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Volumn 41, Issue 22, 2013, Pages 10241-10253

ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 8; MEDIATOR COMPLEX; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN MED14; RNA POLYMERASE II; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG;

EID: 84890407490     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt837     Document Type: Article
Times cited : (10)

References (52)
  • 1
    • 80555135917 scopus 로고    scopus 로고
    • Regulation of primary response genes
    • Fowler, T., Sen, R. and Roy, A.L. (2011) Regulation of primary response genes. Mol. Cell, 44, 348-360.
    • (2011) Mol. Cell , vol.44 , pp. 348-360
    • Fowler, T.1    Sen, R.2    Roy, A.L.3
  • 2
    • 79953163396 scopus 로고    scopus 로고
    • Lessons on transcriptional control from the serum response network
    • Galbraith, M.D. and Espinosa, J.M. (2011) Lessons on transcriptional control from the serum response network. Curr. Opin. Genet. Dev., 21, 160-166.
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 160-166
    • Galbraith, M.D.1    Espinosa, J.M.2
  • 3
    • 0038702223 scopus 로고    scopus 로고
    • Ternary complex factors: Prime nuclear targets for mitogen-activated protein kinases
    • Shaw, P.E. and Saxton, J. (2003) Ternary complex factors: prime nuclear targets for mitogen-activated protein kinases. Int. J. Biochem. Cell Biol., 35, 1210-1226.
    • (2003) Int. J. Biochem. Cell Biol , vol.35 , pp. 1210-1226
    • Shaw, P.E.1    Saxton, J.2
  • 4
    • 0348049997 scopus 로고    scopus 로고
    • ETS ternary complex transcription factors
    • Buchwalter, G., Gross, C. and Wasylyk, B. (2004) ETS ternary complex transcription factors. Gene, 324, 1-14.
    • (2004) Gene , vol.324 , pp. 1-14
    • Buchwalter, G.1    Gross, C.2    Wasylyk, B.3
  • 6
    • 0026695645 scopus 로고
    • Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter
    • Gille, H., Sharrocks, A.D. and Shaw, P.E. (1992) Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature, 358, 414-417.
    • (1992) Nature , vol.358 , pp. 414-417
    • Gille, H.1    Sharrocks, A.D.2    Shaw, P.E.3
  • 7
    • 1542285164 scopus 로고    scopus 로고
    • SUMO promotes HDACmediated transcriptional repression
    • Yang, S.H. and Sharrocks, A.D. (2004) SUMO promotes HDACmediated transcriptional repression. Mol. Cell, 13, 611-617.
    • (2004) Mol. Cell , vol.13 , pp. 611-617
    • Yang, S.H.1    Sharrocks, A.D.2
  • 8
    • 21844440558 scopus 로고    scopus 로고
    • PIASx acts as an Elk-1 coactivator by facilitating derepression
    • Yang, S.H. and Sharrocks, A.D. (2005) PIASx acts as an Elk-1 coactivator by facilitating derepression. EMBO J., 24, 2161-2171.
    • (2005) EMBO J , vol.24 , pp. 2161-2171
    • Yang, S.H.1    Sharrocks, A.D.2
  • 9
    • 40849120908 scopus 로고    scopus 로고
    • MAP kinasemediated c-fos regulation relies on a histone acetylation relay switch
    • O'Donnell, A., Yang, S.H. and Sharrocks, A.D. (2008) MAP kinasemediated c-fos regulation relies on a histone acetylation relay switch. Mol. Cell, 29, 780-785.
    • (2008) Mol. Cell , vol.29 , pp. 780-785
    • O'Donnell, A.1    Yang, S.H.2    Sharrocks, A.D.3
  • 10
    • 34548801789 scopus 로고    scopus 로고
    • The molecular basis of eukaryotic transcription
    • Kornberg, R.D. (2007) The molecular basis of eukaryotic transcription. Proc. Natl Acad. Sci. USA, 104, 12955-12961.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 12955-12961
    • Kornberg, R.D.1
  • 11
    • 0036671095 scopus 로고    scopus 로고
    • Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction
    • Davis, J.A., Takagi, Y., Kornberg, R.D. and Asturias, F.A. (2002) Structure of the yeast RNA polymerase II holoenzyme: mediator conformation and polymerase interaction. Mol. Cell, 10, 409-415.
