The effect of RNAi silencing of p62 using an osmotic polysorbitol transporter on autophagy and tumorigenesis in lungs of K-rasLA1 mice

Biomaterials

Volumn 35, Issue 5, 2014, Pages 1584-1596

  Islam, Mohammad Ariful ^a,b,c   Shin, Ji Young ^b   Yun, Cheol Heui ^a,b,c   Cho, Chong Su ^a,b   Seo, Hwi Won ^b   Chae, Chanhee ^b   Cho, Myung Haing ^b,d  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Autophagy activation; P62 silencing; Polysorbitol transporter; Tumor suppression

Indexed keywords

CELL ENGINEERING; CELL PROLIFERATION; CHEMICAL ACTIVATION; CHEMOTHERAPY; MAMMALS; OSMOSIS; PROTEINS; SCAFFOLDS (BIOLOGY); TUMORS;

AUTOPHAGY; MATRIX PROTEINS; P62 SILENCING; POLYSORBITOL TRANSPORTER; PROLIFERATIVE CELLS; SCAFFOLD PROTEIN; TUMOR SUPPRESSION; VASCULAR ENDOTHELIAL GROWTH FACTOR;

CELL DEATH;

K RAS PROTEIN; SMALL INTERFERING RNA; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER INHIBITION; CARCINOGENESIS; CELL ACTIVATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE SILENCING; IMMUNOHISTOCHEMISTRY; INTERNALIZATION; LUNG CARCINOGENESIS; MALE; MOLECULAR WEIGHT; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; SURFACE CHARGE; WESTERN BLOTTING;

MUS;

AUTOPHAGY ACTIVATION; K-RAS(LA1) MICE; P62 SILENCING; POLYSORBITOL TRANSPORTER; TUMOR SUPPRESSION;

ANIMALS; AUTOPHAGY; CARCINOGENESIS; CARRIER PROTEINS; GENE SILENCING; GENES, RAS; GOLGI APPARATUS; IN SITU NICK-END LABELING; LUNG NEOPLASMS; MALE; MICE; RNA INTERFERENCE; SORBITOL; TRANSCRIPTION FACTORS;

EID: 84890234172     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.11.010     Document Type: Article

References (31)

