Acne scars: Pathogenesis, classification and treatment

Dermatology Research and Practice

Volumn 2010, Issue 1, 2010, Pages

  Fabbrocini, Gabriella ^a   Annunziata, M C ^a   D'Arco, V ^a   De Vita, V ^a   Lodi, G ^a   Mauriello, M C ^a   Pastore, F ^a   Monfrecola, G ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80053401235     PISSN: None     EISSN: 16876113     Source Type: Journal    
DOI: 10.1155/2010/893080     Document Type: Review

References (120)

1. Ghodsi S. Z., Orawa H., Zouboulis C. C., Prevalence, severity, and severity risk factors of acne in high school pupils: a community-based study. Journal of Investigative Dermatology 2009 129 9 2136 2141 2-s2.0-70349747081 10.1038/jid.2009.47
2. Williams C., Layton A. M., Persistent acne in women: implications for the patient and for therapy. American Journal of Clinical Dermatology 2006 7 5 281 290 2-s2.0-34347221247 10.2165/00128071-200607050-00002 (Pubitemid 46998578)
3. Capitanio B., Sinagra J. L., dermped@ifo.it Bordignon V., Fei P. C., Picardo M., Zouboulis C. C., Underestimated clinical features of postadolescent acne. Journal of the American Academy of Dermatology 2010 63 5 782 788 10.1016/j.jaad.2009.11.021
4. Layton A. M., Henderson C. A., Cunliffe W. J., A clinical evaluation of acne scarring and its incidence. Clinical and Experimental Dermatology 1994 19 4 303 308 2-s2.0-0028068210 10.1111/j.1365-2230.1994.tb01200.x (Pubitemid 24231230)
5. Cunliffe W. J., Gould D. J., Prevalence of facial acne vulgaris in late adolescence and in adults. British Medical Journal 1979 1 6171 1109 1110 2-s2.0-0018343644 (Pubitemid 9153234)
6. Kurokawa I., Danby F. W., Ju Q., Wang X., Xiang L. F., Xia L., Chen W., Nagy I., Picardo M., Suh D. H., Ganceviciene R., Schagen S., Tsatsou F., Zouboulis C. C., New developments in our understanding of acne pathogenesis and treatment. Experimental Dermatology 2009 18 10 821 832 2-s2.0-70349869101 10.1111/j.1600-0625.2009.00890.x
7. Zouboulis C. C., Acne and sebaceous gland function. Clinics in Dermatology 2004 22 5 360 366 2-s2.0-8844260410 10.1016/j.clindermatol.2004.03. 004 (Pubitemid 39535276)
8. Alestas T., Ganceviciene R., Fimmel S., Müller-Decker K., Zouboulis C. C., Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands. Journal of Molecular Medicine 2006 84 1 75 87 2-s2.0-30744436829 10.1007/s00109-005-0715-8 (Pubitemid 43099526)
9. Makrantonaki E., Zouboulis C. C., Testosterone metabolism to 5 α -dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes. British Journal of Dermatology 2007 156 3 428 432 2-s2.0-33846953513 10.1111/j.1365-2133.2006.07671.x
10. Nagy I., Pivarcsi A., Kis K., Koreck A., Bodai L., McDowell A., Seltmann H., Patrick S., Zouboulis C. C., Kemény L., Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes. Microbes and Infection 2006 8 8 2195 2205 2-s2.0-33748366355 10.1016/j.micinf.2006.04.001 (Pubitemid 44335873)
11. Kim J., Ochoa M.-T., Krutzik S. R., Takeuchi O., Uematsu S., Legaspi A. J., Brightbill H. D., Holland D., Cunliffe W. J., Akira S., Sieling P. A., Godowski P. J., Modlin R. L., Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. Journal of Immunology 2002 169 3 1535 1541 2-s2.0-0036681834 (Pubitemid 34809200)
12. Wolfram D., Tzankov A., Pülzl P., Piza-Katzer H., Hypertrophic scars and keloids-a review of their pathophysiology, risk factors, and therapeutic management. Dermatologic Surgery 2009 35 2 171 181 2-s2.0-58849158732 10.1111/j.1524-4725.2008.34406.x
