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Volumn 13, Issue 1, 2014, Pages 25-43

Anticoagulant failure in coagulopathic patients: PTT confounding and other pitfalls

Author keywords

(activated) partial thromboplastin time (PTT); Confounding; Disseminated intravascular coagulation (DIC); Heparin induced thrombocytopenia (HIT); Hepatic necrosis; International normalized ratio (INR); Limb amputation; Low molecular weight heparin (LMWH); Microvascular thrombosis; Unfractionated heparin (UFH); Warfarin induced venous limb gangrene

Indexed keywords

ARGATROBAN; BLOOD CLOTTING FACTOR 8; DALTEPARIN; DANAPAROID; FONDAPARINUX; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; WARFARIN;

EID: 84890467615     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2013.823946     Document Type: Review
Times cited : (75)

References (80)
  • 1
    • 45949086068 scopus 로고    scopus 로고
    • Parenteral anticoagulants: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
    • DOI 10.1378/chest.08-0689
    • Hirsh J, Bauer KA, Donati MB, et al. Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest 2008;133(6 Suppl):141S-59S (Pubitemid 351892966)
    • (2008) Chest , vol.133 , Issue.6 SUPPL. 6
    • Hirsh, J.1    Bauer, K.A.2    Donati, M.B.3    Gould, M.4    Samama, M.M.5    Weitz, J.I.6
  • 3
    • 84882591231 scopus 로고    scopus 로고
    • Warkentin TE Greinacher A editors. Heparin-induced thrombocytopenia. 5th edition CRC Press Boca Raton, FL
    • Greinacher A. Recombinant hirudin for the treatment of heparin-induced thrombocytopenia. In: Warkentin TE, Greinacher A, editors. Heparin-induced thrombocytopenia. 5th edition. CRC Press, Boca Raton, FL; 2013. 388-428
    • (2013) Recombinant Hirudin for the Treatment of Heparin-induced Thrombocytopenia , pp. 388-428
    • Greinacher, A.1
  • 4
    • 0026432629 scopus 로고
    • Oral anticoagulant drugs
    • Hirsh J. Oral anticoagulant drugs. N Engl J Med 1991;324(26):1865-75
    • (1991) N Engl J Med , vol.324 , Issue.26 , pp. 1865-1875
    • Hirsh, J.1
  • 5
    • 4644230820 scopus 로고    scopus 로고
    • The pharmacology and management of the vitamin K antagonists: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    • DOI 10.1378/chest.126.3-suppl.204S
    • Ansell J, Hirsh J, Poller L, et al. The pharmacology and management of the vitamin K antagonists: The Seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 2004;126(3 Suppl):204S-33S (Pubitemid 39297955)
    • (2004) Chest , vol.126 , Issue.3 SUPPL.
    • Ansell, J.1    Hirsh, J.2    Poller, L.3    Bussey, H.4    Jacobson, A.5    Hijlek, E.6
  • 6
    • 79960644200 scopus 로고    scopus 로고
    • HIT paradigms and paradoxes
    • Warkentin TE. HIT paradigms and paradoxes. J Thromb Haemost 2011;9(Suppl 1):105-17
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 1 , pp. 105-117
    • Warkentin, T.E.1
  • 7
    • 33751252564 scopus 로고    scopus 로고
    • Monitoring unfractionated heparin with the aPTT: Time for a fresh look
    • DOI 10.1160/TH06-05-0290
    • Eikelboom JW, Hirsh J. Monitoring unfractionated heparin with the aPTT: Time for a fresh look. Thromb Haemost 2006;96(5):547-52 (Pubitemid 44782532)
    • (2006) Thrombosis and Haemostasis , vol.96 , Issue.5 , pp. 547-552
    • Eikelboom, J.W.1    Hirsh, J.2
  • 8
    • 84877249391 scopus 로고    scopus 로고
    • Activated partial thromboplastin time and anti-Xa measurements in heparin monitoring: Biochemical basis for discordance
    • Takemoto CM, Streiff MB, Shermock KM, et al. Activated partial thromboplastin time and anti-Xa measurements in heparin monitoring: biochemical basis for discordance. Am J Clin Pathol 2013;139(4):450-6
    • Am J Clin Pathol 2013 , vol.139 , Issue.4 , pp. 450-456
    • Takemoto, C.M.1    Streiff, M.B.2    Shermock, K.M.3
  • 9
    • 84856804647 scopus 로고    scopus 로고
    • Parenteral anticoagulants antithrombotic therapy and prevention of thrombosis
    • 9th edition: american college of chest physicians evidence-based clinical practice guidelines
    • Garcia DA, Baglin TP, Weitz JI, Samama MM. Parenteral anticoagulants. Antithrombotic therapy and prevention of thrombosis, 9th edition: American College of Chest Physicians Evidence-based Clinical Practice Guidelines. Chest 2012;141(2 Suppl):e24S-43S
    • (2012) Chest , vol.141 , Issue.2 SUPPL.
