The HLA-B*3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes

Diabetologia

Volumn 54, Issue 7, 2011, Pages 1702-1709

  Baschal, E E ^a   Baker, P R ^a   Eyring, K R ^a   Siebert, J C ^b   Jasinski, J M ^a   Eisenbarth, G S ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

^b CytoAnalytics   (United States)

Author keywords

Association study; Genetics; HLA class I; HLA B; HLA B*39; MHC; Type 1 diabetes

Indexed keywords

ARTICLE; CONTROLLED STUDY; GENE; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HAPLOTYPE; HLA B GENE; HLA DQB1 GENE; HLA DRB1 GENE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; RISK FACTOR; SIBLING; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; DIABETES MELLITUS, TYPE 1; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HLA-B ANTIGENS; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS;

EID: 79959709799     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2161-1     Document Type: Article

References (30)

1. JX She MP Marron 1998 Genetic susceptibility factors in type 1 diabetes: linkage, disequilibrium and functional analyses Curr Opin Immunol 10 682 689 9914216 10.1016/S0952-7915(98)80089-7 1:CAS:528:DyaK1MXhtlGr (Pubitemid 28558584)
2. M Rewers TL Bugawan JM Norris, et al. 1996 Newborn screening for HLA markers associated with IDDM: Diabetes Autoimmunity Study in the Young (DAISY) Diabetologia 39 807 812 8817105 10.1007/s001250050514 1:STN:280: DyaK28vhsVSntw%3D%3D (Pubitemid 26228110)
3. JA Noble AM Valdes TL Bugawan RJ Apple G Thomson HA Erlich 2002 The HLA class I A locus affects susceptibility to type 1 diabetes Hum Immunol 63 657 664 12121673 10.1016/S0198-8859(02)00421-4 1:CAS:528:DC%2BD38Xlt12nu78%3D (Pubitemid 34816108)
4. AM Valdes HA Erlich JA Noble 2005 Human leukocyte antigen class I B and C loci contribute to type 1 diabetes (T1D) susceptibility and age T1D onset Hum Immunol 66 301 313 15784469 10.1016/j.humimm.2004.12.001 1:CAS:528: DC%2BD2MXisVWqtrs%3D (Pubitemid 40395251)
5. S Nejentsev JM Howson NM Walker, et al. 2007 Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A Nature 450 887 892 18004301 10.1038/nature06406 1:CAS:528:DC%2BD2sXhtl2nsrjF (Pubitemid 350231332)
6. JM Howson NM Walker D Clayton JA Todd 2009 Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A Diabetes Obes Metab 11 Suppl 1 31 45 19143813 10.1111/j.1463-1326.2008.01001.x
7. JM Howson NM Walker DJ Smyth JA Todd 2009 Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families Genes Immun 10 Suppl 1 S74 S84 19956106 10.1038/gene.2009.96 1:CAS:528:DC%2BD1MXhsV2ksLrO
8. S Nejentsev Z Gombos AP Laine, et al. 2000 Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B Diabetes 49 2217 2221 11118029 10.2337/diabetes.49.12.2217 1:CAS:528:DC%2BD3cXos1ejsbs%3D
9. WM Brown J Pierce JE Hilner, et al. 2009 Overview of the MHC fine mapping data Diabetes Obes Metab 11 Suppl 1 2 7 19143809 10.1111/j.1463-1326.2008. 00997.x
10. JC Mychaleckyj JA Noble PV Moonsamy, et al. 2010 HLA genotyping in the international Type 1 Diabetes Genetics Consortium Clin Trials 7 S75 87 20595243 10.1177/1740774510373494
11. LN Zake M Ghaderi YS Park S Babu G Eisenbarth CB Sanjeevi 2002 MHC class I chain-related gene alleles 5 and 5.1 are transmitted more frequently to type 1 diabetes offspring in HBDI families Ann NY Acad Sci 958 309 311 12021130 10.1111/j.1749-6632.2002.tb02993.x 1:CAS:528:DC%2BD38XltFakt78%3D (Pubitemid 34592251)
12. YS Park CB Sanjeevi D Robles, et al. 2002 Additional association of intra-MHC genes, MICA and D6S273, with Addison's disease Tissue Antigens 60 155 163 12392510 10.1034/j.1399-0039.2002.600206.x 1:CAS:528:DC%2BD38XptV2gurk%3D (Pubitemid 35314512)
13. TM Triolo EE Baschal TK Armstrong, et al. 2009 Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes J Clin Endocrinol Metab 94 4517 4523 19820007 10.1210/jc.2009-1308 1:CAS:528:DC%2BD1MXhsVejtb%2FO