13. Cowin A. J., Brosnan M. P., Holmes T. M., Ferguson M. W. J., Endogenous inflammatory response to dermal wound healing in the fetal and adult mouse. Developmental Dynamics 1998 212 3 385 393 2-s2.0-0031749423 10.1002/(SICI)1097- 0177(199807)212:3<385::AID-AJA6>3.0.CO;2-D (Pubitemid 28294867)
14. Martin P., Leibovich S. J., Inflammatory cells during wound repair: the good, the bad and the ugly. Trends in Cell Biology 2005 15 11 599 607 2-s2.0-27744543102 10.1016/j.tcb.2005.09.002 (Pubitemid 41619424)
15. Holland D. B., Jeremy A. H. T., Roberts S. G., Seukeran D. C., Layton A. M., Cunliffe W. J., Inflammation in acne scarring: a comparison of the responses in lesions from patients prone and not prone to scar. British Journal of Dermatology 2004 150 1 72 81 2-s2.0-1242275302 10.1111/j.1365-2133.2004.05749.x (Pubitemid 38234009)
16. Stadelmann W. K., Digenis A. G., Tobin G. R., Physiology and healing dynamics of chronic cutaneous wounds. American Journal of Surgery 1998 176 2A 26S 38S 2-s2.0-0031656215 10.1016/S0002-9610(98)00183-4 (Pubitemid 28460655)
17. Baum C. L., Arpey C. J., Normal cutaneous wound healing: clinical correlation with cellular and molecular events. Dermatologic Surgery 2005 31 6 674 686 2-s2.0-22844434968 (Pubitemid 43093424)
18. Midwood K. S., Williams L. V., Schwarzbauer J. E., Tissue repair and the dynamics of the extracellular matrix. International Journal of Biochemistry and Cell Biology 2004 36 6 1031 1037 2-s2.0-9444234506 10.1016/j.biocel.2003.12.003 (Pubitemid 38501555)
19. Chivot M., Pawin H., Beylot C., Chosidow O., Dreno B., Faure M., Poli F., Revuz J., Acne scars: epidemiology, physiopathology, clinical features and treatment. Annales de Dermatologie et de Venereologie 2006 133 10 813 824 (Pubitemid 44579386)
20. Jacob C. I., Dover J. S., Kaminer M. S., Acne scarring: a classification system and review of treatment options. Journal of the American Academy of Dermatology 2001 45 1 109 117 2-s2.0-0034939613 10.1067/mjd.2001.113451 (Pubitemid 32655703)
21. Goodman G. J., Baron J. A., Postacne scarring: a qualitative global scarring grading system. Dermatologic Surgery 2006 32 12 1458 1466 2-s2.0-33845576561 10.1111/j.1524-4725.2006.32354.x (Pubitemid 44934894)
22. Goodman G. J., Baron J. A., Postacne scarring-a quantitative global scarring grading system. Journal of Cosmetic Dermatology 2006 5 1 48 52 2-s2.0-33645534337 10.1111/j.1473-2165.2006.00222.x
23. Dreno B., Khammari A., Orain N., Noray C., Mérial-Kieny C., Méry S., Nocera T., ECCA grading scale: an original validated acne scar grading scale for clinical practice in dermatology. Dermatology 2006 214 1 46 51 2-s2.0-33845921808 10.1159/000096912 (Pubitemid 46033000)
24. English R. S., Shenefelt P. D., Keloids and hypertrophic scars. Dermatologic Surgery 1999 25 8 631 638 2-s2.0-0032865642 10.1046/j.1524-4725. 1999.98257.x (Pubitemid 29383470)
25. Ghersetich I., Brazzini B., Lotti T., Lotti T. M., Katsambas A. D., Chemical peeling. European Handbook of Dermatological Treatments 2003 2nd Berlin, Germany Springer
26. Ghersetich I., Teofoll P., Gantcheva M., Ribuffo M., Puddu P., Chemical peeling: how, when, why? Journal of the European Academy of Dermatology and Venereology 1997 8 1 1 11 2-s2.0-0031022132 10.1016/S0926-9959(96)00107-9 (Pubitemid 27019035)
