메뉴 건너뛰기




Volumn 25, Issue , 2014, Pages 31-37

Molecular computation in neurons: A modeling perspective

Author keywords

[No Author keywords available]

Indexed keywords

CALCULATION; CELL FUNCTION; CELLULAR MEMORY; CHEMICAL PARAMETERS; CHEMICAL SIGNALING; DECISION MAKING; DENDRITE; MEMORY; MOLECULAR COMPUTATION; NERVE CELL; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NERVE FIBER; PRIORITY JOURNAL; REVIEW; SYNAPSE; ANIMAL; BIOLOGICAL MODEL; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

EID: 84890181390     PISSN: 09594388     EISSN: 18736882     Source Type: Journal    
DOI: 10.1016/j.conb.2013.11.006     Document Type: Review
Times cited : (38)

References (55)
  • 2
    • 0033365730 scopus 로고    scopus 로고
    • Can molecules explain long-term potentiation?
    • Sanes J.R., Lichtman J.W. Can molecules explain long-term potentiation?. Nat Neurosci 1999, 2:597-604.
    • (1999) Nat Neurosci , vol.2 , pp. 597-604
    • Sanes, J.R.1    Lichtman, J.W.2
  • 3
    • 0010424768 scopus 로고
    • A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase
    • Lisman J.E. A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase. Proc Natl Acad Sci U S A 1985, 82:3055-3057.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 3055-3057
    • Lisman, J.E.1
  • 4
    • 48249085332 scopus 로고    scopus 로고
    • Spike timing-dependent plasticity: a Hebbian learning rule
    • Caporale N., Dan Y. Spike timing-dependent plasticity: a Hebbian learning rule. Annu Rev Neurosci 2008, 31:25-46.
    • (2008) Annu Rev Neurosci , vol.31 , pp. 25-46
    • Caporale, N.1    Dan, Y.2
  • 5
    • 15044340596 scopus 로고    scopus 로고
    • Spike-timing-dependent synaptic plasticity depends on dendritic location
    • Froemke R.C., Poo M.-M., Dan Y. Spike-timing-dependent synaptic plasticity depends on dendritic location. Nature 2005, 434:221-225.
    • (2005) Nature , vol.434 , pp. 221-225
    • Froemke, R.C.1    Poo, M.-M.2    Dan, Y.3
  • 6
    • 0036655823 scopus 로고    scopus 로고
    • Biochemical signaling networks decode temporal patterns of synaptic input
    • Bhalla U.S. Biochemical signaling networks decode temporal patterns of synaptic input. J Comput Neurosci 2002, 13:49-62.
    • (2002) J Comput Neurosci , vol.13 , pp. 49-62
    • Bhalla, U.S.1
  • 7
    • 9644270413 scopus 로고    scopus 로고
    • A role for ERKII in synaptic pattern selectivity on the time-scale of minutes
    • Ajay S.M., Bhalla U.S. A role for ERKII in synaptic pattern selectivity on the time-scale of minutes. Eur J Neurosci 2004, 20:2671-2680.
    • (2004) Eur J Neurosci , vol.20 , pp. 2671-2680
    • Ajay, S.M.1    Bhalla, U.S.2
  • 8
    • 77649204115 scopus 로고    scopus 로고
    • Temporal sensitivity of protein kinase a activation in late-phase long term potentiation
    • Kim M., Huang T., Abel T., Blackwell K.T. Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. PLoS Comput Biol 2010, 6:e1000691.
    • (2010) PLoS Comput Biol , vol.6
    • Kim, M.1    Huang, T.2    Abel, T.3    Blackwell, K.T.4
  • 9
    • 0035997011 scopus 로고    scopus 로고
    • Mechanisms for temporal tuning and filtering by postsynaptic signaling pathways
    • Bhalla U.S. Mechanisms for temporal tuning and filtering by postsynaptic signaling pathways. Biophys J 2002, 83:740-752.
    • (2002) Biophys J , vol.83 , pp. 740-752
    • Bhalla, U.S.1
  • 10
    • 33646171899 scopus 로고    scopus 로고
    • A model of the roles of essential kinases in the induction and expression of late long-term potentiation
    • Smolen P., Baxter D.A., Byrne J.H. A model of the roles of essential kinases in the induction and expression of late long-term potentiation. Biophys J 2006, 90:2760-2775.
