-
1
-
-
33749624177
-
Cancer regression in patients after transfer of genetically engineered lymphocytes
-
doi: 10.1126/science.1129003
-
Morgan RA, Dudley ME, Wunderlich JR, Hughes MS, Yang JC, Sherry RM, et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science (2006) 314:126-9. doi: 10.1126/science.1129003
-
(2006)
Science
, vol.314
, pp. 126-129
-
-
Morgan, R.A.1
Dudley, M.E.2
Wunderlich, J.R.3
Hughes, M.S.4
Yang, J.C.5
Sherry, R.M.6
-
2
-
-
84855769575
-
Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies
-
doi:10.1111/j.1365-2249.2011.04517.x
-
Marr LA, Gilham DE, Campbell JD, Fraser AR. Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies. Clin Exp Immunol (2012) 167:216-25. doi:10.1111/j.1365-2249.2011.04517.x
-
(2012)
Clin Exp Immunol
, vol.167
, pp. 216-225
-
-
Marr, L.A.1
Gilham, D.E.2
Campbell, J.D.3
Fraser, A.R.4
-
3
-
-
36349004799
-
Selecting highly affine and well-expressed TCRs for gene therapy of melanoma
-
doi:10.1182/blood-2007-02-075010
-
Jorritsma A, Gomez-Eerland R, Dokter M, van de Kasteele W, Zoet YM, Doxiadis II, et al. Selecting highly affine and well-expressed TCRs for gene therapy of melanoma. Blood (2007) 110:3564-72. doi:10.1182/blood-2007-02-075010
-
(2007)
Blood
, vol.110
, pp. 3564-3572
-
-
Jorritsma, A.1
Gomez-Eerland, R.2
Dokter, M.3
van de Kasteele, W.4
Zoet, Y.M.5
Doxiadis, I.I.6
-
4
-
-
53149126134
-
TCR gene therapy of spontaneous prostate carcinoma requires in vivo T cell activation
-
de Witte MA, Bendle GM, van den Boom MD, Coccoris M, Schell TD, Tevethia SS, et al. TCR gene therapy of spontaneous prostate carcinoma requires in vivo T cell activation. J Immunol (2008) 181:2563-71.
-
(2008)
J Immunol
, vol.181
, pp. 2563-2571
-
-
de Witte, M.A.1
Bendle, G.M.2
van den Boom, M.D.3
Coccoris, M.4
Schell, T.D.5
Tevethia, S.S.6
-
5
-
-
0024580836
-
Generation of effector T cells expressing chimeric T cell receptor with antibody type-specificity
-
Gross G, Gorochov G, Waks T, Eshhar Z. Generation of effector T cells expressing chimeric T cell receptor with antibody type-specificity. Transplant Proc (1989) 2:127-30.
-
(1989)
Transplant Proc
, vol.2
, pp. 127-130
-
-
Gross, G.1
Gorochov, G.2
Waks, T.3
Eshhar, Z.4
-
6
-
-
84874285199
-
Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T cells
-
doi:10.4049/jimmunol.1201314
-
Zhang T, Sentman CL. Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T cells. J Immunol (2013) 190:2455-63. doi:10.4049/jimmunol.1201314
-
(2013)
J Immunol
, vol.190
, pp. 2455-2463
-
-
Zhang, T.1
Sentman, C.L.2
-
7
-
-
84865431753
-
An NKp30-based chimeric antigen receptor promotes T cell effector functions and antitumor efficacy in vivo
-
doi:10.4049/jimmunol.1103495
-
Zhang T, Wu MR, Sentman CL. An NKp30-based chimeric antigen receptor promotes T cell effector functions and antitumor efficacy in vivo. J Immunol (2012) 189:2290-9. doi:10.4049/jimmunol.1103495
-
(2012)
J Immunol
, vol.189
, pp. 2290-2299
-
-
Zhang, T.1
Wu, M.R.2
Sentman, C.L.3
-
8
-
-
84855497162
-
A single autoimmune T cell receptor recognizes more than a million different peptides
-
doi:10.1074/jbc.M111.289488
-
Wooldridge L, Ekeruche-Makinde J, van den Berg HA, Skowera A, Miles JJ, Tan MP, et al. A single autoimmune T cell receptor recognizes more than a million different peptides. J Biol Chem (2012) 287:1168-77. doi:10.1074/jbc.M111.289488
-
(2012)
J Biol Chem
, vol.287
, pp. 1168-1177
-
-
Wooldridge, L.1
Ekeruche-Makinde, J.2
van den Berg, H.A.3
Skowera, A.4
Miles, J.J.5
Tan, M.P.6
-
9
-
-
33749519601
-
Human CD4+ T cells lyse target cells via granzyme/perforin upon circumvention of MHC class II restriction by an antibody-like immunoreceptor
-
Hombach A, Köhler H, Rappl G, Abken H. Human CD4+ T cells lyse target cells via granzyme/perforin upon circumvention of MHC class II restriction by an antibody-like immunoreceptor. J Immunol (2006) 177:5668-75.