27. Landau M., Chemical peels. Clinics in Dermatology 2008 26 2 200 208 2-s2.0-42949125342 10.1016/j.clindermatol.2007.09.012 (Pubitemid 351620988)
28. Goodman G. J., Management of post-acne scarring: what are the options for treatment? American Journal of Clinical Dermatology 2000 1 1 3 17 2-s2.0-0033756412
29. Goodman G. J., Postacne scarring: a review of its pathophysiology and treatment. Dermatologic Surgery 2000 26 9 857 871 2-s2.0-0033824808 10.1046/j.1524-4725.2000.99232.x
30. Bernstein E. F., Lee J., Brown D. B., Yu R., Van Scott E., Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin. Dermatologic Surgery 2001 27 5 429 433 2-s2.0-0035012464 10.1046/j.1524-4725.2001.00234.x (Pubitemid 32436330)
31. Javaheri S. M., Handa S., Kaur I., Kumar B., Safety and efficacy of glycolic acid facial peel in Indian women with melasma. International Journal of Dermatology 2001 40 5 354 357 2-s2.0-0034855193 10.1046/j.1365-4362.2001.01149. x (Pubitemid 32851116)
32. Becker F. F., Langford F. P. J., Rubin M. G., Speelman P., A histological comparison of 50% and 70% glycolic acid peels using solutions with various pHs. Dermatologic Surgery 1996 22 5 463 465 2-s2.0-0029916380 (Pubitemid 26153098)
33. Rook A., Wilkinson D. S., Ebling F. J. G., Textbook of Dermatology 1972 Oxford, UK Blackwell Scientific
34. Van Scott E. J., Yu R. J., Hyperkeratinization, corneocyte cohesion and alpha hydroxy acids. Journal of the American Academy of Dermatology 1984 11 5 867 879 2-s2.0-0021688510 (Pubitemid 15201330)
35. Lynch B. S., Delzell E. S., Bechtel D. H., Toxicology review and risk assessment of resorcinol: thyroid effects. Regulatory Toxicology and Pharmacology 2002 36 2 198 210 2-s2.0-0036979091 10.1006/rtph.2002.1585 (Pubitemid 36160237)
36. Barbaud A., Modiano P., Cocciale M., Reichert S., Schmutz J.-L., The topical application of resorcinol can provoke a systemic allergic reaction. British Journal of Dermatology 1996 135 6 1014 1015 2-s2.0-0029858787 (Pubitemid 26397949)
37. Griffin T. D., Van Scott E. J., Maddin S., The use of pyruvic acid as a chemical peeling agent. Journal of Dermatologic Surgery & Oncology 1989 15 1316
38. Monheit G. D., Medium-depth combination peels. Dermatologic Therapy 2000 13 2 183 191 2-s2.0-0033919171 (Pubitemid 30450611)
39. Van Scott E. J., Yu R. J., Alpha hydroxy acids: therapeutic potentials. Canadian Journal of Dermatology 1989 1 5 108 112
40. Berardesca E., berardesca@berardesca.it Cameli N., Primavera G., Carrera M., Clinical and instrumental evaluation of skin improvement after treatment with a new 50% pyruvic acid peel. Dermatologic Surgery 2006 32 4 526 531 10.1111/j.1524-4725.2006.32106.x
41. Unna P. G., Therapeutiques generales des maladies de la peau. 1882
42. Lazo N. D., Meine J. G., Downing D. T., Lipids are covalently attached to rigid corneocyte protein envelopes existing predominantly as β -sheets: a solid-state nuclear magnetic resonance study. Journal of Investigative Dermatology 1995 105 2 296 300 2-s2.0-0029131753
43. Swinehart J. M., Salicylic acid ointment peeling of the hands and forearms: effective nonsurgical removal of pigmented lesions and actinic damage. Journal of Dermatologic Surgery and Oncology 1992 18 6 495 498 2-s2.0-0026780087