    • (2006) Biophys J , vol.90 , pp. 2760-2775
    • Smolen, P.1    Baxter, D.A.2    Byrne, J.H.3
  • 11
    • 0036678999 scopus 로고    scopus 로고
    • A unified model of NMDA receptor-dependent bidirectional synaptic plasticity
    • Shouval H.Z., Bear M.F., Cooper L.N. A unified model of NMDA receptor-dependent bidirectional synaptic plasticity. Proc Natl Acad Sci U S A 2002, 99:10831-10836.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10831-10836
    • Shouval, H.Z.1    Bear, M.F.2    Cooper, L.N.3
  • 12
    • 33746208993 scopus 로고    scopus 로고
    • Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity
    • Badoual M., Zou Q., Davison A.P., Rudolph M., Bal T., Frégnac Y., Destexhe A. Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity. Int J Neural Syst 2006, 16:79-97.
    • (2006) Int J Neural Syst , vol.16 , pp. 79-97
    • Badoual, M.1    Zou, Q.2    Davison, A.P.3    Rudolph, M.4    Bal, T.5    Frégnac, Y.6    Destexhe, A.7
  • 13
    • 41549148361 scopus 로고    scopus 로고
    • Requirement of an allosteric kinetics of NMDA receptors for spike timing-dependent plasticity
    • Urakubo H., Honda M., Froemke R.C., Kuroda S. Requirement of an allosteric kinetics of NMDA receptors for spike timing-dependent plasticity. J Neurosci 2008, 28:3310-3323.
    • (2008) J Neurosci , vol.28 , pp. 3310-3323
    • Urakubo, H.1    Honda, M.2    Froemke, R.C.3    Kuroda, S.4
  • 14
    • 0031024891 scopus 로고    scopus 로고
    • Synaptic tagging and long-term potentiation
    • Frey U., Morris R.G. Synaptic tagging and long-term potentiation. Nature 1997, 385:533-536.
    • (1997) Nature , vol.385 , pp. 533-536
    • Frey, U.1    Morris, R.G.2
  • 15
    • 39349117773 scopus 로고    scopus 로고
    • A Model of Late Long-Term Potentiation Simulates Aspects of Memory Maintenance
    • Smolen P. A Model of Late Long-Term Potentiation Simulates Aspects of Memory Maintenance. PLoS ONE 2007, 2:e445.
    • (2007) PLoS ONE , vol.2
    • Smolen, P.1
  • 16
    • 58149165031 scopus 로고    scopus 로고
    • Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression
    • Clopath C., Ziegler L., Vasilaki E., Büsing L., Gerstner W. Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression. PLoS Comput Biol 2008, 4:e1000248.
    • (2008) PLoS Comput Biol , vol.4
    • Clopath, C.1    Ziegler, L.2    Vasilaki, E.3    Büsing, L.4    Gerstner, W.5
  • 18
    • 84866113882 scopus 로고    scopus 로고
    • Molecular constraints on synaptic tagging and maintenance of long-term potentiation: a predictive model
    • Smolen P., Baxter D.A., Byrne J.H. Molecular constraints on synaptic tagging and maintenance of long-term potentiation: a predictive model. PLoS Comput Biol 2012, 8:e1002620.
    • (2012) PLoS Comput Biol , vol.8
    • Smolen, P.1    Baxter, D.A.2    Byrne, J.H.3
  • 19
    • 84875980615 scopus 로고    scopus 로고
    • Signaling pathways involved in striatal synaptic plasticity are sensitive to temporal pattern and exhibit spatial specificity
    • Kim B., Hawes S.L., Gillani F., Wallace L.J., Blackwell K.T. Signaling pathways involved in striatal synaptic plasticity are sensitive to temporal pattern and exhibit spatial specificity. PLoS Comput Biol 2013, 9:e1002953.
    • (2013) PLoS Comput Biol , vol.9
    • Kim, B.1    Hawes, S.L.2    Gillani, F.3    Wallace, L.J.4    Blackwell, K.T.5
  • 20
    • 80053202815 scopus 로고    scopus 로고
    • Multiscale interactions between chemical and electric signaling in LTP induction, LTP reversal and dendritic excitability
    • Bhalla U.S. Multiscale interactions between chemical and electric signaling in LTP induction, LTP reversal and dendritic excitability. Neural Netw 2011, 24:943-949.
