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Volumn 38, Issue 12, 2013, Pages 2524-2534

8-hydroxy-efavirenz, the primary metabolite of the antiretroviral drug efavirenz, stimulates the glycolytic flux in cultured rat astrocytes

Author keywords

Astrocytes; Glycolysis; HIV; Lactate; Mitochondria

Indexed keywords

8 HYDROXYEFAVIRENZ; ABACAVIR; ANTIRETROVIRUS AGENT; DRUG METABOLITE; EFAVIRENZ; EMTRICITABINE; INDINAVIR; LACTIC ACID; LAMIVUDINE; LOPINAVIR; NELFINAVIR; NEVIRAPINE; RITONAVIR; ROTENONE; TENOFOVIR; UNCLASSIFIED DRUG; ZIDOVUDINE;

EID: 84890267203     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-013-1165-2     Document Type: Article
Times cited : (30)

References (51)
  • 1
    • 84856452536 scopus 로고    scopus 로고
    • HIV-associated neurological disorders: A guide to pharmacotherapy
    • 22201342 10.2165/11597770-000000000-00000
    • Tan IL, McArthur JC (2012) HIV-associated neurological disorders: a guide to pharmacotherapy. CNS Drugs 26:123-134
    • (2012) CNS Drugs , vol.26 , pp. 123-134
    • Tan, I.L.1    McArthur, J.C.2
  • 2
    • 84865185522 scopus 로고    scopus 로고
    • Human immunodeficiency virus and the central nervous system
    • 22889541 10.1016/j.spen.2012.02.007
    • Mirza A, Rathore MH (2012) Human immunodeficiency virus and the central nervous system. Semin Pediatr Neurol 19:119-123
    • (2012) Semin Pediatr Neurol , vol.19 , pp. 119-123
    • Mirza, A.1    Rathore, M.H.2
  • 3
    • 72249123176 scopus 로고    scopus 로고
    • Intracellular pharmacokinetics of antiretroviral drugs in HIV-infected patients, and their correlation with drug action
    • 20000887 10.2165/11318110-000000000-00000 1:CAS:528:DC%2BC3cXhslOmsrs%3D
    • Bazzoli C, Jullien V, Le Tiec C, Rey E, Mentre F, Taburet AM (2010) Intracellular pharmacokinetics of antiretroviral drugs in HIV-infected patients, and their correlation with drug action. Clin Pharmacokinet 49:17-45
    • (2010) Clin Pharmacokinet , vol.49 , pp. 17-45
    • Bazzoli, C.1    Jullien, V.2    Le Tiec, C.3    Rey, E.4    Mentre, F.5    Taburet, A.M.6
  • 4
    • 77954734865 scopus 로고    scopus 로고
    • Antiretroviral therapy and management of HIV infection
    • 20609987 10.1016/S0140-6736(10)60676-9
    • Volberding PA, Deeks SG (2010) Antiretroviral therapy and management of HIV infection. Lancet 376:49-62
    • (2010) Lancet , vol.376 , pp. 49-62
    • Volberding, P.A.1    Deeks, S.G.2
  • 6
    • 77954624248 scopus 로고    scopus 로고
    • HIV, antiretroviral therapies, and the brain
    • 20425562 10.1007/s11904-010-0042-8
    • Liner KJ 2nd, Ro MJ, Robertson KR (2010) HIV, antiretroviral therapies, and the brain. Curr HIV/AIDS Rep 7:85-91
    • (2010) Curr HIV/AIDS Rep , vol.7 , pp. 85-91
    • Liner II, K.J.1    Ro, M.J.2    Robertson, K.R.3
  • 7
    • 84155171089 scopus 로고    scopus 로고
    • Neurocognitive dysfunction in the highly active antiretroviral therapy era
    • 22156897 10.1097/QCO.0b013e32834ef586 1:CAS:528:DC%2BC3MXhs1Gls7bP
    • Mothobi NZ, Brew BJ (2012) Neurocognitive dysfunction in the highly active antiretroviral therapy era. Curr Opin Infect Dis 25:4-9
    • (2012) Curr Opin Infect Dis , vol.25 , pp. 4-9
    • Mothobi, N.Z.1    Brew, B.J.2
