Detection of PICALM-MLLT10 (CALM-AF10) and outcome in children with T-lineage acute lymphoblastic leukemia

Leukemia

Volumn 27, Issue 12, 2013, Pages 2419-2421

  Lo Nigro, L ^a   Mirabile, E ^a   Tumino, M ^a   Caserta, C ^a   Cazzaniga, G ^b   Rizzari, C ^b   Silvestri, D ^c   Buldini, B ^d   Barisone, E ^e   Casale, F ^f   Luciani, M ^g   Locatelli, F ^g,h   Messina, C ^d   Micalizzi, C ⁱ   Pession, A ^j   Parasole, R ^k   Santoro, N ^l,m   Masera, G ^b   Basso, G ^d   Arico M ^a,c   Valsecchi, M ^c   Biondi, A ^b   Conter, V ^b   more..

^a Center of Pediatric Hematology Oncology   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d Azienda Ospedaliero Universitaria   (Italy)

^e REGINA MARGHERITA CHILDREN S HOSPITAL   (Italy)

^f SECOND UNIVERSITY OF NAPLES   (Italy)

^g BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^h UNIVERSITY OF PAVIA   (Italy)

ⁱ G GASLINI INSTITUTE   (Italy)

^j UNIVERSITY OF BOLOGNA   (Italy)

^k SANTOBONO PAUSILIPON CHILDREN S HOSPITAL   (Italy)

^l POLICLINICO   (Italy)

^m UNIVERSITY OF FLORENCE   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CD33 ANTIGEN; CD34 ANTIGEN; CD4 ANTIGEN; CD5 ANTIGEN; CD7 ANTIGEN; CD8 ANTIGEN; CLATHRIN ASSEMBLY PROTEIN; CLATHRIN ASSEMBLY PROTEIN LIKE LYMPHOID MYELOID LEUKEMIA; HISTONE H3; MICROSOMAL AMINOPEPTIDASE; PREDNISONE; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; CANCER PROGNOSIS; CANCER SURVIVAL; CELL PROLIFERATION; CHILD; CHILDHOOD LEUKEMIA; CHROMOSOME 10; CHROMOSOME 7; CHROMOSOME TRANSLOCATION; EVENT FREE SURVIVAL; FEMALE; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; HUMAN; IMMUNOPHENOTYPING; INFANT; LETTER; LEUKEMIA RELAPSE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MINIMAL RESIDUAL DISEASE; OUTCOME ASSESSMENT; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD; T CELL LEUKEMIA;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MALE; MONOMERIC CLATHRIN ASSEMBLY PROTEINS; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TRANSCRIPTION FACTORS;

EID: 84890428673     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.149     Document Type: Letter

References (15)

1. Pui C-H, Evans WE. Treatment of acute lymphoblastic leukemia. New Engl J Med 2006; 354: 166-178.
2. Graux C, Cools J, Michaux L, Vandenberghe P, Haghemeijer A. Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast. Leukemia 2006; 20: 1496-1510.
3. Groupe Français de Cytogénétique Hématologique (GFCH). t(10;11)(p13-14; q14-21): a new recurrent translocation in T-cell acute lymphoblastic leukemia. Gene Chromosomes Cancer 1991; 3: 411-415.
4. Asnafi V, Radford-Weiss I, Dastugue N, Bayle C, Leboeuf D, Charrin C et al. CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRgd lineage. Blood 2003; 102: 1000-1006.
5. Caudell D, Aplan PD. The role of CALM-AF10 gene fusion in acute leukemia. Leukemia 2008; 22: 678-685.
6. van Grotel M, Meijerink JPP, Beverloo HB, Langerak AW, Buijs-Gaddines JG, Schneider P et al. The outcome of molecular-cytogenetic subgroups in pediatric T-cell acute lymphoblastic leukemia: a retrospective study of patients treated according to DCOG or COALL protocols. Haematologica 2006; 91: 1212-1221.
7. Narita M, Shimizu K, Hayashi Y, Taki T, Taniwaki M, Hosoda F et al. Consistent detection of CALM-AF10 chimaeric transcript in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts. Br J Haematol 1999; 105: 928-937.
8. Schrappe M, Valsecchi MG, Bartram CR, Schrauder A, Panzer-Grümayer R, Mö ricke A et al. Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study. Blood 2011; 118: 2077-2084.
9. Ballerini P, Landman-Parker J, Cayuela JM, Asnafi V, Labopin M, Gandemer V et al. Impact of genotype on survival of children with T-cell acute lymphoblastic leukemia treated according to the French protocol FRALLE-93: the effect of TLX3/HOX11L2 gene expression on outcome. Haematologica 2008; 93: 1658-1665.
10. Van Vlierberghe P, Pieters R, Beverloo HB, Meijerink JPP. Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukemia. Br J Hematol 2008; 143: 153-168.
11. Okada Y, Jiang Q, Lemieux M, Jeannotte L, Su L, Zhang Y. Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L. Nat Cell Biol 2006; 8: 1017-1024.
12. Chen L, Deshpande AJ, Banka D, Bernt KM, Dias S, Buske C et al. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation trough genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia 2013; 27: 813-822.
13. Mulaw MA, Krause AJ, Deshpande AJ, Krause LF, Rouhi A, La Starza R et al. CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12. Leukemia 2012; 26: 1012-1019.
14. Grossman V, Bacher U, Kohlmann A, Artusi V, Klein HU, Dugas M et al. EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia. Br J Haematol 2012; 157: 387-390.
15. McCabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 2012; 492: 108-112.