-
(2006)
J Immunol
, vol.177
, pp. 5668-5675
-
-
Hombach, A.1
Köhler, H.2
Rappl, G.3
Abken, H.4
-
10
-
-
0032201554
-
Transfer of chimeric receptor gene made of variable regions of tumor-specific antibody confers anticarbohydrate specificity on T cells
-
Mezzanzanica D, Canevari S, Mazzoni A, Figini M, Colnaghi MI, Waks T, et al. Transfer of chimeric receptor gene made of variable regions of tumor-specific antibody confers anticarbohydrate specificity on T cells. Cancer Gene Ther (1998) 5:401-7.
-
(1998)
Cancer Gene Ther
, vol.5
, pp. 401-407
-
-
Mezzanzanica, D.1
Canevari, S.2
Mazzoni, A.3
Figini, M.4
Colnaghi, M.I.5
Waks, T.6
-
11
-
-
0030777395
-
T cell targeting of TAG72+ tumor cells by a chimeric receptor with antibody-like specificity for a carbohydrate epitope
-
doi:10.1053/gast.1997.v113.pm9322511
-
Hombach A, Heuser C, Sircar R, Tillmann T, Diehl V, Kruis W, et al. T cell targeting of TAG72+ tumor cells by a chimeric receptor with antibody-like specificity for a carbohydrate epitope. Gastroenterology (1997) 113:1163-70. doi:10.1053/gast.1997.v113.pm9322511
-
(1997)
Gastroenterology
, vol.113
, pp. 1163-1170
-
-
Hombach, A.1
Heuser, C.2
Sircar, R.3
Tillmann, T.4
Diehl, V.5
Kruis, W.6
-
12
-
-
30044442768
-
Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice
-
doi:10.1073/pnas.0504312102
-
Westwood JA, Smyth MJ, Teng MW, Moeller M, Trapani JA, Scott AM, et al. Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice. Proc Natl Acad Sci U S A (2005) 102:19051-6. doi:10.1073/pnas.0504312102
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 19051-19056
-
-
Westwood, J.A.1
Smyth, M.J.2
Teng, M.W.3
Moeller, M.4
Trapani, J.A.5
Scott, A.M.6
-
13
-
-
65249176824
-
Rational development of high-affinity T-cell receptor-like antibodies
-
doi:10.1073/pnas.0901425106
-
Stewart-Jones G, Wadle A, Hombach A, Shenderov E, Held G, Fischer E, et al. Rational development of high-affinity T-cell receptor-like antibodies. Proc Natl Acad Sci U S A (2009) 106:5784-8. doi:10.1073/pnas.0901425106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 5784-5788
-
-
Stewart-Jones, G.1
Wadle, A.2
Hombach, A.3
Shenderov, E.4
Held, G.5
Fischer, E.6
-
14
-
-
0035879290
-
CD4+ T cells engrafted with a recombinant immunoreceptor efficiently lyse target cells in a MHC antigen-and Fas-independent fashion
-
Hombach A, Heuser C, Marquardt T, Wieczarkowiecz A, Groneck V, Pohl C, et al. CD4+ T cells engrafted with a recombinant immunoreceptor efficiently lyse target cells in a MHC antigen-and Fas-independent fashion. J Immunol (2001) 167:1090-6.
