메뉴 건너뛰기




Volumn 98, Issue 12, 2013, Pages

Increased AKT or MEK1/2 activity influences progesterone receptor levels and localization in endometriosis

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROGESTERONE; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B; PROMEGESTONE; PROTEIN KINASE B;

EID: 84890247117     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-1661     Document Type: Article
Times cited : (61)

References (41)
  • 1
    • 58349090850 scopus 로고    scopus 로고
    • Endometriosis
    • Bulun SE. Endometriosis. N Engl J Med. 2009;360:268-279.
    • (2009) N Engl J Med , vol.360 , pp. 268-279
    • Bulun, S.E.1
  • 2
    • 77953956205 scopus 로고    scopus 로고
    • Clinical practice. Endometriosis
    • Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010; 362:2389-2398.
    • (2010) N Engl J Med , vol.362 , pp. 2389-2398
    • Giudice, L.C.1
  • 3
    • 0018888793 scopus 로고
    • Laparoscopy in the diagnosis and management of pelvic pain in adolescents
    • Goldstein DP, deCholnoky C, Emans SJ, Leventhal JM. Laparoscopy in the diagnosis and management of pelvic pain in adolescents. J Reprod Med. 1980;24:251-256.
    • (1980) J Reprod Med , vol.24 , pp. 251-256
    • Goldstein, D.P.1    DeCholnoky, C.2    Emans, S.J.3    Leventhal, J.M.4
  • 5
    • 0021963623 scopus 로고
    • Naproxen sodium in dysmenorrhea secondary to endometriosis
    • Kauppila A, Rönnberg L. Naproxen sodium in dysmenorrhea secondary to endometriosis. Obstet Gynecol. 1985;65:379-383.
    • (1985) Obstet Gynecol , vol.65 , pp. 379-383
    • Kauppila, A.1    Rönnberg, L.2
  • 6
    • 32444451851 scopus 로고    scopus 로고
    • Advances in the management of endometriosis: An update for clinicians
    • Crosignani P, Olive D, Bergqvist A, Luciano A. Advances in the management of endometriosis: an update for clinicians. Hum Reprod Update. 2006;12:179-189.
    • (2006) Hum Reprod Update , vol.12 , pp. 179-189
    • Crosignani, P.1    Olive, D.2    Bergqvist, A.3    Luciano, A.4
  • 7
    • 0027158313 scopus 로고
    • A gonadotropin-Releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis
    • Vercellini P, Trespidi L, Colombo A, Vendola N, Marchini M, Crosignani PG. A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis. Fertil Steril. 1993;60:75-79.
    • (1993) Fertil Steril , vol.60 , pp. 75-79
    • Vercellini, P.1    Trespidi, L.2    Colombo, A.3    Vendola, N.4    Marchini, M.5    Crosignani, P.G.6
  • 8
    • 0032958358 scopus 로고    scopus 로고
    • Effects of 3 month therapy with danazol after laparoscopic surgery for stage III/IV endometriosis: A randomized study
    • Bianchi S, Busacca M, Agnoli B, Candiani M, Calia C, Vignali M. Effects of 3 month therapy with danazol after laparoscopic surgery for stage III/IV endometriosis: a randomized study. Hum Reprod. 1999;14:1335-1337.
    • (1999) Hum Reprod , vol.14 , pp. 1335-1337
    • Bianchi, S.1    Busacca, M.2    Agnoli, B.3    Candiani, M.4    Calia, C.5    Vignali, M.6
  • 9
    • 0034770543 scopus 로고    scopus 로고
    • Endometriosis: Aetiology, pathogenesis and treatment
    • Child TJ, Tan SL. Endometriosis: aetiology, pathogenesis and treatment. Drugs. 2001;61:1735-1750.
    • (2001) Drugs , vol.61 , pp. 1735-1750
    • Child, T.J.1    Tan, S.L.2
  • 10
    • 0038495988 scopus 로고    scopus 로고
    • Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-Based implantation failure and infertility
    • Kao LC, Germeyer A, Tulac S, et al. Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Endocrinology. 2003;144:2870-2881.
    • (2003) Endocrinology , vol.144 , pp. 2870-2881
    • Kao, L.C.1    Germeyer, A.2    Tulac, S.3
  • 11
    • 33644881895 scopus 로고    scopus 로고
    • Progesterone resistance in endometriosis: Link to failure to metabolize estradiol
    • Bulun SE, Cheng YH, Yin P, et al. Progesterone resistance in endometriosis: link to failure to metabolize estradiol. Mol Cell Endocrinol. 2006;248:94-103.
