Topical nicotinamide for seborrheic dermatitis: An open randomized study

Journal of Dermatological Treatment

Volumn 25, Issue 3, 2014, Pages 241-245

  Fabbrocini, Gabriella ^a   Cantelli, Mariateresa ^a   Monfrecola, Giuseppe ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Nicotinamide; Seborrheic dermatitis; Topical treatment

Indexed keywords

NICOTINAMIDE; PLACEBO; SPHINGOLIPID;

ADULT; ARTICLE; BURNING SENSATION; CLINICAL ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ERYTHEMA; FEMALE; FOLLOW UP; HUMAN; MALE; MEDICATION COMPLIANCE; MIDDLE AGED; OPEN STUDY; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEBORRHEIC DERMATITIS; SKIN DISEASE; SKIN INFILTRATE; SKIN PRURITUS; STUDY DESIGN; XERODERMA; YOUNG ADULT;

ADMINISTRATION, TOPICAL; ADULT; DERMATITIS, SEBORRHEIC; DERMATOLOGIC AGENTS; FACE; FEMALE; HUMANS; MALE; MIDDLE AGED; NIACINAMIDE; SKIN CREAM; YOUNG ADULT;

EID: 84890417161     PISSN: 09546634     EISSN: 14711753     Source Type: Journal    
DOI: 10.3109/09546634.2013.814754     Document Type: Article

References (26)

1. Elewski BE. Safe and effective treatment of seborrheic dermatitis. Cutis. 2009;83:333-338
2. Gupta AK, Bluhm R, Cooper EA, et al. Seborrheic dermatitis. Dermatol Clin. 2003;21:401-412
3. Bukvić Mokos Z, Kralj M, Basta-Juzbašić A, Lakoš Jukić I. Seborrheic dermatitis: An update. Acta Dermatovenerol Croat. 2012;20:98-104
4. Reichrath J. Antimycotics: Why are they effective in the treatment of seborrheic dermatitis? Dermatology. 2004;208:174-175
5. Dobrev H, Zissova L. Effect of ketoconazole 2% shampoo on scalp sebum level in patients with seborrhoeic dermatitis. Acta Derm Venereol. 1997;77:132-134
6. Piérard GE, Piérard-Franchimont C, Van Cutsem J, Rurangirwa A, Hoppenbrouwers ML, Schrooten P. Ketoconazole 2% emulsion in the treatment of seborrheic dermatitis. J Dermatol. 1991;30:806-809
7. Seckin D, Gurbuz O, Akin O. Metronidazole 0.75% gel vs. ketoconazole 2% cream in the treatment of facial seborrheic dermatitis: A randomized, double-blind study. J Eur Acad Dermatol Venereol. 2007;21:345-350
8. Chosidow O, Maurette C, Dupuy P. Randomized, open-labeled, noninferiority study between ciclopiroxolamine 1% cream and ketoconazole 2% foaming gel in mild to moderate facial seborrheic dermatitis. Dermatology. 2003;206:233-240
9. Piérard-Franchimont C, Piérard GE. A double-blind placebo-controlled study of ketoconazole + desonide gel combination in the treatment of facial seborrheic dermatitis. Dermatology. 2002;204: 344-347
10. Dreno B, Chosidow O, Revuz J, Moyse D; Study Investigator Group. Lithium gluconate 8% vs ketoconazole 2% in the treatment of seborrhoeic dermatitis: A multicentre, randomized study. Br J Dermatol. 2003;148:1230-1236
11. Shalita AR, Smith JG, Parish LC, Sofman MS, Chalker DK. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol. 1995;34:434-437
12. Fivenson DP, Breneman DL, Rosen GB, Hersh CS, Cardone S, Mutasim D. Nicotinamide and tetracycline therapy of bullous pemphigoid. Arch Dermatol. 1994;130:753-758
13. Koc E, Arca E, Kose O, Akar A. An open, randomized, prospective, comparative study of topical pimecrolimus 1% cream and topical ketoconazole 2% cream in the treatment of seborrheic dermatitis. J Dermatolog Treat. 2009;20:4-9
14. Maiese K, Chong ZZ, Hou J, Shang YC. The vitamin nicotinamide: Translating nutrition into clinical care. Molecules. 2009;14:3446-3485
15. Reddy S, Young M, Ginn S. Immunoexpression of interleukin-1beta in pancreatic islets of NOD mice during cyclophosphamide-Accelerated diabetes: Co-localization in macrophages and endocrine cells and its attenuation with oral nicotinamide. Histochem J. 2001;33:317-327
16. Chen CF, Wang D, Hwang CP, Liu HW, Wei J, Lee RP, et al. The protective effect of niacinamide on ischemia-reperfusion-induced liver injury. J Biomed Sci. 2001;8:446-452
17. Moberg L, Olsson A, Berne C, Felldin M, Foss A, Källen R, et al. Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: Implications for clinical islet transplantation. Transplantation. 2003;76:1285-1288
18. Ungerstedt JS, Blömback M, Söderström T. Nicotinamide is a potent inhibitor of proinflammatory cytokines. Clin Exp Immunol. 2003;131:48-52
19. Traister A, Breitman I, Bar-Lev E, Zvibel I, Harel A, Halpern Z, et al. Nicotinamide induces apoptosis and reduces collagen I and pro-inflammatory cytokines expression in rat hepatic stellate cells. Scand J Gastroenterol. 2005;40:1226-1234
20. Pero RW, Axelsson B, Siemann D, Chaplin D, Dougherty G. Newly discovered anti-inflammatory properties of the benzamides and nicotinamides. Mol Cell Biochem. 1999;193:119-125
21. Hassa PO, Hottiger MO. The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci. 2008;13:3046-3082
22. Yélamos J, Schreiber V, Dantzer F. Toward specific functions of poly(ADP-ribose) polymerase-2. Trends Mol Med. 2008;14:169-178
23. Fabbrocini G, Annunziata MC, D'Arco V, De Vita V, Lodi G, Mauriello MC, et al. Acne scars: Pathogenesis, classification and treatment. Dermatol Res Pract. 2010;2010:893080
24. Virág L, Szabó C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev. 2002;54:375-429.
25. Szabó E, Virág L, Bakondi E, Gyüre L, Haskó G, Bai P, et al. Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity. J Invest Dermatol. 2001;117:74-80
26. Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol. 2000;143:524-531