    • Garcia, D.A.1    Baglin, T.P.2    Weitz, J.I.3    Samama, M.M.4
  • 10
    • 84902034808 scopus 로고    scopus 로고
    • Kitchens CS Konkle BA Kessler CM editors. Consultative hemostasis and thrombosis. 3rd edition. WB Saunders Elsevier, Philadelphia, PA
    • Patriquin C, Crowther M. Antithrombotic agents. In: Kitchens CS, Konkle BA, Kessler CM, editors. Consultative hemostasis and thrombosis. 3rd edition. WB Saunders, Elsevier, Philadelphia, PA; 2013. p. 477-95
    • (2013) Antithrombotic Agents , pp. 477-495
    • Patriquin, C.1    Crowther, M.2
  • 11
    • 84864614235 scopus 로고    scopus 로고
    • Antifactor Xa levels versus activated partial thromboplastin time for monitoring unfractionated heparin
    • Vandiver JW, Vondracek TG. Antifactor Xa levels versus activated partial thromboplastin time for monitoring unfractionated heparin. Pharmacotherapy 2012;32(6):546-58
    • (2012) Pharmacotherapy , vol.32 , Issue.6 , pp. 546-558
    • Vandiver, J.W.1    Vondracek, T.G.2
  • 12
    • 0028118694 scopus 로고
    • A randomized trial comparing activated thromboplastin time with heparin assay in patients with acute venous thromboembolism requiring large daily doses of heparin
    • DOI 10.1001/archinte.154.1.49
    • Levine MN, Hirsh J, Gent M, et al. A randomized trial comparing activated thromboplastin time with heparin assay in patients with acute venous thromboembolism requiring large daily doses of heparin. Arch Intern Med 1994;154(1):49-56 (Pubitemid 24018101)
    • (1994) Archives of Internal Medicine , vol.154 , Issue.1 , pp. 49-56
    • Levine, M.N.1    Hirsh, J.2    Gent, M.3    Turpie, A.G.4    Cruickshank, M.5    Weitz, J.6    Anderson, D.7    Johnson, M.8
  • 13
    • 34547122582 scopus 로고    scopus 로고
    • Warkentin TE Greinacher A editors. Heparin-induced thrombocytopenia. 5th edn CRC Press Boca Raton, FL
    • Warkentin TE. Clinical picture of heparin-induced thrombocytopenia. In: Warkentin TE, Greinacher A, editors. Heparin-induced thrombocytopenia. 5th edn. CRC Press, Boca Raton, FL; 2013. p. 24-76
    • (2013) Clinical Picture of Heparin-induced Thrombocytopenia , pp. 24-76
    • Warkentin, T.E.1
  • 14
    • 0032701196 scopus 로고    scopus 로고
    • Predictors for heparin resistance in patients undergoing coronary artery bypass grafting
    • Ranucci M, Isgrò G, Cazzaniga A, et al. Predictors for heparin resistance in patients undergoing coronary artery bypass grafting. Perfusion 1999;14(6):437-42 (Pubitemid 29537489)
    • (1999) Perfusion , vol.14 , Issue.6 , pp. 437-442
    • Ranucci, M.1    Isgro, G.2    Cazzaniga, A.3    Soro, G.4    Menicanti, L.5    Frigiola, A.6
  • 15
    • 0033497045 scopus 로고    scopus 로고
    • 5-Year incidence of thrombocytosis and the effect of heparin dose response and heparin requirements
    • Goyoso JM. 5-Year incidence of thrombocytosis and the effect of heparin dose response and heparin requirements. J Extra Corp Technol 1999;31(4): 184-90
    • (1999) J Extra Corp Technol , vol.31 , Issue.4 , pp. 184-190
    • Goyoso, J.M.1
  • 16
    • 1942454849 scopus 로고    scopus 로고
    • Heparin resistance and antithrombin: Should it still be called heparin resistance?
