-
1
-
-
0345363003
-
Ras proteins: Recent advances and new functions
-
Rebollo A, Martinez A. Ras proteins: recent advances and new functions. Blood. 1999;94(9):2971-2980.
-
(1999)
Blood.
, vol.94
, Issue.9
, pp. 2971-2980
-
-
Rebollo, A.1
Martinez, A.2
-
2
-
-
78649487698
-
Ras superfamily gefs and gaps: Validated and tractable targets for cancer therapy?
-
Vigil D, Cherfils J, Rossman KL, et al. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat Rev Cancer. 2010;10(12):842-857.
-
(2010)
Nat Rev Cancer.
, vol.10
, Issue.12
, pp. 842-857
-
-
Vigil, D.1
Cherfils, J.2
Rossman, K.L.3
-
3
-
-
20444426889
-
A genetic screen identifies pitx1 as a suppressor of ras activity and tumorigenicity
-
Kolfschoten IG, van Leeuwen B, Berns K, et al. A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Cell. 2005;121(6):849-858.
-
(2005)
Cell.
, vol.121
, Issue.6
, pp. 849-858
-
-
Kolfschoten, I.G.1
Van Leeuwen, B.2
Berns, K.3
-
4
-
-
34547619642
-
Epigenetic silencing of a ca(2+)-regulated ras gtpase-Activating protein rasal defines a new mechanism of ras activation in human cancers
-
Jin H, Wang X, Ying J, et al. Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-Activating protein RASAL defines a new mechanism of Ras activation in human cancers. Proc Natl Acad Sci U S A. 2007;104(30):12353-12358.
-
(2007)
Proc Natl Acad Sci U S A.
, vol.104
, Issue.30
, pp. 12353-12358
-
-
Jin, H.1
Wang, X.2
Ying, J.3
-
5
-
-
59849104569
-
Decreased expression of the ras-gtpase activating protein rasal1 is associated with colorectal tumor progression
-
Ohta M, Seto M, Ijichi H, et al. Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. Gastroenterology. 2009;136(1):206-216.
-
(2009)
Gastroenterology.
, vol.136
, Issue.1
, pp. 206-216
-
-
Ohta, M.1
Seto, M.2
Ijichi, H.3
-
6
-
-
33745486561
-
The genetic and molecular pathogenesis of nf1 and nf2
-
Yohay KH. The genetic and molecular pathogenesis of NF1 and NF2. Semin Pediatr Neurol. 2006;13(1):21-26.
-
(2006)
Semin Pediatr Neurol.
, vol.13
, Issue.1
, pp. 21-26
-
-
Yohay, K.H.1
-
7
-
-
20844435467
-
The nf1 tumor suppressor critically regulates tsc2 and mtor
-
Johannessen CM, Reczek EE, James MF, et al. The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc Natl Acad Sci U S A. 2005;102(24):8573-8578.
-
(2005)
Proc Natl Acad Sci U S A.
, vol.102
, Issue.24
, pp. 8573-8578
-
-
Johannessen, C.M.1
Reczek, E.E.2
James, M.F.3
-
8
-
-
0036700983
-
Genetics of neurofibromatosis 1 and the nf1 gene
-
Viskochil D. Genetics of neurofibromatosis 1 and the NF1 gene. J Child Neurol. 2002;17(8):562-570.
-
(2002)
J Child Neurol.
, vol.17
, Issue.8
, pp. 562-570
-
-
Viskochil, D.1
-
9
-
-
0035833471
-
Spred is a sprouty-related suppressor of ras signalling
-
Wakioka T, Sasaki A, Kato R, et al. Spred is a Sprouty-related suppressor of Ras signalling. Nature. 2001;412(6847):647-651.
-
(2001)
Nature.
, vol.412
, Issue.6847
, pp. 647-651
-
-
Wakioka, T.1
Sasaki, A.2
Kato, R.3
-
10
-
-
0035965203
-
Identification of a dominant negative mutant of sprouty that potentiates fibroblast growth factorbut not epidermal growth factor-induced erk activation
-
Sasaki A, Taketomi T, Wakioka T, et al. Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factorbut not epidermal growth factor-induced ERK activation. J Biol Chem. 2001;276(39):36804-36808.
