High dose of extracellular ATP switched autophagy to apoptosis in anchorage-dependent and anchorage-independent hepatoma cells

Purinergic Signalling

Volumn 9, Issue 4, 2013, Pages 585-598

  Wei, Qing ^a   Zhang, Ying ^a   Sun, Lei ^a   Jia, Xiaoqing ^b   Huai, Wanwan ^a   Yu, Chengcheng ^c   Wan, Zhengkun ^a   Han, Lihui ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c China dmskzs238 163com   (China)

Author keywords

AMPK; Anoikis; Apoptosis; Autophagy; Extracellular ATP; mTOR

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 9; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; S6 KINASE;

ANCHORAGE INDEPENDENT GROWTH; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; AUTOPHAGY; CELL VIABILITY ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; HEPATOMA CELL; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION; TUMOR MICROENVIRONMENT; UPREGULATION; WESTERN BLOTTING; CELL ADHESION; DOSE RESPONSE; DRUG EFFECTS; EXTRACELLULAR FLUID; LIVER CELL CARCINOMA; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; APOPTOSIS; AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR FLUID; HUMANS; TUMOR MICROENVIRONMENT;

EID: 84890548611     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-013-9369-0     Document Type: Article

References (37)

1. Bours MJ, Dagnelie PC, Giuliani AL, Wesselius A, Di Virgilio F (2011) P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation. Front Biosci (Schol Ed) 3: 1443-1456.
2. Apolloni S, Montilli C, Finocchi P, Amadio S (2009) Membrane compartments and purinergic signalling: P2X receptors in neurodegenerative and neuroinflammatory events. FEBS J 276(2): 354-364.
3. Deli T, Csernoch L (2008) Extracellular ATP and cancer: an overview with special reference to P2 purinergic receptors. Pathol Oncol Res 14(3): 219-231.
4. Pellegatti P, Raffaghello L, Bianchi G, Piccardi F, Pistoia V, Di Virgilio F (2008) Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase. PLoS One 3(7): e2599.
5. Robson SC, Sevigny J, Zimmermann H (2006) The E-NTPDase family of ectonucleotidases: structure function relationships and pathophysiological significance. Purinergic Signal 2(2): 409-430.
6. Feng L, Sun X, Csizmadia E, Han L, Bian S, Murakami T, Wang X, Robson SC, Wu Y (2011) Vascular CD39/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphate. Neoplasia 13(3): 206-216.
7. Taddei ML, Giannoni E, Fiaschi T, Chiarugi P (2011) Anoikis: an emerging hallmark in health and diseases. J Pathol. doi: 10. 1002/path. 3000.
8. Taddei ML, Giannoni E, Fiaschi T, Chiarugi P (2012) Anoikis: an emerging hallmark in health and diseases. J Pathol 226(2): 380-393.
9. Zhang Z, Cao L, Li J, Liang X, Liu Y, Liu H, Du J, Qu Z, Cui M, Liu S, Gao L, Ma C, Zhang L, Han L, Sun W (2008) Acquisition of anoikis resistance reveals a synoikis-like survival style in BEL7402 hepatoma cells. Cancer Lett 267(1): 106-115.
10. Giansanti V, Torriglia A, Scovassi AI (2011) Conversation between apoptosis and autophagy: "is it your turn or mine?". Apoptosis 16(4): 321-333.
11. Thorburn A (2008) Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis 13(1): 1-9.
12. Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A (2009) Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ 16(7): 966-975.
13. Corcelle EA, Puustinen P, Jaattela M (2009) Apoptosis and autophagy: targeting autophagy signalling in cancer cells-'trick or treats'? FEBS J 276(21): 6084-6096.
14. Mora R, Regnier-Vigouroux A (2009) Autophagy-driven cell fate decision maker: activated microglia induce specific death of glioma cells by a blockade of basal autophagic flux and secondary apoptosis/necrosis. Autophagy 5(3): 419-421.
15. Guillon-Munos A, van Bemmelen MX, Clarke PG (2006) Autophagy can be a killer even in apoptosis-competent cells. Autophagy 2(2): 140-142.
