Excorporeal normothermic machine perfusion resuscitates pig DCD livers with extended warm ischemia

Journal of Surgical Research

Volumn 173, Issue 2, 2012, Pages

  Xu, Hongzhi ^a,b   Berendsen, Tim ^b   Kim, Karen ^a   Soto Gutiérrez, Alejandro ^b   Bertheium, Francios ^b   Yarmush, Martin L ^b   Hertl, Martin ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Shriners Burn Hospital for Children at Boston   (United States)

Author keywords

ATP; donor after cardiac death (DCD); normothermic machine perfusion (NMP); transplantation; warm ischemia

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINOTRANSFERASE; LIVER ENZYME;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE; BODY TEMPERATURE; CONTROLLED STUDY; CRYOPRESERVATION; DONATION AFTER CARDIAC DEATH; HEMODYNAMICS; HISTOLOGY; LIVER ISCHEMIA; MACHINE; MALE; MORPHOLOGY; NONHUMAN; ORGAN DONOR; PERFUSION; PRIORITY JOURNAL; SWINE;

ANIMALS; BILE; ENERGY METABOLISM; HEMODYNAMICS; LIVER; MALE; ORGAN PRESERVATION; OXYGEN; PERFUSION; SWINE; WARM ISCHEMIA;

EID: 84858299000     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2011.09.057     Document Type: Article

References (22)

1. Tolboom H, Pouw RE, Izamis ML, et al. Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion. Transplantation 2009;87:170.
2. Wheeldon DR, Potter CD, Oduro A, et al. Transforming the "unacceptable" donor: Outcomes from the adoption of a standardized donor management technique. J Heart Lung Transplant 1995; 14:734.
3. Strasberg SM, Howard TK, Molmenti EP, et al. Selecting the donor liver: Risk factors for poor function after orthotopic liver transplantation. Hepatology 1994;20(4 Pt 1):829.
4. Kocak Z, Celik Y, Uzal MC, et al. Isolated bilateral sixth nerve palsy secondary to metastatic carcinoma: A case report with a review of the literature. Clin Neurol Neurosurg 2003;106:51.
5. Chan EY, Olson LC, Kisthard JA, et al. Ischemic cholangiopathy following liver transplantation from donation after cardiac death donors. Liver Transpl 2008;14:604.
6. Merion RM, Pelletier SJ, Goodrich N, et al. Donation after cardiac death as a strategy to increase deceased donor liver availability. Ann Surg 2006;244:555.
7. Reich DJ,Hong JC. Current status of donation after cardiac death liver transplantation. Curr Opin Organ Transplant 2010;15:316.
8. St Peter SD, Imber CJ, Lopez I, et al. Extended preservation of non-heart-beating donor livers with normothermic machine perfusion. Br J Surg 2002;89:609.
9. Brockmann J,Reddy S,Coussios C, et al.Normothermic perfusion: A new paradigm for organ preservation. Ann Surg 2009;250:1.
10. Schön MR, Kollmar O, Wolf S, et al. Liver transplantation after organ preservation with normothermic extracorporeal perfusion. Ann Surg 2001;233:114.
11. Miyagi S, Iwane T, Akamatsu Y, et al. The significance of preserving the energy status and microcirculation in liver grafts from non-heart-beating donor. Cell Transplant 2008;17:173.
12. de Rougemont O, Lehmann K, Clavien PA. Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver. Liver Transpl 2009;15:1172.
13. Jamieson RW, Friend PJ. Organ reperfusion and preservation. Front Biosci 2008;13:221.
14. Jain S, Lee SH, Korneszczuk K, et al. Improved preservation of warm ischemic livers by hypothermic machine perfusion with supplemented University of Wisconsin solution. J Invest Surg 2008;21:83.
15. Berendsen TA. Hepatocyte viability and adenosine triphosphate content decrease linearly over time during conventional cold storage of rat liver grafts. Transplant Proc, 2011 (in press).
16. Sumimoto K, Inagaki K, Yamada K, et al. Reliable indices for the determination of viability of grafted liver immediately after orthotopic transplantation. Bile flow rate and cellular adenosine triphosphate level. Transplantation 1988;46:506.
17. Kamiike W, Burdelski M, Steinhoff G, et al. Adenine nucleotide metabolism and its relation to organ viability in human liver transplantation. Transplantation 1988;45:138.
18. Kamiike W, Watanabe F, Hashimoto T, et al. Changes in cellular levels of ATP and its catabolites in ischemic rat liver. J Biochem 1982;91:1349.
19. Doctor RB, Dahl RH, Salter KD, et al. Reorganization of cholangiocyte membrane domains represents an early event in rat liver ischemia. Hepatology 1999;29:1364.
20. Pine JK, Aldouri A, Young AL, et al. Liver transplantation following donation after cardiac death: An analysis using matched pairs. Liver Transpl 2009;15:1072.
21. Ghonem N, Yoshida J, Stolz DB, et al. Treprostinil, a prostacyclin analog, ameliorates ischemia-reperfusion injury in rat orthotopic liver transplantation. Am J Transplant 2011;11:2508.
22. Sheth H, Hafez T, Glantzounis GK, et al. Glycine maintains mitochondrial activity and bile composition following warm liver ischemia-reperfusion injury. J Gastroenterol Hepatol 2011; 26:194.