The presentation, recognition and management of bipolar depression in primary care

Journal of General Internal Medicine

Volumn 28, Issue 12, 2013, Pages 1648-1656

  Cerimele, Joseph M ^a   Chwastiak, Lydia A ^a,b   Chan, Ya Fen ^a   Harrison, David A ^a   Unützer, Jürgen ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

bipolar disorder; diagnosis; health behavior; psychiatry

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FLUOXETINE; LAMOTRIGINE; LITHIUM; OLANZAPINE; PAROXETINE; PLACEBO; QUETIAPINE; THIAZIDE DIURETIC AGENT; VALPROATE SEMISODIUM; VALPROIC ACID;

ADULT; ALOPECIA; BEDTIME DOSAGE; BIPOLAR DEPRESSION; BIPOLAR DISORDER; BODY MASS; CARDIOVASCULAR DISEASE; CASE REPORT; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL FEATURE; COGNITIVE THERAPY; COMPARATIVE EFFECTIVENESS; CONSTIPATION; DIAGNOSTIC ERROR; DISABILITY; DISEASE DURATION; DYSLIPIDEMIA; GASTROINTESTINAL SYMPTOM; HAMILTON SCALE; HEALTH HAZARD; HEART ARRHYTHMIA; HEPATITIS C; HUMAN; HYPERGLYCEMIA; HYPOMANIA; IRRITABILITY; KIDNEY DISEASE; LONG TERM CARE; LOW BACK PAIN; MAINTENANCE THERAPY; MAJOR DEPRESSION; MALE; MANIA; MASS SCREENING; MEDLINE; MONOTHERAPY; MOOD DISORDER QUESTIONNAIRE; NAUSEA; ORTHOSTATIC HYPOTENSION; POLYDIPSIA; PREDICTIVE VALUE; PREVALENCE; PRIMARY MEDICAL CARE; PSYCHOEDUCATION; PSYCHOMOTOR RETARDATION; REMISSION; RESTLESSNESS; REVIEW; SEDATION; SEXUAL DYSFUNCTION; SIDE EFFECT; SITTING; SLEEP DISORDER; SMOKING; SUICIDE; THYROID DISEASE; TREMOR; URINE RETENTION; VOMITING; WEIGHT GAIN;

ADULT; BIPOLAR DISORDER; BRIEF PSYCHIATRIC RATING SCALE; DISEASE MANAGEMENT; HUMANS; MALE; PRIMARY HEALTH CARE;

EID: 84890427823     PISSN: 08848734     EISSN: 15251497     Source Type: Journal    
DOI: 10.1007/s11606-013-2545-7     Document Type: Review

References (92)