44. Imayama S., Ueda S., Isoda M., Histologic changes in the skin of hairless mice following peeling with salicylic acid. Archives of Dermatology 2000 136 11 1390 1395 2-s2.0-0033766830
45. Grimes P. E., The safety and efficacy of salicylic acid chemical peels in darker racial-ethnic groups. Dermatologic Surgery 1999 25 1 18 22 2-s2.0-0033013808 10.1046/j.1524-4725.1999.08145.x (Pubitemid 29242727)
46. Swinehart J. M., Salicylic acid ointment peeling of the hands and forearms: effective nonsurgical removal of pigmented lesions and actinic damage. Journal of Dermatologic Surgery and Oncology 1992 18 6 495 498 2-s2.0-0026780087
47. Fabbrocini G., De Padova M. P., Tosti A., antonella.tosti@unibo.it Chemical peels: what's new and what isn't new but still works well. Facial Plastic Surgery 2009 25 5 329 336 10.1055/s-0029-1243082
48. Dinner M. I., Artz J. S., The art of the trichloroacetic acid chemical peel. Clinics in Plastic Surgery 1998 25 1 53 62 2-s2.0-0031913512 (Pubitemid 28090976)
49. Slavin J. W., Trichloroacetic acid peels. Aesthetic Surgery Journal 2004 24 5 469 470 2-s2.0-4744374036 10.1016/j.asj.2004.07.008 (Pubitemid 39307506)
50. Al-Waiz M. M., Al-Sharqi A. I., Medium-depth chemical peels in the treatment of acne scars in dark-skinned individuals. Dermatologic Surgery 2002 28 5 383 387 2-s2.0-0036259691 10.1046/j.1524-4725.2002.01081.x (Pubitemid 34596295)
51. Lee J. B., Chung W. G., Kwahck H., Lee K. H., Monheit G., Focal treatment of acne scars with trichloroacetic acid: Chemical reconstruction of skin scars method. Dermatologic Surgery 2002 28 11 1017 1021 2-s2.0-18744369017 10.1046/j.1524-4725.2002.02095.x (Pubitemid 35424801)
52. Fabbrocini G., Cacciapuoti S., Fardella N., Pastore F., Monfrecola G., CROSS technique: chemical reconstruction of skin scars method. Dermatologic Therapy 2008 21 3 S29 S32 2-s2.0-57449115881 10.1111/j.1529-8019.2008.00239.x
53. Yug A., Lane J. E., Howard M. S., Kent D. E., Histologic study of depressed acne scars treated with serial high-concentration (95%) trichloroacetic acid. Dermatologic Surgery 2006 32 8 985 990 2-s2.0-33746896159 10.1111/j.1524-4725.2006.32220.x (Pubitemid 44197445)
54. Alkhawam L., Alam M., m-alam@northwestern.edu Dermabrasion and microdermabrasion. Facial Plastic Surgery 2009 25 5 301 310 10.1055/s-0029- 1243078
55. Shim E. K., Barnette D., Hughes K., Greenway H. T., Microdermabrasion: a clinical and histopathologic study. Dermatologic Surgery 2001 27 6 524 530 2-s2.0-0034973033 10.1046/j.1524-4725.2001.01001.x (Pubitemid 32552905)
56. Freedman B. M., Rueda-Pedraza E., Waddell S. P., The epidermal and dermal changes associated with microdermabrasion. Dermatologic Surgery 2001 27 12 1031 1034 2-s2.0-0035664626 10.1046/j.1524-4725.2001.01031.x (Pubitemid 34019721)
57. Shpall R., Beddingfield F. C. III, Watson D., Lask G. P., Microdermabrasion: a review. Facial Plastic Surgery 2004 20 1 47 50 2-s2.0-1842507345 10.1055/s-2004-822958 (Pubitemid 38451775)
58. Tsai R.-Y., Wang C.-N., Chan H.-L., Aluminum oxide crystal microdermabrasion: a new technique for treating facial scarring. Dermatologic Surgery 1995 21 6 539 542 2-s2.0-0029022627
59. Lloyd J. R., The use of microdermabrasion for acne: a pilot study. Dermatologic Surgery 2001 27 4 329 331 2-s2.0-0035072431 10.1046/j.1524-4725. 2001.00313.x (Pubitemid 32290856)