    • (2011) Neural Netw , vol.24 , pp. 943-949
    • Bhalla, U.S.1
  • 22
    • 44349158874 scopus 로고    scopus 로고
    • Calmodulin Activation by Calcium Transients in the Postsynaptic Density of Dendritic Spines
    • Keller D.X., Franks K.M., Bartol T.M., Sejnowski T.J. Calmodulin Activation by Calcium Transients in the Postsynaptic Density of Dendritic Spines. PLoS ONE 2008, 3:e2045.
    • (2008) PLoS ONE , vol.3
    • Keller, D.X.1    Franks, K.M.2    Bartol, T.M.3    Sejnowski, T.J.4
  • 23
    • 77955495739 scopus 로고    scopus 로고
    • Quantifying the effects of elastic collisions and non-covalent binding on glutamate receptor trafficking in the post-synaptic density
    • Santamaria F., Gonzalez J., Augustine G.J., Raghavachari S. Quantifying the effects of elastic collisions and non-covalent binding on glutamate receptor trafficking in the post-synaptic density. PLoS Comput Biol 2010, 6:e1000780.
    • (2010) PLoS Comput Biol , vol.6
    • Santamaria, F.1    Gonzalez, J.2    Augustine, G.J.3    Raghavachari, S.4
  • 26
    • 77649220774 scopus 로고    scopus 로고
    • A propagating ERKII switch forms zones of elevated dendritic activation correlated with plasticity
    • Ajay S.M., Bhalla U.S. A propagating ERKII switch forms zones of elevated dendritic activation correlated with plasticity. HFSP J 2007, 1:49-66.
    • (2007) HFSP J , vol.1 , pp. 49-66
    • Ajay, S.M.1    Bhalla, U.S.2
  • 29
    • 84871002619 scopus 로고    scopus 로고
    • Short-term plasticity constrains spatial organization of a hippocampal presynaptic terminal
    • Nadkarni S., Bartol T.M., Stevens C.F., Sejnowski T.J., Levine H. Short-term plasticity constrains spatial organization of a hippocampal presynaptic terminal. Proc Natl Acad Sci 2012, 109:14657-14662.
    • (2012) Proc Natl Acad Sci , vol.109 , pp. 14657-14662
    • Nadkarni, S.1    Bartol, T.M.2    Stevens, C.F.3    Sejnowski, T.J.4    Levine, H.5
  • 30
    • 19344362210 scopus 로고    scopus 로고
    • The stability of a stochastic CaMKII switch: dependence on the number of enzyme molecules and protein turnover
    • Miller P., Zhabotinsky A.M., Lisman J.E., Wang X.-J. The stability of a stochastic CaMKII switch: dependence on the number of enzyme molecules and protein turnover. PLoS Biol 2005, 3:e107.
    • (2005) PLoS Biol , vol.3
    • Miller, P.1    Zhabotinsky, A.M.2    Lisman, J.E.3    Wang, X.-J.4
  • 31
    • 36949013689 scopus 로고    scopus 로고
    • STDP in a bistable synapse model based on CaMKII and associated signaling pathways
    • Graupner M., Brunel N. STDP in a bistable synapse model based on CaMKII and associated signaling pathways. PLoS Comput Biol 2007, 3:e221.
    • (2007) PLoS Comput Biol , vol.3
    • Graupner, M.1    Brunel, N.2
  • 33
    • 0033555859 scopus 로고    scopus 로고
    • Emergent properties of networks of biological signaling pathways
    • Bhalla U.S., Iyengar R. Emergent properties of networks of biological signaling pathways. Science 1999, 283:381-387.
    • (1999) Science , vol.283 , pp. 381-387
    • Bhalla, U.S.1    Iyengar, R.2
  • 34
    • 0035426160 scopus 로고    scopus 로고
    • Exploration of signal transduction pathways in cerebellar long-term depression by kinetic simulation
    • Kuroda S., Schweighofer N., Kawato M. Exploration of signal transduction pathways in cerebellar long-term depression by kinetic simulation. J Neurosci 2001, 21:5693-5702.
