-
1
-
-
34250878954
-
Mechanisms of specificity in protein phosphorylation
-
Ubersax, J.A. & Ferrell, J.E. Jr. Mechanisms of specificity in protein phosphorylation. Nat. Rev. Mol. Cell Biol. 8, 530-541 (2007).
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 530-541
-
-
Ubersax, J.A.1
Ferrell Jr., J.E.2
-
2
-
-
79551632876
-
Protein kinase signaling networks in cancer
-
Brognard, J. & Hunter, T. Protein kinase signaling networks in cancer. Curr. Opin. Genet. Dev. 21, 4-11 (2011).
-
(2011)
Curr. Opin. Genet. Dev.
, vol.21
, pp. 4-11
-
-
Brognard, J.1
Hunter, T.2
-
4
-
-
0242300176
-
Targets of the cyclin-dependent kinase Cdk1
-
Ubersax, J.A. et al. Targets of the cyclin-dependent kinase Cdk1. Nature 425, 859-864 (2003).
-
(2003)
Nature
, vol.425
, pp. 859-864
-
-
Ubersax, J.A.1
-
5
-
-
70349546862
-
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution
-
Holt, L.J. et al. Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science 325, 1682-1686 (2009).
-
(2009)
Science
, vol.325
, pp. 1682-1686
-
-
Holt, L.J.1
-
6
-
-
0029849620
-
Cancer cell cycles
-
Sherr, C.J. Cancer cell cycles. Science 274, 1672-1677 (1996).
-
(1996)
Science
, vol.274
, pp. 1672-1677
-
-
Sherr, C.J.1
-
7
-
-
14544270984
-
Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates
-
Loog, M. & Morgan, D.O. Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature 434, 104-108 (2005).
-
(2005)
Nature
, vol.434
, pp. 104-108
-
-
Loog, M.1
Morgan, D.O.2
-
8
-
-
0032167631
-
Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A
-
Schulman, B.A., Lindstrom, D.L. & Harlow, E. Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc. Natl. Acad. Sci. USA 95, 10453-10458 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 10453-10458
-
-
Schulman, B.A.1
Lindstrom, D.L.2
Harlow, E.3
-
9
-
-
79958032419
-
Dynamics of Cdk1 substrate specificity during the cell cycle
-
Kõivomägi, M. et al. Dynamics of Cdk1 substrate specificity during the cell cycle. Mol. Cell 42, 610-623 (2011).
-
(2011)
Mol. Cell
, vol.42
, pp. 610-623
-
-
Kõivomägi, M.1
-
10
-
-
84890133861
-
Multisite phosphorylation networks as signal processors for Cdk1
-
doi:10.1038/nsmb.2706 (3 November 2013
-
Koivomagi, M. et al. Multisite phosphorylation networks as signal processors for Cdk1. Nat. Struct. Mol. Biol. 20, doi:10.1038/nsmb.2706 (3 November 2013).
-
Nat. Struct. Mol. Biol.
, vol.20
-
-
Koivomagi, M.1
-
11
-
-
0000275636
-
Suc1 is an essential gene involved in both the cell cycle and growth in fission yeast
-
Hayles, J., Aves, S. & Nurse, P. suc1 is an essential gene involved in both the cell cycle and growth in fission yeast. EMBO J. 5, 3373-3379 (1986).
-
(1986)
EMBO J.
, vol.5
, pp. 3373-3379
-
-
Hayles, J.1
Aves, S.2
Nurse, P.3
-
12
-
-
0027153159
-
The Cdk-Associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae
-
Tang, Y. & Reed, S.I. The Cdk-Associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev. 7, 822-832 (1993).
-
(1993)
Genes Dev.
, vol.7
, pp. 822-832
-
-
Tang, Y.1
Reed, S.I.2
-
13
-
-
0030292994
-
Cell cycle: Reaching for a role for the Cks proteins
-
Pines, J. Cell cycle: Reaching for a role for the Cks proteins. Curr. Biol. 6, 1399-1402 (1996).
