A metabolic index of ischemic injury for Perfusion-Recovery of cadaveric rat livers

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Perk, Sinem ^a   Izamis, Maria Louisa ^a   Tolboom, Herman ^b   Uygun, Basak ^a   Berthiaume, Francois ^c   Yarmush, Martin L ^a,c   Uygun, Korkut ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ALBUMIN; ARGININE; ASPARTIC ACID; GLUTAMINE; LACTIC ACID; ORNITHINE; TYROSINE;

AMINO ACID ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CADAVER; CONTROLLED STUDY; FEEDBACK SYSTEM; HEART DEATH; LIVER ISCHEMIA; LIVER METABOLISM; LIVER PERFUSION; LIVER TRANSPLANTATION; MALE; METABOLIC REGULATION; METABOLITE; NONHUMAN; PREDICTION; RAT; SENSITIVITY AND SPECIFICITY; ANIMAL; BIOLOGICAL MODEL; DISCRIMINANT ANALYSIS; HUMAN; IN VITRO STUDY; ISCHEMIA; LEWIS RAT; LIVER; METABOLISM; PATHOLOGY; PERFUSION; PRINCIPAL COMPONENT ANALYSIS; REGRESSION ANALYSIS; REPRODUCIBILITY; VASCULARIZATION;

ANIMALS; CADAVER; DISCRIMINANT ANALYSIS; HUMANS; ISCHEMIA; LEAST-SQUARES ANALYSIS; LIVER; MALE; MODELS, BIOLOGICAL; PERFUSION; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, INBRED LEW; REPRODUCIBILITY OF RESULTS; WARM ISCHEMIA;

EID: 83355168950     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028518     Document Type: Article

References (48)