  • 8
    • 83855162737 scopus 로고    scopus 로고
    • The antiretroviral protease inhibitors indinavir and nelfinavir stimulate Mrp1-mediated GSH export from cultured brain astrocytes
    • 22017299 10.1111/j.1471-4159.2011.07544.x 1:CAS:528:DC%2BC38XhsFygtbg%3D
    • Brandmann M, Tulpule K, Schmidt MM, Dringen R (2012) The antiretroviral protease inhibitors indinavir and nelfinavir stimulate Mrp1-mediated GSH export from cultured brain astrocytes. J Neurochem 120:78-92
    • (2012) J Neurochem , vol.120 , pp. 78-92
    • Brandmann, M.1    Tulpule, K.2    Schmidt, M.M.3    Dringen, R.4
  • 9
    • 84876187621 scopus 로고    scopus 로고
    • The antiretroviral protease inhibitor ritonavir accelerates glutathione export from cultured primary astrocytes
    • 23341120 10.1007/s11064-013-0971-x 1:CAS:528:DC%2BC3sXhtlGnt78%3D
    • Arend C, Brandmann M, Dringen R (2013) The antiretroviral protease inhibitor ritonavir accelerates glutathione export from cultured primary astrocytes. Neurochem Res 38:732-741
    • (2013) Neurochem Res , vol.38 , pp. 732-741
    • Arend, C.1    Brandmann, M.2    Dringen, R.3
  • 10
    • 81855194080 scopus 로고    scopus 로고
    • Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes
    • 21958719 10.1016/j.taap.2011.09.008 1:CAS:528:DC%2BC3MXhsV2mtLnO
    • Bumpus NN (2011) Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. Toxicol Appl Pharmacol 257:227-234
    • (2011) Toxicol Appl Pharmacol , vol.257 , pp. 227-234
    • Bumpus, N.N.1
  • 11
    • 84872741417 scopus 로고    scopus 로고
    • Compartmentalization and antiviral effect of efavirenz metabolites in blood plasma, seminal plasma, and cerebrospinal fluid
    • 23166317 10.1124/dmd.112.049601 1:CAS:528:DC%2BC3sXitlGisLg%3D
    • Avery LB, VanAusdall JL, Hendrix CW, Bumpus NN (2013) Compartmentalization and antiviral effect of efavirenz metabolites in blood plasma, seminal plasma, and cerebrospinal fluid. Drug Metab Dispos 41:422-429
    • (2013) Drug Metab Dispos , vol.41 , pp. 422-429
    • Avery, L.B.1    Vanausdall, J.L.2    Hendrix, C.W.3    Bumpus, N.N.4
  • 12
    • 2342531101 scopus 로고    scopus 로고
    • Antiviral drugs in current clinical use
    • 15125867 10.1016/j.jcv.2004.02.009
    • De Clercq E (2004) Antiviral drugs in current clinical use. J Clin Virol 30:115-133
    • (2004) J Clin Virol , vol.30 , pp. 115-133
    • De Clercq, E.1
  • 13
    • 75349090739 scopus 로고    scopus 로고
    • Adverse drug reactions to nonnucleoside reverse transcriptase inhibitor-based antiretroviral regimen: A 24-week prospective study
    • 10.1177/1545109709343967
    • Jena A, Sachdeva RK, Sharma A, Wanchu A (2009) Adverse drug reactions to nonnucleoside reverse transcriptase inhibitor-based antiretroviral regimen: a 24-week prospective study. J Int Assoc Phys AIDS Care (Chic) 8:318-322
    • (2009) J Int Assoc Phys AIDS Care (Chic) , vol.8 , pp. 318-322
    • Jena, A.1    Sachdeva, R.K.2    Sharma, A.3    Wanchu, A.4
  • 14
    • 0037271311 scopus 로고    scopus 로고
    • Long-term assessment of neuropsychiatric adverse reactions associated with efavirenz
    • 12534961 10.1046/j.1468-1293.2003.00136.x 1:CAS:528:DC%2BD3sXhsFOhtLk%3D
