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Volumn 32, Issue 6, 2012, Pages 546-558

Antifactor xa levels versus activated partial thromboplastin time for monitoring unfractionated heparin

Author keywords

Activated partial thromboplastin time; Anti Xa levels; Antifactor Xa levels; APTT; Heparin; Unfractionated heparin monitoring

Indexed keywords

BLOOD CLOTTING FACTOR 10A INHIBITOR; HEPARIN; PROTAMINE;

EID: 84864614235     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1875-9114.2011.01049.x     Document Type: Review
Times cited : (184)

References (56)
  • 1
    • 0029848050 scopus 로고    scopus 로고
    • The relation between the activated partial thromboplastin time response and recurrence in patients with venous thrombosis treated with continuous intravenous heparin
    • Anand S, Ginsberg JS, Kearon C, et al. The relation between the activated partial thromboplastin time response and recurrence in patients with venous thrombosis treated with continuous intravenous heparin. Arch Intern Med 1996;156:1677-81
    • (1996) Arch Intern Med , vol.156 , pp. 1677-81
    • Anand, S.1    Ginsberg, J.S.2    Kearon, C.3
  • 3
    • 0028785452 scopus 로고
    • Heparin: Mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety
    • Hirsh J, Raschke R, Warkentin T, Dalen JE, Deykin D, Poller L. Heparin: mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety. Chest 1995;108:258S-75S
    • (1995) Chest , vol.108
    • Hirsh, J.1    Raschke, R.2    Warkentin, T.3    Dalen, J.E.4    Deykin, D.5    Poller, L.6
  • 4
    • 0031665270 scopus 로고    scopus 로고
    • College of American Pathologists Conference XXXI on Laboratory monitoring of anticoagulant therapy
    • Olson JD, Arkin CF, Brandt JT, et al. College of American Pathologists Conference XXXI on Laboratory monitoring of anticoagulant therapy. Arch Pathol Lab Med 1998;122:782-98
    • (1998) Arch Pathol Lab Med , vol.122 , pp. 782-98
    • Olson, J.D.1    Arkin, C.F.2    Brandt, J.T.3
  • 5
    • 0035125405 scopus 로고    scopus 로고
    • Heparin and lowmolecular-weight heparin mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety
    • Hirsh J, Warkentin T, Shaughnessy S, et al. Heparin and lowmolecular-weight heparin mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety. Chest 2001;119:64S-94S
    • (2001) Chest , vol.119
    • Hirsh, J.1    Warkentin, T.2    Shaughnessy, S.3
  • 6
    • 4644308426 scopus 로고    scopus 로고
    • Heparin and low-molecular weight heparin: The Seventh ACCP Conference on antithrombotic and thrombolytic therapy
    • Hirsh J, Raschke R. Heparin and low-molecular weight heparin: The Seventh ACCP Conference on antithrombotic and thrombolytic therapy. Chest 2004;126:188S-203S
    • (2004) Chest , vol.126
    • Hirsh, J.1    Raschke, R.2
  • 8
    • 29244431984 scopus 로고    scopus 로고
    • To bleed or not to bleed? Is that the question for the PTT?