60. Mandy S. H., Tretinoin in the preoperative and postoperative management of dermabrasion. Journal of the American Academy of Dermatology 1986 15 4 888 889 2-s2.0-0023028255
61. Nelson S., Kauvar A. N. B., An introduction to laser and laser-tissue interactions in dermatology. Principles and Practices in Cutaneous Laser Surgery 2005 Boca Raton, Fla, USA Taylor and Francis Group 70
62. Smith K. J., Skelton H. G., Graham J. S., Hurst C. G., Hackley B. E. Jr., Increased smooth muscle actin, factor XIIIa, and vimentin-positive cells in the papillary dermis of carbon dioxide laser-debrided porcine skin. Dermatologic Surgery 1997 23 10 891 895 2-s2.0-0030723294 (Pubitemid 27476106)
63. Graber E. M., Tanzi E. L., Alster T. S., Side effects and complications of fractional laser photothermolysis: experience with 961 treatments. Dermatologic Surgery 2008 34 3 301 305 2-s2.0-39849083768 10.1111/j.1524-4725. 2007.34062.x
64. Chan H. H. L., Manstein D., Yu C. S., Shek S., Kono T., Wei W. I., The prevalence and risk factors of post-inflammatory hyperpigmentation after fractional resurfacing in Asians. Lasers in Surgery and Medicine 2007 39 5 381 385 2-s2.0-34447294026 10.1002/lsm.20512 (Pubitemid 47041086)
65. 2 laser resurfacing: four cases. Lasers in Surgery and Medicine 2009 41 3 179 184 2-s2.0-64849087770 10.1002/lsm.20753
66. Avram M. M., Tope W. D., Yu T., Szachowicz E., Nelson J. S., Hypertrophic scarring of the neck following ablative fractional carbon dioxide laser resurfacing. Lasers in Surgery and Medicine 2009 41 3 185 188 2-s2.0-64849101840 10.1002/lsm.20755
67. Fournier N., Mordon S., Nonablative remodeling with a 1,540 nm erbium:glass laser. Dermatologic Surgery 2005 31 9 1227 1235 2-s2.0-27744439526 (Pubitemid 41587078)
68. Friedman P. M., Jih M. H., Skover G. R., Payonk G. S., Kimyai-Asadi A., Geronemus R. G., Treatment of atrophic facial acne scars with the 1064-nm Q-switched Nd:YAG laser: six-month follow-up study. Archives of Dermatology 2004 140 11 1337 1341 2-s2.0-8144220517 10.1001/archderm.140.11.1337 (Pubitemid 39473633)
69. Lipper G. M., Perez M., Nonablative acne scar reduction after a series of treatments with a short-pulsed 1,064-nm Neodymium:YAG laser. Dermatologic Surgery 2006 32 8 998 1006 2-s2.0-33746891181 10.1111/j.1524-4725.2006.32222.x (Pubitemid 44197448)
70. Bhatia A. C., Dover J. S., Arndt K. A., Stewart B., Alam M., Patient satisfaction and reported long-term therapeutic efficacy associated with 1,320 nm Nd:YAG laser treatment of acne scarring and photoaging. Dermatologic Surgery 2006 32 3 346 352 2-s2.0-33645450089 10.1111/j.1524-4725.2006.32071.x
71. Tanzi E. L., Alster T. S., Comparison of a 1450-nm diode laser and a 1320-nm Nd:YAG laser in the treatment of atrophic facial scars: a prospective clinical and histologic study. Dermatologic Surgery 2004 30 2 152 157 2-s2.0-1542378407 10.1111/j.1524-4725.2004.30078.x (Pubitemid 38314002)
72. Alster T. S., Lupton J. R., Are all infrared lasers equally effective in skin rejuvenation. Seminars in Cutaneous Medicine and Surgery 2002 21 4 274 279 2-s2.0-0036940587 10.1053/sder.2002.36766 (Pubitemid 36055626)
73. Hasegawa T., Matsukura T., Mizuno Y., Suga Y., Ogawa H., Ikeda S., Clinical trial of a laser device called fractional photothermolysis system for acne scars. Journal of Dermatology 2006 33 9 623 627 2-s2.0-33748369112 10.1111/j.1346-8138.2006.00143.x (Pubitemid 44337307)