    • (2001) J Neurosci , vol.21 , pp. 5693-5702
    • Kuroda, S.1    Schweighofer, N.2    Kawato, M.3
  • 35
    • 84863475698 scopus 로고    scopus 로고
    • A stochastic signaling network mediates the probabilistic induction of cerebellar long-term depression
    • Antunes G., Schutter E.D. A stochastic signaling network mediates the probabilistic induction of cerebellar long-term depression. J Neurosci 2012, 32:9288-9300.
    • (2012) J Neurosci , vol.32 , pp. 9288-9300
    • Antunes, G.1    Schutter, E.D.2
  • 36
    • 77649195559 scopus 로고    scopus 로고
    • A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticity
    • Nakano T., Doi T., Yoshimoto J., Doya K. A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticity. PLoS Comput Biol 2010, 6:e1000670.
    • (2010) PLoS Comput Biol , vol.6
    • Nakano, T.1    Doi, T.2    Yoshimoto, J.3    Doya, K.4
  • 37
    • 14044257954 scopus 로고    scopus 로고
    • Dynamic properties of regulatory motifs associated with induction of three temporal domains of memory in aplysia
    • Pettigrew D.B., Smolen P., Baxter D.A., Byrne J.H. Dynamic properties of regulatory motifs associated with induction of three temporal domains of memory in aplysia. J Comput Neurosci 2005, 18:163-181.
    • (2005) J Comput Neurosci , vol.18 , pp. 163-181
    • Pettigrew, D.B.1    Smolen, P.2    Baxter, D.A.3    Byrne, J.H.4
  • 38
    • 67650815473 scopus 로고    scopus 로고
    • Translational switch for long-term maintenance of synaptic plasticity [Internet]
    • Aslam N., Kubota Y., Wells D., Shouval H.Z. Translational switch for long-term maintenance of synaptic plasticity [Internet]. Mol Syst Biol 2009, 5.
    • (2009) Mol Syst Biol , pp. 5
    • Aslam, N.1    Kubota, Y.2    Wells, D.3    Shouval, H.Z.4
  • 39
    • 61449146200 scopus 로고    scopus 로고
    • Signaling logic of activity-triggered dendritic protein synthesis: an mTOR gate but not a feedback switch
    • Jain P., Bhalla U.S. Signaling logic of activity-triggered dendritic protein synthesis: an mTOR gate but not a feedback switch. PLoS Comput Biol 2009, 5:e1000287.
    • (2009) PLoS Comput Biol , vol.5
    • Jain, P.1    Bhalla, U.S.2
  • 40
    • 57149098589 scopus 로고    scopus 로고
    • Systems biology perspectives on cerebellar long-term depression
    • Ogasawara H., Doi T., Kawato M. Systems biology perspectives on cerebellar long-term depression. Neurosignals 2008, 16:300-317.
    • (2008) Neurosignals , vol.16 , pp. 300-317
    • Ogasawara, H.1    Doi, T.2    Kawato, M.3
  • 41
  • 42
    • 84872936192 scopus 로고    scopus 로고
    • LTP requires a reserve pool of glutamate receptors independent of subunit type
    • Granger A.J., Shi Y., Lu W., Cerpas M., Nicoll R.A. LTP requires a reserve pool of glutamate receptors independent of subunit type. Nature 2013, 493:495-500.
    • (2013) Nature , vol.493 , pp. 495-500
    • Granger, A.J.1    Shi, Y.2    Lu, W.3    Cerpas, M.4    Nicoll, R.A.5
  • 43
    • 80052453779 scopus 로고    scopus 로고
    • Trafficking motifs as the basis for two-compartment signaling systems to form multiple stable states
    • Bhalla U.S. Trafficking motifs as the basis for two-compartment signaling systems to form multiple stable states. Biophys J 2011, 101:21-32.
    • (2011) Biophys J , vol.101 , pp. 21-32
    • Bhalla, U.S.1
  • 44
    • 33749370872 scopus 로고    scopus 로고
    • Molecular switches at the synapse emerge from receptor and kinase traffic
    • Hayer A., Bhalla U.S. Molecular switches at the synapse emerge from receptor and kinase traffic. PLoS Comput Biol 2005, 1:137-154.
    • (2005) PLoS Comput Biol , vol.1 , pp. 137-154
    • Hayer, A.1    Bhalla, U.S.2
  • 45
    • 80755168040 scopus 로고    scopus 로고
    • Dendritic spine dynamics regulate the long-term stability of synaptic plasticity
    • O'Donnell C., Nolan M.F., van Rossum M.C.W. Dendritic spine dynamics regulate the long-term stability of synaptic plasticity. J Neurosci 2011, 31:16142-16156.