    • Lochet P, Peyriere H, Lotthe A, Mauboussin JM, Delmas B, Reynes J (2003) Long-term assessment of neuropsychiatric adverse reactions associated with efavirenz. HIV Med 4:62-66
    • (2003) HIV Med , vol.4 , pp. 62-66
    • Lochet, P.1    Peyriere, H.2    Lotthe, A.3    Mauboussin, J.M.4    Delmas, B.5    Reynes, J.6
  • 16
    • 33749426630 scopus 로고    scopus 로고
    • Neuropsychiatric complications of antiretroviral therapy
    • 16970510 10.2165/00002018-200629100-00004 1:CAS:528:DC%2BD28XhtFyhs7zF
    • Cespedes MS, Aberg JA (2006) Neuropsychiatric complications of antiretroviral therapy. Drug Saf 29:865-874
    • (2006) Drug Saf , vol.29 , pp. 865-874
    • Cespedes, M.S.1    Aberg, J.A.2
  • 17
    • 0035875828 scopus 로고    scopus 로고
    • Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
    • 11192870 10.1097/00002030-200101050-00011 1:CAS:528: DC%2BD3MXotlejsA%3D%3D
    • Marzolini C, Telenti A, Decosterd LA, Greub G, Biollaz J, Buclin T (2001) Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients. Aids 15:71-75
    • (2001) Aids , vol.15 , pp. 71-75
    • Marzolini, C.1    Telenti, A.2    Decosterd, L.A.3    Greub, G.4    Biollaz, J.5    Buclin, T.6
  • 19
    • 55149118695 scopus 로고    scopus 로고
    • Effects of the HIV treatment drugs nevirapine and efavirenz on brain creatine kinase activity
    • 18815873 10.1007/s11011-008-9109-2 1:CAS:528:DC%2BD1cXht12ku7fM
    • Streck EL, Scaini G, Rezin GT, Moreira J, Fochesato CM, Romao PRT (2008) Effects of the HIV treatment drugs nevirapine and efavirenz on brain creatine kinase activity. Metab Brain Dis 23:485-492
    • (2008) Metab Brain Dis , vol.23 , pp. 485-492
    • Streck, E.L.1    Scaini, G.2    Rezin, G.T.3    Moreira, J.4    Fochesato, C.M.5    Romao, P.R.T.6
  • 20
    • 77953756056 scopus 로고    scopus 로고
    • Efavirenz primary and secondary metabolism in vitro and in vivo: Identification of novel metabolic pathways and cytochrome P450 2A6 as the principal catalyst of efavirenz 7-hydroxylation
    • 20335270 10.1124/dmd.109.031393 1:CAS:528:DC%2BC3cXos1Klsbc%3D
    • Ogburn ET, Jones DR, Masters AR, Xu C, Guo Y, Desta Z (2010) Efavirenz primary and secondary metabolism in vitro and in vivo: identification of novel metabolic pathways and cytochrome P450 2A6 as the principal catalyst of efavirenz 7-hydroxylation. Drug Metab Dispos 38:1218-1229
    • (2010) Drug Metab Dispos , vol.38 , pp. 1218-1229
    • Ogburn, E.T.1    Jones, D.R.2    Masters, A.R.3    Xu, C.4    Guo, Y.5    Desta, Z.6
  • 21
    • 0032589627 scopus 로고    scopus 로고
    • Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: Species differences in the metabolism of efavirenz
    • 10534318 1:CAS:528:DyaK1MXntFSht7g%3D
    • Mutlib AE, Chen H, Nemeth GA, Markwalder JA, Seitz SP, Gan LS, Christ DD (1999) Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz. Drug Metab Dispos 27:1319-1333
    • (1999) Drug Metab Dispos , vol.27 , pp. 1319-1333
    • Mutlib, A.E.1    Chen, H.2    Nemeth, G.A.3    Markwalder, J.A.4    Seitz, S.P.5    Gan, L.S.6    Christ, D.D.7
  • 24
    • 84882479655 scopus 로고    scopus 로고
    • Astrocytic energetics during excitatory neurotransmission: What are contributions of glutamate oxidation and glycolysis?