14. JR O'Connell DE Weeks 1998 PedCheck: a program for identification of genotype incompatibilities in linkage analysis Am J Hum Genet 63 259 266 9634505 10.1086/301904 (Pubitemid 30428342)
15. GR Abecasis SS Cherny WO Cookson LR Cardon 2002 Merlin-rapid analysis of dense genetic maps using sparse gene flow trees Nat Genet 30 97 101 11731797 10.1038/ng786 1:CAS:528:DC%2BD38XivVGjtg%3D%3D
16. D Raum Z Awdeh EJ Yunis CA Alper KH Gabbay 1984 Extended major histocompatibility complex haplotypes in type I diabetes mellitus J Clin Invest 74 449 454 6746903 10.1172/JCI111441 1:STN:280:DyaL2c3msFWqtA%3D%3D (Pubitemid 14053992)
17. G Thomson 1995 Mapping disease genes: family-based association studies Am J Hum Genet 57 487 498 7668275 1:STN:280:DyaK2MzpslygsA%3D%3D
18. EE Baschal TA Aly JM Jasinski, et al. 2009 The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than other DR3 haplotypes Diabetes Obes Metab 11 Suppl 1 25 30 19143812 10.1111/j.1463-1326. 2008.01000.x 1:CAS:528:DC%2BD1MXivVWjsbc%3D
19. P Rubinstein M Walker C Carpenter, et al. 1981 Genetics of HLA-disease associations: the use of the haplotype relative risk (HRR) and the "haplo-delta" (Dh) estimates in juvenile diabetes from three racial groups Hum Immunol 3 384 10.1016/0198-8859(81)90023-9 (Pubitemid 12211735)
20. Q Kaas M Ruiz MP Lefranc 2004 IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, T cell receptor and MHC structural data Nucleic Acids Res 32 D208 D210 14681396 10.1093/nar/gkh042 1:CAS:528:DC%2BD3sXhtVSrur3N
21. EE Baschal TA Aly JM Jasinski, et al. 2009 Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes Clin Immunol 132 203 214 19427271 10.1016/j.clim.2009.03.530 1:CAS:528:DC%2BD1MXotl2nsr4%3D
22. LM McKenzie J Pecon-Slattery M Carrington SJ O'Brien 1999 Taxonomic hierarchy of HLA class I allele sequences Genes Immun 1 120 129 11196658 10.1038/sj.gene.6363648 1:CAS:528:DC%2BD3cXktlyhurc%3D (Pubitemid 129627289)
23. CA Alper CE Larsen DP Dubey ZL Awdeh DA Fici EJ Yunis 2006 The haplotype structure of the human major histocompatibility complex Hum Immunol 67 73 84 16698428 10.1016/j.humimm.2005.11.006 1:CAS:528:DC%2BD28Xks1eltrc%3D (Pubitemid 43673910)
24. K Lipponen Z Gombos M Kiviniemi, et al. 2010 Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes Diabetes 59 3253 3256 20739684 10.2337/db10-0167 1:CAS:528:DC%2BC3MXlsVakuw%3D%3D
25. JA Noble AM Valdes MD Varney, et al. 2010 HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium Diabetes 59 2972 2979 20798335 10.2337/db10-0699 1:CAS:528: DC%2BC3cXhsV2nsb3P
26. P Parham DA Lawlor CE Lomen PD Ennis 1989 Diversity and diversification of HLA-A, B, C alleles J Immunol 142 3937 3950 2715640 1:CAS:528: DyaL1MXlt1yhs7g%3D
27. G Vargas-Alarcon E Gomez-Casado J Martinez-Laso, et al. 1997 Differences in intron 2 sequences between B*39061 and B*39062 in Amerindians: comparison with those of B*3901, B*5101, and B*52012 alleles Immunogenetics 45 436 439 9089103 10.1007/s002510050227 1:CAS:528: DyaK2sXjt12qsLY%3D (Pubitemid 27163185)
28. JM Chen DN Cooper N Chuzhanova C Ferec GP Patrinos 2007 Gene conversion: mechanisms, evolution and human disease Nat Rev Genet 8 762 775 17846636 10.1038/nrg2193 1:CAS:528:DC%2BD2sXhtVCrsbzE (Pubitemid 47429210)
29. S Nejentsev H Reijonen B Adojaan, et al. 1997 The effect of HLA-B allele on the IDDM risk defined by DRB1*04 subtypes and DQB1*0302 Diabetes 46 1888 1892 9356041 10.2337/diabetes.46.11.1888 1:CAS:528:DyaK2sXntVKiur8%3D (Pubitemid 27456426)
30. Z Gombos J Wachowicz R Veijola, et al. 2006 Human leukocyte antigen non-class II determinants for type 1 diabetes in the Finnish population Hum Immunol 67 714 721 17002902 10.1016/j.humimm.2006.05.008 1:CAS:528: DC%2BD28XpvV2gsLk%3D (Pubitemid 44416009)