MiR-375 inhibits proliferation of mouse pancreatic progenitor cells by targeting YAP1

Cellular Physiology and Biochemistry

Volumn 32, Issue 6, 2013, Pages 1808-1817

  Zhang, Zhen Wu ^a   Men, Tong ^a   Feng, Rui Cheng ^a   Li, Yun Chao ^a   Zhou, Di ^a   Teng, Chun Bo ^a  

^a NORTHEAST FORESTRY UNIVERSITY   (China)

Author keywords

miR 375; Pancreas; Progenitor cells; Proliferation; YAP1

Indexed keywords

BETA ACTIN; CHOLECYSTOKININ OCTAPEPTIDE; KI 67 ANTIGEN; MESSENGER RNA; MICRORNA 375; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR YAP1;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; GENE SILENCING; GENE TARGETING; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUCIFERASE ASSAY; MOUSE; NONHUMAN; PANCREAS CELL; PANCREATIC PROGENITOR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; WESTERN BLOTTING; ADULT; ADULT STEM CELL; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; EMBRYONIC STEM CELL; PROTEIN TARGETING; SPATIOTEMPORAL ANALYSIS; STOP CODON;

3' UNTRANSLATED REGIONS; 3T3 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BASE SEQUENCE; CELL PROLIFERATION; CELLS, CULTURED; MICE; MICRORNAS; PANCREAS; PHOSPHOPROTEINS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SEQUENCE ALIGNMENT; STEM CELLS;

EID: 84890479052     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000356614     Document Type: Article

References (38)