    • 23838211 10.1016/j.neuint.2013.06.015 1:CAS:528:DC%2BC3sXhtlGru73F
    • Dienel GA (2013) Astrocytic energetics during excitatory neurotransmission: what are contributions of glutamate oxidation and glycolysis? Neurochem Int 63:244-258
    • (2013) Neurochem Int , vol.63 , pp. 244-258
    • Dienel, G.A.1
  • 25
    • 77952356102 scopus 로고    scopus 로고
    • The cytosolic redox state of astrocytes: Maintenance, regulation and functional implications for metabolite trafficking
    • 19883686 10.1016/j.brainresrev.2009.10.003 1:CAS:528:DC%2BC3cXlsFahsb8%3D
    • Hirrlinger J, Dringen R (2010) The cytosolic redox state of astrocytes: maintenance, regulation and functional implications for metabolite trafficking. Brain Res Rev 63:177-188
    • (2010) Brain Res Rev , vol.63 , pp. 177-188
    • Hirrlinger, J.1    Dringen, R.2
  • 27
    • 0021893839 scopus 로고
    • Primary glial cultures as a model for studying hormone action
    • 2985921 10.1016/0076-6879(85)09097-8 1:CAS:528:DyaL2MXktlagsrY%3D
    • Hamprecht B, Löffler F (1985) Primary glial cultures as a model for studying hormone action. Methods Enzymol 109:341-345
    • (1985) Methods Enzymol , vol.109 , pp. 341-345
    • Hamprecht, B.1    Löffler, F.2
  • 28
    • 84921855400 scopus 로고    scopus 로고
    • Primary cultures of astrocytes and neurons as model systems to study the metabolism and metabolite export from brain cells
    • Waagepetersen H, Hirrlinger J (eds)
    • Tulpule K, Hohnholt M, Hirrlinger J, Dringen R (2014) Primary cultures of astrocytes and neurons as model systems to study the metabolism and metabolite export from brain cells. In: Waagepetersen H, Hirrlinger J (eds) Neuromethods: Brain Energy Metabolism (in press)
    • (2014) Neuromethods: Brain Energy Metabolism (In Press)
    • Tulpule, K.1    Hohnholt, M.2    Hirrlinger, J.3    Dringen, R.4
  • 29
    • 0031808935 scopus 로고    scopus 로고
    • Detoxification of exogenous hydrogen peroxide and organic hydroperoxides by cultured astroglial cells assessed by microtiter plate assay
    • 9507143 10.1016/S1385-299X(97)00047-0 1:CAS:528:DyaK1cXisVKgsbY%3D
    • Dringen R, Kussmaul L, Hamprecht B (1998) Detoxification of exogenous hydrogen peroxide and organic hydroperoxides by cultured astroglial cells assessed by microtiter plate assay. Brain Res Brain Res Protoc 2:223-228
    • (1998) Brain Res Brain Res Protoc , vol.2 , pp. 223-228
    • Dringen, R.1    Kussmaul, L.2    Hamprecht, B.3
  • 30
    • 77955092432 scopus 로고    scopus 로고
    • Zinc prevents the copper-induced damage of cultured astrocytes
    • 20600438 10.1016/j.neuint.2010.06.010 1:CAS:528:DC%2BC3cXptlWmtbw%3D
    • Scheiber IF, Schmidt MM, Dringen R (2010) Zinc prevents the copper-induced damage of cultured astrocytes. Neurochem Int 57:314-322
    • (2010) Neurochem Int , vol.57 , pp. 314-322
    • Scheiber, I.F.1    Schmidt, M.M.2    Dringen, R.3
  • 31
    • 71849104860 scopus 로고
    • Protein Measurement with the Folin Phenol Reagent
    • 14907713 1:CAS:528:DyaG38XhsVyrsw%3D%3D
    • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein Measurement with the Folin Phenol Reagent. J Biol Chem 193:265-275
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Lowry, O.H.1    Rosebrough, N.J.2    Farr, A.L.3    Randall, R.J.4
  • 32
    • 0041803001 scopus 로고    scopus 로고
    • +-dependent isocitrate dehydrogenases are expressed in cultured rat neurons, astrocytes, oligodendrocytes and microglial cells
    • 12859674 10.1046/j.1471-4159.2003.01871.x 1:CAS:528:DC%2BD3sXlvF2ntbk%3D
    • +-dependent isocitrate dehydrogenases are expressed in cultured rat neurons, astrocytes, oligodendrocytes and microglial cells. J Neurochem 86:605-614
    • (2003) J Neurochem , vol.86 , pp. 605-614