-
(2001)
J Immunol
, vol.167
, pp. 1090-1096
-
-
Hombach, A.1
Heuser, C.2
Marquardt, T.3
Wieczarkowiecz, A.4
Groneck, V.5
Pohl, C.6
-
15
-
-
37049016015
-
Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells
-
doi:10.1158/0008-5472.CAN-07-1141
-
Moeller M, Kershaw MH, Cameron R, Westwood JA, Trapani JA, Smyth MJ, et al. Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells. Cancer Res (2007) 67:11428-37. doi:10.1158/0008-5472.CAN-07-1141
-
(2007)
Cancer Res
, vol.67
, pp. 11428-11437
-
-
Moeller, M.1
Kershaw, M.H.2
Cameron, R.3
Westwood, J.A.4
Trapani, J.A.5
Smyth, M.J.6
-
16
-
-
0032826041
-
Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus
-
Kreuwel HT, Morgan DJ, Krahl T, Ko A, Sarvetnick N, Sherman LA. Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus. J Immunol (1999) 163:4335-41.
-
(1999)
J Immunol
, vol.163
, pp. 4335-4341
-
-
Kreuwel, H.T.1
Morgan, D.J.2
Krahl, T.3
Ko, A.4
Sarvetnick, N.5
Sherman, L.A.6
-
17
-
-
0031785525
-
How do cytotoxic lymphocytes kill their targets?
-
doi:10.1016/S0952-7915(98)80227-6
-
Shresta S, Pham CT, Thomas DA, Graubert TA, Ley TL. How do cytotoxic lymphocytes kill their targets? Curr Opin Immunol (1998) 10:581-7. doi:10.1016/S0952-7915(98)80227-6
-
(1998)
Curr Opin Immunol
, vol.10
, pp. 581-587
-
-
Shresta, S.1
Pham, C.T.2
Thomas, D.A.3
Graubert, T.A.4
Ley, T.L.5
-
18
-
-
0030823702
-
Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation
-
doi:10.1172/JCI119606
-
Graubert TA, Di Persio JF, Russell JH, Ley TJ. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J Clin Invest (1997) 100:904-11. doi:10.1172/JCI119606
-
(1997)
J Clin Invest
, vol.100
, pp. 904-911
-
-
Graubert, T.A.1
Di Persio, J.F.2
Russell, J.H.3
Ley, T.J.4
-
19
-
-
0034177140
-
Redirected perforin-dependent lysis of colon carcinoma by ex vivo genetically engineered CTL
-
Darcy PK, Haynes NM, Snook MB, Trapani JA, Cerruti L, Jane SM, et al. Redirected perforin-dependent lysis of colon carcinoma by ex vivo genetically engineered CTL. J Immunol (2000) 164:3705-12.
-
(2000)
J Immunol
, vol.164
, pp. 3705-3712
-
-
Darcy, P.K.1
Haynes, N.M.2
Snook, M.B.3
Trapani, J.A.4
Cerruti, L.5
Jane, S.M.6
-
20
-
-
0034176232
-
Granule exocytosis, and not the Fas/Fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4(+) as well as CD8(+) cytotoxic T lymphocytes in humans
-
Yasukawa M, Ohminami H, Arai J, Kasahara Y, Ishida Y, Fujita S. Granule exocytosis, and not the Fas/Fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4(+) as well as CD8(+) cytotoxic T lymphocytes in humans. Blood (2000) 95:2352-5.
