The use of tranexamic acid to reduce blood loss and transfusion in major orthopedic surgery: A meta-analysis

Journal of Surgical Research

Volumn 186, Issue 1, 2014, Pages 318-327

  Huang, Fei ^a   Wu, Dan ^a   Ma, Guangwen ^a   Yin, Zongsheng ^a   Wang, Qing ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Blood loss; Meta analysis; Tranexamic acid; Transfusion

Indexed keywords

TRANEXAMIC ACID;

ARTICLE; BLEEDING; BLOOD TRANSFUSION; DEEP VEIN THROMBOSIS; FRACTURE FIXATION; HUMAN; INTRAOPERATIVE PERIOD; META ANALYSIS; ORTHOPEDIC SURGERY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SPINE SURGERY; TOTAL HIP PROSTHESIS; TOTAL KNEE REPLACEMENT;

BLOOD LOSS; META-ANALYSIS; TRANEXAMIC ACID; TRANSFUSION;

ANTI-ARRHYTHMIA AGENTS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; BLOOD VOLUME; HUMANS; ORTHOPEDIC PROCEDURES; TRANEXAMIC ACID; VENOUS THROMBOSIS;

EID: 84890130037     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.08.020     Document Type: Article

References (61)

1. T.P. Sculco Global blood management in orthopaedic surgery Clin Orthop Relat Res 357 1998 43
2. D. Cardone, and A.A. Klein Perioperative blood conservation Eur J Anaesthesiol 26 2009 722
3. J. Etchason, L. Petz, and E. Keeler The cost effectiveness of preoperative autologous blood donations N Engl J Med 332 1995 719
4. J.F. Hardy, and S. Bélisle Natural and synthetic antifibrinolytics: inert, poisonous or therapeutic agents? Can J Anaesth 44 1997 913
5. L. Massicotte, A.Y. Denault, D. Beaulieu, L. Thibeault, Z. Hevesi, and A. Roy Aprotinin versus tranexamic acid during liver transplantation: impact on blood product requirements and survival Transplantation 91 2011 1273
6. A. Dhir Antifibrinolytics in cardiac surgery Ann Card Anaesth 16 2013 117
7. A. Rannikko, A. Pétas, and K. Taari Tranexamic acid in control of primary hemorrhage during transurethral prostatectomy Urology 64 2004 955
8. M.J. Coetzee The use of topical crushed tranexamic acid tablets to control bleeding after dental surgery and from skin ulcers in haemophilia Haemophilia 13 2007 443
9. J.D. Eubanks Antifibrinolytics in major orthopaedic surgery J Am Acad Orthop Surg 18 2010 132
10. D. Moher, D.J. Cook, S. Eastwood, I. Olkin, D. Rennie, and D.F. Stroup Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of reporting of meta-analyses Lancet 354 1999 1896
11. Handoll H, Elstub L, Elliott J, et al. Cochrane Bone, Joint and Muscle Trauma Group. About the Cochrane collaboration (Cochrane review groups (CRGS)) 2008; Issue 4. Art. No: MUSKINJ.
12. J.P. Higgins, and S.G. Thompson Quantifying heterogeneity in a meta-analysis Stat Med 21 2002 1539
13. K. Ido, M. Neo, and Y. Asada Reduction of blood loss using tranexamic acid in total knee and hip arthroplasties Arch Orthop Trauma Surg 120 2000 518
14. R. Malhotra, V. Kumar, and B. Garg The use of tranexamic acid to reduce blood loss in primary cementless total hip arthroplasty Eur J Orthop Surg Traumatol 21 2011 101
15. M.A. Claeys, N. Vermeersch, and P. Haentjens Reduction of blood loss with tranexamic acid in primary total hip replacement surgery Acta Chir Belg 107 2007 397
16. H. Husted, L. Blønd, S. Sonne-Holm, G. Holm, T.W. Jacobsen, and P. Gebuhr Tranexamic acid reduces blood loss and blood transfusions in primary total hip arthroplasty: a prospective randomized double-blind study in 40 patients Acta Orthop Scand 74 2003 665
17. T. Johansson, L.G. Pettersson, and B. Lisander Tranexamic acid in total hip arthroplasty saves blood and money: a randomized, double-blind study in 100 patients Acta Orthop 76 2005 314
18. G. Benoni, S. Lethagen, P. Nilsson, and H. Fredin Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty Acta Orthop Scand 71 2000 250
