Brain neuronal activation induced by flibanserin treatment in female rats

Psychopharmacology

Volumn 230, Issue 4, 2013, Pages 639-652

  Gelez, Helene ^a   Clement, Pierre ^a   Compagnie, Sandrine ^a   Gorny, Diane ^a   Laurin, Miguel ^a   Allers, Kelly ^b   Sommer, Bernd ^b   Giuliano, Francois ^a,c  

^a LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c RAYMOND POINCARÉ HOSPITAL   (France)

Author keywords

Brain activation; Catecholamine; Motivation; Sexual desire

Indexed keywords

FLIBANSERIN; PROTEIN FOS;

ACUTE DRUG ADMINISTRATION; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARCUATE NUCLEUS; ARTICLE; BRAIN FUNCTION; BRAIN NERVE CELL; BRAIN STEM; CATECHOLAMINE NERVE CELL; CELL ACTIVATION; CELL DENSITY; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MECHANISM; FEMALE; IMMUNOREACTIVITY; LATERAL PARAGIGANTOCELLULAR NUCLEUS; LOCUS CERULEUS; MEDIAL PREOPTIC AREA; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEXUAL BEHAVIOR; SOLITARY TRACT NUCLEUS; VENTRAL TEGMENTUM;

ANIMALS; BENZIMIDAZOLES; BRAIN; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; NEURONS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, LONG-EVANS; SEROTONIN 5-HT1 RECEPTOR AGONISTS; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS;

EID: 84890440589     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-3194-6     Document Type: Article

References (55)