    • (2002) Mol. Cell , vol.10 , pp. 409-415
    • Davis, J.A.1    Takagi, Y.2    Kornberg, R.D.3    Asturias, F.A.4
  • 12
    • 77954759030 scopus 로고    scopus 로고
    • The human Mediator complex: A versatile, genome-wide regulator of transcription
    • Taatjes, D.J. (2010) The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem. Sci., 35, 315-322.
    • (2010) Trends Biochem. Sci. , vol.35 , pp. 315-322
    • Taatjes, D.J.1
  • 13
    • 70449641057 scopus 로고    scopus 로고
    • Progression through the RNA polymerase II CTD cycle
    • Buratowski, S. (2009) Progression through the RNA polymerase II CTD cycle. Mol. Cell, 36, 541-546.
    • (2009) Mol. Cell , vol.36 , pp. 541-546
    • Buratowski, S.1
  • 14
    • 61449143491 scopus 로고    scopus 로고
    • The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function
    • Knuesel, M.T., Meyer, K.D., Bernecky, C. and Taatjes, D.J. (2009) The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes Dev., 23, 439-451.
    • (2009) Genes Dev , vol.23 , pp. 439-451
    • Knuesel, M.T.1    Meyer, K.D.2    Bernecky, C.3    Taatjes, D.J.4
  • 15
    • 76349090199 scopus 로고    scopus 로고
    • CDK8 is a positive regulator of transcriptional elongation within the serum response network
    • Donner, A.J., Ebmeier, C.C., Taatjes, D.J. and Espinosa, J.M. (2010) CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat. Struct. Mol. Biol., 17, 194-201.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 194-201
    • Donner, A.J.1    Ebmeier, C.C.2    Taatjes, D.J.3    Espinosa, J.M.4
  • 17
    • 0037177573 scopus 로고    scopus 로고
    • Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit
    • Stevens, J.L., Cantin, G.T., Wang, G., Shevchenko, A. and Berk, A.J. (2002) Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. Science, 296, 755-758.
    • (2002) Science , vol.296 , pp. 755-758
    • Stevens, J.L.1    Cantin, G.T.2    Wang, G.3    Shevchenko, A.4    Berk, A.J.5
  • 18
    • 65549113969 scopus 로고    scopus 로고
    • Mediator MED23 links insulin signaling to the adipogenesis transcription cascade
    • Wang, W., Huang, L., Huang, Y., Yin, J.W., Berk, A.J., Friedman, J.M. and Wang, G. (2009) Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Dev. Cell, 16, 764-771.
    • (2009) Dev. Cell , vol.16 , pp. 764-771
    • Wang, W.1    Huang, L.2    Huang, Y.3    Yin, J.W.4    Berk, A.J.5    Friedman, J.M.6    Wang, G.7
  • 20
    • 80055076025 scopus 로고    scopus 로고
    • Dimer formation and conformational flexibility ensure cytoplasmic stability and nuclear accumulation of Elk-1
    • Evans, E.L., Saxton, J., Shelton, S.J., Begitt, A., Holliday, N.D., Hipskind, R.A. and Shaw, P.E. (2011) Dimer formation and conformational flexibility ensure cytoplasmic stability and nuclear accumulation of Elk-1. Nuclei Acids Res., 39, 6390-6402.
    • (2011) Nuclei Acids Res. , vol.39 , pp. 6390-6402
    • Evans, E.L.1    Saxton, J.2    Shelton, S.J.3    Begitt, A.4    Holliday, N.D.5    Hipskind, R.A.6    Shaw, P.E.7
  • 21
    • 36248983165 scopus 로고    scopus 로고
    • Mediator complexes and eukaryotic transcription regulation: An overview
    • Casamassimi, A. and Napoli, C. (2007) Mediator complexes and eukaryotic transcription regulation: an overview. Biochimie, 89, 1439-1446.
    • (2007) Biochimie , vol.89 , pp. 1439-1446
    • Casamassimi, A.1    Napoli, C.2
  • 22
    • 28544440730 scopus 로고    scopus 로고
    • Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinasedependent phosphorylation
    • Pandey, P.K., Udayakumar, T.S., Lin, X., Sharma, D., Shapiro, P.S. and Fondell, J.D. (2005) Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinasedependent phosphorylation. Mol. Cell. Biol., 25, 10695-10710.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 10695-10710
    • Pandey, P.K.1    Udayakumar, T.S.2    Lin, X.3    Sharma, D.4    Shapiro, P.S.5    Fondell, J.D.6
  • 23
    • 33344459086 scopus 로고    scopus 로고
    • MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor
    • Chen, W., Rogatsky, I. and Garabedian, M.J. (2006) MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor. Mol Endocrinol, 20, 560-572.