    • Kitchens CS. To bleed or not to bleed? Is that the question for the PTT? J Thromb Haemost 2005;3:2607-11
    • (2005) J Thromb Haemost , vol.3 , pp. 2607-11
    • Kitchens, C.S.1
  • 9
    • 13244278090 scopus 로고    scopus 로고
    • The multiple faces of the partial thromboplastin time APTT
    • Rapaport SI. The multiple faces of the partial thromboplastin time APTT. J Thromb Haemost 2004;2:2250-2
    • (2004) J Thromb Haemost , vol.2 , pp. 2250-2
    • Rapaport, S.I.1
  • 10
    • 33751252564 scopus 로고    scopus 로고
    • Monitoring unfractionated heparin with the aPTT: Time for a fresh look
    • Eikelboom JW, Hirsh J. Monitoring unfractionated heparin with the aPTT: Time for a fresh look. Thromb Haemost 2006;96:547-52
    • (2006) Thromb Haemost , vol.96 , pp. 547-52
    • Eikelboom, J.W.1    Hirsh, J.2
  • 11
    • 0015514101 scopus 로고
    • A prospective study of the value of monitoring heparin treatment with the activated partial thromboplastin time
    • Basu D, Gallus A, Hirsh J, Cade J. A prospective study of the value of monitoring heparin treatment with the activated partial thromboplastin time. N Engl J Med 1972; 287:324-7
    • (1972) N Engl J Med , vol.287 , pp. 324-7
    • Basu, D.1    Gallus, A.2    Hirsh, J.3    Cade, J.4
  • 12
    • 0017335948 scopus 로고
    • Relationship between the anticoagulant and antithrombotic effects of heparin in experimental venous thrombosis
    • Chiu HM, Hirsh J, Yung WL, Regoeczi E, Gent M. Relationship between the anticoagulant and antithrombotic effects of heparin in experimental venous thrombosis. Blood 1977;49:171-84
    • (1977) Blood , vol.49 , pp. 171-84
    • Chiu, H.M.1    Hirsh, J.2    Yung, W.L.3    Regoeczi, E.4    Gent, M.5
  • 13
    • 0021943976 scopus 로고
    • Circadian changes in anticoagulant effect of heparin infused at a constant rate
    • Decousus HA, Croze M, Levi FA, et al. Circadian changes in anticoagulant effect of heparin infused at a constant rate. Br Med Journal 1985;290:341-4
    • (1985) Br Med Journal , vol.290 , pp. 341-4
    • Decousus, H.A.1    Croze, M.2    Levi, F.A.3
  • 14
    • 0023195809 scopus 로고
    • Measurement of heparin in plasma: Influence of inter-subject and circadian variability in heparin sensitivity according to method
    • Scully MF, Decousus HA, Ellis V, et al. Measurement of heparin in plasma: Influence of inter-subject and circadian variability in heparin sensitivity according to method. Thromb Res 1987;46:447-55
    • (1987) Thromb Res , vol.46 , pp. 447-55
    • Scully, M.F.1    Decousus, H.A.2    Ellis, V.3
  • 15
    • 0026683399 scopus 로고
    • Diurnal rhythm in anticoagulant effect of heparin during a low dose constant rate infusion. A study in healthy volunteers
    • Krulder JW, de Boer A, van den Besselaar AM, et al. Diurnal rhythm in anticoagulant effect of heparin during a low dose constant rate infusion. A study in healthy volunteers. Thromb Haemost 1992;68:30-2
    • (1992) Thromb Haemost , vol.68 , pp. 30-2
    • Krulder, J.W.1    De Boer, A.2    Van Den Besselaar, A.M.3
  • 16
    • 0141751601 scopus 로고    scopus 로고
    • Effect of 3.2% vs. 3.8% sodium citrate concentration on anti-Xa levels for patients on therapeutic low-molecular weight heparin
    • Payne S, Mackinnon K, Keeney M, Morrow B, Kovacs MJ. Effect of 3.2% vs. 3.8% sodium citrate concentration on anti-Xa levels for patients on therapeutic low-molecular weight heparin. Clin Lab Haematol 2003;25(30):317-9
    • (2003) Clin Lab Haematol , vol.25 , Issue.30 , pp. 317-9
    • Payne, S.1    Mackinnon, K.2    Keeney, M.3    Morrow, B.4    Kovacs, M.J.5
  • 17
    • 77952004518 scopus 로고    scopus 로고
    • Laboratory monitoring of heparin therapy: Partial thromboplastin time or anti-Xa assay?