-
(2000)
Blood
, vol.95
, pp. 2352-2355
-
-
Yasukawa, M.1
Ohminami, H.2
Arai, J.3
Kasahara, Y.4
Ishida, Y.5
Fujita, S.6
-
21
-
-
19944434233
-
Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR
-
doi:10.1016/j.immuni.2004.12.005
-
Kuball J, Schmitz FW, Voss RH, Ferreira EA, Engel R, Guillaume P, et al. Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR. Immunity (2005) 22:117-29. doi:10.1016/j.immuni.2004.12.005
-
(2005)
Immunity
, vol.22
, pp. 117-129
-
-
Kuball, J.1
Schmitz, F.W.2
Voss, R.H.3
Ferreira, E.A.4
Engel, R.5
Guillaume, P.6
-
22
-
-
10344265510
-
T cell activation by antibody-like immunoreceptors: increase in affinity of the scFv domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity
-
Chmielewski M, Hombach A, Heuser C, Adams GP, Abken H. T cell activation by antibody-like immunoreceptors: increase in affinity of the scFv domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity. J Immunol (2004) 173:7647-53.
-
(2004)
J Immunol
, vol.173
, pp. 7647-7653
-
-
Chmielewski, M.1
Hombach, A.2
Heuser, C.3
Adams, G.P.4
Abken, H.5
-
23
-
-
84879480191
-
Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells
-
doi:10.1158/1078-0432.CCR-13-0330
-
Hudecek M, Lupo-Stanghellini MT, Kosasih PL, Sommermeyer D, Jensen MC, Rader C, et al. Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells. Clin Cancer Res (2013) 19:3153-64. doi:10.1158/1078-0432.CCR-13-0330
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3153-3164
-
-
Hudecek, M.1
Lupo-Stanghellini, M.T.2
Kosasih, P.L.3
Sommermeyer, D.4
Jensen, M.C.5
Rader, C.6
-
24
-
-
84876859096
-
T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy
-
doi:10.1073/pnas.1221609110
-
Zhong S, Malecek K, Johnson LA, Yu Z, Vega-Saenz de Miera E, Darvishian F, et al. T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy. Proc Natl Acad Sci U S A (2013) 110:6973-8. doi:10.1073/pnas.1221609110
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 6973-6978
-
-
Zhong, S.1
Malecek, K.2
Johnson, L.A.3
Yu, Z.4
Vega-Saenz de Miera, E.5
Darvishian, F.6
-
25
-
-
33947633597
-
T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells
-
Hombach AA, Schildgen V, Heuser C, Finnern R, Gilham DE, Abken H. T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells. J Immunol (2007) 178:4650-7.
-
(2007)
J Immunol
, vol.178
, pp. 4650-4657
-
-
Hombach, A.A.1
Schildgen, V.2
Heuser, C.3
Finnern, R.4
Gilham, D.E.5
Abken, H.6
-
26
-
-
20944439742
-
The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens
-
doi:10.1097/01.cji.0000161397.96582.59
-
Guest RD, Hawkins RE, Kirillova N, Cheadle EJ, Arnold J, O'Neill A, et al. The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens. J Immunother (2005) 28:203-11. doi:10.1097/01.cji.0000161397.96582.59
-
(2005)
J Immunother
, vol.28
, pp. 203-211
-
-
Guest, R.D.1
Hawkins, R.E.2
Kirillova, N.3
Cheadle, E.J.4
Arnold, J.5
O'Neill, A.6
-
27
-
-
45549093089
-
Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane
-
James SE, Greenberg PD, Jensen MC, Lin Y, Wang J, Till BG, et al. Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane. J Immunol (2008) 180:7028-38.
-
(2008)
J Immunol
, vol.180
, pp. 7028-7038
-
-
James, S.E.1
Greenberg, P.D.2
Jensen, M.C.3
Lin, Y.4
Wang, J.5
Till, B.G.6
-
28
-
-
84860333968
-
CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
-
doi:10.1182/blood-2011-10-387969
-
Till BG, Jensen MC, Wang J, Qian X, Gopal AK, Maloney DG, et al. CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results. Blood (2012) 119:3940-50. doi:10.1182/blood-2011-10-387969
-
(2012)
Blood
, vol.119
, pp. 3940-3950
-
-
Till, B.G.1
Jensen, M.C.2
Wang, J.3
Qian, X.4
Gopal, A.K.5
Maloney, D.G.6
-
29
-
-
33746114879
-
The kinetic-segregation model: TCR triggering and beyond
-
doi:10.1038/ni1369
-
Davis SJ, van der Merwe PA. The kinetic-segregation model: TCR triggering and beyond. Nat Immunol (2006) 7:803-9. doi:10.1038/ni1369
-
(2006)
Nat Immunol
, vol.7
, pp. 803-809
-
-
Davis, S.J.1
van der Merwe, P.A.2
-
30
-
-
0035576250
-
Tumor specific T cell activation by recombinant immunoreceptors: CD3zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3zeta signaling receptor molecule
-
Hombach A, Wieczarkowiecz A, Marquardt T, Heuser C, Usai L, Pohl C, et al. Tumor specific T cell activation by recombinant immunoreceptors: CD3zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3zeta signaling receptor molecule. J Immunol (2001) 167:6123-31.