    • (2006) Mol Endocrinol , vol.20 , pp. 560-572
    • Chen, W.1    Rogatsky, I.2    Garabedian, M.J.3
  • 27
    • 0027215820 scopus 로고
    • A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
    • Lange-Carter, C.A., Pleiman, C.M., Gardner, A.M., Blumer, K.J. and Johnson, G.L. (1993) A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science, 260, 315-319.
    • (1993) Science , vol.260 , pp. 315-319
    • Lange-Carter, C.A.1    Pleiman, C.M.2    Gardner, A.M.3    Blumer, K.J.4    Johnson, G.L.5
  • 28
    • 0026642522 scopus 로고
    • Elk-1 protein domains required for direct and SRF-assisted DNA-binding
    • Janknecht, R. and Nordheim, A. (1992) Elk-1 protein domains required for direct and SRF-assisted DNA-binding. Nucleic Acids Res., 20, 3317-3324.
    • (1992) Nucleic Acids Res , vol.20 , pp. 3317-3324
    • Janknecht, R.1    Nordheim, A.2
  • 29
    • 0028239101 scopus 로고
    • Inhibition of v-raf-dependent c-fos expression and transformation by a kinasedefective mutant of the mitogen-activated protein kinase Erk2
    • Kortenjann, M., Thomae, O. and Shaw, P.E. (1994) Inhibition of v-raf-dependent c-fos expression and transformation by a kinasedefective mutant of the mitogen-activated protein kinase Erk2. Mol. Cell. Biol., 14, 4815-4824.
    • (1994) Mol. Cell. Biol , vol.14 , pp. 4815-4824
    • Kortenjann, M.1    Thomae, O.2    Shaw, P.E.3
  • 30
    • 0042691723 scopus 로고    scopus 로고
    • Megakaryoblastic leukemia 1 a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes
    • Cen, B., Selvaraj, A., Burgess, R.C., Hitzler, J.K., Ma, Z., Morris, S.W. and Prywes, R. (2003) Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Mol. Cell. Biol., 23, 6597-6608.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 6597-6608
    • Cen, B.1    Selvaraj, A.2    Burgess, R.C.3    Hitzler, J.K.4    Ma, Z.5    Morris, S.W.6    Prywes, R.7
  • 31
    • 0042704734 scopus 로고    scopus 로고
    • Crosstalk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells
    • Hayashida, T., Decaestecker, M. and Schnaper, H.W. (2003) Crosstalk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells. FASEB J., 17, 1576-1578.
    • (2003) FASEB J , vol.17 , pp. 1576-1578
    • Hayashida, T.1    Decaestecker, M.2    Schnaper, H.W.3
  • 32
    • 31444446365 scopus 로고    scopus 로고
    • Cross-talk between bone morphogenetic protein 2 and leukemia inhibitory factor through ERK 1/2 and Smad1 in protection against doxorubicin-induced injury of cardiomyocyte
    • Izumi, M., Masaki, M., Hiramoto, Y., Sugiyama, S., Kuroda, T., Terai, K., Hori, M., Kawase, I. and Hirota, H. (2006) Cross-talk between bone morphogenetic protein 2 and leukemia inhibitory factor through ERK 1/2 and Smad1 in protection against doxorubicin-induced injury of cardiomyocytes. J. Mol. Cell. Cardiol., 40, 224-233.
    • (2006) J. Mol. Cell. Cardiol , vol.40 , pp. 224-233
    • Izumi, M.1    Masaki, M.2    Hiramoto, Y.3    Sugiyama, S.4    Kuroda, T.5    Terai, K.6    Hori, M.7    Kawase, I.8    Hirota, H.9
  • 33
    • 33749344476 scopus 로고    scopus 로고
    • Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription
    • Ross, S., Cheung, E., Petrakis, T.G., Howell, M., Kraus, W.L. and Hill, C. (2006) Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription. EMBO J., 25, 4490-4502.