1. Belmaker RH. Bipolar disorder. N Engl J Med. 2004;351:476-86.
2. World Health Organization. International statistic classification of diseases and related health problems. Geneva: World Health Organization; 2010.
3. Frye MA. Bipolar disorder - a focus on depression. N Engl J Med. 2011;364:51-9.
4. Kessler RC, Akiskal HS, Ames M, et al. Prevalence and effects of mood disorders on work performance in a nationally representative sample of U.S. workers. Am J Psychiatry. 2006;163:1561-8.
5. Simon GE, Bauer MS, Ludman EJ, Operskalski BH, Unützer J. Mood symptoms, functional impairment, and disability in people with bipolar disorder: specific effects of mania and depression. J Clin Psychiatry. 2007;68:1237-45.
6. Rihmer Z, Kiss K. Bipolar disorders and suicidal behavior. Bipolar Disord. 2002;4(suppl1):21-5.
7. Kessler RC, Berglund P, Borges G, Nock M, Wang PS. Trends in suicide ideation, plans, gestures and attempts in the United States, 1990-1992 to 2001-2003. JAMA. 2005;293:2487-95.
8. Merikangas KR, Akiskal HS, Angst J, et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2007;64:543-52.
9. Das AK, Olfson M, Gameroff MH, et al. Screening for bipolar disorder in a primary care practice. JAMA. 2005;293:956-63.
10. Smith DJ, Griffiths E, Kelly M, Hood K, Craddock N, Simpson SA. Unrecognised bipolar disorder in primary care patients with depression. Br J Psychiatry. 2011;199:49-56.
11. Hirschfeld RMA, Cass AR, Holt DC, Carlson CA. Screening for bipolar disorder in patients treated for depression in a family medicine clinic. J Am Board Fam Pract. 2005;18:233-9.
12. Olfson M, Das AK, Gameroff MJ, et al. Bipolar depression in a low-income primary care clinic. Am J Psychiatry. 2005;162:2146-51.
13. Manning JS, Haykal RF, Connor PD, Akiskal HS. On the nature of depressive and anxious states in a family practice setting: the high prevalence of bipolar II and related disorders in a cohort followed longitudinally. Compr Psychiatry. 1997;38:102-8.
14. Judd LL, Akiskal HS, Schletter PJ, et al. The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry. 2002;59:530-7.
15. Judd LL, Akiskal HS, Schletter PJ, et al. A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder. Arch Gen Psychiatry. 2003;60:261-9.
16. Zimmermann P, Brückl T, Nocon A, et al. Hetergeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity. Arch Gen Psychiatry. 2009;66:1341-52.
17. Swann AC, Geller B, Post RM, et al. Practical clues to early recognition of bipolar disorder: a primary care approach. Prim Care Compantion J Clin Psychiatry. 2005;7:15-21.
18. Manning JS. Tools to improve differential diagnosis of bipolar disorder in primary care. Prim Care Companion J Clin Psychiatry. 2010;12(Suppl1):17-22.
19. Mitchell PB, Goodwin GM, Johnson GF, Hirschfield RMA. Diagnostic guidelines for bipolar depression: a probabilistic approach. Bipolar Disord. 2008;10:144-52.
20. Mitchell PB, Wilhelm K, Parker G, Austin MP, Rutgers P, Malhi GS. The clinical features of bipolar depression: a comparison with matched major depressive disorder patients. J Clin Psychiatry. 2001;62:212-6.
21. Goldberg JF, Perlis RH, Bowden CL, et al. Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD. Am J Psychiatry. 2009;166:173-81.
22. Querques J, Kontos N. An approach to the patient with dysregulated mood: major depression and bipolar disorder. Med Clin N Am. 2010;94:1117-26.
23. Center for Quality Assessment and Improvement in Mental Health. The Standards for Bipolar Excellence Project (STABLE). http://www.cqaimh.org/stable. html. Accessed June 2013.
24. Hawton K, Sutton L, Haw C, Sinclair J, Harriss L. Suicide and attempted suicide in bipolar disorder: a systematic review of risk factors. J Clin Psychiatry. 2005;66:693-704.
25. McElroy SL, Altshuler LL, Suppes T, et al. Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder. Am J Psychiatry. 2001;158:420-6.
26. Kilbourne AM, Goodrich DE, O'Donnel AN, Miller CJ. Integrating bipolar disorder management in primary care. Curr Psychiatry Rep. 2012;14:687-95.