19. G. Benoni, H. Fredin, R. Knebel, and P. Nilsson Blood conservation with tranexamic acid in total hip arthroplasty: a randomized, double-blind study in 40 primary operations Acta Orthop Scand 72 2001 442
20. N. Garneti, and J. Field Bone bleeding during total hip arthroplasty after administration of tranexamic acid J Arthroplasty 19 2004 488
21. J.S. McConnell, S. Shewale, N.A. Munro, K. Shah, A.H. Deakin, and A.W. Kinninmonth Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray Acta Orthop 82 2011 660
22. K. Rajesparan, L.C. Biant, M. Ahmad, and R.E. Field The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement J Bone Joint Surg Br 91 2009 776
23. S. Yamasaki, K. Masuhara, and T. Fuji Tranexamic acid reduces blood loss after cementless total hip arthroplasty - prospective randomized study in 40 cases Int Orthop 28 2004 69
24. R.O. Niskanen, and O.L. Korkala Tranexamic acid reduces blood loss in cemented hip arthroplasty: a randomized, double-blind study of 39 patients with osteoarthritis Acta Orthop 76 2005 829
25. E. Lemay, J. Guay, C. Côté, and A. Roy Tranexamic acid reduces the need for allogenic red blood cell transfusions in patients undergoing total hip replacement Can J Anaesth 51 2004 31
26. S.M. Kazemi, F. Mosaffa, and A. Eajazi The effect of tranexamic acid on reducing blood loss in cementless total hip arthroplasty under epidural anesthesia Orthopaedics 33 2010 17
27. G. Ekbäck, K. Axelsson, and L. Ryttberg Tranexamic acid reduces blood loss in total hip replacement surgery Anesth Analg 91 2000 1124
28. R.G. MacGillivray, S.B. Tarabichi, M.F. Hawari, and N.T. Raoof Tranexamic acid to reduce blood loss after bilateral total knee arthroplasty: a prospective, randomized double blind study J Arthroplasty 26 2011 24
29. M.H. Ellis, B. Fredman, E. Zohar, N. Ifrach, and R. Jedeikin The effect of tourniquet application, tranexamic acid, and desmopressin on the procoagulant and fibrinolytic systems during total knee replacement J Clin Anesth 13 2001 509
30. M.A. Camarasa, G. Ollé, and M. Serra-Prat Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial Br J Anaesth 96 2006 576
31. A.J. Jansen, S. Andreica, M. Claeys, J. D'Haese, F. Camu, and K. Jochmans Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty Br J Anaesth 83 1999 596
32. L. Good, E. Peterson, and B. Lisander Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement Br J Anaesth 90 2003 596
33. N. Tanaka, H. Sakahashi, E. Sato, K. Hirose, T. Ishima, and S. Ishii Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee J Bone Joint Surg Br 83 2001 702
34. K. Charoencholvanich, and P. Siriwattanasakul Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial Clin Orthop Relat Res 469 2011 2874
35. E. Zohar, M. Ellis, N. Ifrach, A. Stern, O. Sapir, and B. Fredman The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement Anesth Analg 99 2004 1679
36. J. Wong, A. Abrishami, and H. El Beheiry Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial J Bone Joint Surg Am 92 2010 2503
37. P.C. Lin, C.H. Hsu, W.S. Chen, and J.W. Wang Does tranexamic acid save blood in minimally invasive total knee arthroplasty? Clin Orthop Relat Res 469 2011 1995
38. Molloy DO, H.A. Archbold, L. Ogonda, J. McConway, R.K. Wilson, and D.E. Beverland Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial J Bone Joint Surg Br 89 2007 306
39. S.P. Roy, U.F. Tanki, A. Dutta, S.K. Jain, and O.N. Nagi Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty Knee Surg Sports Traumatol Arthrosc 20 2012 2494
40. G. Benoni, and H. Fredin Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients J Bone Joint Surg Br 78 1996 434
41. P.N. Kakar, N. Gupta, P. Govil, and V. Shah Efficacy and safety of tranexamic acid in control of bleeding following TKR: a randomized clinical trial Indian J Anaesth 53 2009 667
