Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: Cell cycle perturbation and impact of administration schedule in vitro and in vivo

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Montano, Ryan ^a   Thompson, Ruth ^a   Chung, Injae ^b   Hou, Huagang ^a   Khan, Nadeem ^a   Eastman, Alan ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b Duksung Women's University   (South Korea)

Author keywords

Cell cycle perturbation; Chk1; Drug combinations; Gemcitabine; Homologous recombination; MK 8776; Pancreas cancer xenografts

Indexed keywords

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; DEOXYCYTIDINE; DNA DAMAGE; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; HUMANS; MICE; MICE, NUDE; PANCREATIC NEOPLASMS; PYRAZOLES; PYRIMIDINES; RECOMBINATIONAL DNA REPAIR; S PHASE CELL CYCLE CHECKPOINTS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84890458070     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-604     Document Type: Article

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