Use of synthetic Ca2+ channel peptides to study presynaptic function

Modulation of Presynaptic Calcium Channels

Volumn 9789400763340, Issue , 2013, Pages 223-240

  Bucci, Giovanna ^a   Mochida, Sumiko ^b   Stephens, Gary ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF READING   (United Kingdom)

Author keywords

Amino terminal; G protein modulation; I II loop; Synaptic transmission; Synprint site; Synthetic peptide

Indexed keywords

EID: 84890189553     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-94-007-6334-0_10     Document Type: Chapter

References (62)

1. Agler HL, Evans J, Tay LH, Anderson MJ, Colecraft HM, Yue DT (2005) G protein-gated inhibitory module of N-type (CaV2.2) Ca2C channels. Neuron 46:891-904
2. Bean BP (1989) Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature 340:153-156
3. Berrou L, Klein H, Bernatchez G, Parent L (2002) A specific tryptophan in the I-II linker is a key determinant of "-subunit binding and modulation in CaV2.3 calcium channels. Biophys J 83:1429-1442
4. Bezprozvanny I, Scheller RH, Tsien RW (1995) Functional impact of syntaxin on gating of N-type and Q-type calcium channels. Nature 378:623-626
5. Bichet D, Lecomte C, Sabatier JM, Felix R, DeWaard M (2000) Reversibility of the Ca2C channel ?1-" subunit interaction. Biochem Biophys Res Commun 277:729-735
6. Boland LM, Bean BP (1993) Modulation of N-type calcium channels in bullfrog sympathetic neurons by luteinizing hormone-releasing hormone, kinetics and voltage dependence. J Neurosci 13:516-533
7. Bucci G, Mochida S, Stephens GJ (2011) Inhibition of synaptic transmission and G protein modulation by synthetic CaV2.2 Ca2C channel peptides. J Physiol 589:3085-3101
8. Canti C, Page KM, Stephens GJ, Dolphin AC (1999) Identification of residues in the N terminus of ?1B critical for inhibition of the voltage-dependent calcium channel by G"". J Neurosci 19:6855-6864
9. Catterall WA (1999) Interactions of presynaptic Ca2C channels and SNARE proteins in neurotransmitter release. Ann NY Acad Sci 868:144-159
10. Chaplan SR, Pogrel JW, Yaksh TL (1994) Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia. J Pharmacol Exp Ther 269:1117-1123
11. Davies PJ, Ireland DR, McLachlan EM (1996) Sources of Ca2C for different Ca2C-activated KC conductances in neurones of the rat superior cervical ganglion. J Physiol 495:353-366
12. De Waard M, Witcher DR, Pragnell M, Liu H, Campbell KP (1995) Properties of the ?1-" anchoring site in voltage-dependent Ca2C channels. J Biol Chem 270:12056-12064
13. De Waard M, Liu H, Walker D, Scott VE, Gurnett CA, Campbell KP (1997) Direct binding of G-protein "" complex to voltage-dependent calcium channels. Nature 385:446-450
14. Dolphin AC (2003) G protein modulation of voltage-gated calcium channels. Pharmacol Rev 55:607-627
15. Eaholtz G, Scheuer T., Catterall WA (1994) Restoration of inactivation and block of open sodium channels by an inactivation gate peptide. Neuron 12:1041-1048
16. Furukawa T, Miura R, Mori Y, Strobeck M, Suzuki K, Ogihara Y, Asano T, Morishita R, Hashii M, Higashida H, Yoshii M, Nukada T (1998) Differential interactions of the C terminus and the cytoplasmic I-II loop of neuronal Ca2C channels with G-protein ? and "" subunits II. Evidence for direct binding. J Biol Chem 273:17595-17603
17. Herlitze S, Garcia DE, Mackie K, Hille B, Scheuer T., Catterall WA (1996) Modulation of Ca2C channels by G protein "" subunits. Nature 380:258-262
18. Herlitze S, Hockerman GH, Scheuer T., CatterallWA (1997) Molecular determinants of inactivation and G protein modulation in the intracellular loop connecting domains I and II of the calcium channel ?1A subunit. Proc Natl Acad Sci USA 94:1512-1516
19. Hohaus A, Poteser M, Romanin C, Klugbauer N, Hofmann F, Morano I, Haase H, Groschner K (2000) Modulation of the smooth-muscle L-type Ca2C channel ?1 subunit (?1C-b) by the "2a subunit, a peptide which inhibits binding of " to the I-II linker of ?1 induces functional uncoupling. Biochem J 348:657-665
20. Ikeda SR (1996) Voltage-dependent modulation of N-type calcium channels by G-protein "" subunits. Nature 380:255-258
