-
1
-
-
58149202128
-
Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
-
Baud V, Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 2009; 8: 33-40.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 33-40
-
-
Baud, V.1
Karin, M.2
-
2
-
-
4043088499
-
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
-
Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004; 118: 285-296.
-
(2004)
Cell
, vol.118
, pp. 285-296
-
-
Greten, F.R.1
Eckmann, L.2
Greten, T.F.3
Park, J.M.4
Li, Z.W.5
Egan, L.J.6
-
3
-
-
33745298519
-
Nuclear factor-kappaB in cancer development and progression
-
Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006; 441: 431-436.
-
(2006)
Nature
, vol.441
, pp. 431-436
-
-
Karin, M.1
-
4
-
-
25844459154
-
NF-kappaB: Linking inflammation and immunity to cancer development and progression
-
Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005; 5: 749-759.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
5
-
-
4644324186
-
NF-kappaB functions as a tumour promoter in inflammation-associated cancer
-
Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004; 431: 461-466.
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
Porat, R.M.2
Stein, I.3
Abramovitch, R.4
Amit, S.5
Kasem, S.6
-
6
-
-
84866641762
-
NF-kappaB in cancer: A matter of life and death
-
Aggarwal BB, Sung B. NF-kappaB in cancer: a matter of life and death. Cancer Discov 2011; 1: 469-471.
-
(2011)
Cancer Discov
, vol.1
, pp. 469-471
-
-
Aggarwal, B.B.1
Sung, B.2
-
7
-
-
84872600554
-
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stemcell-like properties
-
Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Goktuna SI, Ziegler PK et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stemcell-like properties. Cell 2013; 152: 25-38.
-
(2013)
Cell
, vol.152
, pp. 25-38
-
-
Schwitalla, S.1
Fingerle, A.A.2
Cammareri, P.3
Nebelsiek, T.4
Goktuna, S.I.5
Ziegler, P.K.6
-
8
-
-
66649127621
-
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma
-
Compagno M, Lim WK, Grunn A, Nandula SV, Brahmachary M, Shen Q et al. Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature 2009; 459: 717-721.
-
(2009)
Nature
, vol.459
, pp. 717-721
-
-
Compagno, M.1
Lim, W.K.2
Grunn, A.3
Nandula, S.V.4
Brahmachary, M.5
Shen, Q.6
-
9
-
-
0041967054
-
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
-
Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, Courtois G. The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature 2003; 424: 801-805.
-
(2003)
Nature
, vol.424
, pp. 801-805
-
-
Kovalenko, A.1
Chable-Bessia, C.2
Cantarella, G.3
Israel, A.4
Wallach, D.5
Courtois, G.6
-
10
-
-
41149136296
-
Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
-
Lenz G, Davis RE, Ngo VN, Lam L, George TC, Wright GW et al. Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science 2008; 319: 1676-1679.
-
(2008)
Science
, vol.319
, pp. 1676-1679
-
-
Lenz, G.1
Davis, R.E.2
Ngo, V.N.3
Lam, L.4
George, T.C.5
Wright, G.W.6
-
11
-
-
66549086135
-
The NF-{kappa}B negative regulator TNFAIP3 A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas
-
Novak U, Rinaldi A, Kwee I, Nandula SV, Rancoita PM, Compagno M et al. The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas. Blood 2009; 113: 4918-4921.
-
(2009)
Blood
, vol.113
, pp. 4918-4921
-
-
Novak, U.1
Rinaldi, A.2
Kwee, I.3
Nandula, S.V.4
Rancoita, P.M.5
Compagno, M.6
-
12
-
-
0042467554
-
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
-
Brummelkamp TR, Nijman SM, Dirac AM, Bernards R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature 2003; 424: 797-801.
-
(2003)
Nature
, vol.424
, pp. 797-801
-
-
Brummelkamp, T.R.1
Nijman, S.M.2
Dirac, A.M.3
Bernards, R.4
-
13
-
-
34547562418
-
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
-
Annunziata CM, Davis RE, Demchenko Y, Bellamy W, Gabrea A, Zhan F et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 2007; 12: 115-130.
-
(2007)
Cancer Cell
, vol.12
, pp. 115-130
-
-
Annunziata, C.M.1
Davis, R.E.2
Demchenko, Y.3
Bellamy, W.4
Gabrea, A.5
Zhan, F.6
-
14
-
-
34547660308
-
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
-
Keats JJ, Fonseca R, Chesi M, Schop R, Baker A, Chng WJ et al. Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell 2007; 12: 131-144.
-
(2007)
Cancer Cell
, vol.12
, pp. 131-144
-
-
Keats, J.J.1
Fonseca, R.2
Chesi, M.3
Schop, R.4
Baker, A.5
Chng, W.J.6
-
15
-
-
77955660663
-
Diverse somatic mutation patterns and pathway alterations in human cancers
-
Kan Z, Jaiswal BS, Stinson J, Janakiraman V, Bhatt D, Stern HM et al. Diverse somatic mutation patterns and pathway alterations in human cancers. Nature 2010; 466: 869-873.
