Effect of low frequency magnetic fields on melanoma: Tumor inhibition and immune modulation

BMC Cancer

Volumn 13, Issue , 2013, Pages 1-11

  Nie, Yunzhong ^a   Du, Leilei ^a   Mou, Yongbin ^a   Xu, Zhenjun ^a   Weng, Leihua ^a   Du, Youwei ^a   Zhu, Yanan ^a   Hou, Yayi ^a   Wang, Tingting ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Immune function; Magnetic fields; Melanoma

Indexed keywords

CYTOKINE; TUMOR MARKER; AUTACOID; CD40 ANTIGEN;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CELL COUNT; CELL CYCLE ARREST; CELL PROLIFERATION; CELL ULTRASTRUCTURE; CHROMATIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; DECOMPOSITION; DENDRITIC CELL; FEMALE; FLOW CYTOMETRY; IMMUNOCOMPETENT CELL; IMMUNOLOGICAL PARAMETERS; IMMUNOMODULATION; IMMUNOREGULATION; IN VITRO STUDY; INNATE IMMUNITY; LOW FREQUENCY MAGNETIC FIELD; LUNG METASTASIS; LYMPHOCYTE COUNT; MAGNETIC FIELD; MELANOMA; MELANOMA B16; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; SURVIVAL RATE; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; APOPTOSIS; BLOOD; CELL CYCLE CHECKPOINT; CELL DIFFERENTIATION; CYTOLOGY; EXPERIMENTAL MELANOMA; IMMUNOLOGY; METABOLISM; MORTALITY; PATHOLOGY; RADIATION EXPOSURE; SPLEEN; T LYMPHOCYTE SUBPOPULATION; TUMOR VOLUME;

ANIMALS; ANTIGENS, CD40; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOKINES; DENDRITIC CELLS; FEMALE; INFLAMMATION MEDIATORS; MAGNETIC FIELDS; MELANOMA; MELANOMA, EXPERIMENTAL; MICE; SPLEEN; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TUMOR BURDEN;

EID: 84890127766     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-582     Document Type: Article

References (29)