42. S.T. Hiippala, L.J. Strid, and M.I. Wennerstrand Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty Anesth Analg 84 1997 839
43. S. Hiippala, L. Strid, and M. Wennerstrand Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty Br J Anaesth 74 1995 534
44. M. Veien, J.V. Sørensen, F. Madsen, and P. Juelsgaard Tranexamic acid given intraoperatively reduces blood loss after total knee replacement: a randomized, controlled study Acta Anaesthesiol Scand 46 2002 1206
45. K. Chareancholvanich, P. Siriwattanasakul, R. Narkbunnam, and C. Pornrattanamaneewong Temporary clamping of drain combined with tranexamic acid reduce blood loss after total knee arthroplasty: a prospective randomized controlled trial BMC Musculoskelet Disord 13 2012 124
46. J.C. Alvarez, F.X. Santiveri, I. Ramos, E. Vela, L. Puig, and F. Escolano Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied Transfusion 48 2008 519
47. N.M. Orpen, C. Little, G. Walker, and E.J. Crawfurd Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients Knee 13 2006 106
48. J.M. Engel, T. Hohaus, R. Ruwoldt, T. Menges, I. Jürgensen, and G. Hempelmann Regional hemostatic status and blood requirements after total knee arthroplasty with and without tranexamic acid or aprotinin Anesth Analg 92 2001 775
49. P.J. Zufferey, M. Miquet, and S. Quenet Tranexamic acid in hip fracture surgery: a randomized controlled trial Br J Anaesth 104 2010 23
50. M. Sadeghi, and A. Mehr-Aein Does a single bolus dose of tranexamic acid reduce blood loss and transfusion requirements during hip fracture surgery? A prospective randomized double blind study in 67 patients Acta Med Iran 45 2007 437
51. D.T. Neilipovitz, K. Murto, L. Hall, N.J. Barrowman, and W.M. Splinter A randomized trial of tranexamic acid to reduce blood transfusion for scoliosis surgery Anesth Analg 93 2001 82
52. R.J. Taghaddomi, H. Mashhadinezhad, and A.R.S. Attar The effect of intravenous tranexamic acid on blood loss in lumbar hernial disc resection under inhalation and total intravenous anesthesia Iran Red Crescent Med J 11 2009 265
53. N.F. Sethna, D. Zurakowski, R.M. Brustowicz, J. Bacsik, L.J. Sullivan, and F. Shapiro Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery Anesthesiology 102 2005 727
54. J. Wong, H. El Beheiry, and Y.R. Rampersaud Tranexamic acid reduces perioperative blood loss in adult patients having spinal fusion surgery Anesth Analg 107 2008 1479
55. S. Elwatidy, Z. Jamjoom, E. Elgamal, A. Zakaria, A. Turkistani, and A. El-Dawlatly Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: a prospective, randomized, double-blind, placebo-controlled study Spine (Phila Pa 1976) 33 2008 2577
56. T. Tsutsumimoto, M. Shimogata, H. Ohta, M. Yui, I. Yoda, and H. Misawa Tranexamic acid reduces perioperative blood loss in cervical laminoplasty: a prospective randomized study Spine (Phila Pa 1976) 36 2011 1913
57. M.R. Farrokhi, A.P. Kazemi, H.R. Eftekharian, and K. Akbari Efficacy of prophylactic low dose of tranexamic acid in spinal fixation surgery: a randomized clinical trial J Neurosurg Anesthesiol 23 2011 290
58. C. Xu, A. Wu, and Y. Yue Which is more effective in adolescent idiopathic scoliosis surgery: batroxobin, tranexamic acid or a combination? Arch Orthop Trauma Surg 132 2012 25
59. K. Ker, P. Edwards, P. Perel, H. Shakur, and I. Roberts Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis BMJ 344 2012
60. Z.G. Yang, W.P. Chen, and L.D. Wu Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis J Bone Joint Surg Am 94 2012 1153
61. M. Sukeik, S. Alshryda, F.S. Haddad, and J.M. Mason Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement J Bone Joint Surg Br 93 2011 39