    • Lehman CM, Frank EL. Laboratory monitoring of heparin therapy: Partial thromboplastin time or anti-Xa assay? Lab Medicine 2009;40:47-51
    • (2009) Lab Medicine , vol.40 , pp. 47-51
    • Lehman, C.M.1    Frank, E.L.2
  • 18
    • 84864633753 scopus 로고    scopus 로고
    • Diagnostica Stago. STA rotachrom heparin [package insert]. Parsippany NJ
    • Diagnostica Stago. STA rotachrom heparin [package insert]. Parsippany, NJ: 2009
    • (2009)
  • 19
    • 0030014877 scopus 로고    scopus 로고
    • The therapeutic range for heparin therapy: Relationship between six activated partial thromboplastin time reagents and two heparin assays
    • Kitchen S, Preston FE. The therapeutic range for heparin therapy: Relationship between six activated partial thromboplastin time reagents and two heparin assays. Thromb Haemost 1996;75:734-9
    • (1996) Thromb Haemost , vol.75 , pp. 734-9
    • Kitchen, S.1    Preston, F.E.2
  • 20
    • 0026652032 scopus 로고
    • Optimal therapeutic level of heparin therapy in patients with venous thrombosis
    • Hull RD, Raskob GE, Rosenbloom D, et al. Optimal therapeutic level of heparin therapy in patients with venous thrombosis. Arch Intern Med 1992;152:1589-95
    • (1992) Arch Intern Med , vol.152 , pp. 1589-95
    • Hull, R.D.1    Raskob, G.E.2    Rosenbloom, D.3
  • 21
    • 0030679685 scopus 로고    scopus 로고
    • Inability of the activated partial thromboplastin time to predict heparin levels
    • Baker BA, Adelman MD, Smith PA, Osborn JC. Inability of the activated partial thromboplastin time to predict heparin levels. Arch Intern Med 1997;157:2475-9
    • (1997) Arch Intern Med , vol.157 , pp. 2475-9
    • Baker, B.A.1    Adelman, M.D.2    Smith, P.A.3    Osborn, J.C.4
  • 23
    • 0031852711 scopus 로고    scopus 로고
    • Comparing different lots of activated partial thromboplastin time reagent: Analysis of two methods
    • Rosborough TK. Comparing different lots of activated partial thromboplastin time reagent: Analysis of two methods. Am J Clin Pathol 1998;110:173-7
    • (1998) Am J Clin Pathol , vol.110 , pp. 173-7
    • Rosborough, T.K.1
  • 25
    • 0035847579 scopus 로고    scopus 로고
    • Use of a fixed activated partial thromboplastin time ratio to establish a therapeutic range for unfractionated heparin
    • Bates SM, Weitz JI, Johnston M, Hirsh J, Ginsberg JS. Use of a fixed activated partial thromboplastin time ratio to establish a therapeutic range for unfractionated heparin. Arch Intern Med 2001;161:385-91
    • (2001) Arch Intern Med , vol.161 , pp. 385-91
    • Bates, S.M.1    Weitz, J.I.2    Johnston, M.3    Hirsh, J.4    Ginsberg, J.S.5
  • 26
    • 0032812237 scopus 로고    scopus 로고
    • Correlation of activated clotting time and activated partial thromboplastin time to plasma heparin concentration
    • Koerber JM, Smythe MA, Begle RL, Mattson JC, Kershaw BP, Westley SJ. Correlation of activated clotting time and activated partial thromboplastin time to plasma heparin concentration. Pharmacotherapy 1999;19:922-31
    • (1999) Pharmacotherapy , vol.19 , pp. 922-31
    • Koerber, J.M.1    Smythe, M.A.2    Begle, R.L.3    Mattson, J.C.4    Kershaw, B.P.5    Westley, S.J.6
  • 27
    • 1642502270 scopus 로고    scopus 로고
    • Suboptimal monitoring and dosing of unfractionated heparin in comparative studies with low-molecular-weight heparin
    • Raschke R, Hirsh J, Guidry JR. Suboptimal monitoring and dosing of unfractionated heparin in comparative studies with low-molecular-weight heparin. Ann Intern Med 2003;138:720-3
    • (2003) Ann Intern Med , vol.138 , pp. 720-3
    • Raschke, R.1    Hirsh, J.2    Guidry, J.R.3
  • 28
    • 0028356281 scopus 로고