27. Gaynes BN, Rush AJ, Trivedi M, et al. A direct comparison of presenting characteristics of depressed outpatients from primary vs. specialty care settings: preliminary findings from the STARD clinical trial. Gen Hosp Psychiatry. 2005;27:87-96.
28. Hajek T, Slaney C, Garnham J, Ruzickova M, Passmore M, Alda M. Clinical correlates of current level of functioning in primary care-treated bipolar patients. Bipolar Disord. 2005;7:286-91.
29. Miller CJ, Abraham KM, Bajor LA, et al. Quality of life among patients with bipolar disorder in primary care versus community mental health settings. J Affect Disord. 2012. doi: 10.1016/j.jad.2012.08.045.
30. Weissman MM, Neria Y, Gameroff MJ, et al. Positive screens for psychiatric disorders in primary care: a long-term follow-up of patients who were not in treatment. Psychiatr Serv. 2010;61:151-9.
31. Kroenke K, Spitzer R, Williams J. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606-13.
32. Katon W. Collaborative depression care models: from development to dissemination. Am J Prev Med. 2012;42:550-2.
33. Gaynes BN, Rush AJ, Trivedi MH, et al. Primary versus specialty care outcomes for depressed outpatients with measurement-based bare: results from STARD. J Gen Intern Med. 2008;23:551-60.
34. Hirschfeld RMA, Williams JBW, Spitzer RL, et al. Development and validation of a screening instrument for bipolar spectrum disorder: the mood disorder questionnaire. Am J Psychiatry. 2000;157:1873-5.
35. Zimmerman M, Galione JN, Ruggero CJ, et al. Screening for bipolar disorder and finding borderline personality disorder. J Clin Psychiatry. 2010;71:1212-7.
36. Zimmerman M, Galione JN, Chelminski I, Young D, Dalrymple K. Psychiatric diagnoses in patients who screen positive on the Mood Disorder Questionnaire: implications for using the scale as a case-finding instrument for bipolar disorder. Psychiatry Res. 2011;185:444-9.
37. Zimmerman M. Misuse of the Mood Disorders Questionnaire as a case-finding measure and a critique of the concept of using a screening scale for bipolar disorder in psychiatric practice. Bipolar Disord. 2012;14:127-34.
38. Kessler RC, Akiskal HS, Angst J, et al. Validity of the assessment of bipolar spectrum disorders in the WHO CIDI 3.0. J Affect Disord. 2006;96:259-69.
39. Roshanaei-Moghaddam B, Katon W. Premature mortality from general medical illnesses among persons with bipolar disorder: a review. Psychiatr Serv. 2009;60:147-56.
40. Kupfer DJ. The increasing medical burden in bipolar disorder. JAMA. 2005;293:2528-30.
41. Kilbourne AM, Cornelius JR, Han X, et al. Burden of general medical conditions among individuals with bipolar disorder. Bipolar Disord. 2004;6:368-73.
42. McElroy SL, Keck PE. Obesity in bipolar disorder: an overview. Curr Psychiatry Rep. 2012;14:650-8.
43. Goldstein BI, Kemp DE, Soczynska JK, McIntyre RS. Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature. J Clin Psychiatry. 2009;70:1078-90.
44. Waxmonsky JA, Thomas MR, Miklowitz DJ, et al. Prevalence and correlates of tobacco use in bipolar disorder: data from the first 2000 participants in the Systematic Treatment Enhancement Program. Gen Hosp Psychiatry. 2005;27:321-8.
45. Dickerson F, Stallings CR, Origoni AR, et al. Cigarette smoking among persons with schizophrenia or bipolar disorder in routine clinical settings, 1999-2011. Psychiatr Serv. 2012. doi: 10.1176/appi.ps.001432012.
46. Lasser K, Boyd JW, Woolhandler S, Himmelstein DU, McCormick D, Bor DH. Smoking and mental illness: a population-based prevalence study. JAMA. 2000;284:2606-10.
47. Simon GE, Von Korff M, Saunders K, et al. Associations between obesity and psychiatric disorders in the US adult population. Arch Gen Psychiatry. 2006;63:824-30.
48. Chwastiak LA, Rosenheck RA, Kazis LE. Association of psychiatric illness and obesity, physical inactivity, and smoking among a national sample of veterans. Psychosomatics. 2011;52:230-6.
49. Perron BE, Howard MO, Nienhuis JK, Bauer MS, Woodward AT, Kilbourne AM. Prevalence and burden of general medical conditions among adults with bipolar disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry. 2009;70:1407-15.