1. Allers KA, Dremencov E, Ceci A, Flik G, Ferger B, Cremers TI, Ittrich C, Sommer B (2010) Acute and repeated flibanserin administration in female rats modulates monoamines differentially accross brain areas: a microdialysis study. J Sex Med 7:1757-1767
2. Aubert Y, Gustison ML, Gardner LA, Bohl MA, Lange JR, Allers KA, Sommer B, Datson NA, Abbott DH (2012) Flibanserin and 8-OH-DPAT implicate serotonin in association between female marmoset monkey sexual behavior and changes in pair-bond quality. J Sex Med 9:694-707
3. Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083-1152
4. Basson R (2001) Using a different model for female sexual response to address women's problematic low sexual desire. J Sex Marital Ther 27:395-403
5. Beach FA (1976) Sexual attractivity, proceptivity, and receptivity in female mammals. Horm Behav 7:105-138
6. Biały M, Kaczmarek L (1996) c-Fos expression as a tool to search for the neurobiological base of the sexual behaviour of males. Acta Neurobiol Exp 56:567-577
7. Borsini F, Evans K, Jason K, Rohde F, Alexander B, Pollentier S (2002) Pharmacology of flibanserin. CNS Drug Rev 8:117-142
8. Carr DB, Sesack SR (2000) Projections from the rat prefrontal cortex to the ventral tegmental area: target specificity in the synaptic associations with mesoaccumbens and mesocortical neurons. J Neurosci 20:3864-3873
9. Compaan JC, Groenink L, van der Gugten J, Maes RA, Olivier B (1996) 5-HT1A receptor agonist flesinoxan enhances Fos immunoreactivity in rat central amygdala, bed nucleus of the stria terminalis and hypothalamus. Eur J Neurosci 8:2340-2347
10. Compaan JC, Groenink L, Van der Gugten J, Maes RA, Olivier B (1997) Pretreatment with 5-HT1A receptor agonist flesinoxan attenuates Fos protein in rat hypothalamus. Eur J Pharmacol 324:161-168
11. Coria-Avila GA, Pfaus JG (2007) Neuronal activation by stimuli that predict sexual reward in female rats. Neuroscience 148:623-632
12. Daniels D, Miselis RR, Flanagan-Cato LM (1999) Central neuronal circuit innervating the lordosis-producing muscles defined by transneuronal transport of pseudorabies virus. J Neurosci 19:2823-2833
13. Derogatis LR, Komer L, Katz M, Moreau M, Kimura T, Garcia M Jr, Wunderlich G, Pyke R (2012) Treatment of hypoactive sexual desire disorder in premenopausal women: efficacy of flibanserin in the VIOLET Study. J Sex Med 9:1074-1085
14. Erskine MS, Hanrahan SB (1997) Effects of paced mating on c-fos gene expression in the female rat brain. J Neuroendocrinol 9:903-912
15. Fay R, Kubin L (2000) Pontomedullary distribution of 5-HT2A receptor-like protein in the rat. J Comp Neurol 418:323-345
16. Fields HL, Hjelmstad GO, Margolis EB, Nicola SM (2007) Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement. Annu Rev Neurosci 30:289-316
17. Gelez H, Allers K, Sommer B, Giuliano F (2010) Chronic flibanserin treatment increases solicitations in the female rat. J Sex Med 7:118
18. Gelez H, Greggain-Mohr J, Pfaus JG, Allers K, Giuliano F (2013) Flibanserin treatment increases appetitive sexual motivation in the female rat. J Sex Med 10:1231-1239
19. Giuliano F, Pfaus JG, Balasubramanian S, Hedlund P, Hisasue S, Marson L, Wallen K (2010) Experimental models for the study of male and female sexual functions. J Sex Med 7:2970-2995
20. Greggain J, Allers K, Sommer B, Pfaus J (2010) Effects of repeated flibanserin treatment on appetitive sexual behaviors in male and female rats. J Sex Med 7:395
21. Hajós-Korcsok E, Sharp T (1999) Effect of 5-HT(1A) receptor ligands on Fos-like immunoreactivity in rat brain: evidence for activation of noradrenergic transmission. Synapse 34:145-153
22. Hoshina Y, Takeo T, Nakano K, Sato T, Sakuma Y (1994) Axon-sparing lesion of the preoptic area enhances receptivity and diminishes proceptivity among components of female rat sexual behavior. Behav Brain Res 61:197-204
23. Hughes P, Dragunow M (1995) Induction of immediate early genes and the control of neurotransmitter-regulated gene expression within the nervous system. Pharmacol Rev 47:133-178
24. Humphries MD, Prescott TJ (2010) The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward. Prog Neurobiol 90:385-417
25. Kaplan HS (1977) Hypoactive sexual desire. J Sex Marital Ther 3:3-9
26. Kerfoot EC, Williams CL (2011) Interactions between brainstem noradrenergic neurons and the nucleus accumbens shell in modulating memory for emotionally arousing events. Learn Mem 18:405-413
27. Kline DD, Takacs KN, Ficker E, Kunze DL (2002) Dopamine modulates synaptic transmission in the nucleus of the solitary tract. J Neurophysiol 88:2736-2744