-
(2001)
J Biol Chem.
, vol.276
, Issue.39
, pp. 36804-36808
-
-
Sasaki, A.1
Taketomi, T.2
Wakioka, T.3
-
11
-
-
41849102400
-
Raf kinase inhibitory protein: A signal transduction modulator and metastasis suppressor
-
Granovsky AE, Rosner MR. Raf kinase inhibitory protein: A signal transduction modulator and metastasis suppressor. Cell Res. 2008;18(4):452-457.
-
(2008)
Cell Res.
, vol.18
, Issue.4
, pp. 452-457
-
-
Granovsky, A.E.1
Rosner, M.R.2
-
12
-
-
0041836252
-
Dual-specificity phosphatase 5 (dusp5) as a direct transcriptional target of tumor suppressor p53
-
Ueda K, Arakawa H, Nakamura Y. Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53. Oncogene. 2003;22(36):5586-5591.
-
(2003)
Oncogene.
, vol.22
, Issue.36
, pp. 5586-5591
-
-
Ueda, K.1
Arakawa, H.2
Nakamura, Y.3
-
13
-
-
0038243934
-
Potential tumor suppressive pathway involving dusp6mkp-3 in pancreatic cancer
-
Furukawa T, Sunamura M, Motoi F, et al. Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. Am J Pathol. 2003;162(6):1807-1815.
-
(2003)
Am J Pathol.
, vol.162
, Issue.6
, pp. 1807-1815
-
-
Furukawa, T.1
Sunamura, M.2
Motoi, F.3
-
14
-
-
84993915355
-
Tumour suppressors: Role of nuclear pten revealed
-
Wrighton KH. Tumour suppressors: Role of nuclear PTEN revealed. Nat Rev Cancer. 2011;11(3):154.
-
(2011)
Nat Rev Cancer
, vol.11
, Issue.3
, pp. 154
-
-
Wrighton, K.H.1
-
15
-
-
56749176442
-
Lkb1; linking cell structure and tumor suppression
-
Hezel AF, Bardeesy N. LKB1; linking cell structure and tumor suppression. Oncogene. 2008;27(55):6908-6919.
-
(2008)
Oncogene.
, vol.27
, Issue.55
, pp. 6908-6919
-
-
Hezel, A.F.1
Bardeesy, N.2
-
16
-
-
79956088595
-
The long and winding road to rational treatment of cancer associated with lkb1/ampk/tsc/mtorc1 signaling
-
van Veelen W, Korsse SE, van de LL, et al. The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling. Oncogene. 2011;30(20):2289-2303
-
(2011)
Oncogene.
, vol.30
, Issue.20
, pp. 2289-2303
-
-
Van Veelen, W.1
Korsse, S.E.2
Van De, L.L.3
-
17
-
-
70349174971
-
The rassf proteins in cancer; from epigenetic silencing to functional characterization
-
Richter AM, Pfeifer GP, Dammann RH. The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Biochim Biophys Acta. 2009;1796(2):114-128.
-
(2009)
Biochim Biophys Acta.
, vol.1796
, Issue.2
, pp. 114-128
-
-
Richter, A.M.1
Pfeifer, G.P.2
Dammann, R.H.3
-
18
-
-
33644829154
-
Stops along the ras pathway in human genetic disease
-
Bentires-Alj M, Kontaridis MI, Neel BG. Stops along the RAS pathway in human genetic disease. Nat Med. 2006;12(3):283-285.
-
(2006)
Nat Med.
, vol.12
, Issue.3
, pp. 283-285
-
-
Bentires-Alj, M.1
Kontaridis, M.I.2
Neel, B.G.3
-
19
-
-
34548328245
-
Germline loss-of-function mutations in spred1 cause a neurofibromatosis 1-like phenotype
-
Brems H, Chmara M, Sahbatou M, et al. Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype. Nat Genet. 2007;39(9):1120-1126.
-
(2007)
Nat Genet.