    • An attempt to standardize the aPTT for heparin monitoring, using the P.T. ISI/INR system of calibration. Results of a 13 centre study
    • Reed SV, Haddon ME, Denson KWE. An attempt to standardize the aPTT for heparin monitoring, using the P.T. ISI/INR system of calibration. Results of a 13 centre study. Thromb Res 1994;74:515-22
    • (1994) Thromb Res , vol.74 , pp. 515-22
    • Reed, S.V.1    Haddon, M.E.2    Denson, K.W.E.3
  • 29
    • 0028878422 scopus 로고
    • The aPTT monitoring of heparin -The IST/ICSH collaborative study
    • Van der Velde EA, Poller L. The aPTT monitoring of heparin -The IST/ICSH collaborative study. Thromb Haemost 1995;73:73-81
    • (1995) Thromb Haemost , vol.73 , pp. 73-81
    • Van Der Velde, E.A.1    Poller, L.2
  • 30
    • 0030836719 scopus 로고    scopus 로고
    • Preparation of lyophilized partial thromboplastin time reagent composed of synthetic phospholipids: Usefulness for monitoring heparin therapy
    • Van den Besselaar AMHP, Neuteboom J, Meeuwisse-Braun J, Bertina RM. Preparation of lyophilized partial thromboplastin time reagent composed of synthetic phospholipids: Usefulness for monitoring heparin therapy. Clin Chem 1997;43:1215-22
    • (1997) Clin Chem , vol.43 , pp. 1215-22
    • Van Den Besselaar, A.M.H.P.1    Neuteboom, J.2    Meeuwisse-Braun, J.3    Bertina, R.M.4
  • 31
    • 0025174959 scopus 로고
    • Monitoring heparin therapy: Relationships between the activated partial thromboplastin time and heparin assays based on exvivo heparin samples
    • Van den Besselaar AM, meeuwisse-Braun J, Bertina RM. Monitoring heparin therapy: Relationships between the activated partial thromboplastin time and heparin assays based on exvivo heparin samples. Thromb Haemost 1990;63:16-23
    • (1990) Thromb Haemost , vol.63 , pp. 16-23
    • Van Den Besselaar, A.M.1    Meeuwisse-Braun, J.2    Bertina, R.M.3
  • 32
    • 0019474985 scopus 로고
    • Esterolytic method for determination of heparin in plasma
    • Kapke GF, Feld RD, Witte DL, Owen WG. Esterolytic method for determination of heparin in plasma. Clin Chem 1981;27:526-9
    • (1981) Clin Chem , vol.27 , pp. 526-9
    • Kapke, G.F.1    Feld, R.D.2    Witte, D.L.3    Owen, W.G.4
  • 33
    • 0023474227 scopus 로고
    • Clinical evaluation of a new one-stage clotting assay for heparin and low molecular weight heparins
    • Harenberg J. Clinical evaluation of a new one-stage clotting assay for heparin and low molecular weight heparins. J Mal Vasc 1987;12(Suppl B):68-70
    • (1987) J Mal Vasc , vol.12 , Issue.SUPPL. B , pp. 68-70
    • Harenberg, J.1
  • 34
    • 0036761802 scopus 로고    scopus 로고
    • Monitoring of unfractionated heparin with the activated partial thromboplastin time: Determination of therapeutic ranges
    • Van den Besselaar AMHP, Sturk A, Reijnierse GLA. Monitoring of unfractionated heparin with the activated partial thromboplastin time: Determination of therapeutic ranges. Thromb Res 2002;107:235-40
    • (2002) Thromb Res , vol.107 , pp. 235-40
    • Van Den Besselaar, A.M.H.P.1    Sturk, A.2    Reijnierse, G.L.A.3
  • 35
    • 57749172924 scopus 로고    scopus 로고
    • Interlaboratory agreement in the monitoring of unfractionated heparin using the anti-factor Xa-correlated activated partial thromboplastin time
    • Cuker A, Ptashkin B, Konkle A, et al. Interlaboratory agreement in the monitoring of unfractionated heparin using the anti-factor Xa-correlated activated partial thromboplastin time. J Thromb Haem 2008;7:80-6
    • (2008) J Thromb Haem , vol.7 , pp. 80-6
    • Cuker, A.1    Ptashkin, B.2    Konkle, A.3
  • 36
    • 85073244855 scopus 로고    scopus 로고
    • The heparin anti-Xa therapeutic Range: Are we there yet?