-
(1996)
Curr. Biol.
, vol.6
, pp. 1399-1402
-
-
Pines, J.1
-
14
-
-
1842477477
-
Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma
-
Shapira, M. et al. Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma. Cancer 100, 1615-1621 (2004).
-
(2004)
Cancer
, vol.100
, pp. 1615-1621
-
-
Shapira, M.1
-
15
-
-
51349096486
-
Cyclin-dependent kinase-Associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells
-
Martinsson-Ahlzén, H.S. et al. Cyclin-dependent kinase-Associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells. Mol. Cell Biol. 28, 5698-5709 (2008).
-
(2008)
Mol. Cell Biol.
, vol.28
, pp. 5698-5709
-
-
Martinsson-Ahlzén, H.S.1
-
16
-
-
46049116296
-
Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death
-
Lan, Y. et al. Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death. Int. J. Cancer 123, 543-551 (2008).
-
(2008)
Int. J. Cancer
, vol.123
, pp. 543-551
-
-
Lan, Y.1
-
17
-
-
67649448827
-
High Cks1 expression in transgenic and carcinogen-initiated mammary tumors is not always accompanied by reduction in p27Kip1
-
Westbrook, L. et al. High Cks1 expression in transgenic and carcinogen-initiated mammary tumors is not always accompanied by reduction in p27Kip1. Int. J. Oncol. 34, 1425-1431 (2009).
-
(2009)
Int. J. Oncol.
, vol.34
, pp. 1425-1431
-
-
Westbrook, L.1
-
18
-
-
0035092687
-
The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27
-
Ganoth, D. et al. The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27. Nat. Cell Biol. 3, 321-324 (2001).
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 321-324
-
-
Ganoth, D.1
-
19
-
-
0035265829
-
A CDK-independent function of mammalian Cks1: Targeting of SCFSkp2 to the CDK inhibitor p27Kip1
-
Spruck, C. et al. A CDK-independent function of mammalian Cks1: Targeting of SCFSkp2 to the CDK inhibitor p27Kip1. Mol. Cell 7, 639-650 (2001).
-
(2001)
Mol. Cell
, vol.7
, pp. 639-650
-
-
Spruck, C.1
-
20
-
-
0042304165
-
Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast
-
Morris, M.C. et al. Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast. Nature 423, 1009-1013 (2003).
-
(2003)
Nature
, vol.423
, pp. 1009-1013
-
-
Morris, M.C.1
-
21
-
-
11344274449
-
A kinase-independent function of Cks1 and Cdk1 in regulation of transcription
-
Yu, V.P., Baskerville, C., Grunenfelder, B. & Reed, S.I. A kinase-independent function of Cks1 and Cdk1 in regulation of transcription. Mol. Cell 17, 145-151 (2005).
-
(2005)
Mol. Cell
, vol.17
, pp. 145-151
-
-
Yu, V.P.1
Baskerville, C.2
Grunenfelder, B.3
Reed, S.I.4
-
22
-
-
0035969559
-
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
-
Nash, P. et al. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414, 514-521 (2001).
-
(2001)
Nature
, vol.414
, pp. 514-521
-
-
Nash, P.1
-
23
-
-
23744495013
-
Cdk1-dependent regulation of the mitotic inhibitor Wee1
-
Harvey, S.L., Charlet, A., Haas, W., Gygi, S.P. & Kellogg, D.R. Cdk1-dependent regulation of the mitotic inhibitor Wee1. Cell 122, 407-420 (2005).
-
(2005)
Cell
, vol.122
, pp. 407-420
-
-
Harvey, S.L.1
Charlet, A.2
Haas, W.3
Gygi, S.P.4
Kellogg, D.R.5
-
24
-
-
33947304756
-
Substrate competition as a source of ultrasensitivity in the inactivation of Wee1
-
Kim, S.Y. & Ferrell, J.E. Jr. Substrate competition as a source of ultrasensitivity in the inactivation of Wee1. Cell 128, 1133-1145 (2007).