1. Nixon R.A. Autophagy in neurodegenerative disease: friend, foe or turncoat?. Trends Neurosci 2006, 29:528-535.
2. Klionsky D.J. The molecular machinery of autophagy: unanswered questions. JCell Sci 2005, 118:7-18.
3. Pankiv S., Clausen T.H., Lamark T., Brech A., Bruun J.A., Outzen H., et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. JBiol Chem 2007, 282:24131-24145.
4. Puissant A., Fenouille N., Auberger P. When autophagy meets cancer through p62/SQSTM1. Am J Cancer Res 2012, 2:397-413.
5. Bjorkoy G., Lamark T., Brech A., Outzen H., Perander M., Overvatn A., et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. JCell Biol 2005, 171:603-614.
6. Mathew R., Karp C.M., Beaudoin B., Vuong N., Chen G.H., Chen H.Y., et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009, 137:1062-1075.
7. Fire A., Xu S.Q., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391:806-811.
8. Whitehead K.A., Langer R., Anderson D.G. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov 2009, 8:129-138.
9. Leuschner F., Dutta P., Gorbatov R., Novobrantseva T.I., Donahoe J.S., Courties G., et al. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol 2011, 29:1005-1010.
10. Islam M.A., Yun C.H., Choi Y.J., Shin J.Y., Arote R., Jiang H.L., et al. Accelerated gene transfer through a polysorbitol-based transporter mechanism. Biomaterials 2011, 32:9908-9924.
11. Luu Q.P., Shin J.Y., Kim Y.K., Islam M.A., Kang S.K., Cho M.H., et al. High gene transfer by the osmotic polysorbitol-mediated transporter through the selective caveolae endocytic pathway. Mol Pharm 2012, 9:2206-2208.
12. Islam M.A., Shin J.Y., Firdous J., Park T.E., Choi Y.J., Cho M.H., et al. The role of osmotic polysorbitol-based transporter in RNAi silencing via caveolae-mediated endocytosis and COX-2 expression. Biomaterials 2012, 33:8868-8880.
13. Chang S.H., Hong S.H., Jiang H.L., Minai-Tehrani A., Yu K.N., Lee J.H., et al. GOLGA2/GM130, cis-golgi matrix protein, is a novel target of anticancer gene therapy. Mol Ther 2012, 20:2052-2063.
14. Kim H.W., Park I.K., Cho C.S., Lee K.H., Beck G.R., Colburn N.H., et al. Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice. Cancer Res 2004, 64:7971-7976.
15. Minai-Tehrani A., Chang S.H., Kwon J.T., Hwang S.K., Kim J.E., Shin J.Y., et al. Aerosol delivery of lentivirus-mediated O-glycosylation mutant osteopontin suppresses lung tumorigenesis in K-ras (LA1) mice. Cell Oncol (Dordr) 2013, 36:15-26.
16. Yu K.N., Minai-Tehrani A., Chang S.H., Hwang S.K., Hong S.H., Kim J.E., et al. Aerosol delivery of small hairpin osteopontin blocks pulmonary metastasis of breast cancer in mice. Plos One 2010, 5. e15623.
17. Shin J.Y., Hong S.H., Kang B., Minai-Tehrani A., Cho M.H. Overexpression of beclin1 induced autophagy and apoptosis in lungs of K-ras mice. Lung Cancer 2013, 81:362-370.
18. Shin J.Y., Lim H.T., Minai-Tehrani A., Noh M.S., Kim J.E., Kim J.H., et al. Aerosol delivery of beclin1 enhanced the anti-tumor effect of radiation in the lungs of K-rasLA1 mice. JRadiat Res 2012, 53:506-515.
19. Mok H., Lee S.H., Park J.W., Park T.G. Multimeric small interfering ribonucleic acid for highly efficient sequence-specific gene silencing. Nat Mater 2010, 9:272-278.
20. Ma M., Li F., Yuan Z.F., Zhuo R.X. Influence of hydroxyl groups on the biological properties of cationic polymethacrylates as gene vectors. Acta Biomater 2010, 6:2658-2665.
21. Wang S.H., Singh R.D., Godin L., Pagano R.E., Hubmayr R.D. Endocytic response of type I alveolar epithelial cells to hypertonic stress. Am J Physiol Lung Cell Mol Physiol 2011, 300:L560-L568.
22. Piras A., Gianetto D., Conte D., Bosone A., Vercelli A. Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure. Plos One 2011, 6:e22514.
23. Kuma A., Hatano M., Matsui M., Yamamoto A., Nakaya H., Yoshimori T., et al. The role of autophagy during the early neonatal starvation period. Nature 2004, 432:1032-1036.
24. Mizushima N., Ohsumi Y., Yoshimori T. Autophagosome formation in mammalian cells. Cell Struct Funct 2002, 27:421-429.
25. Chang S.H., Minai-Tehrani A., Shin J.Y., Park S., Kim J.E., Yu K.N., et al. Beclin1-induced autophagy abrogates radioresistance of lung cancer cells by suppressing osteopontin. JRadiat Res 2012, 53:422-432.
26. Rogan M.T., Richards K.S. Echinococcus granulosus: invitro effect of monensin on the tegument of the protoscolex. Parasitology 1986, 93:347-355.
27. Affenzeller M.J., Darehshouri A., Andosch A., Lutz C., Lutz-Meindl U. Salt stress-induced cell death in the unicellular green alga Micrasterias denticulata. JExp Bot 2009, 60:939-954.
28. Han Y.K., Kim Y.G., Kim J.Y., Lee G.M. Hyperosmotic stress induces autophagy and apoptosis in recombinant chinese hamster ovary cell culture. Biotechnol Bioeng 2010, 105:1187-1192.
29. Liu Y.M., Xiong Y., Bassham D.C. Autophagy is required for tolerance of drought and salt stress in plants. Autophagy 2009, 5:954-963.
30. Slavikova S., Ufaz S., Avin-Wittenberg T., Levanony H., Galili G. An autophagy-associated Atg8 protein is involved in the responses of Arabidopsis seedlings to hormonal controls and abiotic stresses. JExp Bot 2008, 59:4029-4043.
31. Wen S.H., Stolarov J., Myers M.P., Su J.D., Wigler M.H., Tonks N.K., et al. PTEN controls tumor-induced angiogenesis. Proc Natl Acad Sci USA 2001, 98:4622-4627.