The feline bile salt export pump: A structural and functional comparison with canine and human Bsep/BSEP

BMC Veterinary Research

Volumn 9, Issue , 2013, Pages

  van Beusekom, Cyrina D ^a   van den Heuvel, Jeroen J M W ^b   Koenderink, Jan B ^b   Schrickx, Johannes A ^a   Russel, Frans G M ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

ABCB11; Bile acids; BSEP; Cat; Dog; Drugs; Inhibitor; Liver; Toxicity; Transporter

Indexed keywords

ANIMALIA; CANIS FAMILIARIS; FELIDAE;

ABC TRANSPORTER; ABCB11 PROTEIN, HUMAN; BILE ACID;

AMINO ACID SEQUENCE; ANIMAL; ANIMAL DISEASE; ARTICLE; CAT; CHEMISTRY; COMPARATIVE STUDY; DOG; GENETICS; HEK293 CELL LINE; HUMAN; LIVER; LIVER DISEASE; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; BILE ACIDS AND SALTS; CATS; CLONING, MOLECULAR; DOGS; HEK293 CELLS; HUMANS; LIVER; LIVER DISEASES; MOLECULAR SEQUENCE DATA;

EID: 84890531764     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/1746-6148-9-259     Document Type: Article

References (21)

1. Kullak-Ublick GA, Meier PJ. Mechanisms of cholestasis. Clin Liver Dis 2000, 4(2):357-385. 10.1016/S1089-3261(05)70114-8, 11232196.
2. Nicolaou M, Andress EJ, Zolnerciks JK, Dixon PH, Williamson C, Linton KJ. Canalicular ABC transporters and liver disease. J Pathol 2012, 226(2):300-315. 10.1002/path.3019, 21984474.
3. Kubitz R, Droge C, Stindt J, Weissenberger K, Haussinger D. The bile salt export pump (BSEP) in health and disease. Clin Res Hepatol Gastroenterol 2012, 36(6):536-553. 10.1016/j.clinre.2012.06.006, 22795478.
4. Funk C, Ponelle C, Scheuermann G, Pantze M. Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat. Mol Pharmacol 2001, 59(3):627-635.
5. Horikawa M, Kato Y, Tyson CA, Sugiyama Y. Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans. Drug Metab Pharmacokinet 2003, 18(1):16-22. 10.2133/dmpk.18.16, 15618715.
6. Stieger B. The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation. Handb Exp Pharmacol 2011, 201(201):205-259.
7. Watson PJ. Chronic hepatitis in dogs: a review of current understanding of the aetiology, progression, and treatment. Vet J 2004, 167(3):228-241. 10.1016/S1090-0233(03)00118-7, 15080872.
8. Bunch SE. Hepatotoxicity associated with pharmacologic agents in dogs and cats. Vet Clin North Am Small Anim Pract 1993, 23(3):659-670.
9. Woodward KN. Veterinary pharmacovigilance: Part 3: adverse effects of veterinary medicinal products in animals and on the environment. J Vet Pharmacol Ther 2005, 28(2):171-184. 10.1111/j.1365-2885.2005.00647.x, 15842306.
10. Daniels JS, Lai Y, South S, Chiang PC, Walker D, Feng B, Mireles R, Whiteley LO, McKenzie JW, Stevens J, Mourey R, Anderson D, Davis JW. Inhibition of hepatobiliary transporters by a novel kinase inhibitor contributes to hepatotoxicity in beagle dogs. Drug Metab Lett 2013, 7:15-22.
11. Yabuuchi H, Tanaka K, Maeda M, Takemura M, Oka M, Ohashi R, Tamai I. Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins. Biopharm Drug Dispos 2008, 29(8):441-448. 10.1002/bdd.629, 18985798.
12. Noe J, Stieger B, Meier PJ. Functional expression of the canalicular bile salt export pump of human liver. Gastroenterology 2002, 123(5):1659-1666. 10.1053/gast.2002.36587, 12404240.
13. Wittgen HGM, Van Den Heuvel JJMW, Van Den Broek PHH, Dinter-Heidorn H, Koenderink JB, Russel FGM. Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4. Drug Metab Disposition 2011, 39(7):1294-1302.
14. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254. 10.1016/0003-2697(76)90527-3, 942051.
15. Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, Hofmann AF, Meier PJ. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem 1998, 273(16):10046-10050. 10.1074/jbc.273.16.10046, 9545351.
16. Sato T, Kodan A, Kimura Y, Ueda K, Nakatsu T, Kato H. Functional role of the linker region in purified human P-glycoprotein. FEBS J 2009, 276(13):3504-3516. 10.1111/j.1742-4658.2009.07072.x, 19490125.
17. Kolling R, Losko S. The linker region of the ABC-transporter Ste6 mediates ubiquitination and fast turnover of the protein. EMBO J 1997, 16(9):2251-2261. 10.1093/emboj/16.9.2251, 1169827, 9171340.
18. Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ. The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology 2002, 123(5):1649-1658. 10.1053/gast.2002.36591, 12404239.
19. Washizu T, Tomoda I, Kaneko JJ. Serum bile acid composition of the dog, cow, horse and human. J Vet Med Sci 1991, 53(1):81-86. 10.1292/jvms.53.81, 1830784.
20. Wildgrube HJ, Stockhausen H, Petri J, Fussel U, Lauer H. Naturally occurring conjugated bile acids, measured by high-performance liquid chromatography, in human, dog, and rabbit bile. J Chromatogr 1986, 353:207-213.
21. Perwaiz S, Tuchweber B, Mignault D, Gilat T, Yousef IM. Determination of bile acids in biological fluids by liquid chromatography-electrospray tandem mass spectrometry. J Lipid Res 2001, 42(1):114-119.