-
(2007)
Cell
, vol.128
, pp. 1133-1145
-
-
Kim, S.Y.1
Ferrell Jr., J.E.2
-
25
-
-
82555205273
-
Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase
-
Kõivomägi, M. et al. Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. Nature 480, 128-131 (2011).
-
(2011)
Nature
, vol.480
, pp. 128-131
-
-
Kõivomägi, M.1
-
26
-
-
79251534050
-
Ultrasensitivity in the Regulation of Cdc25C by Cdk1
-
Trunnell, N.B., Poon, A.C., Kim, S.Y. & Ferrell, J.E. Jr. Ultrasensitivity in the Regulation of Cdc25C by Cdk1. Mol. Cell 41, 263-274 (2011).
-
(2011)
Mol. Cell
, vol.41
, pp. 263-274
-
-
Trunnell, N.B.1
Poon, A.C.2
Kim, S.Y.3
Ferrell Jr., J.E.4
-
27
-
-
84861790525
-
Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control
-
Burke, J.R., Hura, G.L. & Rubin, S.M. Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control. Genes Dev. 26, 1156-1166 (2012).
-
(2012)
Genes Dev.
, vol.26
, pp. 1156-1166
-
-
Burke, J.R.1
Hura, G.L.2
Rubin, S.M.3
-
28
-
-
0001424903
-
An amplified sensitivity arising from covalent modification in biological systems
-
Goldbeter, A. & Koshland, D.E. Jr. An amplified sensitivity arising from covalent modification in biological systems. Proc. Natl. Acad. Sci. USA 78, 6840-6844 (1981).
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, pp. 6840-6844
-
-
Goldbeter, A.1
Koshland Jr., D.E.2
-
29
-
-
0030445778
-
Tripping the switch fantastic: How a protein kinase cascade can convert graded inputs into switch-like outputs
-
Ferrell, J.E. Jr. Tripping the switch fantastic: How a protein kinase cascade can convert graded inputs into switch-like outputs. Trends Biochem. Sci. 21, 460-466 (1996).
-
(1996)
Trends Biochem. Sci.
, vol.21
, pp. 460-466
-
-
Ferrell Jr., J.E.1
-
30
-
-
66249102308
-
Multisite protein phosphorylation: From molecular mechanisms to kinetic models
-
Salazar, C. & Hofer, T. Multisite protein phosphorylation: From molecular mechanisms to kinetic models. FEBS J. 276, 3177-3198 (2009).
-
(2009)
FEBS J.
, vol.276
, pp. 3177-3198
-
-
Salazar, C.1
Hofer, T.2
-
31
-
-
67650360968
-
Unlimited multistability in multisite phosphorylation systems
-
Thomson, M. & Gunawardena, J. Unlimited multistability in multisite phosphorylation systems. Nature 460, 274-277 (2009).
-
(2009)
Nature
, vol.460
, pp. 274-277
-
-
Thomson, M.1
Gunawardena, J.2
-
32
-
-
77949562877
-
Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts
-
Deibler, R.W. & Kirschner, M.W. Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts. Mol. Cell 37, 753-767 (2010).
-
(2010)
Mol. Cell
, vol.37
, pp. 753-767
-
-
Deibler, R.W.1
Kirschner, M.W.2
-
33
-
-
80053342612
-
A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast
-
Harvey, S.L. et al. A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast. Mol. Biol. Cell 22, 3595-3608 (2011).
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 3595-3608
-
-
Harvey, S.L.1
-
34
-
-
0029034120
-
Crystal structure of the human cell cycle protein CksHs1: Single domain fold with similarity to kinase N-lobe domain
-
Arvai, A.S., Bourne, Y., Hickey, M.J. & Tainer, J.A. Crystal structure of the human cell cycle protein CksHs1: Single domain fold with similarity to kinase N-lobe domain. J. Mol. Biol. 249, 835-842 (1995).
