The HLA-B*39 allele increases type 1 diabetes risk conferred by HLA-DRB1*04:04-DQB1*03:02 and HLA-DRB1*08-DQB1*04 class II haplotypes

Human Immunology

Volumn 75, Issue 1, 2014, Pages 65-70

  Mikk, M L ^a   Kiviniemi, M ^a   Laine, A P ^a   Harkonen T ^b   Veijola, R ^c   Simell, O ^d   Knip, M ^b,e,f   Ilonen, J ^a,g  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF HELSINKI AND HELSINKI UNIVERSITY HOSPITAL   (Finland)

^c OULU UNIVERSITY HOSPITAL   (Finland)

^d TURKU UNIVERSITY HOSPITAL   (Finland)

^e TAMPERE UNIVERSITY HOSPITAL   (Finland)

^f FOLKHÄLSAN RESEARCH CENTER   (Finland)

^g UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

HLA B39 ANTIGEN; HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN; LANTHANIDE;

ARTICLE; CONTROLLED STUDY; DISEASE MARKER; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SCREENING; GENOTYPE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; HYBRIDIZATION; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; NUCLEAR FAMILY; OLIGONUCLEOTIDE PROBE; PRIORITY JOURNAL; REGISTER; SENSITIVITY AND SPECIFICITY; AFBAC; AFFECTED FAMILY BASED CONTROL; ALLELE; DNA SEQUENCE; FINLAND; GENETIC PREDISPOSITION; GENETICS; TDT; TRANSMISSION DISEQUILIBRIUM TEST;

AFBAC; AFFECTED FAMILY BASED CONTROL; TDT; TRANSMISSION DISEQUILIBRIUM TEST;

ALLELES; DIABETES MELLITUS, TYPE 1; FINLAND; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HLA-B39 ANTIGEN; HLA-DRB1 CHAINS; HUMANS; REGISTRIES; SEQUENCE ANALYSIS, DNA;

EID: 84890210417     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2013.09.008     Document Type: Article

References (23)

1. Noble J.A., Erlich H.A. Genetics of type 1 diabetes. Cold Spring Harb Perspect Med 2012, 2:1-15.
2. *0302-positive haplotypes associated with IDDM. The childhood diabetes in Finland study group. Eur J Immunogenet 1997, 24:357-363.
3. Nejentsev S., Gombos Z., Laine A.P., Veijola R., Knip M., Simell O., et al. Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B. Diabetes 2000, 49:2217-2221.
4. Noble J.A., Valdes A.M., Bugawan T.L., Apple R.J., Thomson G., Erlich H.A. The HLA class I A locus affects susceptibility to type 1 diabetes. Hum Immunol 2002, 63:657-664.
5. Valdes A.M., Erlich H.A., Noble J.A. Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset. Hum Immunol 2005, 66:301-313.
6. Nejentsev S., Howson J.M., Walker N.M., Szeszko J., Field S.F., Stevens H.E., et al. Localisation of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007, 450:887-892.
7. Howson J.M., Walker N.M., Clayton D., Todd J.A. Type 1 diabetes genetics C confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes Obes & Metab 2009, 11(Suppl. 1):31-45.
8. Noble J.A., Valdes A.M., Varney M.D., Carlson J.A., Moonsamy P., Fear A.L., et al. HLA class I and genetic susceptibility to type 1 diabetes: results from the type 1 diabetes genetics consortium. Diabetes 2010.
9. *3906 allele imparts a high risk of diabetes only on spesific HLA-DR/DQ haplotypes. Diabetologia 2011, 54:1702-1709.
10. *0302. Diabetes 1997, 46:1888-1892.
11. Kupila A., Muona P., Simell T., Arvilommi P., Savolainen H., Hamalainen A.M., et al. Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort. Diabetologia 2001, 44:290-297.
12. Klitz W., Maiers M., Spellman S., Baxter-Lowe L.A., Schmeckpeper B., Williams T.M., et al. New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans. Tissue Antigens 2003, 62:296-307.
13. Nejentsev S., Sjoroos M., Soukka T., Knip M., Simell O., Lovgren T., et al. Population-based genetic screening for the estimation of type 1 diabetes mellitus risk in Finland: selective genotyping of markers in the HLA-DQB1, HLA-DQA1 and HLA-DRB1 loci. Diabet Med 1999, 16:985-992.
14. Kiviniemi M., Hermann R., Nurmi J., Ziegler A.G., Knip M., Simell O., et al. A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the environmental determinants of diabetes in the young) study. Diabetes Technol Ther 2007, 9:460-472.
15. Kiviniemi M., Nurmi J., Lovgren T., Ilonen J. Locked nucleic acid (LNA) probes in high-throughput genetic analysis: application to an assay for type 1 diabetes-related HLA-DQB1 alleles. Clin Biochem 2005, 38:1015-1022.
16. Bunce M., O'Neill C.M., Barnardo M.C., Krausa P., Browning M.J., Morris P.J., et al. Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5, & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens 1995, 46:355-367.
17. Spielman R.S., McGinnis R.E., Ewens W.J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993, 52:506-516.
18. Hermann R., Turpeinen H., Laine A.P., Veijola R., Knip M., Simell O., et al. HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: an analysis of 622 nuclear families. Tissue Antigens 2003, 62:162-169.
19. Singal D.P., Blajchman M.A. Histocompatibility (HL-A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus. Diabetes 1973, 22:429-432.
20. Nerup J., Platz P., Andersen O.O., Christy M., Lyngsoe J., Poulsen J.E., et al. HL-A antigens and diabetes mellitus. Lancet 1974, 2:864-866.
21. Gombos Z., Wachowicz J., Veijola R., Akerblom H.K., Simell O., Knip M., et al. Human leukocyte antigen non-class II determinants for type 1 diabetes in the Finnish population. Hum Immunol 2006, 67:714-721.
22. Haimila K., Peräsaari J., Linjama T., Koskela S., Saarinen T., Saarinen T., et al. HLA antigen, allele and haplotype frequencies and their use in virtual panel reactive antigen calculations in the Finnish population. Tissue Antigens 2013, 81:35-43.
23. Maiers M., Gragert L., Klitz W. High-resolution HLA alleles and haplotypes in the United States population. Hum Immunol 2007, 68:779-788.