Rescue of the cold preserved rat liver by hypothermic oxygenated machine perfusion

American Journal of Transplantation

Volumn 6, Issue 5 I, 2006, Pages 903-912

  Dutkowski, P ^a   Graf, R ^a   Clavien, P A ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Machine liver perfusion; Mitochondrial integrity; Reactive oxygen species

Indexed keywords

CASPASE; CYTOCHROME C OXIDASE; GLUTATHIONE; LACTATE DEHYDROGENASE; LIVER ENZYME; SUPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILE FLOW; BODY TEMPERATURE; CELL DISRUPTION; CHEMICAL ANALYSIS; CONTROLLED STUDY; CRYOPRESERVATION; ELECTRON TRANSPORT; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME RELEASE; LIPID PEROXIDATION; LIVER PERFUSION; MALE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; OXYGENATION; PRIORITY JOURNAL; RAT; REPERFUSION; TRANSMISSION ELECTRON MICROSCOPY; WARMING; ANIMAL; ANIMAL MODEL; BILE; BROWN NORWAY RAT; COLD; CRYOANESTHESIA; ENERGY METABOLISM; LIVER; METABOLISM; METHODOLOGY; ORGAN PRESERVATION; PHYSIOLOGY; SECRETION; ULTRASTRUCTURE;

ANIMALS; BILE; COLD; ENERGY METABOLISM; GLUTATHIONE; HYPOTHERMIA, INDUCED; L-LACTATE DEHYDROGENASE; LIVER; MALE; MODELS, ANIMAL; ORGAN PRESERVATION; RATS; RATS, INBRED BN; REPERFUSION; SUPEROXIDES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 33745241665     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2006.01264.x     Document Type: Article

References (41)

