Determination and extension of the limits to static cold storage using subnormothermic machine perfusion

International Journal of Artificial Organs

Volumn 36, Issue 11, 2013, Pages 775-780

  Bruinsma, Bote G ^a   Berendsen, Tim A ^a   Izamis, Maria Louisa ^a   Yarmush, Martin L ^a,b   Uygun, Korkut ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Adenosine triphophate; Cold ischemia; Liver; Machine perfusion; Preservation; Transplantation

Indexed keywords

ADENOSINETRIPHOSPHATE; DIGITAL STORAGE; RECOVERY;

ADENOSINE TRIPHOPHATE; ADENOSINE TRIPHOSPHATE; CELLULAR FUNCTION; COLD ISCHEMIA; ENERGY; ISCHAEMIA; MACHINE PERFUSION; METABOLIC ACTIVITY; PRESERVATION; TRANSPLANTATION;

COLD STORAGE;

ADENOSINE TRIPHOSPHATE; GLUTAMINE; HYDROCORTISONE; INSULIN; PENICILLIN DERIVATIVE; STREPTOMYCIN;

ANIMAL TISSUE; ARTICLE; BUBBLE TRAP; CATHETER; CONTROLLED STUDY; CRYOPRESERVATION; EQUIPMENT; FEMALE; LIVER FUNCTION; LIVER PRESERVATION; LIVER TRANSPLANTATION; MALE; MASTERFLEX L S PUMP; MEMBRANE OXYGENATOR; NONHUMAN; RAT; SUBNORMOTHERMIC MACHINE PERFUSION; VASCULAR RESISTANCE; ANIMAL; LIVER; ORGAN PRESERVATION; PERFUSION; VASCULARIZATION;

ANIMALS; CRYOPRESERVATION; LIVER; LIVER TRANSPLANTATION; ORGAN PRESERVATION; PERFUSION;

EID: 84890307275     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.5301/ijao.5000250     Document Type: Article

References (31)