50. Weber NS, Fisher JA, Cowan DN, Niebuhr DW. Psychiatric and general medical conditions comorbid with bipolar disorder in the national hospital discharge survey. Psychiatr Serv. 2011;62:1152-8.
51. Soreca I, Fagiolini A, Frank E, Houck PR, Thompson WK, Kupfer DJ. Relationship of general medical burden, duration of illness and age in patients with bipolar I disorder. J Psychiatr Res. 2008;42:956-61.
52. Bradford DW, Kim MM, Braxton LE, Marx CE, Butterfield M, Elbogen EB. Access to medical care among persons with psychotic and major affective disorders. Psychiatr Serv. 2008;59:847-52.
53. Chwastiak LA, Rosenheck RA, Kazis LE. Utilization of primary care by veterans with psychiatric illness in the National Department of Veterans Affairs health care system. J Gen Intern Med. 2008;23:1835-40.
54. Kilbourne AM, Goodrich D, Miklowitz DJ, Austin K, Post EP, Bauer MD. Characteristics of patients with bipolar disorder managed in VA primary care or specialty mental health care settings. Psychiatr Serv. 2010;61:500-7.
55. Strakowski SM, DelBello MP, Fleck DE, Arndt S. Effects of co-occurring alcohol abuse on the course of bipolar disorder following a first hospitalization for mania. Arch Gen Psychiatry. 2005;62:851-8.
56. Cerimele JM, Katon WJ. The impact of health risk behaviors on the course and symptoms of schizophrenia and bipolar disorder: a systematic review. Gen Hosp Psychiatry. 2013;35:16-22.
57. Pirraglia PA, Biswas K, Kilbourne AM, Fenn H, Bauer MS. A prospective study of the impact of comorbid medical disease on bipolar disorder outcomes. J Affect Disord. 2009;115:355-9.
58. Strakowski SM, DelBello MP, Fleck DE, Arndt S. The impact of substance abuse on the course of bipolar disorder. Biol Psychiatry. 2000;48:477-85.
59. Fenn HH, Bauer MS, Alshuler L, et al. Medical comorbidity and health-related quality of life in bipolar disorder across the adult age span. J Affect Disord. 2005;86:47-60.
60. Tondo L, Baldessarini RJ, Hennen J, Floris G. Lithium maintenance treatment of depression and mania in bipolar I and bipolar II disorders. Am J Psychiatry. 1998;155:638-45.
61. Goodwin FK, Fireman B, Simon GE, Hunkeler EM, Lee J, Revicki D. Suicide risk in bipolar disorder during treatment with lithium and divalproex. JAMA. 2003;290:1467-73.
62. Geddes JR, Burgess S, Hawton K, Jamison K, Goodwin GM. Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials. Am J Psychiatry. 2004;161:217-22.
63. Young AH, McElroy SL, Bauer M, et al. A double-blind, placebo-controlled study of quetiapine and lithium monotherapy in adults in the acute phase of bipolar depression (EMBOLDEN I). J Clin Psychiatry. 2010;71:150-62.
64. Vieta E, Locklear J, Gunther O, et al. Treatment options for bipolar depression: a systematic review of randomized, controlled trials. J Clin Psychopharmacol. 2010;30:579-90.
65. Bond DJ, Lam RW, Yatham LN. Divalproex sodium versus placebo in the treatment of acute bipolar depression: a systematic review and meta-analysis. J Affect Disord. 2010;124:228-34.
66. Geddes JR, Calabrese JR, Goodwin GM. Lamotrigine treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomized trials. Br J Psychiatry. 2009;194:4-9.
67. Calabrese JR, Huffman RF, White RL, et al. Lamotrigine in the acute treatment of bipolar depression: results of five double-blind, placebo-controlled clinical trials. Bipolar Disord. 2008;10:323-33.
68. Nivoli AMA, Colom F, Murru A, et al. New treatment guidelines for acute bipolar depression: a systematic review. J Affect Disord. 2011;129:14-26.
69. Sidor MM, MacQueen GM. Antidepressants for the acute treatment of bipolar depression: a systematic review and meta-analysis. J Clin Psychiatry. 2011;72:156-67.
70. Ghaemi SN, Wingo AP, Filkowski MA, Baldessarini RJ. Long-term antidepressant treatment in bipolar disorder: meta-analyses of benefits and risks. Acta Psychiatr Scand. 2008;118:347-56.
71. Amsterdam JD, Shults J. Efficacy and safety of long-term fluoxetine versus lithium monotherapy of bipolar II disorder: a randomized, double-blind, placebo-substitution study. Am J Psychiatry. 2010;167:792-800.