1. Vajdova K, Graf R, Clavien PA. ATP-supplies in the cold preserved liver: A long neglected factor of viability. Hepatology 2002; 36: 1543-1552.
2. Dutkowski P, Krug A, Krysiak M, Dünschede F, Seifert JK, Junginger T. Detection of mitochondrial electron chain carrier redox status by transhepatic light intensity during rat liver reperfusion. Cryobiology 2003; 47: 125-142.
3. Selzner N, Rudiger H, Graf R, Clavien PA. Protective strategies against ischemic injury of the liver. Gastroenterology 2003; 125: 917-936.
4. Vajdowa K, Smrekova R, Mislanova C, Kukan M, Lutterova M. Cold preservation-induced sensitivity of rat hepatocytes function to rewarming injury and its prevention by short-term reperfusion. Hepatology 2000; 32: 289-296.
5. Sindram D, Porte RJ, Hoffmann MR, Bentley RC, Clavien PA. Synergism between platelets and leukocytes in inducing endothelial cell apoptosis in the cold ischemic rat liver: A Kupffer cell-mediated injury. FASEB J 2001; 15: 1230-1232.
6. Dutkowski P, Schönfeld S, Heinrich T et al. Reduced oxidative stress during acellular reperfusion of the rat liver after hypothermic oscillating perfusion. Transplantation 1999; 68: 44-50.
7. Lee CY, Zhang JX, Jones JW, Southard JH, Clemens MG. Functional recovery of preserved livers following warm ischemia: Improvement by machine perfusion preservation. Transplantation 2002; 74: 944-951.
8. Dutkowski P, Odermatt B, Heinrich T et al. Hypothermic oscillating liver perfusion stimulates ATP synthesis prior to transplantation. J Surg Res 1998; 80: 365-372.
9. Schön MR, Kollmar O, Wolf S et al. Liver transplantation after organ preservation with normothermic extracorporeal perfusion. Ann Surg 2001; 233: 114-123.
10. Butler AJ, Rees MA, Wight DG et al. Successful extracorporeal porcine liver perfusion for 72 hr. Transplantation 2002; 77: 1212-1218.
11. Dutkowski P, Schönfeld S, Odermatt B, Heinrich T, Junginger T. Rat liver preservation by hypothermic oscillating liver perfusion compared to simple cold storage. Cryobiology 1998; 36: 61-70.
12. Morgan GR, Sanabria JR, Clavien PA et al. Correlation of donor nutritional status with sinusoidal lining cell viability and liver function in the rat. Transplantation 1991; 51: 1176-1183.
13. 2 formation. FASEB J 2000; 14: 1953-1964.
14. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG, Brenner DA. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. Liver Transpl Surg 1999; 5: 182-193.
15. Shinoda M, Shimazu M, Matsuda S et al. c-Jun N-terminal kinase activation during warm hepatic ischemia/reperfusion injuries in a rat model. Wound Repair Regen 2002; 10: 314-319.
16. Kataoka M, Shimizu H, Mitsuhashi N et al. Effect of cold-ischemia time on C-X-C chemokine expression and neutrophil accumulation in the graft liver after orthotopic liver transplantation in rats. Transplantation 2002; 73: 1730-1735.
17. Araya J, Tsuruma T, Hirata K et al. The regulation of HGF and TGF-β by an angiotensin II type 1 receptor antagonist in hepatic ischemia-reperfusion injury. Transplant Proc 2003; 35: 107-110.
18. Liu J, Yagi T, Sadamori H et al. Annexin V assay-proven anti-apoptotic effect of ascorbic acid glucoside after cold ischemia/reperfusion injury in rat liver transplantation. Acta Med Okayama 2003; 57: 209-216.
19. Brustovetsky N, Dubinsky JM, Antonsson B, Jemmerson R. Two pathways for tBID-induced cytochrome c release from rat brain mitochondria: BAK- versus BAX-dependence. J Neurochem 2003; 84: 196-207.
20. St Peter SD, Imber CI, Friend PJ. Liver and kidney preservation by perfusion. Lancet 2002; 359: 604-613.
21. van de Plaats A, 't Hart NA, Verkerke GJ, Leuvenink HG, Ploeg RJ, Rakhorst G. Hypothermic machine preservation in liver transplantation revisited : Concepts and criteria in the new millennium. Ann Biomed Eng 2004; 32: 623-631.
22. Compagnon P, Clement B, Campion JP, Boudjema K. Effects of hypothermic machine perfusion on rat liver function depending on the route of perfusion. Transplantation 2001; 72: 606-614.
23. Jain S, Xu H, Duncan H et al. Ex vivo study of flow dynamics and endothelial cell structure during extended hypothermic machine perfusion preservation of livers. Cryobiology 2004; 48: 322-332.
24. Xu H. Lee CY, Clemens MG, Zhang JX. Prolonged hypothermic machine perfusion preserves hepatocellular function but potentiates endothelial cell dysfunction in rat livers. Transplantation 2004; 77: 1676-1682.
25. Clavien PA, Harvey PR, Strasberg SM. Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies. Transplantation 1992; 53: 957-978.
26. Vreugdenhil PK, Rankin MA, Southard JH. Cold storage sensitizes hepatoctes to oxidative stress injury. Transplant Int 1997; 10: 379-385.
27. Vreugdenhil PK, Ametani M, Haworth RA, Southard JH. Biphasic mechanism for hypothermic induced loss of protein synthesis in hepatocytes. Transplantation 1999; 67: 1468-1473.
28. Ohkochi N, Endoh T, Oikawa K, Seya K, Satomi S. Fragility of the electron transport chain and superoxide generation in mitochondria of the liver graft after cold ischemia. Transplantation 1999; 67: 1173-1177.
29. Selzner N, Selzner M, Tian Y, Kadry Z, Clavien PA. Cold ischemia decreases liver regeneration after partial liver transplantation in the rat: A TNFα/IL6 dependent mechanism. Hepatology 2002; 36: 812-818.
30. Kukan M, Vajdova K, Lutterova M et al. Improvement of rat liver function by energy repletion after the preservation period: Implications for hepatic graft management. Cryobiology 2001; 43: 303-309.
31. Leducq N, Delams-Beauvieux MC, Bourel-Marchasson I et al. Mitochondrial permeability transition during hypothermic to normothermic reperfusion in rat liver demonstrated by the protective effect of cyclosporin A. Biochem J 1998; 336: 501-506.
32. Rauen U, Petrat F, Sustmann R, de Groot H. Iron-induced mitochondrial permeability transition in cultured hepatocytes. J Hepatology 2004; 40: 607-615.
33. Sammut IA, Thorniley MS, Simpkin S, Fuller BF, Bates TE, Green CJ. Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology 1998; 36: 49-60.
34. Isaacson Y, Salem O, Shepherd RE, van Thiel DH. Lactobionic acid as an iron chelator: A rationale for its effectiveness as an organ preservant. Life Sci 1989; 45: 2373-2380.
35. Imber CJ, St Peter SD Lopez de Cenarruzabeita I, Pigott D et al. Advantages of normothermic perfusion over cold storage in liver preservation. Transplantation 2002; 73: 701-709.
36. Lauschke H, Olschewski P, Tolba R, Schulz S, Minor T. Oxygenated machine perfusion mitigates surface antigen expression and improves preservation of predamaged donor livers. Cryobiology 2003; 1: 53-60.
37. Minor T, Saad S, Nagelschmidt M et al. Successful transplantation of porcine livers after warm ischemic insult in situ and cold preservation including postconditioning with gaseous oxygen. Transplantation 1998; 65: 1262-1264.
38. Minor T, Saad S, Kotting M, Nagelschmidt M, Paul A. Endischemic oxygen persufflation to improve viability of marginal preserved donor livers. Transplant Int 1998; 11: 400-403.
39. Bessems M, Doorschodt BM, Vliet AK, van Gulik TM. Improved rat liver preservation by hypothermic continuous machine perfusion using polysol, a new, enriched preservation solution. Liver Transpl 2005; 11: 539-546.
40. Bessems M, Doorschodt BM, Vliet AK, van Gulik TM. Machine perfusion preservation of the non-heart-beating donor rat livers using polysol, a new preservation solution. Transplant Proc 2005; 37: 326-328.
41. Lee CY, Jain S, Duncan HM et al. Survival transplantation of preserved non-heart-beating donor rat livers: Preservation by hypothermic machine perfusion. Transplantation 2003; 76: 1432-1436.