    • DOI 10.1053/j.jvca.2004.01.013
    • Levy JH. Heparin resistance and antithrombin: should it still be called heparin resistance? J Cardiothorac Vasc Anesth 2004;18(2):129-30 (Pubitemid 38506854)
    • (2004) Journal of Cardiothoracic and Vascular Anesthesia , vol.18 , Issue.2 , pp. 129-130
    • Levy, J.H.1
  • 17
    • 77957695786 scopus 로고    scopus 로고
    • Activated clotting times, heparin responses, and antithrombin: Have we been wrong all these years?
    • Levy JH, Sniecinski RM. Activated clotting times, heparin responses, and antithrombin: have we been wrong all these years? Anesth Analg 2010;111(4):833-5
    • (2010) Anesth Analg , vol.111 , Issue.4 , pp. 833-835
    • Levy, J.H.1    Sniecinski, R.M.2
  • 18
    • 77951668099 scopus 로고    scopus 로고
    • Monitoring heparin anticoagulation in the acute phase response
    • Uprichard J, Manning RA, Laffan MA. Monitoring heparin anticoagulation in the acute phase response. Br J Haematol 2010;149(4):613-19
    • (2010) Br J Haematol , vol.149 , Issue.4 , pp. 613-619
    • Uprichard, J.1    Manning, R.A.2    Laffan, M.A.3
  • 19
    • 0014128106 scopus 로고
    • Kaolin partial thromboplastin time: High levels of procoagulants producing short clotting times or masking deficiencies of other procoagulants or low concentrations of anticoagulants
    • Edson VR, Krivit W, White JG. Kaolin partial thromboplastin time: high levels of procoagulants producing short clotting times or masking deficiencies of other procoagulants or low concentrations of anticoagulants. J Lab Clin Med 1967;70(3):463-70
    • (1967) J Lab Clin Med , vol.70 , Issue.3 , pp. 463-470
    • Edson, V.R.1    Krivit, W.2    White, J.G.3
  • 20
    • 0033059794 scopus 로고    scopus 로고
    • Monitoring unfractionated heparin therapy with antifactor Xa activity results in fewer monitoring tests and dosage changes than monitoring with the activated partial thromboplastin time
    • DOI 10.1592/phco.19.9.760.31547
    • Rosborough TK. Monitoring unfractionated heparin therapy with antifactor Xa activity results in fewer monitoring tests and dosage changes that monitoring with the activated partial thromboplastin time. Pharmacotherapy 1999;19(6):760-6 (Pubitemid 29277977)
    • (1999) Pharmacotherapy , vol.19 , Issue.6 , pp. 760-766
    • Rosborough, T.K.1
  • 21
    • 79960803338 scopus 로고    scopus 로고
    • Activated partial thromboplastin time versus antifactor Xa heparin assay in monitoring unfractionated heparin by continuous intravenous infusion
    • Guervil DJ, Rosenberg AF, Winterstein AG, et al. Activated partial thromboplastin time versus antifactor Xa heparin assay in monitoring unfractionated heparin by continuous intravenous infusion. Ann Pharmacother 2011;45(7-8):861-8
    • (2011) Ann Pharmacother , vol.45 , Issue.7-8 , pp. 861-868
    • Guervil, D.J.1    Rosenberg, A.F.2    Winterstein, A.G.3
  • 22
    • 0022873142 scopus 로고
    • Effect of warfarin on the activated partial thromboplastin time
    • Hauser VM, Rozek SL. Effect of warfarin on the activated partial thromboplastin time. Drug Intell Clin Pharm 1986;20(12):964-7 (Pubitemid 17227923)
    • (1986) Drug Intelligence and Clinical Pharmacy , vol.20 , Issue.12 , pp. 964-967
    • Hauser, V.M.1    Rozek, S.L.2
  • 24
    • 84890465118 scopus 로고    scopus 로고
    • Marder VJ Aird WC Bennett JS Schulman S White GC editors. Hemostasis and thrombosis: basic principles and clinical practice. 6th edition Lippincott Williams &Wilkins, Philadelphia
    • Warkentin TE. Coumarin-induced skin necrosis and venous limb gangrene. In: Marder VJ, Aird WC, Bennett JS, Schulman S, White GC, editors. Hemostasis and thrombosis: basic principles and clinical practice. 6th edition. Lippincott Williams &Wilkins, Philadelphia; 2013. p. 1308-17