-
(2010)
Nature
, vol.466
, pp. 869-873
-
-
Kan, Z.1
Jaiswal, B.S.2
Stinson, J.3
Janakiraman, V.4
Bhatt, D.5
Stern, H.M.6
-
17
-
-
78651476339
-
Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing
-
Pflueger D, Terry S, Sboner A, Habegger L, Esgueva R, Lin PC et al. Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing. Genome Res 2011; 21: 56-67.
-
(2011)
Genome Res
, vol.21
, pp. 56-67
-
-
Pflueger, D.1
Terry, S.2
Sboner, A.3
Habegger, L.4
Esgueva, R.5
Lin, P.C.6
-
18
-
-
34249993765
-
Integrative genomic approaches identify IKBKE as a breast cancer oncogene
-
Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF et al. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell 2007; 129: 1065-1079.
-
(2007)
Cell
, vol.129
, pp. 1065-1079
-
-
Boehm, J.S.1
Zhao, J.J.2
Yao, J.3
Kim, S.Y.4
Firestein, R.5
Dunn, I.F.6
-
19
-
-
70449109147
-
Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma
-
Meylan E, Dooley AL, Feldser DM, Shen L, Turk E, Ouyang C et al. Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature 2009; 462: 104-107.
-
(2009)
Nature
, vol.462
, pp. 104-107
-
-
Meylan, E.1
Dooley, A.L.2
Feldser, D.M.3
Shen, L.4
Turk, E.5
Ouyang, C.6
-
20
-
-
77951706304
-
Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis
-
Basseres DS, Ebbs A, Levantini E, Baldwin AS. Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis. Cancer Res 2010; 70: 3537-3546.
-
(2010)
Cancer Res
, vol.70
, pp. 3537-3546
-
-
Basseres, D.S.1
Ebbs, A.2
Levantini, E.3
Baldwin, A.S.4
-
21
-
-
70449091786
-
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
-
Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 2009; 462: 108-112.
-
(2009)
Nature
, vol.462
, pp. 108-112
-
-
Barbie, D.A.1
Tamayo, P.2
Boehm, J.S.3
Kim, S.Y.4
Moody, S.E.5
Dunn, I.F.6
-
22
-
-
84855946746
-
KrasG12D-induced IKK2/beta/NF-kappaB activation by IL-1alpha and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma
-
Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z et al. KrasG12D-induced IKK2/beta/NF-kappaB activation by IL-1alpha and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell 2012; 21: 105-120.
-
(2012)
Cancer Cell
, vol.21
, pp. 105-120
-
-
Ling, J.1
Kang, Y.2
Zhao, R.3
Xia, Q.4
Lee, D.F.5
Chang, Z.6
-
23
-
-
80053389114
-
TRAF6 is an amplified oncogene bridging the RAS and NF-kappaB pathways in human lung cancer
-
Starczynowski DT, Lockwood WW, Delehouzee S, Chari R, Wegrzyn J, Fuller M et al. TRAF6 is an amplified oncogene bridging the RAS and NF-kappaB pathways in human lung cancer. J Clin Invest 2011; 121: 4095-4105.
-
(2011)
J Clin Invest
, vol.121
, pp. 4095-4105
-
-
Starczynowski, D.T.1
Lockwood, W.W.2
Delehouzee, S.3
Chari, R.4
Wegrzyn, J.5
Fuller, M.6
-
24
-
-
77749297990
-
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB
-
Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T et al. An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat Med 2010; 16: 286-294.
-
(2010)
Nat Med
, vol.16
, pp. 286-294
-
-
Min, J.1
Zaslavsky, A.2
Fedele, G.3
McLaughlin, S.K.4
Reczek, E.E.5
De Raedt, T.6
-
25
-
-
84934436838
-
Physiological roles and mechanisms of signaling by TRAF2 and TRAF5
-
Au PY, Yeh WC. Physiological roles and mechanisms of signaling by TRAF2 and TRAF5. Adv Exp Med Biol 2007; 597: 32-47.
-
(2007)
Adv Exp Med Biol
, vol.597
, pp. 32-47
-
-
Au, P.Y.1
Yeh, W.C.2
-
26
-
-
0033485542
-
NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase
-
Pomerantz JL, Baltimore D. NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J 1999; 18: 6694-6704.
-
(1999)
EMBO J
, vol.18
, pp. 6694-6704
-
-
Pomerantz, J.L.1
Baltimore, D.2
-
27
-
-
23144449789
-
Ubiquitin signalling in the NF-kappaB pathway
-
Chen ZJ. Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol 2005; 7: 758-765.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 758-765
-
-
Chen, Z.J.1
-
28
-
-
65949114424
-
Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation
-
Thomas GS, Zhang L, Blackwell K, Habelhah H. Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation. Cancer Res 2009; 69: 3665-3672.