-
(2001)
J Immunol
, vol.167
, pp. 6123-6131
-
-
Hombach, A.1
Wieczarkowiecz, A.2
Marquardt, T.3
Heuser, C.4
Usai, L.5
Pohl, C.6
-
31
-
-
14244265418
-
Engineering T-cells with antibody based chimeric receptors for effective cancer therapy
-
Thislethwaite F, Mansoor W, Gilham DE, Hawkins RE. Engineering T-cells with antibody based chimeric receptors for effective cancer therapy. Curr Opin Mol Ther (2005) 7:48-55.
-
(2005)
Curr Opin Mol Ther
, vol.7
, pp. 48-55
-
-
Thislethwaite, F.1
Mansoor, W.2
Gilham, D.E.3
Hawkins, R.E.4
-
32
-
-
0032531091
-
Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product
-
Finney HM, Lawson AD, Bebbington CR, Weir AN. Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J Immunol (1998) 161:2791-7.
-
(1998)
J Immunol
, vol.161
, pp. 2791-2797
-
-
Finney, H.M.1
Lawson, A.D.2
Bebbington, C.R.3
Weir, A.N.4
-
33
-
-
33847367680
-
Costimulation tunes tumor-specific activation of redirected T cells in adoptive immunotherapy
-
doi:10.1007/s00262-006-0249-0
-
Hombach A, Abken H. Costimulation tunes tumor-specific activation of redirected T cells in adoptive immunotherapy. Cancer Immunol Immunther (2007) 56:731-7. doi:10.1007/s00262-006-0249-0
-
(2007)
Cancer Immunol Immunther
, vol.56
, pp. 731-737
-
-
Hombach, A.1
Abken, H.2
-
34
-
-
84880094711
-
Of chimeric antigen receptors and antibodies: OX40 and 41BB costimulation sharpen up T cell-based immunotherapy of cancer
-
doi:10.2217/imt.13.54
-
Hombach AA, Abken H. Of chimeric antigen receptors and antibodies: OX40 and 41BB costimulation sharpen up T cell-based immunotherapy of cancer. Immunotherapy (2013) 5:677-81. doi:10.2217/imt.13.54
-
(2013)
Immunotherapy
, vol.5
, pp. 677-681
-
-
Hombach, A.A.1
Abken, H.2
-
35
-
-
0033677159
-
Coupling CD28 co-stimulation to immunoglobulin T-cell receptor molecules: the dynamics of T-cell proliferation and death
-
doi:10.1097/00002371-200011000-00004
-
Beecham EJ, Ma Q, Ripley R, Junghans RP. Coupling CD28 co-stimulation to immunoglobulin T-cell receptor molecules: the dynamics of T-cell proliferation and death. J Immunother (2000) 23:631-42. doi:10.1097/00002371-200011000-00004
-
(2000)
J Immunother
, vol.23
, pp. 631-642
-
-
Beecham, E.J.1
Ma, Q.2
Ripley, R.3
Junghans, R.P.4
-
36
-
-
0035266137
-
T cell activation by recombinant receptors: CD28 costimulation is required for IL-2 secretion and receptor mediated T cell proliferation but does not affect receptor mediated target cell lysis
-
Hombach A, Sent D, Schneider C, Heuser C, Koch D, Pohl C, et al. T cell activation by recombinant receptors: CD28 costimulation is required for IL-2 secretion and receptor mediated T cell proliferation but does not affect receptor mediated target cell lysis. Cancer Res (2001) 61:1976-82.