    • (2013) Coumarin-induced Skin Necrosis and Venous Limb Gangrene , pp. 1308-1317
    • Warkentin, T.E.1
  • 25
    • 0029852157 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: IgG-Mediated platelet activation, platelet microparticle generation, and altered Procoagulant/Anticoagulant balance in the pathogenesis of thrombosis and venous limb gangrene complicating heparin-induced thrombocytopenia
    • DOI 10.1016/S0887-7963(96)80001-0
    • Warkentin TE. Heparin-induced thrombocytopenia: igG-mediated platelet activation, platelet microparticle generation, and altered procoagulant/ anticoagulant balance in the pathogenesis of thrombosis and venous limb gangrene complicating heparin-induced thrombocytopenia. Transfus Med Rev 1996;10(4):249-58 (Pubitemid 26354134)
    • (1996) Transfusion Medicine Reviews , vol.10 , Issue.4 , pp. 249-258
    • Warkentin, T.E.1
  • 26
    • 82755161996 scopus 로고    scopus 로고
    • Laboratory testing for heparin-induced thrombocytopenia: A conceptual framework and implications for diagnosis
    • Warkentin TE, Greinacher A, Gruel Y, et al. Laboratory testing for heparin-induced thrombocytopenia: a conceptual framework and implications for diagnosis. J Thromb Haemost 2011;9(12):2498-500
    • (2011) J Thromb Haemost , vol.9 , Issue.12 , pp. 2498-2500
    • Warkentin, T.E.1    Greinacher, A.2    Gruel, Y.3
  • 27
    • 0038392539 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: Pathogenesis and management
    • DOI 10.1046/j.1365-2141.2003.04334.x
    • Warkentin TE. Heparin-induced thrombocytopenia: pathogenesis and management. Br J Haematol 2003;121(4):535-55 (Pubitemid 36645375)
    • (2003) British Journal of Haematology , vol.121 , Issue.4 , pp. 535-555
    • Warkentin, T.E.1
  • 28
    • 0037610515 scopus 로고    scopus 로고
    • An improved definition of immune heparin-induced thrombocytopenia in postoperative orthopedic patients
    • DOI 10.1001/archinte.163.20.2518
    • Warkentin TE, Roberts RS, Hirsh J, Kelton JG. An improved definition of immune heparin-induced thrombocytopenia in postoperative orthopedic patients. Arch Intern Med 2003;163(20):2518-24 (Pubitemid 37385796)
    • (2003) Archives of Internal Medicine , vol.163 , Issue.20 , pp. 2518-2524
    • Warkentin, T.E.1    Roberts, R.S.2    Hirsh, J.3    Kelton, J.G.4
  • 29
    • 0029035681 scopus 로고
    • Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin
    • Warkentin TE, Levine MN, Hirsh J, et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 1995;332(20):1330-5
    • (1995) N Engl J Med , vol.332 , Issue.20 , pp. 1330-1335
    • Warkentin, T.E.1    Levine, M.N.2    Hirsh, J.3
  • 30
    • 84882702920 scopus 로고    scopus 로고
    • Warkentin TE Greinacher A editors. Heparin-induced thrombocytopenia. 5th edition CRC Press Boca Raton, FL
    • Linkins LA, Lee DH. Frequency of heparin-induced thrombocytopenia. In: Warkentin TE, Greinacher A, editors. Heparin-induced thrombocytopenia. 5th edition. CRC Press, Boca Raton, FL; 2013. p. 110-50
    • (2013) Frequency of Heparin-induced Thrombocytopenia , pp. 110-150
    • Linkins, L.A.1    Lee, D.H.2
  • 31
    • 0028014541 scopus 로고
    • Heparin-associated thrombocytopenia: Isolation of the antibody and characterization of a multimolecular PF4-heparin complex as the major antigen
    • Greinacher A, Potzsch B, Amiral J, et al. Heparin-Associated thrombocytopenia: isolation of the antibody and characterization of a multimolecular PF4-heparin complex as the major antigen. Thromb Haemost 1994;71(2):247-51 (Pubitemid 24047336)
    • (1994) Thrombosis and Haemostasis , vol.71 , Issue.2 , pp. 247-251