-
(2009)
Cancer Res
, vol.69
, pp. 3665-3672
-
-
Thomas, G.S.1
Zhang, L.2
Blackwell, K.3
Habelhah, H.4
-
29
-
-
84861133652
-
MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma
-
Wood KC, Konieczkowski DJ, Johannessen CM, Boehm JS, Tamayo P, Botvinnik OB et al. MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma. Sci Signal 2012; 5: rs4.
-
(2012)
Sci Signal
, vol.5
, pp. 4
-
-
Wood, K.C.1
Konieczkowski, D.J.2
Johannessen, C.M.3
Boehm, J.S.4
Tamayo, P.5
Botvinnik, O.B.6
-
30
-
-
79953046542
-
FAS and NF-kappaB signalling modulate dependence of lung cancers on mutant EGFR
-
Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R et al. FAS and NF-kappaB signalling modulate dependence of lung cancers on mutant EGFR. Nature 2011; 471: 523-526.
-
(2011)
Nature
, vol.471
, pp. 523-526
-
-
Bivona, T.G.1
Hieronymus, H.2
Parker, J.3
Chang, K.4
Taron, M.5
Rosell, R.6
-
31
-
-
65649114699
-
Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation
-
Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM et al. Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation. Mol Cell 2009; 34: 461-472.
-
(2009)
Mol Cell
, vol.34
, pp. 461-472
-
-
Hutti, J.E.1
Shen, R.R.2
Abbott, D.W.3
Zhou, A.Y.4
Sprott, K.M.5
Asara, J.M.6
-
32
-
-
77249119762
-
The landscape of somatic copy-number alteration across human cancers
-
Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J et al. The landscape of somatic copy-number alteration across human cancers. Nature 2010; 463: 899-905.
-
(2010)
Nature
, vol.463
, pp. 899-905
-
-
Beroukhim, R.1
Mermel, C.H.2
Porter, D.3
Wei, G.4
Raychaudhuri, S.5
Donovan, J.6
-
33
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
Cancer Genome Atlas Network
-
Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 2012; 490: 61-70.
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
-
34
-
-
79959838081
-
Integrated genomic analyses of ovarian carcinoma
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 2011; 474: 609-615.
-
(2011)
Nature
, vol.474
, pp. 609-615
-
-
-
35
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas Network
-
Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487: 330-337.
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
-
36
-
-
58249115041
-
TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis
-
Blackwell K, Zhang L, Thomas GS, Sun S, Nakano H, Habelhah H. TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis. Mol Cell Biol 2009; 29: 303-314.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 303-314
-
-
Blackwell, K.1
Zhang, L.2
Thomas, G.S.3
Sun, S.4
Nakano, H.5
Habelhah, H.6
-
37
-
-
61849157254
-
TNFR signaling: Ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes
-
Karin M, Gallagher E. TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunol Rev 2009; 228: 225-240.
-
(2009)
Immunol Rev
, vol.228
, pp. 225-240
-
-
Karin, M.1
Gallagher, E.2
-
38
-
-
58149301485
-
PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination
-
Li S, Wang L, Dorf ME. PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. Mol Cell 2009; 33: 30-42.
-
(2009)
Mol Cell
, vol.33
, pp. 30-42
-
-
Li, S.1
Wang, L.2
Dorf, M.E.3
-
40
-
-
84875810173
-
IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex
-
Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ et al. IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. Cell Rep 2013; 3: 724-733.
-
(2013)
Cell Rep
, vol.3
, pp. 724-733
-
-
Zhou, A.Y.1
Shen, R.R.2
Kim, E.3
Lock, Y.J.4
Xu, M.5
Chen, Z.J.6
-
41
-
-
0042991379
-
Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors
-
Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M et al. Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell 2003; 114: 359-370.
-
(2003)
Cell
, vol.114
, pp. 359-370
-
-
Bassing, C.H.1
Suh, H.2
Ferguson, D.O.3
Chua, K.F.4
Manis, J.5
Eckersdorff, M.6
-
42
-
-
77949587674
-
Lentiviral vectors to probe and manipulate the Wnt signaling pathway
-
Fuerer C, Nusse R. Lentiviral vectors to probe and manipulate the Wnt signaling pathway. PloS One 2010; 5: e9370.
-
(2010)
PloS One
, vol.5
, pp. e9370
-
-
Fuerer, C.1
Nusse, R.2
-
43
-
-
84859169877
-
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012; 483: 603-607.
-
(2012)
Nature
, vol.483
, pp. 603-607
-
-
Barretina, J.1
Caponigro, G.2
Stransky, N.3
Venkatesan, K.4
Margolin, A.A.5
Kim, S.6
|