Molecular profiling of tumor cells in cerebrospinal fluid and matched primary tumors from metastatic breast cancer patients with leptomeningeal carcinomatosis

Cancer Research

Volumn 73, Issue 23, 2013, Pages 7134-7143

  Magbanua, Mark Jesus M ^a,b   Melisko, Michelle ^a,b   Roy, Ritu ^b   Sosa, Eduardo V ^a,b   Hauranieh, Louai ^a,b   Kablanian, Andrea ^a,b   Eisenbud, Lauren E ^a,b   Ryazantsev, Artem ^a,b   Au, Alfred ^a,b   Scott, Janet H ^a,b   Park, John W ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTB GENE; ADULT; AGED; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER PATIENT; CARCINOMATOUS MENINGITIS; CELL ISOLATION; CEREBROSPINAL FLUID TUMOR CELL; CIRCULATING TUMOR CELL; CLINICAL ARTICLE; CLONE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENRICHMENT CULTURE; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GAPDH GENE; GENE DOSAGE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GUSB GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGENETICS; METASTASIS POTENTIAL; MIDDLE AGED; MOLECULAR BIOLOGY; ONCOGENE MYC; PRIMARY TUMOR; PRIORITY JOURNAL; REPRODUCIBILITY; RPLP0 GENE; RPS18 GENE; SOMATIC MUTATION; TFRC GENE; TUMOR CELL;

EID: 84890290887     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-2051     Document Type: Article

References (29)

1. Chamberlain MC. Leptomeningeal metastasis. Semin Neurol 2010;30:236-44.
2. Chamberlain MC. Neurotoxicity of intra-CSF liposomal cytarabine (DepoCyt) administered for the treatment of leptomeningeal metastases: a retrospective case series. J Neurooncol 2012;109:143-8.
3. Groves MD, Glantz MJ, Chamberlain MC, Baumgartner KE, Conrad CA, Hsu S, et al. A multicenter phase II trial of intrathecal topotecan in patients with meningeal malignancies. Neuro-oncology 2008;10:208-15.
4. Niwinska A, Rudnicka H, Murawska M. Breast cancer leptomeningeal metastasis: propensity of breast cancer subtypes for leptomeninges and the analysis of factors influencing survival. Med Oncol 2013;30:408.
5. Chowdhary S, Chamberlain M. Leptomeningeal metastases: current concepts and management guidelines. J Natl Compr Cancer Netw 2005;3:693-703.
6. Meriggi F, Zaniboni A. Newer avenues for the treatment of leptomeningeal carcinomatosis. Cent Nerv Syst Agents Med Chem 2011;11:38-44.
7. Weston CL, Glantz MJ, Connor JR. Detection of cancer cells in the cerebrospinal fluid: current methods and future directions. Fluids Barriers CNS 2011;8:14.
8. Magbanua MJ, Sosa EV, Scott JH, Simko J, Collins C, Pinkel D, et al. Isolation and genomic analysis of circulating tumor cells from castration resistant metastatic prostate cancer. BMC Cancer 2012;12:78.
9. Magbanua MJ, Sosa EV, Roy R, Eisenbud LE, Scott JH, Olshen A, et al. Genomic profiling of isolated circulating tumor cells from metastatic breast cancer patients. Cancer Res 2013;73:30-40.
10. Magbanua MJ, Park JW. Isolation of circulating tumor cells by immunomagnetic enrichment and fluorescence-activated cell sorting (IE/FACS) for molecular profiling. Methods 2013;S1046-2023:00278-8.
11. Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 2004;351:781-91.
12. Beadling C, Heinrich MC, Warrick A, Forbes EM, Nelson D, Justusson E, et al. Multiplex mutation screening by mass spectrometry evaluation of 820 cases from a personalized cancer medicine registry. J Mol Diagn 2011;13:504-13.
13. Magbanua MJ, Hauranieh L, Pendyala P, Sosa EV, Scott JH, Rugo HS, et al. Isolation of highly pure circulating tumor cells from metastatic breast cancer patients for gene expression analysis. Cancer Res 71:24, 2011 (suppl; abstr P4-07-17).
14. Fridlyand J, Snijders AM, Ylstra B, Li H, Olshen A, Segraves R, et al. Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer 2006;6:96.
15. Olshen AB, Venkatraman ES, Lucito R, Wigler M. Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics 2004;5:557-72.
16. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004;5:R80.
17. Blaveri E, Brewer JL, Roydasgupta R, Fridlyand J, DeVries S, Koppie T, et al. Bladder cancer stage and outcome by array-based comparative genomic hybridization. Clin Cancer Res 2005;11:7012-22.
18. Taylor R. Interpretation of the correlation-coefficient - a basic review. J Diagn Med Sonog 1990;6:35-9.
19. Leversha MA, Han J, Asgari Z, Danila DC, Lin O, Gonzalez-Espinoza R, et al. Fluorescence in situ hybridization analysis of circulating tumor cells in metastatic prostate cancer. Clin Cancer Res 2009;15:2091-7.
20. Ramsey B, Bai T, Newell AH, Troxell M, Park B, Olson S, et al. GRB7 protein over-expression and clinical outcome in breast cancer. Breast Cancer Res Treat 2011;127:659-69.
21. Nadler Y, Gonzalez AM, Camp RL, Rimm DL, Kluger HM, Kluger Y. Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer. Ann Oncol 2010;21:466-73.
22. Ahmed AR, Griffiths AB, Tilby MT, Westley BR, May FE. TFF3 is a normal breast epithelial protein and is associated with differentiated phenotype in early breast cancer but predisposes to invasion and metastasis in advanced disease. Am J Pathol 2012;180:904-16.
23. Salmans ML, Zhao F, Andersen B. The estrogen-regulated anterior gradient 2 (AGR2) protein in breast cancer: a potential drug target and biomarker. Breast Cancer Res 2013;15:204.
24. Punnoose EA, Atwal SK, Spoerke JM, Savage H, Pandita A, Yeh RF, et al. Molecular biomarker analyses using circulating tumor cells. PloS ONE 2010;5:e12517.
25. You F, Roberts LA, Kang SP, Nunes RA, Dias C, Iglehart JD, et al. Low-level expression of HER2 and CK19 in normal peripheral blood mononuclear cells: relevance for detection of circulating tumor cells. J Hematol Oncol 2008;1:2.
26. Sieuwerts AM, Kraan J, Bolt J, van der Spoel P, Elstrodt F, Schutte M, et al. Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells. J Natl Cancer Inst 2009;101:61-6.
27. Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, et al. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science 2013;339:580-4.
28. Park IH, Kwon Y, Ro JY, Lee KS, Ro J. Concordant HER2 status between metastatic breast cancer cells in CSF and primary breast cancer tissue. Breast Cancer Res Treat 2010;123:125-8.
29. Mir O, Ropert S, Alexandre J, Lemare F, Goldwasser F. High-dose intrathecal trastuzumab for leptomeningeal metastases secondary to HER-2 overexpressing breast cancer. Ann Oncol 2008;19:1978-80.