-
(2001)
Cancer Res
, vol.61
, pp. 1976-1982
-
-
Hombach, A.1
Sent, D.2
Schneider, C.3
Heuser, C.4
Koch, D.5
Pohl, C.6
-
37
-
-
33947203783
-
CD28 costimulation overcomes transforming growth factor-beta-mediated repression of proliferation of redirected human CD4+ and CD8+ T cells in an antitumor cell attack
-
doi:10.1158/0008-5472.CAN-06-2098
-
Koehler H, Kofler D, Hombach A, Abken H. CD28 costimulation overcomes transforming growth factor-beta-mediated repression of proliferation of redirected human CD4+ and CD8+ T cells in an antitumor cell attack. Cancer Res (2007) 67:2265-73. doi:10.1158/0008-5472.CAN-06-2098
-
(2007)
Cancer Res
, vol.67
, pp. 2265-2273
-
-
Koehler, H.1
Kofler, D.2
Hombach, A.3
Abken, H.4
-
38
-
-
84881322406
-
The weal and woe of costimulation in the adoptive therapy of cancer with chimeric antigen receptor (CAR)-redirected T cells
-
doi:10.2174/1566524011313070003
-
Hombach AA, Holzinger A, Abken H. The weal and woe of costimulation in the adoptive therapy of cancer with chimeric antigen receptor (CAR)-redirected T cells. Curr Mol Med (2013) 13:1079-88. doi:10.2174/1566524011313070003
-
(2013)
Curr Mol Med
, vol.13
, pp. 1079-1088
-
-
Hombach, A.A.1
Holzinger, A.2
Abken, H.3
-
39
-
-
78650967548
-
CD28 cosignalling does not affect the activation threshold in a chimeric antigen receptor redirected T cell attack
-
doi:10.1038/gt.2010.127
-
Chmielewski M, Hombach AA, Abken H. CD28 cosignalling does not affect the activation threshold in a chimeric antigen receptor redirected T cell attack. Gene Ther (2011) 18:62-72. doi:10.1038/gt.2010.127
-
(2011)
Gene Ther
, vol.18
, pp. 62-72
-
-
Chmielewski, M.1
Hombach, A.A.2
Abken, H.3
-
40
-
-
0036141994
-
Costimulation and endogenous MHC ligands contribute to T cell recognition
-
doi:10.1038/ni741
-
Wülfing C, Sumen C, Sjaastad MD, Wu LC, Dustin ML, Davis MM. Costimulation and endogenous MHC ligands contribute to T cell recognition. Nat Immunol (2002) 3:42-7. doi:10.1038/ni741
-
(2002)
Nat Immunol
, vol.3
, pp. 42-47
-
-
Wülfing, C.1
Sumen, C.2
Sjaastad, M.D.3
Wu, L.C.4
Dustin, M.L.5
Davis, M.M.6
-
41
-
-
14544307446
-
T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signalling in selected T cells
-
doi:10.1073/pnas.0406867102
-
Purtic B, Pitcher LA, van Oers NSC, Wülfing C. T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signalling in selected T cells. Proc Natl Acad Sci U S A (2005) 102:2904-9. doi:10.1073/pnas.0406867102
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 2904-2909
-
-
Purtic, B.1
Pitcher, L.A.2
van Oers, N.S.C.3
Wülfing, C.4
-
42
-
-
0037331525
-
Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation
-
doi:10.1016/S1074-7613(03)00019-0
-
Holler PD, Kranz DM. Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity (2003) 18:255-64. doi:10.1016/S1074-7613(03)00019-0
-
(2003)
Immunity
, vol.18
, pp. 255-264
-
-
Holler, P.D.1
Kranz, D.M.2
-
43
-
-
77949906674
-
Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation
-
doi:10.4049/jimmunol.0902869
-
Bhatia S, Sun K, Almo SC, Nathenson SG, Hodes RJ. Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation. J Immunol (2010) 184:1821-8. doi:10.4049/jimmunol.0902869
-
(2010)
