Repetitive exposure to a 60-Hz time-varying magnetic field induces DNA double-strand breaks and apoptosis in human cells

Biochemical and Biophysical Research Communications

Volumn 400, Issue 4, 2010, Pages 739-744

  Kim, Jiyeon ^a   Ha, Chang Seung ^b   Lee, Hae June ^b   Song, Kiwon ^a  

^a Yonsei University   (South Korea)

^b Pusan National University   (South Korea)

Author keywords

H2AX; Apoptosis; DNA double strand break (DSB); P Chk2; P p38; Time varying MF

Indexed keywords

CHECKPOINT KINASE 2; DOUBLE STRANDED DNA; MITOGEN ACTIVATED PROTEIN KINASE P38;

APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MAGNETIC FIELD; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

APOPTOSIS; CELL LINE; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; ELECTROMAGNETIC FIELDS; HISTONES; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 77957263579     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.08.140     Document Type: Article

References (29)

1. Moriyama K., Yoshitomi K. Apartment electrical wiring: a cause of extremely low frequency magnetic field exposure in residential areas. Bioelectromagnetics 2005, 26:238-241.
2. Mezei G., Kheifets L.I., Nelson L.M., et al. Household appliance use and residential exposure to 60 Hz magnetic fields. J. Expo. Anal. Environ. Epidemiol. 2001, 11:41-49.
3. Cleary S.F. A review of in vitro studies: low-frequency electromagnetic fields. Am. Ind. Hyg. Assoc. J. 1993, 54:178-185.
4. Wertheimer N., Leeper E. Electrical wiring configurations and childhood cancer. Am. J. Epidemiol. 1979, 109:273-284.
5. Bowman J.D., Thomas D.C., London S.J., et al. Hypothesis: the risk of childhood leukemia is related to combinations of power-frequency and static magnetic fields. Bioelectromagnetics 1995, 16:48-59.
6. Feychting M., Ahlbom A. Magnetic fields and cancer in children residing near Swedish high-voltage power lines. J. Epidemiol. 1993, 138:467-481.
7. Savitz D.A., Wachtel H., Barnes F., et al. Case control study of childhood cancer and exposure to 60 Hz magnetic fields. Am. J. Epidemiol. 1988, 128:21-38.
8. Winker R., Ivancsits S., Pilger A., et al. Chromosomal damage in human diploid fibroblasts by intermittent exposure to extremely low-frequency electromagnetic fields. Mutat. Res. 2005, 585:43-49.
9. Ivancsits S., Diem E., Pilger A., et al. Induction of DNA strand breaks by intermittent exposure to extremely-low-frequency electromagnetic fields in human diploid fibroblasts. Mutat. Res. 2002, 519:1-13.
10. Lai H., Singh N.P. Acute exposure to a 60 Hz magnetic field increases DNA strand breaks in rat brain cells. Bioelectromagnetics 1997, 18:156-165.
11. McNamee J.P., Bellier P.V., Chauhan V., et al. Evaluating DNA damage in rodent brain after acute 60 Hz magnetic-field exposure. Radiat. Res. 2005, 164:791-797.
12. Kim Y.W., Kim H.S., Lee J.S., et al. Effects of 60 Hz 14 μT magnetic field on the apoptosis of testicular germ cell in mice. Bioelectromagnetics 2009, 30:66-72.
13. Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 2001, 411:366-374.
14. van Gent D.C., Hoeijmakers J.H., Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2001, 2:196-206.
15. Rogakou E.P., Pilch D.R., Orr A.H., et al. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 1998, 273:5858-5868.
16. Paull T.T., Rogakou E.P., Yamazaki V., et al. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 2000, 10:886-895.
17. Rappold I., Iwabuchi K., Date T., et al. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J. Cell Biol. 2001, 153:613-620.
18. Hiroyuki N., Makoto N. DNA damage checkpoints in mammals. Mutagenesis 2006, 21:3-9.
19. Roos W.P., Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol. Med. 2006, 12:440-450.
20. Zarubin T., Han J. Activation and signaling of the p38 MAP kinase pathway. Cell Res. 2005, 15:11-18.
21. Havelka A.M., Berndtsson M., Olofsson M.H., et al. Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an " off-target" effect?. Mini Rev. Med. Chem. 2007, 7:1035-1039.
22. Phong M.S., Van Horn R.D., Li S., et al. p38 Mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cells. Mol. Cell Biol. 2010, 30:3816-3826.
23. Ho C.Y., Li H.Y. DNA damage during mitosis invokes a JNK-mediated stress response that leads to cell death. J. Cell Biochem. 2010, 110:725-731.
24. Reinhardt H.C., Aslanian A.S., Lees J.A., et al. p53-Deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 2007, 11:175-189.
25. Vistica D.T., Skehan P., Scudiero D., et al. Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production. Cancer Res. 1991, 51:2515-2520.
26. Kim J.Y., Kim T.H., Kim S.S. Anti-inflammatory effect of a human prothrombin fragment-2-derived peptide, NSA9, in EOC2 microglia. Biochem. Biophys. Res. Commun. 2008, 368:779-785.
27. Schreiber G.H., Swaen G.M., Meijers J.M., et al. Cancer mortality and residence near electricity transmission equipment: a retrospective cohort study. Int. J. Epidemiol. 1993, 22:9-15.
28. O'Driscoll M., Gennery A.R., Seidel J., et al. An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair (Amst.) 2004, 3:1227-1235.
29. Helleday T., Petermann E., Lundin C., et al. DNA repair pathways as targets for cancer therapy. Nat. Rev. Cancer 2008, 8:193-204.