-
(1995)
J. Mol. Biol.
, vol.249
, pp. 835-842
-
-
Arvai, A.S.1
Bourne, Y.2
Hickey, M.J.3
Tainer, J.A.4
-
35
-
-
0028877368
-
Crystal structure of the cell cycle-regulatory protein suc1 reveals a β-hinge conformational switch
-
Bourne, Y. et al. Crystal structure of the cell cycle-regulatory protein suc1 reveals a β-hinge conformational switch. Proc. Natl. Acad. Sci. USA 92, 10232-10236 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 10232-10236
-
-
Bourne, Y.1
-
36
-
-
0029918062
-
Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1
-
Bourne, Y. et al. Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. Cell 84, 863-874 (1996).
-
(1996)
Cell
, vol.84
, pp. 863-874
-
-
Bourne, Y.1
-
37
-
-
25844441096
-
Structural basis of the Cks1-dependent recognition of p27Kip1 by the SCFSkp2 ubiquitin ligase
-
Hao, B. et al. Structural basis of the Cks1-dependent recognition of p27Kip1 by the SCFSkp2 ubiquitin ligase. Mol. Cell 20, 9-19 (2005).
-
(2005)
Mol. Cell
, vol.20
, pp. 9-19
-
-
Hao, B.1
-
38
-
-
0033601171
-
The Xenopus Suc1/Cks protein promotes the phosphorylation of G2/M regulators
-
Patra, D., Wang, S.X., Kumagai, A. & Dunphy, W.G. The Xenopus Suc1/Cks protein promotes the phosphorylation of G2/M regulators. J. Biol. Chem. 274, 36839-36842 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 36839-36842
-
-
Patra, D.1
Wang, S.X.2
Kumagai, A.3
Dunphy, W.G.4
-
39
-
-
7744234408
-
Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control
-
Mimura, S., Seki, T., Tanaka, S. & Diffley, J.F. Phosphorylation- dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature 431, 1118-1123 (2004).
-
(2004)
Nature
, vol.431
, pp. 1118-1123
-
-
Mimura, S.1
Seki, T.2
Tanaka, S.3
Diffley, J.F.4
-
40
-
-
0037023719
-
Solution NMR study of the monomeric form of p13suc1 protein sheds light on the hinge region determining the affinity for a phosphorylated substrate
-
Odaert, B. et al. Solution NMR study of the monomeric form of p13suc1 protein sheds light on the hinge region determining the affinity for a phosphorylated substrate. J. Biol. Chem. 277, 12375-12381 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 12375-12381
-
-
Odaert, B.1
-
41
-
-
16344389701
-
Cation-π interactions in protein-protein interfaces
-
Crowley, P.B. & Golovin, A. Cation-π interactions in protein-protein interfaces. Proteins 59, 231-239 (2005).
-
(2005)
Proteins
, vol.59
, pp. 231-239
-
-
Crowley, P.B.1
Golovin, A.2
-
42
-
-
84873521371
-
Phosphorylation variation during the cell cycle scales with structural propensities of proteins
-
Tyanova, S., Cox, J., Olsen, J., Mann, M. & Frishman, D. Phosphorylation variation during the cell cycle scales with structural propensities of proteins. PLOS Comput. Biol. 9, e1002842 (2013).
-
(2013)
PLOS Comput. Biol.
, vol.9
-
-
Tyanova, S.1
Cox, J.2
Olsen, J.3
Mann, M.4
Frishman, D.5
-
43
-
-
34547588389
-
PrDOS: Prediction of disordered protein regions from amino acid sequence
-
Ishida, T. & Kinoshita, K. PrDOS: Prediction of disordered protein regions from amino acid sequence. Nucleic Acids Res. 35, W460-W464 (2007).
-
(2007)
Nucleic Acids Res.
, vol.35
-
-
Ishida, T.1
Kinoshita, K.2
-
44
-
-
0028998865
-
Cell cycle regulation of a Xenopus Wee1-like kinase
-
Mueller, P.R., Coleman, T.R. & Dunphy, W.G. Cell cycle regulation of a Xenopus Wee1-like kinase. Mol. Biol. Cell 6, 119-134 (1995).