1. Abt PL, Desai NM, Crawford MD, Forman LM, Markmann JW, et al. (2004) Survival following liver transplantation from non-heart-beating donors. Annals of Surgery 239: 87-92.
2. Tolboom H, Izamis ML, Sharma N, Milwid JM, Uygun B, et al. (2011) Subnormothermic Machine Perfusion at Both 20 degrees C and 30 degrees C Recovers Ischemic Rat Livers for Successful Transplantation. J Surg Res.
3. Abt PL, Fisher CA, Singhal AK, (2006) Donation after cardiac death in the US: History and use. Journal of the American College of Surgeons 203: 208-225.
4. Mateo R, Cho Y, Singh G, Stapfer M, Donovan J, et al. (2006) Risk Factors for Graft Survival After Liver Transplantation from Donation After Cardiac Death Donors: An Analysis of OPTN/UNOS Data. American Journal of Transplantation 6: 791-796.
5. Bessems M, Doorschodt BM, van Vliet AK, van Gulik TM, (2005) Improved rat liver preservation by hypothermic continuous machine perfusion using Polysol, a new, enriched preservation solution. Liver Transplantation 11: 539-546.
6. Bessems M, Doorschodt BM, Kolkert JLP, Vetelainen RL, van Vliet AK, et al. (2007) Preservation of steatotic livers: A comparison between cold storage and machine perfusion preservation. Liver Transplantation 13: 497-504.
7. Dutkowski P, Graf R, Clavien PA, (2006) Rescue of the cold preserved rat liver by hypothermic oxygenated machine perfusion. Am J Transplant 6: 903-912.
8. Dutkowski P, Furrer K, Tian Y, Graf R, Clavien PA, (2006) Novel Short-term Hypothermic Oxygenated Perfusion (HOPE) System Prevents Injury in Rat Liver Graft From Non-Heart Beating Donor. Ann Surg 244: 968-977.
9. de Rougemont O, Breitenstein S, Leskosek B, Weber A, Graf R, et al. (2009) One hour hypothermic oxygenated perfusion (HOPE) protects nonviable liver allografts donated after cardiac death. Ann Surg 250: 674-683.
10. Lee CY, Jain S, Duncan HM, Zhang JX, Jones JW, et al. (2003) Survival transplantation of preserved non-heartbeating donor rat livers: Preservation by hypothermic machine perfusion. Transplantation 76: 1432-1436.
11. Xu H, Lee CY, Clemens MG, Zhang JX, (2004) Pronlonged hypothermic machine perfusion preserves hepatocellular function but potentiates endothelial cell dysfunction in rat livers. Transplantation 77: 1676-1682.
12. Tolboom H, Pouw R, Izamis M, Milwid J, Sharma N, et al. (2009) Recovery of Warm Ischemic Rat Liver Grafts by Normothermic Extracorporeal Perfusion. Transplantation 87: 170-177.
13. Tolboom H, Milwid JM, Izamis ML, Uygun K, Berthiaume F, et al. (2008) Sequential cold storage and normothermic perfusion of the ischemic rat liver. Transplantation Proceedings 40: 1306-1309.
14. Tolboom H, Pouw R, Uygun K, Tanimura Y, Izamis ML, et al. (2007) A model for normothermic preservation of the rat liver. Tissue Eng 13: 2143-2151.
15. Cinar A, Parulekar SJ, Undey C, Birol G, (2003) Batch Fermentation: Modeling, monitoring, and control: Marcel Dekker.
16. Eriksson L, Johansson E, Kettaneh-Wold N, Trygg J, Wikstrom C, et al. (2006) Multi- and Megavariate Data Analysis Part I: Basic Principles and Applications: Umetrics.
17. Heijnen BH vVS, Straatsburg IH, van Gulik TM, (2001) Pronounced effect of minor changes in body temperature on ischemia and reperfusion injury in rat liver. J Appl Physiol 91: 265-268.
18. Dutkowski P, Furrer K, Tian Y, Graf R, Clavien PA, (2006) Novel short-term hypothermic oxygenated perfusion (HOPE) system prevents injury in rat liver graft from non-heart beating donor. Annals of Surgery 244.
19. Delriviere L, Gibbs P, Kobayashi E, Goto S, Kamada N, et al. (1996) Detailed modified technique for safer harvesting and preparation of liver graft in the rat. Microsurgery 17: 690-696.
20. Delriviere L, Gibbs P, Kobayashi E, Goto S, Kamada N, et al. (1998) Technical details for safer venous and biliary anastomoses for liver transplantation in the rat. Microsurgery 18: 12-18.
21. Kamada N, Calne RY, (1979) Orthotopic liver transplantation in the rat. Technique using cuff for portal vein anastomosis and biliary drainage. Transplantation 28: 47-50.
22. Lee K, Berthiaume F, Stephanopoulos GN, Yarmush DM, Yarmush ML, (2000) Metabolic flux analysis of postburn hepatic hypermetabolism. Metab Eng 2: 312-327.
23. Dunn JC, Tompkins RG, Yarmush ML, (1991) Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol Prog 7: 237-245.
24. Jackson JE, (1980) Principal components and factor analysis: Part I- Principal Components. J Quality Technol 12: 201-213.
25. Tracy ND, Young JC, Mason RL, (1992) Multivariate control charts for individual observations. J Quality Contr 24: 88-95.
26. Nomikos P, MacGregor JF, (1994) Monitoring Batch Processes Using Multi-way Principal Component Analysis. AIChE J 40: 1361-1375.
27. Nomikos P, MacGregor JF, (1995) Multi-way partial least squares in monitoring batch processes. Chemometr Intell Lab 30: 97-108.
28. Nomikos P, MacGregor JF, (1995) Multivariate SPC Charts For Monitoring Batch Processes. Technometrics 37: 41-59.
29. Undey C, Cinar A, (2002) Statistical monitoring of multi-stage, multi-phase batch processes. IEEE Contr Syst Mag 22: 40-52.
30. Wold S, Geladi P, Esbensen K, Öhman J, (1987) Multi-way principal components and PLS analysis. J Chemometr 1: 41-56.
31. Wold S, Kettaneh N, Friden H, Holmberg A, (1998) Modeling and diagnostics of batch processes and analogous kinetic experiments. Chemometr Intell Lab 44: 331-340.
32. Box GEP, (1954) Some theorems on quadratic forms applied in the study of analysis of variance problems: Effect of inequality of variance in one-way classification. Ann Math Statist 25: 290-302.
33. Miller P, Swanson RE, Heckler CF, (1998) Contribution plots: The missing link in multivariate quality control. Appl Math Comp Sci 8: 775-792.
34. Wise BM, Ricker NL, Veltkamp DF, Kowalski BR, (1990) A theoretical basis for the use of principal component models for monitoring multivariate processes. Process Control Qual 1: 41-51.
35. Efron B, (1982) The jackknife, the bootstrap, and other resampling plans Philadelphia SIAM.
36. Efron B, Tibshirani RJ, (1993) An introduction to the bootstrap Boca Raton, FL Chapman & Hall/CRC Press.
37. Uygun K, Tolboom H, Izamis M-L, Uygun B, Sharma NS, et al. (2010) Diluted Blood Reperfusion as a Model for Transplantation of Ischemic Rat Livers: Alt is a Direct Indicator of Viability. Transplantation Proc in press.
38. Berendsen TA, Izamis ML, Xu H, Liu Q, Hertl M, et al. (2011) Hepatocyte viability and adenosine triphosphate content decrease linearly over time during conventional cold storage of rat liver grafts. Transplantation Proceedings 43: 1484-1488.
39. Durante W, Johnson FK, Johnson RA, (2006) Arginase: a critical regulator of nitric oxide syntehsis and vascular function. Clinical and Experimental Pharmacology and Physiology 34: 906-911.
40. Yang L, Lewis CM, Chandrasekharan UM, Kinney CM, DiCorleto PE, et al. (2006) Arginase activity is increased by thrombin: a mechanism for endothelial dysfunction in arterial thrombosis. J Am Coll Surg 203: 817-826.
41. Palacios-Calender M, Hollis V, Mitchison M, Frakich N, Unitt D, et al. (2007) Cytochrome c oxidase regulates endogenous nitric oxide availability in respiring cells: A possible explanation for hypoxic vasodilation. PNAS 104: 508-503.
42. Varadarajan R, Golden-Mason L, Young L, McLoughlin P, Nolan N, et al. (2004) Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation. Tranplantation 78: 250-256.
43. Towler MC, Hardie DG, (2007) AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 100: 328-341.
44. Curran RD, Ferrari FK, Kispert PH, Stadler J, Stuehr DJ, et al. (1991) Nitric oxide and nitric oxide-generating compounds inhibit hepatocyte protein synthesis. FASEB J 5: 2085-2092.
45. Hems R, Ross BD, Berry MN, Krebs HA, (1966) Gluconeogenesis in the perfused rat liver. Biochem J 101: 284-292.
46. Uygun K, Uygun B, Matthew HW, Huang Y, (2010) Optimization-based metabolic control analysis. Biotechnol Prog 26: 1567-1579.
47. Uygun K, Matthew HW, Huang Y, (2007) Investigation of metabolic objectives in cultured hepatocytes. Biotechnol Bioeng 97: 622-637.
48. Sariyar B, Perk S, Akman U, Hortacsu A, (2006) Monte Carlo sampling and principal component analysis of flux distributions yield topological and modular information on metabolic networks. J Theor Biol 242: 389-400.