Increased c-Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency

Cancer Science

Volumn 102, Issue 4, 2011, Pages 784-791

  Tanaka, Hiroki ^a   Tamura, Akitoshi ^a   Sekai, Miho ^a   Hamazaki, Yoko ^a   Minato, Nagahiro ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MYC PROTEIN; PROTEIN; PROTEIN P53; RAP PROTEIN; SPA 1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER RESISTANCE; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; GAMMA RADIATION; GENE MUTATION; GENE SILENCING; GENETIC ANALYSIS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; INTRACELLULAR SIGNALING; LEUKEMIA; MOUSE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PRELEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; WHOLE BODY RADIATION;

ANIMALS; BLAST CRISIS; BLOTTING, WESTERN; DNA DAMAGE; FLOW CYTOMETRY; GAMMA RAYS; GTPASE-ACTIVATING PROTEINS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; MYELOPROLIFERATIVE DISORDERS; NUCLEAR PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-MYC; RAP1 GTP-BINDING PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEIN P53; WHOLE-BODY IRRADIATION;

EID: 79952753803     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.01850.x     Document Type: Article

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