Intranasal nanoparticles of basic fibroblast growth factor for brain delivery to treat Alzheimer's disease

International Journal of Pharmaceutics

Volumn 461, Issue 1-2, 2014, Pages 192-202

  Zhang, Chi ^a,b   Chen, Jie ^a,b   Feng, Chengcheng ^a,b   Shao, Xiayan ^a,b   Liu, Qingfeng ^a,b   Zhang, Qizhi ^a,b   Pang, Zhiqing ^a,b   Jiang, Xinguo ^a,b  

^a FUDAN UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Alzheimer's disease (AD); Basic fibroblast growth factor (bFGF); Brain delivery; Intranasal administration; Nanoparticles; Solanum tuberosum lectin (STL)

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; CHOLINE ACETYLTRANSFERASE; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR I 125; IBOTENIC ACID; N ACETYLGLUCOSAMINE; NANOPARTICLE; RADIOPHARMACEUTICAL AGENT; SOLANUM TUBEROSUM LECTIN; UNCLASSIFIED DRUG; MACROGOL DERIVATIVE; NEUROPROTECTIVE AGENT; PLANT LECTIN; POLYESTER; POLYETHYLENE GLYCOL-POLY(LACTIDE-CO-GLYCOLIDE);

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN; CEREBELLUM; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SAFETY; DRUG TARGETING; DRUG TRANSPORT; ENZYME ACTIVITY; HIPPOCAMPUS; HISTOPATHOLOGY; IN VIVO STUDY; ISOTOPE TRACING; MALE; MAZE TEST; NEUROPROTECTION; NONHUMAN; NOSE MUCOSA; OLFACTORY BULB; ORGAN DISTRIBUTION; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN BINDING; RAT; SPATIAL LEARNING; SPATIAL MEMORY; ZETA POTENTIAL; ANIMAL; BLOOD BRAIN BARRIER; CHEMISTRY; DISEASE MODEL; HUMAN; INTRANASAL DRUG ADMINISTRATION; METABOLISM; PATHOPHYSIOLOGY; POTATO; SPRAGUE DAWLEY RAT;

ADMINISTRATION, INTRANASAL; ALZHEIMER DISEASE; ANIMALS; AREA UNDER CURVE; BLOOD-BRAIN BARRIER; BRAIN; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; FIBROBLAST GROWTH FACTOR 2; HUMANS; IBOTENIC ACID; MALE; NANOPARTICLES; NEUROPROTECTIVE AGENTS; PARTICLE SIZE; PLANT LECTINS; POLYESTERS; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SOLANUM TUBEROSUM;

EID: 84890299023     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.11.049     Document Type: Article

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