    • Smythe MA, Mattson JC, Koerber JM. The heparin anti-Xa therapeutic Range: Are we there yet? (Editorial). Chest 2002;121:303-4
    • (2002) Editorial). Chest , vol.121 , pp. 303-4
    • Smythe, M.A.1    Mattson, J.C.2    Koerber, J.M.3
  • 37
    • 0024153910 scopus 로고
    • Intravenous thrombolysis in myocardial infarction. Influence of the quality of the anticoagulation on the early recurrence rate of angina or infarction
    • Camilleri JF, Bonnet JL, Bouvier JL, et al. Intravenous thrombolysis in myocardial infarction. Influence of the quality of the anticoagulation on the early recurrence rate of angina or infarction. Arch Mal Coeur Vaiss 1988;81(9):1037-41
    • (1988) Arch Mal Coeur Vaiss , vol.81 , Issue.9 , pp. 1037-41
    • Camilleri, J.F.1    Bonnet, J.L.2    Bouvier, J.L.3
  • 38
    • 0021189964 scopus 로고
    • The antithrombotic effect of heparin in deep venous thrombosis: Relation to four heparin assays
    • Holm HA, Abildgaard U, Kalvenes S, et al. The antithrombotic effect of heparin in deep venous thrombosis: Relation to four heparin assays. Acta Med Scand 1984;216:287-93
    • (1984) Acta Med Scand , vol.216 , pp. 287-93
    • Holm, H.A.1    Abildgaard, U.2    Kalvenes, S.3
  • 39
    • 0023003183 scopus 로고
    • Continuous intravenous heparin compared with intermittent subcutaneous heparin in the initial treatment of proximal-vein thrombosis
    • Hull RD, Raskob GE, Hirsh J, et al. Continuous intravenous heparin compared with intermittent subcutaneous heparin in the initial treatment of proximal-vein thrombosis. N Engl J Med 1986;315:1109-14
    • (1986) N Engl J Med , vol.315 , pp. 1109-14
    • Hull, R.D.1    Raskob, G.E.2    Hirsh, J.3
  • 40
    • 0027517894 scopus 로고
    • The weight-based heparin dosing nomogram compared with a "standard care" nomogram: A randomized controlled trial
    • Raschke RA, Reilly BM, Guidry JR, Fontana JR, Srinivas S. The weight-based heparin dosing nomogram compared with a "standard care" nomogram: A randomized controlled trial. Ann Intern Med 1993;119:874-81
    • (1993) Ann Intern Med , vol.119 , pp. 874-81
    • Raschke, R.A.1    Reilly, B.M.2    Guidry, J.R.3    Fontana, J.R.4    Srinivas, S.5
  • 41
    • 0038311561 scopus 로고    scopus 로고
    • Relationship of activated partial thromboplastin time to coronary events and bleeding in patients with acute coronary syndromes who receive heparin
    • Anand SS, Yusuf S, Pogue J, Ginsberg JS, Hirsh J. Relationship of activated partial thromboplastin time to coronary events and bleeding in patients with acute coronary syndromes who receive heparin. Circulation 2003;107:2884-8
    • (2003) Circulation , vol.107 , pp. 2884-8
    • Anand, S.S.1    Yusuf, S.2    Pogue, J.3    Ginsberg, J.S.4    Hirsh, J.5
  • 42
    • 0024565260 scopus 로고
    • Comparison of high-dose with low-dose subcutaneous heparin to prevent left ventricular mural thrombosis in patients with acute transmural anterior myocardial infarction
    • Turpie AG, Robinson JG, Doyle DJ, et al. Comparison of high-dose with low-dose subcutaneous heparin to prevent left ventricular mural thrombosis in patients with acute transmural anterior myocardial infarction. N Engl J Med 1989;320(6):352-7