    • Minich, T.1    Yokota, S.2    Dringen, R.3
  • 35
    • 77952327640 scopus 로고    scopus 로고
    • Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes
    • 19584905 10.3389/neuro.14.001.2009 1:CAS:528:DC%2BC3MXpt1Grs7w%3D
    • Schmidt MM, Dringen R (2009) Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes. Front Neuroenergetics 1:1-10
    • (2009) Front Neuroenergetics , vol.1 , pp. 1-10
    • Schmidt, M.M.1    Dringen, R.2
  • 37
    • 79954427251 scopus 로고    scopus 로고
    • Copper accelerates glycolytic flux in cultured astrocytes
    • 21318477 10.1007/s11064-011-0419-0 1:CAS:528:DC%2BC3MXhvVahurk%3D
    • Scheiber IF, Dringen R (2011) Copper accelerates glycolytic flux in cultured astrocytes. Neurochem Res 36:894-903
    • (2011) Neurochem Res , vol.36 , pp. 894-903
    • Scheiber, I.F.1    Dringen, R.2
  • 38
    • 84856799997 scopus 로고    scopus 로고
    • Formate generated by cellular oxidation of formaldehyde accelerates the glycolytic flux in cultured astrocytes
    • 22258934 10.1002/glia.22292
    • Tulpule K, Dringen R (2012) Formate generated by cellular oxidation of formaldehyde accelerates the glycolytic flux in cultured astrocytes. Glia 60:582-593
    • (2012) Glia , vol.60 , pp. 582-593
    • Tulpule, K.1    Dringen, R.2
  • 39
    • 34447130298 scopus 로고    scopus 로고
    • Lactic acidosis in HIV patients receiving highly active antiretroviral therapy
    • 17682581 1:STN:280:DC%2BD2svmsVOisA%3D%3D
    • Chow YW, Leong CL, Chow HL, Hooi LS (2007) Lactic acidosis in HIV patients receiving highly active antiretroviral therapy. Med J Malaysia 62:78-80
    • (2007) Med J Malaysia , vol.62 , pp. 78-80
    • Chow, Y.W.1    Leong, C.L.2    Chow, H.L.3    Hooi, L.S.4
  • 40
    • 80051948389 scopus 로고    scopus 로고
    • Accumulation of PVP- coated silver nanoparticles by cultured astrocytes
    • 21852719 10.1088/0957-4484/22/37/375101
    • Luther EM, Koehler Y, Diendorf J, Epple M, Dringen R (2011) Accumulation of PVP- coated silver nanoparticles by cultured astrocytes. Nanotechnology 22:375101
    • (2011) Nanotechnology , vol.22 , pp. 375101
    • Luther, E.M.1    Koehler, Y.2    Diendorf, J.3    Epple, M.4    Dringen, R.5
  • 42
    • 84867288689 scopus 로고    scopus 로고
    • Antiretroviral neurotoxicity
    • 22811264 10.1007/s13365-012-0120-3 1:CAS:528:DC%2BC38XhsVyiu7fM
    • Robertson K, Liner J, Meeker RB (2012) Antiretroviral neurotoxicity. J Neurovirol 18:388-399
    • (2012) J Neurovirol , vol.18 , pp. 388-399
    • Robertson, K.1    Liner, J.2    Meeker, R.B.3
  • 43
    • 0021984524 scopus 로고
    • Effects of antimycin, glucose deprivation, and serum on cultures of neurons, astrocytes, and neuroblastoma cells
    • 3964824 10.1111/j.1471-4159.1985.tb07123.x 1:CAS:528:DyaL2MXktlyktA%3D%3D
    • Pauwels PJ, Opperdoes FR, Trouet A (1985) Effects of antimycin, glucose deprivation, and serum on cultures of neurons, astrocytes, and neuroblastoma cells. J Neurochem 44:143-148
    • (1985) J Neurochem , vol.44 , pp. 143-148
    • Pauwels, P.J.1    Opperdoes, F.R.2    Trouet, A.3
  • 44
    • 33747164762 scopus 로고    scopus 로고
    • Management of advanced HIV disease: Resistance, antiretroviral brain penetration and malignancies
    • 16939552 10.1111/j.1742-1241.2006.01073.x 1:STN:280: DC%2BD28rhs1yrsQ%3D%3D
    • Boffito M, Pillay D, Wilkins E (2006) Management of advanced HIV disease: resistance, antiretroviral brain penetration and malignancies. Int J Clin Pract 60:1098-1106
    • (2006) Int J Clin Pract , vol.60 , pp. 1098-1106
    • Boffito, M.1    Pillay, D.2    Wilkins, E.3
  • 46
    • 33847058002 scopus 로고    scopus 로고
    • Efavirenz/emtricitabine/tenofovir disoproxil fumarate fixed-dose combination: First-line therapy for all?