1. Stanger BZ, Tanaka AJ, Melton DA: Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 2007;445:886-891.
2. Burdon T, Smith A, Savatier P: Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol 2002;12:432-438.
3. Alarcon C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, Barlas A, Miller AN, Manova-Todorova K, Macias MJ, Sapkota G, Pan D, Massague J: Nuclear cdks drive smad transcriptional activation and turnover in bmp and tgf-beta pathways. Cell 2009;139:757-769.
4. Zhao B, Li L, Lei Q, Guan KL: The hippo-yap pathway in organ size control and tumorigenesis: an updated version. Genes Dev 2010;24:862-874.
5. Zhao B, Tumaneng K, Guan KL: The hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol 2011;13:877-883.
6. Csibi A, Blenis J: Hippo-yap and mtor pathways collaborate to regulate organ size. Nat Cell Biol 2012;14:1244-1245.
7. Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein LS, Abujarour R, Ding S, Guan KL: The role of yap transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev 2010;24:1106-1118.
8. Camargo FD, Gokhale S, Johnnidis JB, Fu D, Bell GW, Jaenisch R, Brummelkamp TR: Yap1 increases organ size and expands undifferentiated progenitor cells. Curr Biol 2007;17:2054-2060.
9. Zhang H, Pasolli HA, Fuchs E: Yes-associated protein (yap) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci U S A 2011;108:2270-2275.
10. Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD: Yap1 acts downstream of alpha-catenin to control epidermal proliferation. Cell 2011;144:782-795.
11. Gittes GK: Developmental biology of the pancreas: a comprehensive review. Dev Biol 2009;326:4-35.
12. Gu G, Dubauskaite J, Melton DA: Direct evidence for the pancreatic lineage: ngn3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002;129:2447-2457.
13. Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV: The role of the transcriptional regulator ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 2002;32:128-134.
14. George NM, Day CE, Boerner BP, Johnson RL, Sarvetnick NE: Hippo signaling regulates pancreas development through inactivation of yap. Mol Cell Biol 2012;32:5116-5128.
15. Gao T, Zhou D, Yang C, Singh T, Penzo-Mendez A, Maddipati R, Tzatsos A, Bardeesy N, Avruch J, Stanger BZ: Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology 2013;144:1543-1553.
16. Bonner-Weir S, Toschi E, Inada A, Reitz P, Fonseca SY, Aye T, Sharma A: The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr Diabetes 2004;5:S16-22.
17. Rovira M, Scott SG, Liss AS, Jensen J, Thayer SP, Leach SD: Isolation and characterization of centroacinar/ terminal ductal progenitor cells in adult mouse pancreas. Proc Natl Acad Sci USA 2010;107:75-80.
18. Liu AM, Poon RT, Luk JM: Microrna-375 targets hippo-signaling effector yap in liver cancer and inhibits tumor properties. Biochem Biophys Res Commun 2010;394:623-627.
19. Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M: A pancreatic islet-specific microrna regulates insulin secretion. Nature 2004;432:226-230.
20. Zhang ZW, Zhang LQ, Ding L, Wang F, Sun YJ, An Y, Zhao Y, Li YH, Teng CB: Microrna-19b downregulates insulin 1 through targeting transcription factor neurod1. Febs Lett 2011;585:2592-2598.
21. Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, Wang Y, Halder G, Finegold MJ, Lee JS, Johnson RL: Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci USA 2010;107:1437-1442.
22. Lewis BP, Burge CB, Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microrna targets. Cell 2005;120:15-20.
23. Bartel DP: Micrornas: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-297.
24. Poy MN, Hausser J, Trajkovski M, Braun M, Collins S, Rorsman P, Zavolan M, Stoffel M: Mir-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci US A 2009;106:5813-5818.
25. Zhou J, Song S, Cen J, Zhu D, Li D, Zhang Z: Microrna-375 is downregulated in pancreatic cancer and inhibits cell proliferation in vitro. Oncol Res 2012;20:197-203.
26. Nohata N, Hanazawa T, Kikkawa N, Mutallip M, Sakurai D, Fujimura L, Kawakami K, Chiyomaru T, Yoshino H, Enokida H, Nakagawa M, Okamoto Y, Seki N: Tumor suppressive microrna-375 regulates oncogene aeg-1/ mtdh in head and neck squamous cell carcinoma (hnscc). J Hum Genet 2011;56:595-601.
27. Tsukamoto Y, Nakada C, Noguchi T, Tanigawa M, Nguyen LT, Uchida T, Hijiya N, Matsuura K, Fujioka T, Seto M, Moriyama M: Microrna-375 is downregulated in gastric carcinomas and regulates cell survival by targeting pdk1 and 14-3-3zeta. Cancer Res 2010;70:2339-2349.
28. Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML: Tead/tef transcription factors utilize the activation domain of yap65, a src/yes-associated protein localized in the cytoplasm. Genes Dev 2001;15:1229-1241.
29. Zhao B, Li L, Tumaneng K, Wang CY, Guan KL: A coordinated phosphorylation by lats and ck1 regulates yap stability through scf (beta-trcp). Genes Dev 2010;24:72-85.
30. Lynn FC, Skewes-Cox P, Kosaka Y, McManus MT, Harfe BD, German MS: Microrna expression is required for pancreatic islet cell genesis in the mouse. Diabetes 2007;56:2938-2945.
31. Yu SJ, Hu JY, Kuang XY, Luo JM, Hou YF, di GH, Wu J, Shen ZZ, Song HY, Shao ZM: Microrna-200a promotes anoikis resistance and metastasis by targeting yap1 in human breast cancer. Clin Cancer Res 2013;19:1389-1399.
32. Ehsanian R, Brown M, Lu H, Yang XP, Pattatheyil A, Yan B, Duggal P, Chuang R, Doondeea J, Feller S, Sudol M, Chen Z, Van Waes C: Yap dysregulation by phosphorylation or deltanp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets. Oncogene 2010;29:6160-6171.
33. Lonardo E, Hermann PC, Heeschen C: Pancreatic cancer stem cells - update and future perspectives. Mol Oncol 2010;4:431-442.
34. Pan D: The hippo signaling pathway in development and cancer. Dev Cell 2010;19:491-505.
35. Xu MZ, Yao TJ, Lee NP, Ng IO, Chan YT, Zender L, Lowe SW, Poon RT, Luk JM: Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma. Cancer 2009;115:4576-4585.
36. Wang Y, Dong Q, Zhang Q, Li Z, Wang E, Qiu X: Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer. Cancer Sci 2010;101:1279-1285.
37. Zhang X, George J, Deb S, Degoutin JL, Takano EA, Fox SB, Bowtell DD, Harvey KF: The hippo pathway transcriptional co-activator, yap, is an ovarian cancer oncogene. Oncogene 2011;30:2810-2822.
38. Muramatsu T, Imoto I, Matsui T, Kozaki K, Haruki S, Sudol M, Shimada Y, Tsuda H, Kawano T, Inazawa J: Yap is a candidate oncogene for esophageal squamous cell carcinoma. Carcinogenesis 2011;32:389-398.