    • (1989) N Engl J Med , vol.320 , Issue.6 , pp. 352-7
    • Turpie, A.G.1    Robinson, J.G.2    Doyle, D.J.3
  • 43
    • 0029938993 scopus 로고    scopus 로고
    • Activated partial thromboplastin time and outcome after thrombolytic therapy for acute myocardial infarction
    • Granger CB, Hirsh J, Califf RM, et al. Activated partial thromboplastin time and outcome after thrombolytic therapy for acute myocardial infarction. Circulation 1996;93:870-8
    • (1996) Circulation , vol.93 , pp. 870-8
    • Granger, C.B.1    Hirsh, J.2    Califf, R.M.3
  • 44
    • 0028118694 scopus 로고
    • A randomized trial comparing activated thromboplastin time with heparin assay in patients with acute venous thromboembolism requiring large daily doses of heparin
    • Levine MN, Hirsh J, Gent M, et al. A randomized trial comparing activated thromboplastin time with heparin assay in patients with acute venous thromboembolism requiring large daily doses of heparin. Arch Intern Med 1994;154:49-56
    • (1994) Arch Intern Med , vol.154 , pp. 49-56
    • Levine, M.N.1    Hirsh, J.2    Gent, M.3
  • 45
    • 0033059794 scopus 로고    scopus 로고
    • Monitoring unfractionated heparin therapy with antifactor Xa activity results in fewer monitoring tests and dosage changes than monitoring with activated partial thromboplastin time
    • Rosborough TK. Monitoring unfractionated heparin therapy with antifactor Xa activity results in fewer monitoring tests and dosage changes than monitoring with activated partial thromboplastin time. Pharmacotherapy 1999;19:760-6
    • (1999) Pharmacotherapy , vol.19 , pp. 760-6
    • Rosborough, T.K.1
  • 46
    • 2942614745 scopus 로고    scopus 로고
    • Achieving target antifactor Xa activity with a heparin protocol based on sex, age, height, and weight
    • Rosborough TK, Shepherd MF. Achieving target antifactor Xa activity with a heparin protocol based on sex, age, height, and weight. Pharmacotherapy 2004;24:713-9
    • (2004) Pharmacotherapy , vol.24 , pp. 713-9
    • Rosborough, T.K.1    Shepherd, M.F.2
  • 47
    • 77949612404 scopus 로고    scopus 로고
    • Weight-based heparin protocol using antifactor Xa monitoring
    • Smith ML, Wheeler KE. Weight-based heparin protocol using antifactor Xa monitoring. Am J Health-Syst Pharm 2010;67:371-4
    • (2010) Am J Health-Syst Pharm , vol.67 , pp. 371-4
    • Smith, M.L.1    Wheeler, K.E.2
  • 49
    • 79960803338 scopus 로고    scopus 로고
    • Activated partial thromboplastin time versus antifactor Xa heparin assay in monitoring unfractionated heparin by continuous intravenous infusion
    • Guervil DJ, Rosenberg AF, Winterstein AG, Harris NS, Johns TE, Zumberg MS. Activated partial thromboplastin time versus antifactor Xa heparin assay in monitoring unfractionated heparin by continuous intravenous infusion. Ann Pharmacother 2011;45:861-8
    • (2011) Ann Pharmacother , vol.45 , pp. 861-8
    • Guervil, D.J.1    Rosenberg, A.F.2    Winterstein, A.G.3    Harris, N.S.4    Johns, T.E.5    Zumberg, M.S.6
  • 50
    • 0021880148 scopus 로고
    • Heparin assays and bleeding complications in treatment of deep venous thrombosis with particular reference to retroperitoneal bleeding