, vol.39
, Issue.9
, pp. 1120-1126
-
-
Brems, H.1
Chmara, M.2
Sahbatou, M.3
-
22
-
-
0032535770
-
A national cancer data base report on 53856 cases of thyroid carcinoma treated in the u.s. 1985-1995 [see comments]
-
Hundahl SA, Fleming ID, Fremgen AM, et al. A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995 [see comments]. Cancer. 1998;83(12):2638-2648.
-
(1998)
Cancer.
, vol.83
, Issue.12
, pp. 2638-2648
-
-
Hundahl, S.A.1
Fleming, I.D.2
Fremgen, A.M.3
-
23
-
-
84875361065
-
Molecular pathogenesis and mechanisms of thyroid cancer
-
Xing M. Molecular pathogenesis and mechanisms of thyroid cancer. Nat Rev Cancer. 2013;13(3):184-199.
-
(2013)
Nat Rev Cancer.
, vol.13
, Issue.3
, pp. 184-199
-
-
Xing, M.1
-
24
-
-
21244457181
-
Braf mutation in thyroid cancer
-
Xing M. BRAF mutation in thyroid cancer. Endocr Relat Cancer. 2005;12(2):245-262.
-
(2005)
Endocr Relat Cancer.
, vol.12
, Issue.2
, pp. 245-262
-
-
Xing, M.1
-
25
-
-
37349131738
-
Braf mutation in papillary thyroid cancer: Pathogenic role, molecular bases, and clinical implications
-
Xing M. BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications. Endocr Rev. 2007;28(7):742-762.
-
(2007)
Endocr Rev.
, vol.28
, Issue.7
, pp. 742-762
-
-
Xing, M.1
-
26
-
-
78349300635
-
Genetic alterations in the phosphatidylinositol-3 kinase/akt pathway in thyroid cancer
-
Xing M. Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer. Thyroid. 2010;20(7):697-706.
-
(2010)
Thyroid.
, vol.20
, Issue.7
, pp. 697-706
-
-
Xing, M.1
-
27
-
-
33947284529
-
Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/akt pathway in thyroid cancer
-
Hou P, Liu D, Shan Y, et al. Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer. Clin Cancer Res. 2007;13(4):1161-1170.
-
(2007)
Clin Cancer Res.
, vol.13
, Issue.4
, pp. 1161-1170
-
-
Hou, P.1
Liu, D.2
Shan, Y.3
-
28
-
-
70349741010
-
Genetic alterations in the phosphoinositide 3-kinase/akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of akt and mammalian target of rapamycin
-
Liu D, Hou P, Liu Z, et al. Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin. Cancer Res. 2009;69(18):7311-7319.
-
(2009)
Cancer Res.
, vol.69
, Issue.18
, pp. 7311-7319
-
-
Liu, D.1
Hou, P.2
Liu, Z.3
-
29
-
-
33947290100
-
Suppression of braf/mek/map kinase pathway restores expression of iodide-metabolizing genes in thyroid cells expressing the v600e braf mutant
-
Liu D, Hu S, Hou P, et al. Suppression of BRAF/MEK/MAP kinase pathway restores expression of iodide-metabolizing genes in thyroid cells expressing the V600E BRAF mutant. Clin Cancer Res. 2007;13(4):1341-1349.
-
(2007)
Clin Cancer Res.
, vol.13
, Issue.4
, pp. 1341-1349
-
-
Liu, D.1
Hu, S.2
Hou, P.3
-
30
-
-
55549084534
-
Association of pten gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/akt signaling pathway in thyroid tumors
-
Hou P, Ji M, Xing M. Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors. Cancer. 2008;113(9):2440-2447.
-
(2008)
Cancer.
, vol.113
, Issue.9
, pp. 2440-2447
-
-
Hou, P.1
Ji, M.2
Xing, M.3
-
31
-
-
1642272931
-
Early occurrence of rassf1a hypermethylation and its mutual exclusion with braf mutation in thyroid tumorigenesis
-
Xing M, Cohen Y, Mambo E, et al. Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis. Cancer Res. 2004;64(5):1664-1668.
-
(2004)
Cancer Res.