    • 17266471 10.1517/14656566.8.3.371 1:CAS:528:DC%2BD2sXhtFGltbk%3D
    • Goicoechea M, Best B (2007) Efavirenz/emtricitabine/tenofovir disoproxil fumarate fixed-dose combination: first-line therapy for all? Expert Opin Pharmacother 8:371-382
    • (2007) Expert Opin Pharmacother , vol.8 , pp. 371-382
    • Goicoechea, M.1    Best, B.2
  • 47
    • 0038002981 scopus 로고    scopus 로고
    • The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: Implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity
    • 12676886 10.1124/jpet.103.049601 1:CAS:528:DC%2BD3sXkvF2ksr8%3D
    • Ward BA, Gorski JC, Jones DR, Hall SD, Flockhart DA, Desta Z (2003) The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J Pharmacol Exp Ther 306:287-300
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 287-300
    • Ward, B.A.1    Gorski, J.C.2    Jones, D.R.3    Hall, S.D.4    Flockhart, D.A.5    Desta, Z.6
  • 48
    • 34548106741 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein activity at the primate blood-brain barrier increases the distribution of Nelfinavir into the brain but not into the cerebrospinal fluid
    • 17591677 10.1124/dmd.107.016220 1:CAS:528:DC%2BD2sXpslKru70%3D
    • Kaddoumi A, Choi SU, Kinman L, Whittington D, Tsai CC, Ho RJY, Anderson BD, Unadkat JD (2007) Inhibition of P-glycoprotein activity at the primate blood-brain barrier increases the distribution of Nelfinavir into the brain but not into the cerebrospinal fluid. Drug Metab Dispos 35:1459-1462
    • (2007) Drug Metab Dispos , vol.35 , pp. 1459-1462
    • Kaddoumi, A.1    Choi, S.U.2    Kinman, L.3    Whittington, D.4    Tsai, C.C.5    Ho, R.J.Y.6    Anderson, B.D.7    Unadkat, J.D.8
  • 49
    • 84863473201 scopus 로고    scopus 로고
    • Sweet sixteen for ANLS
    • 22027938 10.1038/jcbfm.2011.149 1:CAS:528:DC%2BC38XpvVSjt7k%3D
    • Pellerin L, Magistretti PJ (2012) Sweet sixteen for ANLS. J Cereb Blood Flow Metab 32:1152-1166
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 1152-1166
    • Pellerin, L.1    Magistretti, P.J.2
  • 50
  • 51
    • 74949124717 scopus 로고    scopus 로고
    • Inherited metabolic disorders and stroke part 1: Fabry disease and mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes
    • 20065125 10.1001/archneurol.2009.309
    • Testai FD, Gorelick PB (2010) Inherited metabolic disorders and stroke part 1: Fabry disease and mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. Arch Neurol 67:19-24
    • (2010) Arch Neurol , vol.67 , pp. 19-24
    • Testai, F.D.1    Gorelick, P.B.2


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