74. Graber E. M., Tanzi E. L., Alster T. S., Side effects and complications of fractional laser photothermolysis: experience with 961 treatments. Dermatologic Surgery 2008 34 3 301 305 2-s2.0-39849083768 10.1111/j.1524-4725. 2007.34062.x
75. Alster T. S., Tanzi E. L., Lazarus M., The use of fractional laser photothermolysis for the treatment of atrophic scars. Dermatologic Surgery 2007 33 3 295 299 2-s2.0-33846848843 10.1111/j.1524-4725.2007.33059.x (Pubitemid 46328222)
76. Hantash B. M., Bedi V. P., Kapadia B., Rahman Z., Jiang K., Tanner H., Chan K. F., Zachary C. B., In vivo histological evaluation of a novel ablative fractional resurfacing device. Lasers in Surgery and Medicine 2007 39 2 96 107 2-s2.0-33947171418 10.1002/lsm.20468 (Pubitemid 46411402)
77. 2 ablative fractional resurfacing. Lasers in Surgery and Medicine 2008 40 6 381 386 2-s2.0-49249097066 10.1002/lsm.20659
78. Waibel J., Beer K., Narurkar V., Alster T., Preliminary observations on fractional ablative resurfacing devices: clinical impressions. Journal of Drugs in Dermatology 2009 8 5 481 485 2-s2.0-67649853287
79. Hantash B. M., Bedi V. P., Chan K. F., Zachary C. B., Ex vivo histological characterization of a novel ablative fractional resurfacing device. Lasers in Surgery and Medicine 2007 39 2 87 95 2-s2.0-33947160491 10.1002/lsm.20405 (Pubitemid 46411401)
80. Hantash B. M., Bedi V. P., Kapadia B., Rahman Z., Jiang K., Tanner H., Chan K. F., Zachary C. B., In vivo histological evaluation of a novel ablative fractional resurfacing device. Lasers in Surgery and Medicine 2007 39 2 96 107 2-s2.0-33947171418 10.1002/lsm.20468 (Pubitemid 46411402)
81. Alster T. S., West T. B., Resurfacing of atrophic facial acne scars with a high-energy, pulsed carbon dioxide laser. Dermatologic Surgery 1996 22 2 151 155 2-s2.0-0030060819 (Pubitemid 26069620)
82. Goodman G. J., Postacne scarring: a review of its pathophysiology and treatment. Dermatologic Surgery 2000 26 9 857 871 2-s2.0-0033824808 10.1046/j.1524-4725.2000.99232.x
83. Koo S. H., Yoon E. S., Ahn D. S., Park S. H., Laser punch-out for acne scars. Aesthetic Plastic Surgery 2001 25 1 46 51 2-s2.0-0035077215 10.1007/s002660010094 (Pubitemid 32234930)
84. Grevelink J. M., White V. R., Concurrent use of laser skin resurfacing and punch excision in the treatment of facial acne scarring. Dermatologic Surgery 1998 24 5 527 530 2-s2.0-0031965877 (Pubitemid 28225954)
85. Matsuoka L. Y., Acne and related disorders. Clinics in Plastic Surgery 1993 20 1 35 41 2-s2.0-0027393829 (Pubitemid 23063993)
86. Ellis D. A., Michell M. J., Surgical treatment of acne scarring: non-linear scar revision. Journal of Otolaryngology 1987 16 2 116 119 2-s2.0-0023142709 (Pubitemid 17052388)
87. Trimble J. R., Dermal overgrafting in dermatology. Journal of Dermatologic Surgery and Oncology 1983 9 12 987 993 2-s2.0-0021017442 (Pubitemid 14178269)
88. Burres S. A., Recollagenation of acne scars. Dermatologic Surgery 1996 22 4 364 367 2-s2.0-0029864266 (Pubitemid 26144661)
89. Besecker B., Hart C. G., A new treatment option for acne scars: allograft dermis. Dermatology nursing / Dermatology Nurses Association 1999 11 2 111 114 2-s2.0-0033106772
90. Ellenbogen R., Invited comment on autologous fat injection. Annals of Plastic Surgery 1990 24 297
