MicroRNA-375 is downregulated in pancreatic cancer and inhibits cell proliferation in vitro

Oncology Research

Volumn 20, Issue 5-6, 2013, Pages 197-203

  Zhou, Jian ^a   Song, Shiduo ^a   Cen, Jiannong ^b   Zhu, Dongming ^a   Li, Dechun ^a   Zhang, Zixiang ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b Jiangsu Institute of Hematology   (China)

Author keywords

Apoptosis; Clinicopathological features; MicroRNA 375; Pancreatic cancer

Indexed keywords

CCK8 PROTEIN; MICRORNA 375; PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER LOCALIZATION; CANCER SIZE; CANCER TISSUE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; GENDER; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GROWTH RATE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LYMPH NODE METASTASIS; MALE; PANCREAS CANCER; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

EID: 84875635496     PISSN: 09650407     EISSN: 15553906     Source Type: Journal    
DOI: 10.3727/096504013X13589503482734     Document Type: Article

References (31)

1. Guo, X.; Cui, Z. Current diagnosis and treatment of pancreatic cancer in China. Pancreas 31(1): 13-22; 2005.
2. Russo, S.; Butler, J.; Ove, R.; Blackstock, A. W. Locally advanced pancreatic cancer: A review. Semin. Oncol. 34(4): 327-334; 2007.
3. Li, D.; Xie, K.; Wolff, R.; Abbruzzese, J. L. Pancreatic cancer. Lancet 363(9414): 1049-1057; 2004.
4. Vincent, A.; Herman, J.; Schulick, R.; Hruban, R. H.; Goggins, M. Pancreatic cancer. Lancet 378(9791): 607-620; 2011.
5. Bartel, D. P. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116(2): 281-297; 2004.
6. Baek, D.; Villen, J.; Shin, C.; Camargo, F. D.; Gygi, S. P.; Bartel, D. P. The impact of microRNAs on protein output. Nature 455(7209): 64-71; 2008.
7. Croce, C. M. Causes and consequences of microRNA dys-regulation in cancer. Nat. Rev. Genet. 10(10): 704-714; 2009.
8. Moriyama, T.; Ohuchida, K.; Mizumoto, K.; Yu, J.; Sato, N.; Nabae, T.; Takahata, S.; Toma, H.; Nagai, E.; Tanaka, M. MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance. Mol. Cancer Ther. 8(5): 1067-1074; 2009.
9. Ryu, J. K.; Hong, S. M.; Karikari, C. A.; Hruban, R. H.; Goggins, M. G.; Maitra, A. Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma. Pancreatology 10(1): 66-73; 2010.
10. Ji, Q.; Hao, X.; Zhang, M.; Tang, W.; Yang, M.; Li, L.; Xiang, D.; Desano, J. T.; Bommer, G. T.; Fan, D. and others. MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PloS One 4(8):e6816; 2009.
11. Liffers, S. T.; Munding, J. B.; Vogt, M.; Kuhlmann, J. D.; Verdoodt, B.; Nambiar, S.; Maghnouj, A.; Mirmohammadsadegh, A.; Hahn, S. A.; Tannapfel, A. MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B. Lab. Invest. 91(10): 1472-1479; 2011.
12. Yu, J.; Ohuchida, K.; Mizumoto, K.; Fujita, H.; Nakata, K.; Tanaka, M. MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion. Cancer Biol. Ther. 10(8): 748-757; 2010.
13. Poy, M. N.; Eliasson, L.; Krutzfeldt, J.; Kuwajima, S.; Ma, X.; Macdonald, P. E.; Pfeffer, S.; Tuschl, T.; Rajewsky, N.; Rorsman, P.; et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature 432(7014): 226-230; 2004.
14. Hui, A. B.; Bruce, J. P.; Alajez, N. M.; Shi, W.; Yue, S.; Perez-Ordonez, B.; Xu, W.; O'Sullivan, B.; Waldron, J.; Cummings, B.; et al. Significance of dysregulated metad-herin and microRNA-375 in head and neck cancer. Clin. Cancer Res. 17(24): 7539-7550; 2011.
15. Liu, A. M.; Poon, R. T.; Luk, J. M. MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties. Biochem. Biophys. Res. Commun. 394(3): 623-627; 2010.