72. Vieta E, Martinez-Aran A, Goikolea JM, et al. A randomized trial comparing paroxetine and venlafaxine in the treatment of bipolar depressed patients taking mood stabilizers. J Clin Psychiatry. 2002;63:508-12.
73. Antidepressant therapy in treating bipolar type II major depression. ClinicalTrials.gov Web site. http://www.clinicaltrials.gov/ct2/show/NCT00602537? term=antidepressant+bipolar&rank=4. Updated July 2012. Accessed December 20th, 2012.
74. Sachs GS, Nierenberg AA, Calabrese JR, et al. Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med. 2007;356:1711-22.
75. Goldberg JF, Perlis RH, Ghaemi SH, et al. Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD. Am J Psychiatry. 2007;164:1348-55.
76. Tondo L, Vazquez G, Baldessarini RJ. Mania associated with antidepressant treatment: comprehensive meta-analytic review. Acta Psychiatr Scand. 2010;121:404-14.
77. Bauer MS, Wisniewski SR, Marangell LB, et al. Are antidepressants associated with new-onset suicidality in bipolar disorder? A prospective study of participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). J Clin Psychiatry. 2006;67:48-55.
78. McElroy SL, Kotwal R, Kaneria R, Keck PE. Antidepressants and suicidal behavior in bipolar disorder. Bipolar Disord. 2006;8:596-617.
79. Suppes T, Vieta E, Liu S, Brecher M, Paulsson B. Maintenance treatment for patients with bipolar I disorder: results from a North American study of quetiapine in combincation with lithium or divalproex (Trial 127). Am J Psychiatry. 2009;166:476-88.
80. Geddes JR, Goodwin GM, Rendell J, et al. Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomized open-label trial. Lancet. 2010;375:385-95.
81. Miklowitz DJ, Otto MW, Frank E, et al. Psychosocial treatments for bipolar depression: a 1 year randomized trial from the systematic treatment enhancement program. Arch Gen Psychiatr. 2007;64:419-27.
82. Frank R, Soreca I, Swartz HA, et al. The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder. Am J Psychiatry. 2008;165:1559-65.
83. Benyon S, Soares-Wesier K, Woolacott N, Duffy S, Geddes JR. Psychosocial interventions for the prevention of relapse in bipolar disorder: systematic review of controlled trials. Br J Psychiatry. 2008;192:5-11.
84. Colom F, Vieta E, Martinez-Aran A, et al. A randomized trial on the efficacy of group psychoeducation in the prophylaxis of recurrences in bipolar patients whose disease is in remission. Arch Gen Psychiatry. 2003;60:402-7.
85. Thota AB, Sipe TA, Byard GJ, et al. Collaborative care to improve the management of depressive disorders: a community guide systematic review and meta-analysis. Am J Prev Med. 2012;42:525-38.
86. Woltmann E, Grogan-Kaylor A, Perron B, Geordes H, Kilbourne AM, Bauer MS. Comparative effectiveness of collaborative chronic care models for mental health conditions across primary, specialty, and behavioral health care settings: systematic review and meta-analysis. Am J Psychiatry. 2012;169:790-804.
87. Bauer MS, McBride L, Williford WO, et al. Collaborative care for bipolar disorder: part II. impact on clinical outcome, function and costs. Psychiatr Serv. 2006;57:937-45.
88. Simon GE, Ludman EJ, Bauer MS, Unützer J, Operskalski B. Long-term effectiveness and cost of a systematic care program for bipolar disorder. Arch Gen Psychiatry. 2006;63:500-8.
89. Kilbourne AM, Post EP, Nossek A, Drill L, Cooley S, Bauer MS. Improving medical and psychiatric outcomes among individuals with bipolar disorder: a randomized controlled trial. Psychiatr Serv. 2008;59:760-8.
90. Bauer MS, Biswas K, Kilbourne AM. Enhancing multi-year guideline concordance for bipolar disorder through collaborative care. Am J Psychiatry. 2009;166:1244-50.
91. Hirschfeld RMA. Guideline Watch for the Practice Guideline for the treatment of patients with bipolar disorder. Arlington, VA: American Psychiatric Association; 2005.
92. Schneider R, Levenson JL. Psychiatry essentials for primary care. Chapter 6: Bipolar disorders. Philadelphia: American College of Physicians Press; 2008:87-107.