91. Goodman G. J., Postacne scarring: a review of its pathophysiology and treatment. Dermatologic Surgery 2000 26 9 857 871 2-s2.0-0033824808 10.1046/j.1524-4725.2000.99232.x
92. Fernandes D., Minimally invasive percutaneous collagen induction. Oral and Maxillofacial Surgery Clinics of North America 2005 17 1 51 63 2-s2.0-13244249552 10.1016/j.coms.2004.09.004 (Pubitemid 40186196)
93. Fabbrocini G., gafabbro@unina.it Fardella N., Monfrecola A., Proietti I., Innocenzi D., Acne scarring treatment using skin needling. Clinical and Experimental Dermatology 2009 34 8 874 879 10.1111/j.1365-2230.2009.03291.x
94. Kang W. H., Kim Y. J., Pyo W. S., Park S. J., Kim J. H., jiehoon@naver.com Atrophic acne scar treatment using triple combination therapy: dot peeling, subcision and fractional laser. Journal of Cosmetic and Laser Therapy 2009 11 4 212 215 10.3109/14764170903134326
95. Berman B., Perez O. A., Konda S., Kohut B. E., Viera M. H., Delgado S., Zell D., Li Q., A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management. Dermatologic Surgery 2007 33 11 1291 1302 2-s2.0-35448972539 10.1111/j.1524-4725.2007.33280.x
96. Mustoe T. A., Cooter R. D., Gold M. H., Hobbs F. D. R., Ramelet A.-A., Shakespeare P. G., Stella M., Téot L., Wood F. M., Ziegler U. E., International clinical recommendations on scar management. Plastic and Reconstructive Surgery 2002 110 2 560 571 2-s2.0-0036312318 (Pubitemid 34815962)
97. Kelly A. P., Medical and surgical therapies for keloids. Dermatologic Therapy 2004 17 2 212 218 2-s2.0-2442655265 10.1111/j.1396-0296.2004.04022.x (Pubitemid 38656914)
98. Nemeth A. J., Keloids and hypertrophic scars. Journal of Dermatologic Surgery and Oncology 1993 19 8 738 746 2-s2.0-0027819238 (Pubitemid 24182894)
99. Atiyeh B. S., aata@terra.net.lb Nonsurgical management of hypertrophic scars: evidence-based therapies, standard practices, and emerging methods. Aesthetic Plastic Surgery 2007 31 5 468 492 10.1007/s00266-006-0253-y (Pubitemid 47437506)
100. Manuskiatti W., Fitzpatrick R. E., Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. Archives of Dermatology 2002 138 9 1149 1155 2-s2.0-0036715319 (Pubitemid 35025686)
101. Boutli-Kasapidou F., Tsakiri A., Anagnostou E., Mourellou O., Hypertrophic and keloidal scars: an approach to polytherapy. International Journal of Dermatology 2005 44 4 324 327 2-s2.0-17444389314 10.1111/j.1365-4632. 2004.02570.x (Pubitemid 40542152)
102. Rusciani L., Rossi G., Bono R., Use of cryotherapy in the treatment of keloids. Journal of Dermatologic Surgery and Oncology 1993 19 6 529 534 2-s2.0-0027893196 (Pubitemid 24173970)
103. Layton A. M., Yip J., Cunliffe W. J., A comparison of intralesional triamcinolone and cryosurgery in the treatment of acne keloids. British Journal of Dermatology 1994 130 4 498 501 2-s2.0-0028337593 10.1111/j.1365-2133.1994. tb03385.x (Pubitemid 24204671)
104. Apfelberg D. B., Maser M. R., Lash H., Preliminary results of argon and carbon dioxide laser treatment of keloid scars. Lasers in Surgery and Medicine 1984 4 3 283 290 (Pubitemid 15214445)
105. Castro D. J., Abergel R. P., Meeker C., Effects of the Nd:YAG laser on DNA synthesis and collagen production in human skin fibroblast cultures. Annals of Plastic Surgery 1983 11 3 214 222 (Pubitemid 13017649)
106. Norris J. E. C., The effect of carbon dioxide laser surgery on the recurrence of keloids. Plastic and Reconstructive Surgery 1991 87 1 44 53 2-s2.0-0026034235