1. Todo S, Nery J, Yanaga K, Podesta L, Gordon RD, Starzl TE. Extended preservation of human liver grafts with UW solution. JAMA. 1989;261(5):711-714.
2. Jamieson NV, Sundberg R, Lindell S, et al. Preservation of the canine liver for 24-48 h using simple cold storage with UW solution. Transplantation. 1988;46(4):517-522.
3. Adam R, Bismuth H, Diamond T, et al. Effect of extended cold ischaemia with UW solution on graft function after liver transplantation. Lancet. 1992;340(8832):1373-1376.
4. Moore DE, Feurer ID, Speroff T, et al. Impact of donor, technical, and recipient risk factors on survival and quality of life after liver transplantation. Arch Surg. 2005;140(3):273-277.
5. Xu H, Berendsen T, Kim K, et al. Excorporeal normothermic machine perfusion resuscitates pig DCD livers with extended warm ischemia. J Surg Res. 2011;173(2):e83-e88.
6. Berendsen TA, Bruinsma BG, Lee J, et al. A simplified subnormothermic machine perfusion system restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation. Transplant Res. 2012;1(1):6.
7. Dutkowski P, Furrer K, Tian Y, Graf R, Clavien PA. Novel short-term hypothermic oxygenated perfusion (HOPE) system prevents injury in rat liver graft from non-heart beating donor. Ann Surg. 2006;244(6):968-976, discussion 976-977.
8. Tolboom H, Pouw RE, Izamis ML, et al. Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion. Transplantation. 2009;87(2):170-177.
9. Perk S, Izamis ML, Tolboom H, Uygun B, Yarmush ML, Uygun K. A fitness index for transplantation of machineperfused cadaveric rat livers. BMC Res Notes. 2012;5:325.
10. Izamis ML, Berendsen TA, Uygun K, Yarmush ML. Addressing the donor liver shortage with EX VIVO machine perfusion. J Healthc Eng. 2012;3(2):279-298.
11. Dutkowski P, Graf R, Clavien PA. Rescue of the cold preserved rat liver by hypothermic oxygenated machine perfusion. Am J Transplant. 2006;6(5 Pt 1):903-912.
12. Perk S, Izamis ML, Tolboom H, et al. A metabolic index of ischemic injury for perfusion-recovery of cadaveric rat livers. PLoS One. 2011;6(12):e28518.
13. Tolboom H, Milwid JM, Izamis ML, Uygun K, Berthiaume F, Yarmush ML. Sequential cold storage and normothermic perfusion of the ischemic rat liver. Transplant Proc. 2008;40(5):1306-1309.
14. Schön MR, Kollmar O, Akkoc N, et al. Cold ischemia affects sinusoidal endothelial cells while warm ischemia affects hepatocytes in liver transplantation. Transplant Proc. 1998;30(5):2318-2320.
15. Ikeda T, Yanaga K, Kishikawa K, Kakizoe S, Shimada M, Sugimachi K. Ischemic injury in liver transplantation: difference in injury sites between warm and cold ischemia in rats. Hepatology. 1992;16(2):454-461.
16. Qing DK. Prolonging warm ischemia reduces the cold preservation limits of liver grafts in swine. Hepatobiliary Pancreat Dis Int. 2006;5(4):515-520.
17. Kamada N, Calne RY. Orthotopic liver transplantation in the rat. Technique using cuff for portal vein anastomosis and biliary drainage. Transplantation. 1979;28(1):47-50.
18. Berendsen TA, Izamis ML, Xu H, et al. Hepatocyte viability and adenosine triphosphate content decrease linearly over time during conventional cold storage of rat liver grafts. Transplant Proc. 2011;43(5):1484-1488.
19. de Rougemont O, Breitenstein S, Leskosek B, et al. One hour hypothermic oxygenated perfusion (HOPE) protects nonviable liver allografts donated after cardiac death. Ann Surg. 2009;250(5):674-683.
20. Ma Y, Wu LW, Wu JL, et al. Energy metabolism and survival of liver grafts from non-heart-beating donor rats with warm ischemia injury. Hepatobiliary Pancreat Dis Int. 2006;5(4):521-525.
21. Lanir A, Jenkins RL, Caldwell C, Lee RG, Khettry U, Clouse ME. Hepatic transplantation survival: correlation with adenine nucleotide level in donor liver. Hepatology. 1988;8(3):471-475.
22. Kamiike W, Burdelski M, Steinhoff G, Ringe B, Lauchart W, Pichlmayr R. Adenine nucleotide metabolism and its relation to organ viability in human liver transplantation. Transplantation. 1988;45(1):138-143.
23. Morimoto T, Kusumoto K, Isselhard W. Impairment of grafts by short-term warm ischemia in rat liver transplantation. Transplantation. 1991;52(3):424-431.
24. Mitchell SJ, Churchill TA, Winslet MC, Fuller BJ. Energy metabolism following prolonged hepatic cold preservation: benefits of interrupted hypoxia on the adenine nucleotide pool in rat liver. Cryobiology. 1999;39(2):130-137.
25. Karwinski W, Husøy AM, Farstad M, Søreide O. Sixty minutes of normothermic ischemia in the rat liver: correlation between adenine nucleotides and bile excretion. J Surg Res. 1989;46(2):99-103.
26. Sumimoto K, Inagaki K, Yamada K, Kawasaki T, Dohi K. Reliable indices for the determination of viability of grafted liver immediately after orthotopic transplantation. Bile flow rate and cellular adenosine triphosphate level. Transplantation. 1988;46(4):506-509.
27. Imber CJ, St Peter SD, Lopez de Cenarruzabeitia I, et al. Advantages of normothermic perfusion over cold storage in liver preservation. Transplantation. 2002;73(5):701-709.
28. Ferrigno A, Rizzo V, Boncompagni E, et al. Machine perfusion at 20°C reduces preservation damage to livers from non-heart beating donors. Cryobiology. 2011;62(2):152-158.
29. Rojas A, Chen L, Bartlett RH, Arenas JD. Assessment of liver function during extracorporeal membrane oxygenation in the non-heart beating donor swine. Transplant Proc. 2004;36(5):1268-1270.
30. Brockmann J, Reddy S, Coussios C, et al. Normothermic perfusion: a new paradigm for organ preservation. Ann Surg. 2009;250(1):1-6.
31. Wang L, Florman S, Roayaie S, et al. Differential in vivo recovery of sinusoidal endothelial cells, hepatocytes, and Kupffer cells after cold preservation and liver transplantation in rats. Transplantation. 1998;66(5):573-578.