    • (2006) Mol Cell Endocrinol , vol.248 , pp. 94-103
    • Bulun, S.E.1    Cheng, Y.H.2    Yin, P.3
  • 12
    • 33947628632 scopus 로고    scopus 로고
    • Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17beta-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Sp1: A mechanism for defective estradiol metabolism
    • discussion 391.e7-e8
    • Cheng YH, Imir A, Fenkci V, Yilmaz MB, Bulun SE. Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17beta-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Sp1: a mechanism for defective estradiol metabolism. Am J Obstet Gynecol. 2007;196:391.e1-e7; discussion 391.e7-e8.
    • (2007) Am J Obstet Gynecol , vol.196
    • Cheng, Y.H.1    Imir, A.2    Fenkci, V.3    Yilmaz, M.B.4    Bulun, S.E.5
  • 13
    • 34547114483 scopus 로고    scopus 로고
    • Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis
    • Burney RO, Talbi S, Hamilton AE, et al. Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis. Endocrinology. 2007;148:3814-3826.
    • (2007) Endocrinology , vol.148 , pp. 3814-3826
    • Burney, R.O.1    Talbi, S.2    Hamilton, A.E.3
  • 14
    • 79953270203 scopus 로고    scopus 로고
    • Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis
    • Aghajanova L, Tatsumi K, Horcajadas JA, et al. Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011;84: 801-815.
    • (2011) Biol Reprod , vol.84 , pp. 801-815
    • Aghajanova, L.1    Tatsumi, K.2    Horcajadas, J.A.3
  • 15
    • 67749099442 scopus 로고    scopus 로고
    • Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFB, and β-Catenin pathways and activation of intrinsic apoptotic mechanisms
    • Banu SK, Lee J, Speights VO Jr, Starzinski-Powitz A, Arosh JA. Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFB, and β-catenin pathways and activation of intrinsic apoptotic mechanisms. Mol Endocrinol. 2009;23:1291- 1305.
    • (2009) Mol Endocrinol , vol.23 , pp. 1291-1305
    • Banu, S.K.1    Lee, J.2    Speights, Jr.V.O.3    Starzinski-Powitz, A.4    Arosh, J.A.5
  • 16
    • 74749104852 scopus 로고    scopus 로고
    • 17βE2 promotes cell proliferation in endometriosis by decreasing PTEN via NFB-Dependent pathway
    • Zhang H, Zhao X, Liu S, Li J, Wen Z, Li M. 17βE2 promotes cell proliferation in endometriosis by decreasing PTEN via NFB-dependent pathway. Mol Cell Endocrinol. 2010;317:31-43.
    • (2010) Mol Cell Endocrinol , vol.317 , pp. 31-43
    • Zhang, H.1    Zhao, X.2    Liu, S.3    Li, J.4    Wen, Z.5    Li, M.6
  • 17
    • 84862908356 scopus 로고    scopus 로고
    • Increased activation of the PI3K/AKT pathway compromises decidualization of stromal cells from endometriosis
    • Yin X, Pavone ME, Lu Z, Wei J, Kim JJ. Increased activation of the PI3K/AKT pathway compromises decidualization of stromal cells from endometriosis. J Clin Endocrinol Metab. 2012;97:E35-E43.
    • (2012) J Clin Endocrinol Metab , vol.97
    • Yin, X.1    Pavone, M.E.2    Lu, Z.3    Wei, J.4    Kim, J.J.5
  • 18
    • 77449109106 scopus 로고    scopus 로고
    • Differential regulation of Akt phosphorylation in endometriosis
    • Cinar O, Seval Y, Uz YH, et al. Differential regulation of Akt phosphorylation in endometriosis. Reprod Biomed Online. 2009;19: 864-871.
    • (2009) Reprod Biomed Online , vol.19 , pp. 864-871
    • Cinar, O.1    Seval, Y.2    Uz, Y.H.3
  • 19
    • 70349310109 scopus 로고    scopus 로고
    • Increased mitogen-Activated protein kinase kinase/extracellularly regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis reduces 3′,5′-Cyclic adenosine 5′-monophosphate inhibition of cyclin D1
    • Velarde MC, Aghajanova L, Nezhat CR, Giudice LC. Increased mitogen-activated protein kinase kinase/extracellularly regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis reduces 3′,5′-cyclic adenosine 5′-monophosphate inhibition of cyclin D1. Endocrinology. 2009;150:4701- 4712.
