528: DyaL2MXjs1Kh 10.1021/bi00321a022 6529558 (Pubitemid 15167729)
16. P Harper CE Elwin G Cederblad 1988 Pharmacokinetics of bolus intravenous and oral doses of L-carnitine in healthy subjects Eur J Clin Pharmacol 35 69 75 1:CAS:528:DyaL1cXlvV2iu7s%3D 10.1007/BF00555510 3220097
17. EP Brass 1995 Pharmacokinetic considerations for the therapeutic use of carnitine in hemodialysis patients Clin Ther 17 176 185 1:STN:280: DyaK2MzjvFeksg%3D%3D 10.1016/0149-2918(95)80017-4 7614519
18. Schulz J, Kroepke R, Schepky A, Eckert J, Koop U, Faenger S. Cosmetic combination product for improving appearance. U.S. Patent 11, 839, 384, Aug. 28, 2008.
19. Madison Metabolomics Consortium Database, ( http://mmcd.nmrfam.wisc.edu/ test/cqsearch.py?cqid=cq-09878 ) (assessed 10/01/09).
20. MI Haq E Smith DN John M Kalavala C Edwards A Anstey, et al. 2009 Clinical administration of microneedles: skin puncture, pain and sensation Biomed Microdevices 11 35 47 1:STN:280:DC%2BD1M7hvVKntA%3D%3D 10.1007/s10544-008-9208-1 18663579
21. Y Xie B Xu Y Gao 2005 Controlled transdermal delivery of model drug compounds by MEMS microneedle array Nanomedicine 1 184 190 1:CAS:528: DC%2BD2MXpsFCgtLw%3D 17292077
22. Y Qiu Y Gao K Hu F Li 2008 Enhancement of skin permeation of docetaxel: a novel approach combining microneedle and elastic liposomes J Control Release 129 144 150 1:CAS:528:DC%2BD1cXnsFaltbc%3D 10.1016/j.jconrel.2008.04.019 18538885
23. Y Wu Y Qiu S Zhang G Qin Y Gao 2008 Microneedle-based drug delivery: studies on delivery parameters and biocompatibility Biomed Microdevices 10 601 610 1:CAS:528:DC%2BD1cXpsVGntL8%3D 10.1007/s10544-008-9171-x 18324474
24. Li X, Zhao R, Qin Z, Zhang J, Zhai S, Qiu Y, et al. Microneedle pretreatment improves efficacy of cutaneous topical anesthesia. Am J Emerg Med. doi: 10.1016/j.ajem.2008.10.001.
25. N Kanikkannan J Singh P Ramarao 2001 Transdermal iontophoretic transport of timolol maleate: effect of age and species J Control Release 71 99 105 1:CAS:528:DC%2BD3MXhs1WjsL8%3D 10.1016/S0168-3659(01)00208-5 11245911 (Pubitemid 32195444)
26. R van der Geest M Danhof HE Bodde 1997 Iontophoretic delivery of apomorphine. I: In Vitro optimization and validation Pharm Res 14 1798 1803 10.1023/A:1012100417645 9453071 (Pubitemid 28062928)
27. Stinchcomb AL, Banks SL. Methods and compositions for enhancing the viability of microneedle pores. U.S. Patent 12, 325, 919, Jun. 4, 2009.
28. G Li A Badkar S Nema CS Kolli AK Banga 2009 In Vitro transdermal delivery of therapeutic antibodies using maltose microneedles Int J Pharm 368 109 115 1:CAS:528:DC%2BD1MXhsFertrY%3D 10.1016/j.ijpharm.2008.10.008 18996461
29. T Macedo LH Block AJ Shukla 1993 Release of tolmetin from carbomer gel systems Drug Dev Ind Pharm 19 887 902 1:CAS:528:DyaK3sXis1Srurc%3D 10.3109/03639049309062989
30. J Ceulemans A Ludwig 2002 Optimisation of carbomer viscous eye drops: an In Vitro experimental design approach using rheological techniques Eur J Pharm Biopharm 54 41 50 1:CAS:528:DC%2BD38XkslKisbo%3D 10.1016/S0939-6411(02)00036-X 12084501 (Pubitemid 34663855)
31. K Matsuda H Yuasa J Watnabe 1998 Physiological mechanism-based analysis of dose-dependentgastrointestinal absorption of L-carnitine in rats Biopharm Drug Dispos 19 465 472 1:CAS:528:DyaK1cXmslKgt7k%3D 10.1002/(SICI)1099- 081X(199810)19:7<465::AID-BDD126>3.0.CO;2-E 9818713 (Pubitemid 28474563)