21. Keith RK, Poage RE, Yokoyama CT, Catterall WA, Meriney SD (2007) Bidirectional modulation of transmitter release by calcium channel/syntaxin interactions in vivo. J Neurosci 25: 6984-6996
22. Leroy J, Richards MW, Butcher AJ, Nieto-Rostro M, Pratt WS, Davies A, Dolphin AC (2005) Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for "1 but not for palmitoylated "2, implicating an additional binding site in the regulation of channel voltage-dependent properties. J Neurosci 25:6984-6996
23. Li B, Zhong H, Scheuer T., Catterall WA (2004) Functional role of a C-terminal G""-binding domain of CaV2. 2 channels. Mol Pharm 66:761-769
24. Ma H, Mochida S (2007) A cholinergic model synapse to elucidate protein function at presynaptic terminals. Neurosci Res 57:491-498
25. Matthews EA, Dickenson AH (2001) Effects of spinally delivered N-and P-type voltage-dependent calcium channel antagonists on dorsal horn neuronal responses in a rat model of neuropathy. Pain 92:235-246
26. Mochida S, Saisu H, Kobayashi H, Abe T (1995) Impairment of syntaxin by botulinum neurotoxin C1 or antibodies inhibits acetylcholine release but not Ca2C channels channel activity. Neuroscience 65:905-915
27. Mochida S, Sheng ZH, Baker C, Kobayashi H, Catterall WA (1996) Inhibition of neurotransmission by peptides containing the synaptic protein interaction site of N-type Ca2C channels. Neuron 17:781-788
28. Mochida S, Yokoyama CT, KimDK, Itoh K, CatterallWA (1998) Evidence for a voltage-dependent enhancement of neurotransmitter release mediated via the synaptic protein interaction site of N-type Ca2C channels. Proc Natl Acad Sci USA 95:14523-14528
29. Mochida S, Westenbroek RE, Yokoyama CT, Itoh K, Catterall WA (2003) Subtype-selective reconstitution of synaptic transmission in sympathetic ganglion neurons by expression of exogenous calcium channels. Proc Natl Acad Sci USA 100:2813-2818
30. Opatowsky Y, Chen CC, Campbell KP, Hirsch JA (2004) Structural analysis of the voltagedependent calcium channel " subunit functional core and its complex with the ?1 interaction domain. Neuron 42:387-399
31. Page KM, Canti C, Stephens GJ, Berrow NS, Dolphin AC (1998) Identification of the amino terminus of neuronal Ca2C channel ?1 subunits ?1B and ?1E as an essential determinant of G-protein modulation. J Neurosci 18:4815-4824
32. Page KM, Heblich F, Margas W, Pratt W, Nieto-Rostro M, Chagger K, Sandhu K, Davies A, Dolphin AC (2010) N terminus is key to the dominant negative suppression of CaV2 calcium channels, implications for episodic ataxia type 2. J Biol Chem 285:835-844
33. Park J, Luo ZD (2010) Calcium channel functions in pain processing. Channels (Austin) 4: 510-517
34. Pragnell M, De Waard M, Mori Y, Tanabe T, Snutch TP, Campbell KP (1994) Calcium channel "-subunit binds to a conserved motif in the I-II cytoplasmic linker of the ?1-subunit. Nature 368:67-70
35. Qin N, Platano D, Olcese R, Stefani E, Birnbaumer L (1997) Direct interaction of G"" with a C-terminal G""-binding domain of the Ca2C channel ?1 subunit is responsible for channel inhibition by G protein-coupled receptors. Proc Natl Acad Sci USA 94:8866-8871
36. Rettig J, Sheng ZH, Kim DK, Hodson CD, Snutch TP, Catterall WA (1996) Isoform-specific interaction of the ?1A subunits of brain Ca2C channels with the presynaptic proteins syntaxin and SNAP-25. Proc Natl Acad Sci USA 93:7363-7368
37. Rettig J, Heinemann C, Ashery U, Sheng ZH, Yokoyama CT, Catterall WA, Neher E (1997) Alteration of Ca2C dependence of neurotransmitter release by disruption of Ca2C channel/syntaxin interaction. J Neurosci 17:6647-6656
38. Richman RW, Strock J, Hains MD, Cabanilla NJ, Lau KK, Siderovski DP, Diversé-Pierluissi M (2005) RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channel. J Biol Chem 280:1521-1518
39. Saegusa H, Kurihara T, Zong S, Kazuno A, Matsuda Y, Nonaka T, Han W, Toriyama H, Tanabe T (2001) Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2C channel. EMBO J 20:2349-2356
40. Sasaki T, Shibasaki T, Béguin P, Nagashima K, Miyazaki M, Seino S (2005) Direct inhibition of the interaction between alpha-interaction domain and beta-interaction domain of voltagedependent Ca2C channels by Gem. J Biol Chem 280:9308-9312