16. Tsukamoto, Y.; Nakada, C.; Noguchi, T.; Tanigawa, M.; Nguyen, L. T.; Uchida, T.; Hijiya, N.; Matsuura, K.; Fujioka, T.; Seto, M. and others. MicroRNA-375 is down-regulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res. 70(6): 2339-2349; 2010.
17. Dai, X.; Chiang, Y.; Wang, Z.; Song, Y.; Lu, C.; Gao, P.; Xu, H. Expression levels of microRNA-375 in colorectal carcinoma. Mol. Med. Rep. 5(5): 1299-1304; 2012.
18. Bloomston, M.; Frankel, W. L.; Petrocca, F.; Volinia, S.; Alder, H.; Hagan, J. P.; Liu, C. G.; Bhatt, D.; Taccioli, C.; Croce, C. M. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA 297(17): 1901-1908; 2007.
19. Basu, A.; Alder, H.; Khiyami, A.; Leahy, P.; Croce, C. M.; Haldar, S. MicroRNA-375 and MicroRNA-221: Potential noncoding RNAs associated with antiprolifera-tive activity of benzyl isothiocyanate in pancreatic cancer. Genes Cancer 2(2): 108-119; 2011.
20. Wang, X.; Tang, S.; Le, S. Y.; Lu, R.; Rader, J. S.; Meyers, C.; Zheng, Z. M. Aberrant expression of onco-genic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PloS One 3(7): e2557; 2008.
21. Chun-Zhi, Z.; Lei, H.; An-Ling, Z.; Yan-Chao, F.; Xiao, Y.; Guang-Xiu, W.; Zhi-Fan, J.; Pei-Yu, P.; Qing-Yu, Z.; Chun-Sheng, K. MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresis-tance by targeting PTEN. BMC Cancer 10:367; 2010.
22. Ma, L.; Teruya-Feldstein, J.; Weinberg, R. A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449(7163): 682-688; 2007.
23. Chang, K. H.; Mestdagh, P.; Vandesompele, J.; Kerin, M. J.; Miller, N. MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer. BMC Cancer 10:173; 2010.
24. Faggad, A.; Kasajima, A.; Weichert, W.; Stenzinger, A.; Elwali, N. E.; Dietel, M.; Denkert, C. Down-regulation of the microRNA processing enzyme Dicer is a prognostic factor in human colorectal cancer. Histopathology 61(4): 552-561; 2012.
25. Lu, J.; Getz, G.; Miska, E. A.; Alvarez-Saavedra, E.; Lamb, J.; Peck, D.; Sweet-Cordero, A.; Ebert, B. L.; Mak, R. H.; Ferrando, A. A.; et al. MicroRNA expression profiles classify human cancers. Nature 435(7043): 834-838; 2005.
26. Kota, J.; Chivukula, R. R.; O'Donnell, K. A.; Wentzel, E. A.; Montgomery, C. L.; Hwang, H. W.; Chang, T. C.; Vivekanandan, P.; Torbenson, M.; Clark, K. R.; et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137(6): 1005-1017; 2009.
27. Panarelli, N. C.; Chen, Y. T.; Zhou, X. K.; Kitabayashi, N.; Yantiss, R. K. MicroRNA expression aids the pre-operative diagnosis of pancreatic ductal adenocarcinoma. Pancreas 41(5): 685-690; 2012.
28. Szafranska, A. E.; Davison, T. S.; John, J.; Cannon, T.; Sipos, B.; Maghnouj, A.; Labourier, E.; Hahn, S. A. MicroRNA expression alterations are linked to tumorigen-esis and non-neoplastic processes in pancreatic ductal ade-nocarcinoma. Oncogene 26(30): 4442-4452; 2007.
29. Giovannetti, E.; Funel, N.; Peters, G. J.; Del Chiaro, M.; Erozenci, L. A.; Vasile, E.; Leon, L. G.; Pollina, L. E.; Groen, A.; Falcone, A.; et al. MicroRNA-21 in pancreatic cancer: Correlation with clinical outcome and pharmaco-logic aspects underlying its role in the modulation of gem-citabine activity. Cancer Res. 70(11): 4528-4538; 2010.
30. Lee, E. J.; Gusev, Y.; Jiang, J.; Nuovo, G. J.; Lerner, M. R.; Frankel, W. L.; Morgan, D. L.; Postier, R. G.; Brackett, D. J.; Schmittgen, T. D. Expression profiling identifies microRNA signature in pancreatic cancer. Int. J. Cancer 120(5): 1046-1054; 2007.
31. He, X. X.; Chang, Y.; Meng, F. Y.; Wang, M. Y.; Xie, Q. H.; Tang, F.; Li, P. Y.; Song, Y. H.; Lin, J. S. MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo. Oncogene 31(28): 3357-3369; 2012.