    • (2009) Endocrinology , vol.150 , pp. 4701-4712
    • Velarde, M.C.1    Aghajanova, L.2    Nezhat, C.R.3    Giudice, L.C.4
  • 20
    • 0033967491 scopus 로고    scopus 로고
    • Phosphorylation of human progesterone receptors at serine-294 by mitogen-Activated protein kinase signals their degradation by the 26S proteasome
    • Lange CA, Shen T, Horwitz KB. Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome. Proc Natl Acad Sci U S A. 2000;97:1032-1037.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 1032-1037
    • Lange, C.A.1    Shen, T.2    Horwitz, K.B.3
  • 21
    • 79951722712 scopus 로고    scopus 로고
    • Inhibiting the PI3K/Akt pathway reversed progestin resistance in endometrial cancer
    • Gu C, Zhang Z, Yu Y, et al. Inhibiting the PI3K/Akt pathway reversed progestin resistance in endometrial cancer. Cancer Sci. 2011; 102:557-564.
    • (2011) Cancer Sci , vol.102 , pp. 557-564
    • Gu, C.1    Zhang, Z.2    Yu, Y.3
  • 22
    • 84864265147 scopus 로고    scopus 로고
    • Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin
    • Pant A, Lee, II, Lu Z, Rueda BR, Schink J, Kim JJ. Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin. PLoS One. 2012;7:e41593.
    • (2012) PLoS One , vol.7
    • Pant, A.1    Lee, I.I.2    Lu, Z.3    Rueda, B.R.4    Schink, J.5    Kim, J.J.6
  • 23
    • 0028323555 scopus 로고
    • Isolation, characterization, and comparison of human endometrial and endometriosis cells in vitro
    • Ryan IP, Schriock ED, Taylor RN. Isolation, characterization, and comparison of human endometrial and endometriosis cells in vitro. J Clin Endocrinol Metab. 1994;78:642-649.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 642-649
    • Ryan, I.P.1    Schriock, E.D.2    Taylor, R.N.3
  • 25
    • 0030925413 scopus 로고    scopus 로고
    • Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice
    • Bruner KL, Matrisian LM, Rodgers WH, Gorstein F, Osteen KG. Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. J Clin Invest. 1997;99:2851-2857.
    • (1997) J Clin Invest , vol.99 , pp. 2851-2857
    • Bruner, K.L.1    Matrisian, L.M.2    Rodgers, W.H.3    Gorstein, F.4    Osteen, K.G.5
  • 26
    • 0036775117 scopus 로고    scopus 로고
    • Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude mice
    • Bruner-Tran KL, Eisenberg E, Yeaman GR, Anderson TA, McBean J, Osteen KG. Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude mice. J Clin Endocrinol Metab. 2002;87:4782-4791.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4782-4791
    • Bruner-Tran, K.L.1    Eisenberg, E.2    Yeaman, G.R.3    Anderson, T.A.4    McBean, J.5    Osteen, K.G.6
  • 27
    • 33646036184 scopus 로고    scopus 로고
    • Down-Regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget
    • Bruner-Tran KL, Zhang Z, Eisenberg E, Winneker RC, Osteen KG. Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget. J Clin Endocrinol Metab. 2006;91:1554- 1560.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1554-1560
    • Bruner-Tran, K.L.1    Zhang, Z.2    Eisenberg, E.3    Winneker, R.C.4    Osteen, K.G.5
  • 28
    • 59749105973 scopus 로고    scopus 로고
    • Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis
    • Attar E, Tokunaga H, Imir G, et al. Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab. 2009;94:623-631.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 623-631
    • Attar, E.1    Tokunaga, H.2    Imir, G.3
  • 29
    • 35848947442 scopus 로고    scopus 로고
    • Decidualization of the human endometrium: Mechanisms, functions, and clinical perspectives
    • Gellersen B, Brosens IA, Brosens JJ. Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives. Semin Reprod Med. 2007;25:445-453.
    • (2007) Semin Reprod Med , vol.25 , pp. 445-453
    • Gellersen, B.1    Brosens, I.A.2    Brosens, J.J.3
  • 30
    • 0141842624 scopus 로고    scopus 로고
    • CyclicAMPand progesterone receptor crosstalk in human endometrium: A decidualizing affair
    • Gellersen B, Brosens J. CyclicAMPand progesterone receptor crosstalk in human endometrium: a decidualizing affair. J Endocrinol. 2003;178:357-372.
    • (2003) J Endocrinol , vol.178 , pp. 357-372
    • Gellersen, B.1    Brosens, J.2
  • 31
    • 29444431775 scopus 로고    scopus 로고
    • Progestins regulate the expression and activity of the forkhead transcription factorFOXO1 in differentiating human endometrium
    • Labied S, Kajihara T, Madureira PA, et al. Progestins regulate the expression and activity of the forkhead transcription factorFOXO1 in differentiating human endometrium. Mol Endocrinol. 2006;20: 35-44.