    • Greinacher, A.1    Potzsch, B.2    Amiral, J.3    Dummel, V.4    Eichner, A.5    Mueller-Eckhardt, C.6
  • 32
    • 0034235911 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: New evidence for the dynamic binding of purified anti-PF4-heparin antibodies to platelets and the resultant platelet activation
    • Newman PM, Chong BH. Heparin-induced thrombocytopenia: new evidence for the dynamic binding of purified anti-PF4-heparin antibodies to platelets and the resultant platelet activation. Blood 2000;96(1):182-7 (Pubitemid 30456469)
    • (2000) Blood , vol.96 , Issue.1 , pp. 182-187
    • Newman, P.M.1    Chong, B.H.2
  • 33
    • 33847388520 scopus 로고    scopus 로고
    • Drug-induced immune-mediated thrombocytopenia - From purpura to thrombosis
    • DOI 10.1056/NEJMp068309
    • Warkentin TE. Drug-induced immune-mediated thrombocytopenia-from purpura to thrombosis. N Engl J Med 2007;356(9):891-3 (Pubitemid 46339907)
    • (2007) New England Journal of Medicine , vol.356 , Issue.9 , pp. 891-893
    • Warkentin, T.E.1
  • 34
    • 67649335993 scopus 로고    scopus 로고
    • Aird WC editor. Endothelial Biomedicine. Cambridge University Press Cambridge
    • Greinacher A, Warkentin TE. Heparin-induced thrombocytopenia. In: Aird WC, editor. Endothelial Biomedicine. Cambridge University Press, Cambridge; 2007. p. 1344-51
    • (2007) Heparin-induced Thrombocytopenia , pp. 1344-1351
    • Greinacher, A.1    Warkentin, T.E.2
  • 35
    • 67849106551 scopus 로고    scopus 로고
    • Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia
    • Rauova L, Arepally G, McKenzie SE, et al. Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia. J Thromb Haemost 2009;7(Suppl 1):249-52
    • (2009) J Thromb Haemost , vol.7 , Issue.SUPPL. 1 , pp. 249-252
    • Rauova, L.1    Arepally, G.2    McKenzie, S.E.3
  • 36
    • 0030281338 scopus 로고    scopus 로고
    • A 14-year study of heparin-induced thrombocytopenia
    • DOI 10.1016/S0002-9343(96)00258-6, PII S0002934396002586
    • Warkentin TE, Kelton JG. A 14-year study of heparin-induced thrombocytopenia. Am J Med 1996;101(5):502-7 (Pubitemid 126335970)
    • (1996) American Journal of Medicine , vol.101 , Issue.5 , pp. 502-507
    • Warkentin, T.E.1    Kelton, J.G.2
  • 37
    • 22144446420 scopus 로고    scopus 로고
    • Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis. A retrospective of 408 patients
    • DOI 10.1160/TH04-12-0825
    • Greinacher A, Farner B, Kroll H, et al. Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis. A retrospective analysis of 408 patients. Thromb Haemost 2005;94(1):132-5 (Pubitemid 40974717)
    • (2005) Thrombosis and Haemostasis , vol.94 , Issue.1 , pp. 132-135
    • Greinacher, A.1    Farner, B.2    Kroll, H.3    Kohlmann, T.4    Warkentin, T.E.5    Eichler, P.6
  • 38
    • 66949114594 scopus 로고    scopus 로고
    • Heparin-induced anaphylactic and anaphylactoid reactions: Two distinct but overlapping syndromes
    • Warkentin TE, Greinacher A. Heparin-induced anaphylactic and anaphylactoid reactions: Two distinct but overlapping syndromes. Expert Opin Drug Saf 2009;8(2):129-44
    • (2009) Expert Opin Drug Saf , vol.8 , Issue.2 , pp. 129-144
    • Warkentin, T.E.1    Greinacher, A.2
  • 41
    • 0032873201 scopus 로고    scopus 로고
    • Multicentric warfarin-induced skin necrosis complicating heparin-induced thrombocytopenia
    • DOI 10.1002/(SICI)1096-8652(199909)62:1<44::AID-AJH7>3.0.CO;2-F
    • Warkentin TE, Sikov WM, Lillicrap DP. Multicentric warfarin-induced skin necrosis complicating heparin-induced thrombocytopenia. Am J Hematol 1999;62(1):44-8 (Pubitemid 29416711)
    • (1999) American Journal of Hematology , vol.62 , Issue.1 , pp. 44-48
    • Warkentin, T.E.1    Sikov, W.M.2    Lillicrap, D.P.3