-
(1995)
Mol. Biol. Cell
, vol.6
, pp. 119-134
-
-
Mueller, P.R.1
Coleman, T.R.2
Dunphy, W.G.3
-
45
-
-
0027236688
-
Two distinct mechanisms for negative regulation of the Wee1 protein kinase
-
Tang, Z., Coleman, T.R. & Dunphy, W.G. Two distinct mechanisms for negative regulation of the Wee1 protein kinase. EMBO J. 12, 3427-3436 (1993).
-
(1993)
EMBO J.
, vol.12
, pp. 3427-3436
-
-
Tang, Z.1
Coleman, T.R.2
Dunphy, W.G.3
-
46
-
-
0026757270
-
An array of insulin-Activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase
-
Mukhopadhyay, N.K. et al. An array of insulin-Activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase. J. Biol. Chem. 267, 3325-3335 (1992).
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 3325-3335
-
-
Mukhopadhyay, N.K.1
-
47
-
-
77952387813
-
Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding
-
Burke, J.R., Deshong, A.J., Pelton, J.G. & Rubin, S.M. Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding. J. Biol. Chem. 285, 16286-16293 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 16286-16293
-
-
Burke, J.R.1
Deshong, A.J.2
Pelton, J.G.3
Rubin, S.M.4
-
48
-
-
0033854055
-
Cks1 is required for G1 cyclin-cyclin-dependent kinase activity in budding yeast
-
Reynard, G.J., Reynolds, W., Verma, R. & Deshaies, R.J. Cks1 is required for G1 cyclin-cyclin-dependent kinase activity in budding yeast. Mol. Cell Biol. 20, 5858-5864 (2000).
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 5858-5864
-
-
Reynard, G.J.1
Reynolds, W.2
Verma, R.3
Deshaies, R.J.4
-
49
-
-
33644874235
-
The integration of macromolecular diffraction data
-
Leslie, A.G. The integration of macromolecular diffraction data. Acta Crystallogr. D Biol. Crystallogr. 62, 48-57 (2006).
-
(2006)
Acta Crystallogr. D Biol. Crystallogr.
, vol.62
, pp. 48-57
-
-
Leslie, A.G.1
-
50
-
-
0026817874
-
Identification of heavy-Atom derivatives by normal probability methods
-
Howell, P.L. & Smith, G.D. Identification of heavy-Atom derivatives by normal probability methods. J. Appl. Cryst. 25, 81-86 (1992).
-
(1992)
J. Appl. Cryst.
, vol.25
, pp. 81-86
-
-
Howell, P.L.1
Smith, G.D.2
-
51
-
-
34447508216
-
Phaser crystallographic software
-
McCoy, A.J. et al. Phaser crystallographic software. J. Appl. Crystallogr. 40, 658-674 (2007).
-
(2007)
J. Appl. Crystallogr.
, vol.40
, pp. 658-674
-
-
McCoy, A.J.1
-
53
-
-
76449098262
-
PHENIX: A comprehensive Python-based system for macromolecular structure solution
-
Adams, P.D. et al. PHENIX: A comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr. D Biol. Crystallogr. 66, 213-221 (2010).
-
(2010)
Acta Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 213-221
-
-
Adams, P.D.1
-
54
-
-
33645714857
-
Phosphate-binding tag, a new tool to visualize phosphorylated proteins
-
Kinoshita, E., Kinoshita-Kikuta, E., Takiyama, K. & Koike, T. Phosphate-binding tag, a new tool to visualize phosphorylated proteins. Mol. Cell Proteomics 5, 749-757 (2006).
-
(2006)
Mol. Cell Proteomics
, vol.5
, pp. 749-757
-
-
Kinoshita, E.1
Kinoshita-Kikuta, E.2
Takiyama, K.3
Koike, T.4
|