    • (2011) J Neurosci , vol.31 , pp. 16142-16156
    • O'Donnell, C.1    Nolan, M.F.2    van Rossum, M.C.W.3
  • 46
    • 0032167980 scopus 로고    scopus 로고
    • Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus
    • Nusser Z., Lujan R., Laube G., Roberts J.D., Molnar E., Somogyi P. Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus. Neuron 1998, 21:545-559.
    • (1998) Neuron , vol.21 , pp. 545-559
    • Nusser, Z.1    Lujan, R.2    Laube, G.3    Roberts, J.D.4    Molnar, E.5    Somogyi, P.6
  • 47
    • 4143118798 scopus 로고    scopus 로고
    • Signaling in small subcellular volumes. I. Stochastic and diffusion effects on individual pathways
    • Bhalla U.S. Signaling in small subcellular volumes. I. Stochastic and diffusion effects on individual pathways. Biophys J 2004, 87:733-744.
    • (2004) Biophys J , vol.87 , pp. 733-744
    • Bhalla, U.S.1
  • 48
    • 27144517984 scopus 로고    scopus 로고
    • Interlinked fast and slow positive feedback loops drive reliable cell decisions
    • Brandman O., Ferrell J.E., Li R., Meyer T. Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science 2005, 310:496-498.
    • (2005) Science , vol.310 , pp. 496-498
    • Brandman, O.1    Ferrell, J.E.2    Li, R.3    Meyer, T.4
  • 49
    • 13844266723 scopus 로고    scopus 로고
    • Cascade models of synaptically stored memories
    • Fusi S., Drew P.J., Abbott L.F. Cascade models of synaptically stored memories. Neuron 2005, 45:599-611.
    • (2005) Neuron , vol.45 , pp. 599-611
    • Fusi, S.1    Drew, P.J.2    Abbott, L.F.3
  • 50
    • 63249118904 scopus 로고    scopus 로고
    • Interlinked dual-time feedback loops can enhance robustness to stochasticity and persistence of memory
    • Smolen P., Baxter D.A., Byrne J.H. Interlinked dual-time feedback loops can enhance robustness to stochasticity and persistence of memory. Phys Rev E Stat Nonlin Soft Matter Phys 2009, 79:031902.
    • (2009) Phys Rev E Stat Nonlin Soft Matter Phys , vol.79 , pp. 031902
    • Smolen, P.1    Baxter, D.A.2    Byrne, J.H.3
  • 51
    • 22144441670 scopus 로고    scopus 로고
    • Graded bidirectional synaptic plasticity is composed of switch-like unitary events
    • O'Connor D.H., Wittenberg G.M., Wang S.S.-H. Graded bidirectional synaptic plasticity is composed of switch-like unitary events. Proc Natl Acad Sci U S A 2005, 102:9679-9684.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9679-9684
    • O'Connor, D.H.1    Wittenberg, G.M.2    Wang, S.S.-H.3
  • 52
    • 67650360968 scopus 로고    scopus 로고
    • Unlimited multistability in multisite phosphorylation systems
    • Thomson M., Gunawardena J. Unlimited multistability in multisite phosphorylation systems. Nature 2009, 460:274-277.
    • (2009) Nature , vol.460 , pp. 274-277
    • Thomson, M.1    Gunawardena, J.2
  • 54
    • 26444508473 scopus 로고    scopus 로고
    • Clusters of interacting receptors can stabilize synaptic efficacies
    • Shouval H.Z. Clusters of interacting receptors can stabilize synaptic efficacies. Proc Natl Acad Sci U S A 2005, 102:14440-14445.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 14440-14445
    • Shouval, H.Z.1
  • 55
    • 77649152514 scopus 로고    scopus 로고
    • Connectivity reflects coding: a model of voltage-based STDP with homeostasis
    • Clopath C., Büsing L., Vasilaki E., Gerstner W. Connectivity reflects coding: a model of voltage-based STDP with homeostasis. Nat Neurosci 2010, 13:344-352.
    • (2010) Nat Neurosci , vol.13 , pp. 344-352
    • Clopath, C.1    Büsing, L.2    Vasilaki, E.3    Gerstner, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.