  • 42
    • 0037434883 scopus 로고    scopus 로고
    • Delayed-onset heparin-induced thrombocytopenia and cerebral thrombosis after a single administration of unfractionated heparin [7]
    • DOI 10.1056/NEJM200303133481120
    • Warkentin TE, Bernstein RA. Delayed-onset heparin-induced thrombocytopenia and cerebral thrombosis after a single administration of unfractionated heparin. N Engl J Med 2003;348(11):1067-9 (Pubitemid 36302259)
    • (2003) New England Journal of Medicine , vol.348 , Issue.11 , pp. 1067-1069
    • Warkentin, T.E.1    Bernstein, R.A.2
  • 43
    • 77955119891 scopus 로고    scopus 로고
    • Agents for the treatment of heparin-induced thrombocytopenia
    • Warkentin TE. Agents for the treatment of heparin-induced thrombocytopenia. Hematol/Oncol Clin N Am 2010;24(4):755-75
    • (2010) Hematol/Oncol Clin N Am , vol.24 , Issue.4 , pp. 755-775
    • Warkentin, T.E.1
  • 44
    • 0033576811 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation
    • DOI 10.1056/NEJM199908193410807
    • Levi M, ten Cate H. Disseminated intravascular coagulation. N Engl J Med 1999;341(8):586-92 (Pubitemid 29384168)
    • (1999) New England Journal of Medicine , vol.341 , Issue.8 , pp. 586-592
    • Levi, M.1    Ten Cate, H.2
  • 45
    • 61849136778 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology
    • Levi M, Toh CH, Thachil J, Watson HG. Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology. Br J Haematol 2009;145(1):24-33
    • (2009) Br J Haematol , vol.145 , Issue.1 , pp. 24-33
    • Levi, M.1    Toh, C.H.2    Thachil, J.3    Watson, H.G.4
  • 48
    • 28444447383 scopus 로고    scopus 로고
    • Lepirudin in patients with heparin-induced thrombocytopenia - Results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3
    • DOI 10.1111/j.1538-7836.2005.01623.x
    • Lubenow N, Eichler P, Lietz T, Greinacher A; HIT Investigators Group. Lepirudin in patients with heparin-induced thrombocytopenia-results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3. J Thromb Haemost 2005;3(11):2428-36 (Pubitemid 41727158)
    • (2005) Journal of Thrombosis and Haemostasis , vol.3 , Issue.11 , pp. 2428-2436
    • Lubenow, N.1    Eichler, P.2    Lietz, T.3    Greinacher, A.4
  • 53
    • 63849194816 scopus 로고    scopus 로고
    • Dosing lepirudin in patients with heparin-induced thrombocytopenia and normal or impaired renal function: A single-center experience with patients
    • Tschudi M, Lammle B, Alberio L. Dosing lepirudin in patients with heparin-induced thrombocytopenia and normal or impaired renal function: a single-center experience with patients. Blood 2009;113(11):2402-9
    • (2009) Blood , vol.113 , Issue.11 , pp. 2402-2409
    • Tschudi, M.1    Lammle, B.2    Alberio, L.3
  • 54
    • 43949108861 scopus 로고    scopus 로고
    • The direct thrombin inhibitor hirudin
    • DOI 10.1160/TH07-11-0693
    • Greinacher A, Warkentin TE. The direct thrombin inhibitor hirudin. Thromb Haemost 2008;99(5):819-29 (Pubitemid 351705298)
    • (2008) Thrombosis and Haemostasis , vol.99 , Issue.5 , pp. 819-829
    • Greinacher, A.1    Warkentin, T.E.2
  • 55
    • 79960629597 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: Real world issues
    • Linkins LA, Warkentin TE. Heparin-induced thrombocytopenia: real world issues. Semin Thromb Hemost 2011;37(6):653-63
    • (2011) Semin Thromb Hemost , vol.37 , Issue.6 , pp. 653-663
    • Linkins, L.A.1    Warkentin, T.E.2
  • 56
    • 56749125053 scopus 로고    scopus 로고
    • Laboratory testing for fibrinogen abnormalities
    • Verhovsek M, Moffat KA, Hayward CPM. Laboratory testing for fibrinogen abnormalities. Am J Hematol 2008;83(12):928-31
    • (2008) Am J Hematol , vol.83 , Issue.12 , pp. 928-931