    • (2006) EMBO J , vol.25 , pp. 4490-4502
    • Ross, S.1    Cheung, E.2    Petrakis, T.G.3    Howell, M.4    Kraus, W.L.5    Hill, C.6
  • 34
    • 14644427848 scopus 로고    scopus 로고
    • Mediator requirement for both recruitment and postrecruitment steps in transcription initiation
    • Wang, G., Balamotis, M.A., Stevens, J.L., Yamaguchi, Y., Handa, H. and Berk, A.J. (2005) Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol. Cell, 17, 683-694.
    • (2005) Mol. Cell , vol.17 , pp. 683-694
    • Wang, G.1    Balamotis, M.A.2    Stevens, J.L.3    Yamaguchi, Y.4    Handa, H.5    Berk, A.J.6
  • 35
    • 0033579464 scopus 로고    scopus 로고
    • Sequence-and structure-based prediction of eukaryotic protein phosphorylation sites
    • Blom, N., Gammeltoft, S. and Brunak, S. (1999) Sequence-and structure-based prediction of eukaryotic protein phosphorylation sites. J. Mol. Biol., 294, 1351-1362.
    • (1999) J. Mol. Biol , vol.294 , pp. 1351-1362
    • Blom, N.1    Gammeltoft, S.2    Brunak, S.3
  • 36
    • 23144434356 scopus 로고    scopus 로고
    • KinasePhos: A web tool for identifying protein kinase-specific phosphorylation sites
    • Huang, H.D., Lee, T.Y., Tseng, S.W. and Horng, J.T. (2005) KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites. Nucleic Acids Res., 33, W226-229.
    • (2005) Nucleic Acids Res , vol.33
    • Huang, H.D.1    Lee, T.Y.2    Tseng, S.W.3    Horng, J.T.4
  • 37
    • 0001603028 scopus 로고    scopus 로고
    • An activator binding module of yeast RNA polymerase II holoenzyme
    • Lee, Y.C., Park, J.M., Min, S., Han, S.J. and Kim, Y.J. (1999) An activator binding module of yeast RNA polymerase II holoenzyme. Mol. Cell. Biol., 19, 2967-2976.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 2967-2976
    • Lee, Y.C.1    Park, J.M.2    Min, S.3    Han, S.J.4    Kim, Y.J.5
  • 38
    • 0036645671 scopus 로고    scopus 로고
    • The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development
    • Ito, M., Okano, H.J., Darnell, R.B. and Roeder, R.G. (2002) The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J., 21, 3464-3475.
    • (2002) EMBO J , vol.21 , pp. 3464-3475
    • Ito, M.1    Okano, H.J.2    Darnell, R.B.3    Roeder, R.G.4
  • 40
    • 0035834772 scopus 로고    scopus 로고
    • The structural and functional organization of the yeast mediator complex
    • Kang, J.S., Kim, S.H., Hwang, M.S., Han, S.J., Lee, Y.C. and Kim, Y.J. (2001) The structural and functional organization of the yeast mediator complex. J. Biol. Chem., 276, 42003-42010.
    • (2001) J. Biol. Chem , vol.276 , pp. 42003-42010
    • Kang, J.S.1    Kim, S.H.2    Hwang, M.S.3    Han, S.J.4    Lee, Y.C.5    Kim, Y.J.6
  • 41
    • 79953162883 scopus 로고    scopus 로고
    • Function and regulation of the mediator complex
    • Conaway, R.C. and Conaway, J.W. (2011) Function and regulation of the mediator complex. Curr. Opin. Genet. Dev., 21, 1-6.
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 1-6
    • Conaway, R.C.1    Conaway, J.W.2
  • 42
    • 84867185411 scopus 로고    scopus 로고
    • Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation
    • Yin, J.W., Liang, Y., Park, J.Y., Chen, D., Yao, X., Xiao, Q., Liu, Z., Jiang, B., Fu, Y., Bao, M. et al. (2012) Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes Dev., 26, 2192-2205.
