Life-stage-, sex-, and dose-dependent dietary toxicokinetics and relationship to toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D) in rats: Implications for toxicity test dose selection, design, and interpretation

Toxicological Sciences

Volumn 136, Issue 2, 2013, Pages 294-307

  Saghir, Shakil A ^a,e   Marty, Mary S ^b   Zablotny, Carol L ^b   Passage, Julie K ^b   Perala, Adam W ^b   Neal, Barbara H ^c   Hammond, Larry ^d   Bus, James S ^c  

^a Intrinsik Environmental Sciences Inc   (Canada)

^b DOW CHEMICAL COMPANY   (United States)

^c EXPONENT INC   (United States)

^d Toxicology Subcommittee   (United States)

^e AGA KHAN UNIVERSITY   (Pakistan)

Author keywords

2,4 D; 2,4 dichlorophenoxyacetic acid; Development; Perinatal; Pharmacokinetics; PK; Rats; TK; Toxicity; Toxicokinetics

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; ORGANIC ANION TRANSPORTER;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; DOSE DEPENDENT TOXICOKINETIC; DRUG BLOOD LEVEL; FEMALE; GESTATION PERIOD; KIDNEY CLEARANCE; LACTATION; LIFE CYCLE STAGE; LIFE STAGE DEPENDENT TOXICITY; MALE; MARE; MATING; MAXIMUM TOLERATED DOSE; MILK; NONHUMAN; PERINATAL PERIOD; PROGENY; PUP (RODENT); RAT; SEX ALLOCATION; SPRAGUE DAWLEY RAT; TOXICITY TESTING; TOXICOKINETICS; TOXICOLOGICAL PARAMETERS; WEANING; WEIGHT CHANGE;

2,4-D; 2,4-DICHLOROPHENOXYACETIC ACID; DEVELOPMENT; PERINATAL; PHARMACOKINETICS; PK; RATS.; TK; TOXICITY; TOXICOKINETICS;

2,4-DICHLOROPHENOXYACETIC ACID; ANIMALS; AREA UNDER CURVE; BODY WEIGHT; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; FEMALE; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; TOXICITY TESTS;

EID: 84890392389     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft212     Document Type: Article

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