    • Verhovsek, M.1    Moffat, K.A.2    Cpm, H.3
  • 57
    • 27844481103 scopus 로고    scopus 로고
    • Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation
    • DOI 10.1160/TH05-03-0154
    • Warkentin TE, Greinacher A, Craven S, et al. Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation. Thromb Haemost 2005;94(5):958-64 (Pubitemid 41645934)
    • (2005) Thrombosis and Haemostasis , vol.94 , Issue.5 , pp. 958-964
    • Warkentin, T.E.1    Greinacher, A.2    Craven, S.3    Dewar, L.4    Sheppard, J.-A.I.5    Ofosu, F.A.6
  • 61
    • 0014784319 scopus 로고
    • Intravascular coagulation associated with pneumococcal bacteremia and symmetrical peripheral gangrene
    • Stossel TP, Levy R. Intravascular coagulation associated with pneumococcal bacteremia and symmetrical peripheral gangrene. Arch Intern Med 1970;125(5):876-8
    • (1970) Arch Intern Med , vol.125 , Issue.5 , pp. 876-878
    • Stossel, T.P.1    Levy, R.2
  • 62
    • 0021838243 scopus 로고
    • Symmetrical peripheral gangrene and disseminated intravascular coagulation
    • DOI 10.1001/archderm.121.8.1057
    • Molos MA, Hall JC. Symmetrical peripheral gangrene and disseminated intravascular coagulation. Arch Dermatol 1985;121(8):1057-61 (Pubitemid 15014951)
    • (1985) Archives of Dermatology , vol.121 , Issue.8 , pp. 1057-1061
    • Molos, M.A.1    Hall, J.C.2
  • 63
    • 0027250054 scopus 로고
    • Symmetrical peripheral gangrene (purpura fulminans) complicating pneumococcal sepsis
    • Johansen K, Hansen ST Jr. Symmetrical peripheral gangrene (purpura fulminans) complicating pneumococcal sepsis. Am J Surg 1993;165(5):642-5 (Pubitemid 23278684)
    • (1993) American Journal of Surgery , vol.165 , Issue.5 , pp. 642-645
    • Johansen, K.1    Hansen Jr., S.T.2
  • 64
  • 65
    • 0026676920 scopus 로고
    • Symmetrical peripheral gangrene: Association with noradrenaline administration
    • DOI 10.1007/BF01694349
    • Hayes MA, Yau EHS, Hinds CJ, Watson JD. Symmetrical peripheral gangrene: association with noradrenaline administration. Intensive Care Med 1992;18(7):433-6 (Pubitemid 23009493)
    • (1992) Intensive Care Medicine , vol.18 , Issue.7 , pp. 433-436
    • Hayes, M.A.1    Yau, E.H.S.2    Hinds, C.J.3    Watson, J.D.4
  • 67
    • 33644859949 scopus 로고    scopus 로고
    • Treatment effects of high-dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation
    • Kienast J, Juers M, Wiedermann CJ, et al. Treatment effects of high-dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation. J Thromb Haemost 2006;4(1):90-7
    • (2006) J Thromb Haemost , vol.4 , Issue.1 , pp. 90-97
    • Kienast, J.1    Juers, M.2    Wiedermann, C.J.3
  • 68
    • 33646455014 scopus 로고    scopus 로고
    • Benefit/risk profile of high-dose antithrombin in patients with severe sepsis treated with and without concomitant heparin
    • Hoffmann JN, Wiedermann CJ, Juers M, et al. Benefit/risk profile of high-dose antithrombin in patients with severe sepsis treated with and without concomitant heparin. Thromb Haemost 2006;95(5):850-6
    • (2006) Thromb Haemost , vol.95 , Issue.5 , pp. 850-856
    • Hoffmann, J.N.1    Wiedermann, C.J.2    Juers, M.3
  • 69
    • 84874767067 scopus 로고    scopus 로고
    • Hypoxic liver injury and cholestasis in critically ill patients
    • Horvatits T, Trauner M, Fuhrmann V. Hypoxic liver injury and cholestasis in critically ill patients. Curr Opin Crit Care 2013;19(2):128-32
    • (2013) Curr Opin Crit Care , vol.19 , Issue.2 , pp. 128-132
    • Horvatits, T.1    Trauner, M.2    Fuhrmann, V.3
  • 70
    • 84863525767 scopus 로고    scopus 로고
    • Hypoxic hepatitis
    • Henrion J. Hypoxic hepatitis. Liver Int 2012;32(7):1039-52
