Design, synthesis, and biological testing of novel naphthoquinones as substrate-based inhibitors of the quinol/fumarate reductase from Wolinella succinogenes

Journal of Medicinal Chemistry

Volumn 56, Issue 23, 2013, Pages 9530-9541

  Nasiri, Hamid Reza ^a,e   Madej, M Gregor ^b,f   Panisch, Robin ^a   Lafontaine, Michael ^c   Bats, Jan W ^a   Lancaster, C Roy D ^b,c   Schwalbe, Harald ^a,d  

^a GOETHE UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 BROMO 3 ETHYL 1,4 NAPHTHOQUINONE; 2 BROMO 3 HEXYL 1,4 NAPHTHOQUINONE; 2 BROMO 3 METHYL 1,4 NAPHTHOQUINONE; 2 ETHYL 3 METHOXY 1,4 NAPHTHOQUINONE; 2 HEXYL 3 METHOXY 1,4 NAPHTHOQUINONE; 2 HYDROXY 3 (3 PHENYLPROPYL) 1,4 NAPHTHOQUINONE; ALKYL GROUP; BACTERIAL PROTEIN; ENZYME INHIBITOR; FUMARATE REDUCTASE; HYDROXYL GROUP; LAWSONE; PHTHIOCOL; QUINOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BIOLOGICAL ACTIVITY; CAMPYLOBACTER JEJUNI; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HELICOBACTER PYLORI; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION; TAUTOMER; WOLINELLA SUCCINOGENES;

EID: 84890481276     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400978u     Document Type: Article

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