107. Lawrence W. T., In search of the optimal treatment of keloids: report of a series and a review of the literature. Annals of Plastic Surgery 1991 27 2 164 178 2-s2.0-0026324603
108. Sherman R., Rosenfeld H., Experience with the Nd:YAG laser in the treatment of keloid scars. Annals of Plastic Surgery 1988 21 3 231 235 2-s2.0-0023762532
109. Kuo Y.-R., Wu W.-S., Jeng S.-F., Huang H.-C., Yang K. D., Sacks J. M., Wang F.-S., wangfs@ms33.hinet.net Activation of ERK and p38 kinase mediated keloid fibroblast apoptosis after flashlamp pulsed-dye laser treatment. Lasers in Surgery and Medicine 2005 36 1 31 37 10.1002/lsm.20129 (Pubitemid 40224028)
110. Kuo Y.-R., Wu W.-S., Jeng S.-F., Wang F.-S., Huang H.-C., Lin C.-Z., Yang K. D., yangkd@adm.cgmh.org.tw Suppressed TGF- β 1 expression is correlated with up-regulation of matrix metalloproteinase-13 in keloid regression after flashlamp pulsed-dye laser treatment. Lasers in Surgery and Medicine 2005 36 1 38 42 10.1002/lsm.20104 (Pubitemid 40224029)
111. Alster T. S., Williams C. M., Treatment of keloid sternotomy scars with 585 nm flashlamp-pumped pulsed-dye laser. Lancet 1995 345 8959 1198 1200 2-s2.0-0029048864
112. Alster T., Laser scar revision: Comparison study of 585-nm pulsed dye laser with and without intralesional corticosteroids. Dermatologic Surgery 2003 29 1 25 29 2-s2.0-0037237721 10.1046/j.1524-4725.2003.29024.x (Pubitemid 36114725)
113. Alster T. S., Nanni C. A., Pulsed dye laser treatment of hypertrophic burn scars. Plastic and Reconstructive Surgery 1998 102 6 2190 2195 2-s2.0-0031741949 (Pubitemid 28518549)
114. Alster T., Zaulyanov-Scanlon L., Laser scar revision: a review. Dermatologic Surgery 2007 33 2 131 140 2-s2.0-33846794921 10.1111/j.1524-4725. 2006.33030.x (Pubitemid 46208102)
115. Manuskiatti W., Wanitphakdeedecha R., Fitzpatrick R. E., Effect of pulse width of a 595-nm flashlamp-pumped pulsed dye laser on the treatment response of keloidal and hypertrophic sternotomy scars. Dermatologic Surgery 2007 33 2 152 161 2-s2.0-33846809479 10.1111/j.1524-4725.2006.33033.x (Pubitemid 46208105)
116. Dierickx C., Goldman M. P., Fitzpatrick R. E., Alster T. S., Laser treatment of erythematous/hypertrophic and pigmented scars in 26 patients. Plastic and Reconstructive Surgery 1995 95 1 84 92 2-s2.0-0028878104
117. Bowes L. E., Nouri K., Berman B., Jimenez G., Pardo R., Rodriguez L., Spencer J. M., Treatment of pigmented hypertrophic scars with the 585 nm pulsed dye laser and the 532 nm frequency-doubled Nd:YAG laser in the Q-switched and variable pulse modes: a comparative study. Dermatologic Surgery 2002 28 8 714 719 2-s2.0-0036677933 10.1046/j.1524-4725.2002.01058.x (Pubitemid 34913281)
118. Manuskiatti W., Wanitphakdeedecha R., Fitzpatrick R. E., Effect of pulse width of a 595-nm flashlamp-pumped pulsed dye laser on the treatment response of keloidal and hypertrophic sternotomy scars. Dermatologic Surgery 2007 33 2 152 161 2-s2.0-33846809479 10.1111/j.1524-4725.2006.33033.x (Pubitemid 46208105)
119. Goldman M. P., Fitzpatrick R. E., Laser treatment of scars. Dermatologic Surgery 1995 21 8 685 687 2-s2.0-0029134688
120. Riedel F., Hormann K., Plastic surgery of skin defects in the face. Principles and prospective. HNO 2005 53 12 1020 1036 (Pubitemid 41751769)