28. Landa AI, Gargiulo AJ, Gargiulo MM, Cabrera RJ, Bregonzio C, Lafuente Sánchez JV, Gargiulo PA (2009) Alpha and beta noradrenergic mediation of NMDA glutamatergic effects on lordosis behaviour and plasmatic LH concentrations in the primed female rat. J Neural Transm 116:551-557
29. Manaker S, Verderame HM (1990) Organization of serotonin 1A and 1B receptors in the nucleus of the solitary tract. J Comp Neurol 301:535-553
30. Marazziti D, Palego L, Giromella A, Mazzoni MR, Borsini F, Mayer N, Naccarato AG, Lucacchini A, Cassano GB (2002) Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain. Int J Neuropsychopharmacol 5:131-140
31. Margolis EB, Mitchell JM, Ishikawa J, Hjelmstad GO, Fields HL (2008) Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition. J Neurosci 28:8908-8913
32. Margolis EB, Coker AR, Driscoll JR, Lemaître AI, Fields HL (2010) Reliability in the identification of midbrain dopamine neurons. PLoS One 5(e15222):1-6
33. Marson L, McKenna KE (1990) The identification of a brainstem site controlling spinal sexual reflexes in male rats. Brain Res 515:303-308
34. Marson L, Murphy AZ (2006) Identification of neural circuits involved in female genital responses in the rat: a dual virus and anterograde tracing study. Am J Physiol Regul Integr Comp Physiol 291:419-428
35. Marson L, Cai R, Makhanova N (2003) Identification of spinal neurons involved in the urethrogenital reflex in the female rat. J Comp Neurol 462:355-370
36. Masters WH, Johnson VE (1966) Human sexual response. Bantam, New York
37. Miller SM, Lonstein JS (2009) Dopaminergic projections to the medial preoptic area of postpartum rats. Neuroscience 159:1384-1396
38. Miquel MC, Doucet E, Riad M, Adrien J, Vergé D, Hamon M (1992) Effect of the selective lesion of serotoninergic neurons on the regional distribution of 5-HT1A receptor mRNA in the rat brain. Brain Res Mol Brain Res 14:357-362
39. Normandin JJ, Murphy AZ (2008) Nucleus paragigantocellularis afferents in male and female rats: organization, gonadal steroid receptor expression, and activation during sexual behavior. J Comp Neurol 508:771-794
40. Normandin JJ, Murphy AZ (2011) Excitotoxic lesions of the nucleus paragigantocellularis facilitate male sexual behaviour but attenuate female sexual behaviour in rats. Neuroscience 175:212-223
41. Park K, Kang HK, Seo JJ, Kim HJ, Ryu SB, Jeong GW (2001) Blood oxygenation- level-dependent functional magnetic resonance imaging for evaluating cerebral regions of female sexual arousal response. Urology 57:1189-1194
42. Pattij T, Olivier B, Waldinger MD (2005) Animal models of ejaculatory behavior. Curr Pharm Des 11:4069-4077
43. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates, 4th edn. Academic, San Diego
44. Pfaus JG (1996) Homologies of animal and human sexual behaviors. Horm Behav 30:187-200
45. Pfaus JG (2009) Pathways of sexual desire. J Sex Med 6:1506-1533
46. Pfaus JG, Heeb MM (1997) Implications of immediate-early gene induction in the brain following sexual stimulation of female and male rodents. Brain Res Bull 44:397-407
47. Radja F, Laporte AM, Daval G, Vergé D, Gozlan H, Hamon M (1991) Autoradiography of serotonin receptor subtypes in the central nervous system. Neurochem Int 18:1-15
48. Rinaman L (2010) Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure. Brain Res 1350:18-34
49. Simerly RB, Swanson LW (1986) The organization of neural inputs to the medial preoptic nucleus of the rat. J Comp Neurol 246:312-342
50. Simerly RB, Swanson LW (1988) Projections of the medial preoptic nucleus: a Phaseolus vulgaris leucoagglutinin anterograde tract-tracing study in the rat. J Comp Neurol 270:209-242
51. Stahl SM, Sommer B, Allers KA (2011) Multifunctional pharmacology of flibanserin: possible mechanism of therapeutic action in hypoactive sexual desire disorder. J Sex Med 8:15-27
52. Szabo ST, Blier P (2001) Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons. Brain Res 922:9-20
53. Thorp J, Simon J, Dattani D, Taylor L, Kimura T, Garcia M Jr, Lesko L, Pyke R (2012) Treatment of hypoactive sexual desire disorder in premenopausal women: efficacy of flibanserin in the DAISY study. J Sex Med 9:793-804
54. Whitney JF (1986) Effect of medial preoptic lesions on sexual behavior of female rats is determined by test situation. Behav Neurosci 100:230-235
55. Yang LY, Clements LG (2000) MPOA lesions affect female pacing of copulation in rats. Behav Neurosci 114:1191-1202