1. Koh EK, Ryu BK, Jeong DY, et al. A 60-Hz sinusoidal magnetic field induces apoptosis of prostate cancer cells through reactive oxygen species. Int J Radiat Biol 2008, 84(11):945-955. 10.1080/09553000802460206, 19016143.
2. Novikov VV, Novikov GV, Fesenko EE. Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma. Bioelectromagnetics 2009, 30(5):343-351. 10.1002/bem.20487, 19267367.
3. Costa FP, de Oliveira AC, Meirelles R, et al. Treatment of advanced hepatocellular carcinoma with very low levels of amplitude-modulated electromagnetic fields. Br J Cancer 2011, 105(5):640-648. 10.1038/bjc.2011.292, 3188936, 21829195.
4. de Vries E, Coebergh JW. Cutaneous malignant melanoma in Europe. Eur J Cancer 2004, 40:2355-2366. 10.1016/j.ejca.2004.06.003, 15519506.
5. Chen LL, Jaimes N, Barker CA, et al. Desmoplastic melanoma. A review. J Am Acad Dermatol 2013, 68:825-833. 10.1016/j.jaad.2012.10.041, 23267722.
6. Lim LA, Madigan MC, Conway RM. Conjunctival melanoma: a review of conceptual and treatment advances. Clin Ophthalmol 2013, 6:521-31. 3601642, 23515569.
7. Basile A, Zeppa R, Pasquino N, et al. Exposure to 50 Hz electromagnetic field raises the levels of the anti-apoptotic protein BAG3 in melanoma cells. J Cell Physiol 2011, 226(11):2901-2907. 10.1002/jcp.22641, 21302292.
8. Sullivan K, Balin AK, Allen RG. Effects of static magnetic fields on the growth of various types of human cells. Bioelectromagnetics 2011, 32(2):140-147. 10.1002/bem.20624, 21225891.
9. Hu JH, St-Pierre LS, Buckner CA, et al. Growth of injected melanoma cells is suppressed by whole body exposure to specific spatial-temporal configurations of weak intensity magnetic fields. Int J Radiat Biol 2010, 86(2):79-88. 10.3109/09553000903419932, 20148694.
10. Dunn GP, Bruce AT, Ikeda H, et al. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 2002, 3(11):991-998. 10.1038/ni1102-991, 12407406.
11. Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004, 10(9):942-949. 10.1038/nm1093, 15322536.
12. Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 2006, 6(4):295-307. 10.1038/nri1806, 16557261.
13. Frahm J, Lantow M, Lupke M, et al. Alteration in cellular functions in mouse macrophages after exposure to 50 Hz magnetic fields. J Cell Biochem 2006, 99(1):168-177. 10.1002/jcb.20920, 16598759.
14. Gobba F, Bargellini A, Scaringi M, et al. Extremely low frequency-magnetic fields (ELF-EMF) occupational exposure and natural killer activity in peripheral blood lymphocytes. Sci Total Environ 2009, 407(3):1218-1223. 10.1016/j.scitotenv.2008.08.012, 18804846.
15. Wang T, Nie Y, Zhao S, et al. Involvement of midkine expression in the inhibitory effects of low-frequency magnetic fields on cancer cells. Bioelectromagnetics 2011, 32(6):443-452. 10.1002/bem.20654, 21360556.
16. Wang HY, Wang RF. Regulatory T cells and cancer. Curr Opin Immunol 2007, 19(2):217-223. 10.1016/j.coi.2007.02.004, 17306521.
17. Kim S, Im W. Static magnetic fields inhibit proliferation and disperse subcellular localization of gamma complex protein3 in cultured C2C12 myoblast cells. Cell Biochem Biophys 2010, 57(1):1-8. 10.1007/s12013-010-9076-1, 20361274.
18. Sarvestani AS, Abdolmaleki P, Mowla SJ, et al. Static magnetic fields aggravate the effects of ionizing radiation on cell cycle progression in bone marrow stem cells. Micron 2010, 41(2):101-104. 10.1016/j.micron.2009.10.007, 19926297.
19. Kim J, Ha CS, Lee HJ, et al. Repetitive exposure to a 60-Hz time-varying magnetic field induces DNA double-strand breaks and apoptosis in human cells. Biochem Biophys Res Commun 2010, 400(4):739-744. 10.1016/j.bbrc.2010.08.140, 20816755.
20. Teodori L, Albertini MC, Uguccioni F, et al. Static magnetic fields affect cell size, shape, orientation, and membrane surface of human glioblastoma cells, as demonstrated by electron, optic, and atomic force microscopy. Cytometry A 2006, 69(2):75-85.
21. Poeck H, Besch R, Maihoefer C, et al. 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med 2008, 14(11):1256-1263. 10.1038/nm.1887, 18978796.
22. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000, 182(3):311-322. 10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9, 10653597.
23. Tofani S, Barone D, Cintorino M, et al. Static and ELF magnetic fields induce tumor growth inhibition and apoptosis. Bioelectromagnetics 2001, 22(6):419-428. 10.1002/bem.69, 11536283.
24. Swann JB, Smyth MJ. Immune surveillance of tumors. J Clin Invest 2007, 117(5):113711-46.
25. Arenberg DA, White ES, Burdick MD, et al. Improved survival in tumor-bearing SCID mice treated with interferon-gamma-inducible protein 10 (IP-10/CXCL10). Cancer Immunol Immunother 2001, 50(10):533-538. 10.1007/s00262-001-0231-9, 11776375.
26. Wang D, Wang H, Brown J, et al. CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J Exp Med 2006, 203(4):941-951. 10.1084/jem.20052124, 2118273, 16567391.
27. Hoelzinger DB, Smith SE, Mirza N, et al. Blockade of CCL1 inhibits T regulatory cell suppressive function enhancing tumor immunity without affecting T effector responses. J Immunol 2010, 184(12):6833-6842. 10.4049/jimmunol.0904084, 20483762.
28. Balkwill F. Cancer and the chemokine network. Nat Rev Cancer 2004, 4(7):540-550. 10.1038/nrc1388, 15229479.
29. Orimo A, Gupta PB, Sgroi DC, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121(3):335-348. 10.1016/j.cell.2005.02.034, 15882617.