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Volumn 49, Issue 8, 2013, Pages 576-582

Suppression of Grb2 expression improved hepatic steatosis, oxidative stress, and apoptosis induced by palmitic acid in vitro partly through insulin signaling alteration

Author keywords

Apoptosis; Grb2; HepG2; Insulin signaling; Steatosis

Indexed keywords

BAK1 PROTEIN, HUMAN; CASPASE 3; GRB2 PROTEIN, HUMAN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; INSULIN; PALMITIC ACID; PROTEIN BAK;

EID: 84890315754     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-013-9646-9     Document Type: Article
Times cited : (35)

References (17)
  • 1
    • 0035125526 scopus 로고    scopus 로고
    • IRS proteins and beta-cell function
    • 11272176 10.2337/diabetes.50.2007.S140 1:CAS:528:DC%2BD3MXhtVOgtLc%3D
    • Burks D. J.; White M. F. IRS proteins and beta-cell function. Diabetes 50(Suppl 1): S140-145; 2001.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1 , pp. 140-145
    • Burks, D.J.1    White, M.F.2
  • 2
    • 0033536189 scopus 로고    scopus 로고
    • Insulin resistance and lipid metabolism
    • 10418856 10.1016/S0002-9149(99)00355-0 1:CAS:528:DyaK1MXltVWht7c%3D
    • Howard B. V. Insulin resistance and lipid metabolism. Am. J. Cardiol. 84: 28J-32J; 1999.
    • (1999) Am. J. Cardiol. , vol.84
    • Howard, B.V.1
  • 4
    • 38349168403 scopus 로고    scopus 로고
    • Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation
    • 18003605 10.1074/jbc.M704999200 1:CAS:528:DC%2BD1cXks1ersA%3D%3D
    • Kondo A.; Hirayama N.; Sugito Y.; Shono M.; Tanaka T.; Kitamura N. Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation. J. Biol. Chem. 283: 1428-1436; 2008.
    • (2008) J. Biol. Chem. , vol.283 , pp. 1428-1436
    • Kondo, A.1    Hirayama, N.2    Sugito, Y.3    Shono, M.4    Tanaka, T.5    Kitamura, N.6
  • 5
    • 0842291431 scopus 로고    scopus 로고
    • Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10
    • 14615605 10.1210/me.2003-0117 1:CAS:528:DC%2BD2cXhtVChsrg%3D
    • Langlais P.; Dong L. Q.; Ramos F. J.; Hu D.; Li Y.; Quon M. J.; Liu F. Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10. Mol. Endocrinol. 18: 350-358; 2004.
    • (2004) Mol. Endocrinol. , vol.18 , pp. 350-358
    • Langlais, P.1    Dong, L.Q.2    Ramos, F.J.3    Hu, D.4    Li, Y.5    Quon, M.J.6    Liu, F.7
  • 6
    • 84861444859 scopus 로고    scopus 로고
    • Regulation of glucose transport by insulin: Traffic control of GLUT4
    • 22617471 10.1038/nrm3351 1:CAS:528:DC%2BC38XntlSgsbk%3D
    • Leto D.; Saltiel A. R. Regulation of glucose transport by insulin: traffic control of GLUT4. Nat. Rev. Mol. Cell Biol. 13: 383-396; 2012.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 383-396
    • Leto, D.1    Saltiel, A.R.2
  • 7
    • 84860247476 scopus 로고    scopus 로고
    • Eight paths of ERK1/2 signalling pathway regulating hepatocyte proliferation in rat liver regeneration
    • 22227930 10.1007/s12041-011-0107-5 1:CAS:528:DC%2BC38XotVSjt78%3D
    • Li J. W.; Wang G. P.; Fan J. Y.; Chang C. F.; Xu C. S. Eight paths of ERK1/2 signalling pathway regulating hepatocyte proliferation in rat liver regeneration. J. Genet. 90: 435-442; 2011.
    • (2011) J. Genet. , vol.90 , pp. 435-442
    • Li, J.W.1    Wang, G.P.2    Fan, J.Y.3    Chang, C.F.4    Xu, C.S.5
  • 9
    • 67649448956 scopus 로고    scopus 로고
    • Molecular mechanisms involved in NAFLD progression
    • 19352614 10.1007/s00109-009-0464-1 1:CAS:528:DC%2BD1MXns1ersbw%3D
    • Malaguarnera M.; Di Rosa M.; Nicoletti F.; Malaguarnera L. Molecular mechanisms involved in NAFLD progression. J. Mol. Med. 87: 679-695; 2009.
    • (2009) J. Mol. Med. , vol.87 , pp. 679-695
    • Malaguarnera, M.1    Di Rosa, M.2    Nicoletti, F.3    Malaguarnera, L.4
  • 12
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: Common threads and missing links
    • 22385956 10.1016/j.cell.2012.02.017 1:CAS:528:DC%2BC38XjtlSgtrg%3D
    • Samuel V. T.; Shulman G. I. Mechanisms for insulin resistance: common threads and missing links. Cell 148: 852-871; 2012.
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 13
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • 11057895 10.1016/S0092-8674(00)00114-8 1:CAS:528:DC%2BD3cXns1Cltrs%3D
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 103: 211-225; 2000.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 14
    • 1942437497 scopus 로고    scopus 로고
    • Insulin resistance and hypertension
    • 15072967 10.1152/ajpheart.00026.2004 1:CAS:528:DC%2BD2cXkt1ensL0%3D
    • Sowers J. R. Insulin resistance and hypertension. Am. J. Physiol. Heart Circ. Physiol. 286: H1597-1602; 2004.
    • (2004) Am. J. Physiol. Heart Circ. Physiol. , vol.286 , pp. 1597-1602
    • Sowers, J.R.1
  • 15
    • 80052213096 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease
    • 21875310 10.3109/10408363.2011.596521 1:CAS:528:DC%2BC3MXhtFSmtL%2FF
    • Smith B. W.; Adams L. A. Non-alcoholic fatty liver disease. Crit. Rev. Clin. Lab. Sci. 48: 97-113; 2011.
    • (2011) Crit. Rev. Clin. Lab. Sci. , vol.48 , pp. 97-113
    • Smith, B.W.1    Adams, L.A.2
  • 16
    • 3242745192 scopus 로고    scopus 로고
    • Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes
    • 15277403 10.2337/diabetes.53.8.2169 1:CAS:528:DC%2BD2cXmtFGqtL4%3D
    • Tiikkainen M.; Häkkinen A. M.; Korsheninnikova E.; Nyman T.; Mäkimattila S.; Yki-Järvinen H. Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes 53: 2169-2176; 2004.
    • (2004) Diabetes , vol.53 , pp. 2169-2176
    • Tiikkainen, M.1    Häkkinen, A.M.2    Korsheninnikova, E.3    Nyman, T.4    Mäkimattila, S.5    Yki-Järvinen, H.6
  • 17
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • 16799979 10.1002/hep.21223 1:CAS:528:DC%2BD28XnsFWjtrs%3D
    • Wieckowska A.; Zein N. N.; Yerian L. M.; Lopez A. R.; McCullough A. J.; Feldstein A. E. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 44: 27-33; 2006.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3    Lopez, A.R.4    McCullough, A.J.5    Feldstein, A.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.