    • (2012) Genes Dev. , vol.26 , pp. 2192-2205
    • Yin, J.W.1    Liang, Y.2    Park, J.Y.3    Chen, D.4    Yao, X.5    Xiao, Q.6    Liu, Z.7    Jiang, B.8    Fu, Y.9    Bao, M.10
  • 43
    • 77950643587 scopus 로고    scopus 로고
    • MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis
    • Grøntved, L., Madsen, M.S., Boergesen, M., Roeder, R.G. and Mandrup, S. (2010) MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis. Mol. Cell. Biol., 30, 2155-2169.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 2155-2169
    • Grøntved, L.1    Madsen, M.S.2    Boergesen, M.3    Roeder, R.G.4    Mandrup, S.5
  • 44
    • 4344601432 scopus 로고    scopus 로고
    • MED16 and MED23 of Mediator are coactivators of lipopolysaccharide-and heat-shock-induced transcriptional activators
    • Kim, T.W., Kwon, Y.J., Kim, J.M., Song, Y.H., Kim, S.N. and Kim, Y.J. (2004) MED16 and MED23 of Mediator are coactivators of lipopolysaccharide-and heat-shock-induced transcriptional activators. Proc. Natl Acad. Sci. USA, 101, 12153-12158.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 12153-12158
    • Kim, T.W.1    Kwon, Y.J.2    Kim, J.M.3    Song, Y.H.4    Kim, S.N.5    Kim, Y.J.6
  • 45
    • 0030926004 scopus 로고    scopus 로고
    • Mechanism of TGFbeta receptor inhibition by FKBP12
    • Chen, Y.G., Liu, F. and Massague, J. (1997) Mechanism of TGFbeta receptor inhibition by FKBP12. EMBO J., 16, 3866-3876.
    • (1997) EMBO J , vol.16 , pp. 3866-3876
    • Chen, Y.G.1    Liu, F.2    Massague, J.3
  • 46
    • 80455173859 scopus 로고    scopus 로고
    • 14-3-3 Proteins: Diverse functions in cell proliferation and cancer progression
    • Freeman, A.K. and Morrison, D.K. (2011) 14-3-3 Proteins: diverse functions in cell proliferation and cancer progression. Semin. Cell Dev. Biol., 22, 681-687.
    • (2011) Semin. Cell Dev. Biol. , vol.22 , pp. 681-687
    • Freeman, A.K.1    Morrison, D.K.2
  • 47
  • 48
    • 33846010183 scopus 로고    scopus 로고
    • Peptidyl-prolyl cis/trans isomerases and transcription: Is there a twist in the tail
    • Shaw, P.E. (2007) Peptidyl-prolyl cis/trans isomerases and transcription: is there a twist in the tail EMBO Rep., 8, 40-45.
    • (2007) EMBO Rep , vol.8 , pp. 40-45
    • Shaw, P.E.1
  • 49
    • 70350344048 scopus 로고    scopus 로고
    • MAP-ping unconventional protein-DNA interactions
    • Dioum, E.M., Wauson, E.M. and Cobb, M.H. (2009) MAP-ping unconventional protein-DNA interactions. Cell, 139, 462-463.
    • (2009) Cell , vol.139 , pp. 462-463
    • Dioum, E.M.1    Wauson, E.M.2    Cobb, M.H.3
  • 50
    • 0029379778 scopus 로고
    • Activation of ternary complex factor Elk-1 by stress-activated protein kinases
    • Gille, H., Strahl, T. and Shaw, P.E. (1995) Activation of ternary complex factor Elk-1 by stress-activated protein kinases. Curr. Biol., 5, 1191-1200.
    • (1995) Curr. Biol , vol.5 , pp. 1191-1200
    • Gille, H.1    Strahl, T.2    Shaw, P.E.3
  • 51
    • 0028931406 scopus 로고
    • ERK phosphorylation potentiates ELK-1-mediated ternary complex formation and transactivation
    • Gille, H., Kortenjann, M., Thomae, O., Moomaw, C., Slaughter, C., Cobb, M.H. and Shaw, P.E. (1995) ERK phosphorylation potentiates ELK-1-mediated ternary complex formation and transactivation. EMBO J., 14, 951-962.
    • (1995) EMBO J , vol.14 , pp. 951-962
    • Gille, H.1    Kortenjann, M.2    Thomae, O.3    Moomaw, C.4    Slaughter, C.5    Cobb, M.H.6    Shaw, P.E.7
  • 52
    • 0029908198 scopus 로고    scopus 로고
    • Selective response of ternary complex factor Sap1a to different mitogen-activated protein kinase subgroups
    • Strahl, T., Gille, H. and Shaw, P.E. (1996) Selective response of ternary complex factor Sap1a to different mitogen-activated protein kinase subgroups. Proc. Natl Acad. Sci. USA, 93, 11563-11568.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 11563-11568
    • Strahl, T.1    Gille, H.2    Shaw, P.E.3


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