    • Holm HA, Abildgaard U, Kalvenes S. Heparin assays and bleeding complications in treatment of deep venous thrombosis with particular reference to retroperitoneal bleeding. Thromb Haemost 1985;53:278-81
    • (1985) Thromb Haemost , vol.53 , pp. 278-81
    • Holm, H.A.1    Abildgaard, U.2    Kalvenes, S.3
  • 51
    • 0025996472 scopus 로고
    • Identification of risk factors for bleeding during treatment of acute venous thromboembolism with heparin or low molecular heparin
    • Niewenhuis HK, Albada J, Banga JD, et al. Identification of risk factors for bleeding during treatment of acute venous thromboembolism with heparin or low molecular heparin. Blood 1991;78:2337-43
    • (1991) Blood , vol.78 , pp. 2337-43
    • Niewenhuis, H.K.1    Albada, J.2    Banga, J.D.3
  • 52
    • 0032744959 scopus 로고    scopus 로고
    • Heparin monitoring: The confusion continues
    • Smythe M, Koerber BS. Heparin monitoring: The confusion continues. Pharmacotherapy 1999;19:1240-2
    • (1999) Pharmacotherapy , vol.19 , pp. 1240-2
    • Smythe, M.1    Koerber, B.S.2
  • 53
    • 0032955306 scopus 로고    scopus 로고
    • Two instruments to determine activated partial thromboplastin time: Implications for heparin monitoring
    • Taylor CT, Petros WP, Ortel TL. Two instruments to determine activated partial thromboplastin time: Implications for heparin monitoring. Pharmacotherapy 1999;19:383-7
    • (1999) Pharmacotherapy , vol.19 , pp. 383-7
    • Taylor, C.T.1    Petros, W.P.2    Ortel, T.L.3
  • 54
    • 0033995868 scopus 로고    scopus 로고
    • Monitoring unfractionated heparin therapy: Relationship between eight anti-Xa assays and a protamine titration assay
    • Kitchen S, Theaker J, Preston FE. Monitoring unfractionated heparin therapy: Relationship between eight anti-Xa assays and a protamine titration assay. Blood Coagul Fibrinolysis 2000;11:137-44
    • (2000) Blood Coagul Fibrinolysis , vol.11 , pp. 137-44
    • Kitchen, S.1    Theaker, J.2    Preston, F.E.3
  • 55
    • 0033039419 scopus 로고    scopus 로고
    • Three different chromogenic methods do not give equivalent anti-Xa levels for patients on therapeutic low molecular weight heparin (dalteparin) or unfractionated heparin
    • Kovacs MJ, Keeney M, Mackinnon K, Boyle E. Three different chromogenic methods do not give equivalent anti-Xa levels for patients on therapeutic low molecular weight heparin (dalteparin) or unfractionated heparin. Clin Lab Haem 1999;21:55-60
    • (1999) Clin Lab Haem , vol.21 , pp. 55-60
    • Kovacs, M.J.1    Keeney, M.2    Mackinnon, K.3    Boyle, E.4
  • 56
    • 1842479365 scopus 로고    scopus 로고
    • Heparin monitoring and patient safety: A College of American Pathology Q-probes study of 3,431 patients at 140 institutions
    • Valenstein PN, Walsh MK, Meier F. Heparin monitoring and patient safety: A College of American Pathology Q-probes study of 3,431 patients at 140 institutions. Arch Pathol Lab Med 2004;128:397-402.
    • (2004) Arch Pathol Lab Med , vol.128 , pp. 397-402
    • Valenstein, P.N.1    Walsh, M.K.2    Meier, F.3


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