, vol.64
, Issue.5
, pp. 1664-1668
-
-
Xing, M.1
Cohen, Y.2
Mambo, E.3
-
32
-
-
0025276807
-
Cdna cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line
-
Ishizaka Y, Ushijima T, Sugimura T, et al. cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line. Biochem Biophys Res Commun. 1990;168(2):402-408.
-
(1990)
Biochem Biophys Res Commun.
, vol.168
, Issue.2
, pp. 402-408
-
-
Ishizaka, Y.1
Ushijima, T.2
Sugimura, T.3
-
33
-
-
34247330161
-
The tumor suppressor neurofibromin confers sensitivity to apoptosis by ras-dependent and rasindependent pathways
-
Shapira S, Barkan B, Friedman E, et al. The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Rasindependent pathways. Cell Death Differ. 2007;14(5):895-906.
-
(2007)
Cell Death Differ.
, vol.14
, Issue.5
, pp. 895-906
-
-
Shapira, S.1
Barkan, B.2
Friedman, E.3
-
34
-
-
0027491616
-
The gtpase-Activating nf1 fragment of 91 amino acids reverses v-ha-ras-induced malignant phenotype
-
Nur-E-Kamal MS, Varga M, Maruta H. The GTPase-Activating NF1 fragment of 91 amino acids reverses v-Ha-Ras-induced malignant phenotype. J Biol Chem. 1993;268(30):22331-22337.
-
(1993)
J Biol Chem.
, vol.268
, Issue.30
, pp. 22331-22337
-
-
Nur-E-Kamal, M.S.1
Varga, M.2
Maruta, H.3
-
35
-
-
0027533785
-
The neurofibromatosis type 1 gene and its protein product, neurofibromin
-
Gutmann DH, Collins FS. The neurofibromatosis type 1 gene and its protein product, neurofibromin. Neuron. 1993;10(3):335-343.
-
(1993)
Neuron.
, vol.10
, Issue.3
, pp. 335-343
-
-
Gutmann, D.H.1
Collins, F.S.2
-
36
-
-
77953766335
-
B-raf(v600e) and thrombospondin-1 promote thyroid cancer progression
-
Nucera C, Porrello A, Antonello ZA, et al. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A. 2010;107(23):10649-10654.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, Issue.23
, pp. 10649-10654
-
-
Nucera, C.1
Porrello, A.2
Antonello, Z.A.3
-
37
-
-
84055191090
-
Small-molecule mapk inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional braf activation
-
Chakravarty D, Santos E, Ryder M, et al. Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. J Clin Invest. 2011;121(12):4700-4711.
-
(2011)
J Clin Invest.
, vol.121
, Issue.12
, pp. 4700-4711
-
-
Chakravarty, D.1
Santos, E.2
Ryder, M.3
-
38
-
-
33749599164
-
Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and braf mutation in papillary thyroid cancer
-
Hu S, Liu D, Tufano RP, et al. Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer. Int J Cancer. 2006;119(10):2322-2329.
-
(2006)
Int J Cancer.
, vol.119
, Issue.10
, pp. 2322-2329
-
-
Hu, S.1
Liu, D.2
Tufano, R.P.3
-
39
-
-
0029829561
-
Crystal structure of the gtpaseactivating domain of human p120gap and implications for the interaction with ras
-
Scheffzek K, Lautwein A, Kabsch W, et al. Crystal structure of the GTPaseactivating domain of human p120GAP and implications for the interaction with Ras. Nature. 1996;384(6609):591-596.
-
(1996)
Nature.
, vol.384
, Issue.6609
, pp. 591-596
-
-
Scheffzek, K.1
Lautwein, A.2
Kabsch, W.3
-
40
-
-
0030991489
-
Large majority of single-nucleotide mutations along the dystrophin gene can be explained by more than one mechanism of mutagenesis
-
Todorova A, Danieli GA. Large majority of single-nucleotide mutations along the dystrophin gene can be explained by more than one mechanism of mutagenesis. Hum Mutat. 1997;9(6):537-547.
-
(1997)
Hum Mutat.
, vol.9
, Issue.6
, pp. 537-547
-
-
Todorova, A.1
Danieli, G.A.2
|