J Immunol
, vol.184
, pp. 1821-1828
-
-
Bhatia, S.1
Sun, K.2
Almo, S.C.3
Nathenson, S.G.4
Hodes, R.J.5
-
44
-
-
80051775476
-
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
-
doi:10.1126/scitranslmed.3002842
-
Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med (2011) 3:95ra73. doi:10.1126/scitranslmed.3002842
-
(2011)
Sci Transl Med
, vol.3
-
-
Kalos, M.1
Levine, B.L.2
Porter, D.L.3
Katz, S.4
Grupp, S.A.5
Bagg, A.6
-
45
-
-
80051720194
-
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
-
doi:10.1056/NEJMoa1103849
-
Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med (2011) 365:725-33. doi:10.1056/NEJMoa1103849
-
(2011)
N Engl J Med
, vol.365
, pp. 725-733
-
-
Porter, D.L.1
Levine, B.L.2
Kalos, M.3
Bagg, A.4
June, C.H.5
-
46
-
-
84876325876
-
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
-
doi:10.1056/NEJMoa1215134
-
Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med (2013) 368:1509-18. doi:10.1056/NEJMoa1215134
-
(2013)
N Engl J Med
, vol.368
, pp. 1509-1518
-
-
Grupp, S.A.1
Kalos, M.2
Barrett, D.3
Aplenc, R.4
Porter, D.L.5
Rheingold, S.R.6
-
47
-
-
55549145071
-
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
-
doi:10.1038/nm.1882
-
Pule MA, Savoldo B, Myers GD, Rossig C, Russell HV, Dotti G, et al. Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med (2008) 14:1264-70. doi:10.1038/nm.1882
-
(2008)
Nat Med
, vol.14
, pp. 1264-1270
-
-
Pule, M.A.1
Savoldo, B.2
Myers, G.D.3
Rossig, C.4
Russell, H.V.5
Dotti, G.6
-
48
-
-
50549096284
-
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
-
doi:10.1182/blood-2007-12-128843
-
Till BG, Jensen MC, Wang J, Chen EY, Wood BL, Greisman HA, et al. Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood (2008) 112:2261-71. doi:10.1182/blood-2007-12-128843
-
(2008)
Blood
, vol.112
, pp. 2261-2271
-
-
Till, B.G.1
Jensen, M.C.2
Wang, J.3
Chen, E.Y.4
Wood, B.L.5
Greisman, H.A.6
-
49
-
-
33750699642
-
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
-
doi:10.1158/1078-0432.CCR-06-1183
-
Kershaw MH, Westwood JA, Parker LL, Wang G, Eshhar Z, Mavroukakis SA, et al. A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res (2006) 12:6106-15. doi:10.1158/1078-0432.CCR-06-1183
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6106-6115
-
-
Kershaw, M.H.1
Westwood, J.A.2
Parker, L.L.3
Wang, G.4
Eshhar, Z.5
Mavroukakis, S.A.6
-
50
-
-
77950475517
-
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
-
doi:10.1038/mt.2010.24
-
Morgan RA, Yang JC, Kitano M, Dudley ME, Laurencot CM, Rosenberg SA. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther (2010) 18:843-51. doi:10.1038/mt.2010.24
-
(2010)
Mol Ther
, vol.18
, pp. 843-851
-
-
Morgan, R.A.1
Yang, J.C.2
Kitano, M.3
Dudley, M.E.4
Laurencot, C.M.5
Rosenberg, S.A.6
-
51
-
-
77950480974
-
Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial
-
doi:10.1038/mt.2010.31
-
Brentjens R, Yeh R, Bernal Y, Riviere I, Sadelain M. Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial. Mol Ther (2010) 18:666-8. doi:10.1038/mt.2010.31
-
(2010)
Mol Ther
, vol.18
, pp. 666-668
-
-
Brentjens, R.1
Yeh, R.2
Bernal, Y.3
Riviere, I.4
Sadelain, M.5
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