16. Cao L, Han L, Zhang Z, Li J, Qu Z, Du J, Liang X, Liu Y, Liu H, Shi Y, Liu S, Gao L, Sun W (2009) Involvement of anoikis-resistance in the metastasis of hepatoma cells. Exp Cell Res 315(7): 1148-1156.
17. Almonte-Becerril M, Navarro-Garcia F, Gonzalez-Robles A, Vega-Lopez MA, Lavalle C, Kouri JB (2010) Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of osteoarthritis within an experimental model. Apoptosis 15(5): 631-638.
18. Kim YM, Hwang JT, Kwak DW, Lee YK, Park OJ (2007) Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells. Ann N Y Acad Sci 1095: 496-503.
19. Wang X, Pan X, Song J (2010) AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition. Cell Signal 22(11): 1790-1797.
20. Ikenoue T, Hong S, Inoki K (2009) Monitoring mammalian target of rapamycin (mTOR) activity. Methods Enzymol 452: 165-180.
21. Villalonga P, Fernandez de Mattos S, Ridley AJ (2009) RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation. J Biol Chem 284(51): 35287-35296.
22. Moody CA, Scott RS, Amirghahari N, Nathan CO, Young LS, Dawson CW, Sixbey JW (2005) Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A. J Virol 79(9): 5499-5506.
23. Shabbir M, Burnstock G (2009) Purinergic receptor-mediated effects of adenosine 5'-triphosphate in urological malignant diseases. Int J Urol 16(2): 143-150.
24. Stagg J, Smyth MJ (2010) Extracellular adenosine triphosphate and adenosine in cancer. Oncogene 29(39): 5346-5358.
25. Zhang Y, Gong LH, Zhang HQ, Du Q, You JF, Tian XX, Fang WG (2010) Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression. Cancer Lett 293(2): 189-197.
26. Yaguchi T, Saito M, Yasuda Y, Kanno T, Nakano T, Nishizaki T (2010) Higher concentrations of extracellular ATP suppress proliferation of Caco-2 human colonic cancer cells via an unknown receptor involving PKC inhibition. Cell Physiol Biochem 26(2): 125-134.
27. White N, Burnstock G (2006) P2 receptors and cancer. Trends Pharmacol Sci 27(4): 211-217.
28. Pantovic A, Krstic A, Janjetovic K, Kocic J, Harhaji-Trajkovic L, Bugarski D, Trajkovic V (2013) Coordinated time-dependent modulation of AMPK/Akt/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells. Bone 52(1): 524-531.
29. Liu X, Yuan H, Niu Y, Niu W, Fu L (2012) The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice. Biochim Biophys Acta 1822(11): 1716-1726.
30. Green AS, Chapuis N, Lacombe C, Mayeux P, Bouscary D, Tamburini J (2011) LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology. Cell Cycle 10(13): 2115-2120.
31. Bian S, Sun X, Bai A, Zhang C, Li L, Enjyoji K, Junger WG, Robson SC, Wu Y (2013) P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death. PLoS One 8(4): e60184.
32. Sun X, Han L, Seth P, Bian S, Li L, Csizmadia E, Junger WG, Schmelzle M, Usheva A, Tapper EB, Baffy G, Sukhatme VP, Wu Y, Robson SC (2013) Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice. Hepatology 57(1): 205-216.
33. Grander D, Panaretakis T (2010) Autophagy: cancer therapy's friend or foe? Future Med Chem 2(2): 285-297.
34. Moretti L, Yang ES, Kim KW, Lu B (2007) Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy. Drug Resist Updat 10(4-5): 135-143.
35. Clayton A, Al-Taei S, Webber J, Mason MD, Tabi Z (2011) Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production. J Immunol 187(2): 676-683.
36. Wood E, Broekman MJ, Kirley TL, Diani-Moore S, Tickner M, Drosopoulos JH, Islam N, Park JI, Marcus AJ, Rifkind AB (2002) Cell-type specificity of ectonucleotidase expression and upregulation by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Arch Biochem Biophys 407(1): 49-62.
37. Fausther M, Lecka J, Kukulski F, Levesque SA, Pelletier J, Zimmermann H, Dranoff JA, Sevigny J (2007) Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8. Am J Physiol Gastrointest Liver Physiol 292(3): G785-G795.