    • (2012) Liver Int , vol.32 , Issue.7 , pp. 1039-1052
    • Henrion, J.1
  • 71
    • 67649574229 scopus 로고    scopus 로고
    • Incidence and outcome of ischemic hepatitis complicating septic shock
    • Raurich JM, Perez O, Llompart-Pou JA, et al. Incidence and outcome of ischemic hepatitis complicating septic shock. Hepatol Res 2009;39(7):700-5
    • (2009) Hepatol Res , vol.39 , Issue.7 , pp. 700-705
    • Raurich, J.M.1    Perez, O.2    Llompart-Pou, J.A.3
  • 72
    • 0032966067 scopus 로고    scopus 로고
    • A prospective study of the causes of notably raised aspartate aminotransferase of liver origin
    • Whitehead MW, Hawkes ND, Hainsworth I, Kingham JG. A prospective study of the causes of notably raises aspartate aminotransferase of liver origin. Gut 1999;45(1):129-33 (Pubitemid 29301857)
    • (1999) Gut , vol.45 , Issue.1 , pp. 129-133
    • Whitehead, M.W.1    Hawkes, N.D.2    Hainsworth, I.3    Kingham, J.G.C.4
  • 73
    • 0034253912 scopus 로고    scopus 로고
    • Ischemic hepatitis: Clinical presentation and pathogenesis
    • Seeto RK, Fenn B, Rockey DC. Ischemic hepatitis: clinical presentation and pathogenesis. Am J Med 2000;109(2):109-13
    • (2000) Am J Med , vol.109 , Issue.2 , pp. 109-113
    • Seeto, R.K.1    Fenn, B.2    Rockey, D.C.3
  • 74
    • 84865478911 scopus 로고    scopus 로고
    • Acute hepatic necrosis and ischemic limb necrosis
    • Siegal DM, Cook RJ, Warkentin TE. Acute hepatic necrosis and ischemic limb necrosis. N Engl J Med 2012;367(9):879-81
    • (2012) N Engl J Med , vol.367 , Issue.9 , pp. 879-881
    • Siegal, D.M.1    Cook, R.J.2    Warkentin, T.E.3
  • 76
    • 78651102024 scopus 로고    scopus 로고
    • Prospective evaluation of three different diagnostic criteria for disseminated intravascular coagulation
    • Takemitsu T, Wada H, Hatada T, et al. Prospective evaluation of three different diagnostic criteria for disseminated intravascular coagulation. Thromb Haemost 2011;105(1):40-4
    • (2011) Thromb Haemost , vol.105 , Issue.1 , pp. 40-44
    • Takemitsu, T.1    Wada, H.2    Hatada, T.3
  • 77
    • 34147177651 scopus 로고    scopus 로고
    • Coagulation disorders secondary to acute liver failure in Amanita phalloides poisoning: A case report
    • Soysal D, C evik C, Saklamaz A, et al. Coagulation disorders secondary to acute liver failure in Amanita phalloides poisoning: a case report. Turk J Gastroenterol 2006;17(3):198-202 (Pubitemid 46568099)
    • (2006) Turkish Journal of Gastroenterology , vol.17 , Issue.3 , pp. 198-202
    • Soysal, D.1    Cevik, C.2    Saklamaz, A.3    Yetimalar, Y.4    Unsal, B.5
  • 78
    • 82755187620 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia in critically ill patients
    • Warkentin TE. Heparin-induced thrombocytopenia in critically ill patients. Crit Care Clin 2011;27(4):805-23
    • (2011) Crit Care Clin , vol.27 , Issue.4 , pp. 805-823
    • Warkentin, T.E.1
  • 79
    • 34447503698 scopus 로고    scopus 로고
    • Monitoring direct thrombin inhibitors with a plasma diluted thrombin time
    • Love JE, Ferrell C, Chandler WL. Monitoring direct thrombin inhibitors with a plasma diluted thrombin time. Thromb Haemost 2007;98:234-42
    • (2007) Thromb Haemost , vol.98 , pp. 234-242
    • Love, J.E.1    Ferrell, C.2    Chandler, W.L.3
  • 80
    • 84876252367 scopus 로고    scopus 로고
    • Alternative monitoring of argatroban using plasma-diluted thrombin time
    • Wanat MA, Hart SR, Putney D, et al. Alternative monitoring of argatroban using plasma-diluted thrombin time. Ann Pharmacother 2013;47(4):e18
    • (2013) Ann Pharmacother , vol.47 , Issue.4
    • Wanat, M.A.1    Hart, S.R.2    Putney, D.3


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