41. Sheng ZH, Rettig J, Takahashi M, Catterall WA (1994) Identification of a syntaxin-binding site on N-type calcium channels. Neuron 13:1303-1313
42. Sheng ZH, Yokoyama CT, CatterallWA (1997) Phosphorylation of the synaptic protein interaction site on N-type calcium channels inhibits interactions with SNARE proteins. J Neurosci 17:6929-6938
43. Simen AA, Miller RJ (1998) Structural features determining differential receptor regulation of neuronal Ca channels. J Neurosci 18:3689-3698
44. Simen AA, Miller RJ (2000) Involvement of regions in domain I in the opioid receptor sensitivity of ?1B Ca2C channels. Mol Pharm 57:1064-1074
45. Spafford JD, Munno DW, Van Nierop P, Feng ZP, Jarvis SE, Gallin WJ, Smit AB, Zamponi GW, Syed NI (2003) Calcium channel structural determinants of synaptic transmission between identified invertebrate neurons. J Biol Chem 278:4258-4267
46. Staats PS, Yearwood T, Charapata SG, Presley RW, Wallace MS, Byas-Smith M, Fisher R, Bryce DA, Mangieri EA, Luther RR, Mayo M, McGuire D, Ellis D (2004) Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS, a randomized controlled trial. JAMA 291:63-70
47. Stephens GJ,Mochida S (2005) G protein "" subunits mediate presynaptic inhibition of transmitter release from rat superior cervical ganglion neurones in culture. J Physiol 563:765-776
48. Stephens GJ, Robertson B (1995) Inactivation of the cloned potassium channel mouse Kv1.1 by the human Kv3.4 ?ball? peptide and its chemical modification. J Physiol 484:1-13
49. Stephens GJ, Canti C, Page KM, Dolphin AC (1998) Role of domain I of neuronal Ca2C channel ?1 subunits in G protein modulation. J Physiol 509:163-169
50. Stephens GJ, Page KM, Bogdanov Y, Dolphin AC (2000) The ?1B Ca2C channel amino terminus contributes determinants for " subunit-mediated voltage-dependent inactivation properties. J Physiol 525:377-90
51. Tedford HW, Zamponi GW (2006) Direct G protein modulation of CaV2 calcium channels. Pharmacol Rev 58:837-862
52. Van Petegem F, Clark KA, Chatelain FC, Minor DL (2004) Structure of a complex between a voltage-gated calcium channel "-subunit and an ?-subunit domain. Nature 429:671-675
53. Van Petegem F, Duderstadt KE, Clark KA, Wang M, Minor DL (2008) Alanine-scanning mutagenesis defines a conserved energetic hotspot in the CaV?1 AID-CaV" interaction site that is critical for channel modulation. Structure 16:280-294
54. Vanegas H, Schaible H (2000) Effects of antagonists to high-threshold calcium channels upon spinal mechanisms of pain, hyperalgesia and allodynia. Pain 85:9-18
55. Vogl C, Mochida S, Wolff C, Whalley BJ, Stephens GJ (2012) The synaptic vesicle glycoprotein 2A ligand levetiracetam inhibits presynaptic Ca2C channels through an intracellular pathway. Mol Pharmacol 82:199-208
56. Watanabe H, Yamashita T, Saitoh N, Kiyonaka S, Iwamatsu A, Campbell KP, Mori Y, Takahashi T (2010) Involvement of Ca2C channel synprint site in synaptic vesicle endocytosis. J Neurosci 30:655-660
57. Wilson SM, Schmutzler BS, Brittain JM, Dustrude ET, Ripsch MS, Pellman JJ, Yeum TS, Hurley JH, Hingtgen CM, White FA, Khanna R (2012) Inhibition of transmitter release and attenuation of AIDS therapy-Induced and tibial nerve injury-related painful peripheral neuropathy by novel synthetic Ca2C channel peptides. J Biol Chem 287:35065-35077
58. Yokoyama CT, Sheng ZH, CatterallWA (1997) Phosphorylation of the synaptic protein interaction site on N-type calcium channels inhibits interactions with SNARE proteins. J Neurosci 17:6929-6938
59. Yokoyama CT, Myers SJ, Fu J, Mockus SM, Scheuer T., Catterall WA (2005) Mechanism of SNARE protein binding and regulation of Cav2 channels by phosphorylation of the synaptic protein interaction site. Mol Cell Neurosci 28:1-17
60. Zagotta WN, Hoshi T, Aldrich RW (1990) Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science 250:568-571
61. Zamponi GW, Bourinet E, Nelson D, Nargeot J, Snutch TP (1997) Crosstalk between G proteins and protein kinase C mediated by the calcium channel ?1 subunit. Nature 385:442-446
62. Zamponi GW, Lewis RJ, Todorovic SM, Arneric SP, Snutch TP (2009) Role of voltage-gated calcium channels in ascending pain pathways. Brain Res Rev 60:84-89