    • (2006) Mol Endocrinol , vol.20 , pp. 35-44
    • Labied, S.1    Kajihara, T.2    Madureira, P.A.3
  • 32
    • 41549135945 scopus 로고    scopus 로고
    • Progestin treatment induces apoptosis and modulates transforming growth factor-β in the uterine endometrium
    • Rodriguez GC, Rimel BJ, Watkin W, et al. Progestin treatment induces apoptosis and modulates transforming growth factor-β in the uterine endometrium. Cancer Epidemiol Biomarkers Prev. 2008; 17:578-584.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 578-584
    • Rodriguez, G.C.1    Rimel, B.J.2    Watkin, W.3
  • 33
    • 0036282586 scopus 로고    scopus 로고
    • Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis
    • Meresman GF, Augé L, Barañao RI, Lombardi E, Tesone M, Sueldo C. Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis. Fertility and sterility. 2002;77:1141-1147.
    • (2002) Fertility and sterility , vol.77 , pp. 1141-1147
    • Meresman, G.F.1    Augé, L.2    Barañao, R.I.3    Lombardi, E.4    Tesone, M.5    Sueldo, C.6
  • 34
    • 0031918401 scopus 로고    scopus 로고
    • Apoptosis, bcl-2 expression, and proliferative activity in human endometrial stroma and endometrial granulated lymphocytes
    • Jones RK, Searle RF, Stewart JA, Turner S, Bulmer JN. Apoptosis, bcl-2 expression, and proliferative activity in human endometrial stroma and endometrial granulated lymphocytes. Biol Reprod. 1998;58:995-1002.
    • (1998) Biol Reprod , vol.58 , pp. 995-1002
    • Jones, R.K.1    Searle, R.F.2    Stewart, J.A.3    Turner, S.4    Bulmer, J.N.5
  • 35
    • 0042978662 scopus 로고    scopus 로고
    • MAPkinases couple multiple functions of human progesterone receptors: Degradation, transcriptional synergy, and nuclear association
    • QiuM,Lange CA.MAPkinases couple multiple functions of human progesterone receptors: degradation, transcriptional synergy, and nuclear association. J Steroid Biochem Mol Biol. 2003;85:147-157.
    • (2003) J Steroid Biochem Mol Biol , vol.85 , pp. 147-157
    • Qiu, M.1    Lange, C.A.2
  • 36
    • 0037385535 scopus 로고    scopus 로고
    • Mitogen-Activated protein kinase regulates nuclear association of human progesterone receptors
    • Qiu M, Olsen A, Faivre E, Horwitz KB, Lange CA. Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors. Mol Endocrinol. 2003;17:628-642.
    • (2003) Mol Endocrinol , vol.17 , pp. 628-642
    • Qiu, M.1    Olsen, A.2    Faivre, E.3    Horwitz, K.B.4    Lange, C.A.5
  • 37
    • 66149102800 scopus 로고    scopus 로고
    • Progestins activate the AKT pathway in leiomyoma cells and promote survival
    • Hoekstra AV, Sefton EC, Berry E, et al. Progestins activate the AKT pathway in leiomyoma cells and promote survival. J Clin Endocrinol Metab. 2009;94:1768-1774.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1768-1774
    • Hoekstra, A.V.1    Sefton, E.C.2    Berry, E.3
  • 38
    • 0034852802 scopus 로고    scopus 로고
    • Progesterone receptor contains a proline-Rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases
    • Boonyaratanakornkit V, Scott MP, Ribon V, et al. Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases. Mol Cell. 2001;8:269-280.
    • (2001) Mol Cell , vol.8 , pp. 269-280
    • Boonyaratanakornkit, V.1    Scott, M.P.2    Ribon, V.3
  • 39
    • 0037471227 scopus 로고    scopus 로고
    • Estrogen receptor α and Sp1 regulate progesterone receptor gene expression
    • Schultz JR, Petz LN, Nardulli AM. Estrogen receptor α and Sp1 regulate progesterone receptor gene expression. Mol Cell Endocrinol. 2003;201:165-175.
    • (2003) Mol Cell Endocrinol , vol.201 , pp. 165-175
    • Schultz, J.R.1    Petz, L.N.2    Nardulli, A.M.3
  • 40
    • 76249101923 scopus 로고    scopus 로고
    • Estrogen receptor-β, estrogen receptor-β, and progesterone resistance in endometriosis
    • Bulun SE, Cheng YH, Pavone ME, et al. Estrogen receptor-β, estrogen receptor-β, and progesterone resistance in endometriosis. Semin Reprod Med. 2010;28:36-43.
    • (2010) Semin Reprod Med , vol.28 , pp. 36-43
    • Bulun, S.E.1    Cheng, Y.H.2    Pavone, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.