Neutrophils and stroke - Can neutrophils mitigate disease in the central nervous system?

International Immunopharmacology

Volumn 17, Issue 4, 2013, Pages 1218-1225

  Easton, Alexander S ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Blood brain barrier; Inflammation; Neurovascular unit; Neutrophil; Permeability; Stroke

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; APROTININ; BACTERIUM LIPOPOLYSACCHARIDE; CD18 ANTIGEN; CXCL1 CHEMOKINE; ENDOTHELIN 1; ENLIMOMAB; FIBRINOLYTIC AGENT; GLUTAMIC ACID; GRANULOCYTE ANTIBODY; HORSERADISH PEROXIDASE; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; LEUKOTRIENE B4; MYELOPEROXIDASE;

BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN CAPILLARY ENDOTHELIAL CELL; BRAIN EDEMA; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN INJURY; CELL INFILTRATION; CEREBROVASCULAR ACCIDENT; DRUG EFFECT; DRUG TREATMENT FAILURE; EVOKED SOMATOSENSORY RESPONSE; FIBRINOLYTIC THERAPY; HUMAN; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NEUTROPENIA; NEUTROPHIL; NONHUMAN; OUTCOME ASSESSMENT; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; REVIEW; STROKE PATIENT; T LYMPHOCYTE; UMBILICAL VEIN ENDOTHELIAL CELL;

BLOOD-BRAIN BARRIER; INFLAMMATION; NEUROVASCULAR UNIT; NEUTROPHIL; PERMEABILITY; STROKE;

ANIMALS; CENTRAL NERVOUS SYSTEM; HUMANS; NEUTROPHILS; STROKE;

EID: 84890127591     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.06.015     Document Type: Review

References (77)

1. E.P. Cronkite, and T.M. Fliedner Granulocytopoiesis N Engl J Med 270 1964 1347 1352 [CONTD]
2. J.H. Garcia The neuropathology of stroke Hum Pathol 6 1975 583 598
3. C.J. Price, D.K. Menon, A.M. Peters, J.R. Ballinger, R.W. Barber, and K.K. Balan Cerebral neutrophil recruitment, histology, and outcome in acute ischemic stroke: an imaging-based study Stroke 35 2004 1659 1664 (Pubitemid 38823643)
4. C.F. Barker, and R.E. Billingham Immunologically privileged sites Adv Immunol 25 1977 1 54
5. H.E. de Vries, J. Kuiper, A.G. de Boer, T.J.C. Van Berkel, and D.D. Breimer The blood-brain barrier in neuroinflammatory diseases Pharmacol Rev 49 1997 143 155 (Pubitemid 27291032)
6. R.M. Ransohoff, and M.A. Brown Innate immunity in the central nervous system J Clin Invest 122 2012 1164 1171
7. P.B. Andersson, V.H. Perry, and S. Gordon The CNS acute inflammatory response to excitotoxic neuronal cell death Immunol Lett 30 1991 177 181
8. P.B. Andersson, V.H. Perry, and S. Gordon Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system J Exp Med 176 1992 255 259
9. P.B. Andersson, V.H. Perry, and S. Gordon The acute inflammatory response to lipopolysaccharide in CNS parenchyma differs from that in other body tissues Neuroscience 48 1992 169 186
10. I. Galea, I. Bechmann, and V.H. Perry What is immune privilege (not)? Trends Immunol 28 2007 12 18 (Pubitemid 44960159)
11. F. Hayashi, T.K. Means, and A.D. Luster Toll-like receptors stimulate human neutrophil function Blood 102 2003 2660 2669 (Pubitemid 37193610)
12. F. Dallegri, and L. Ottonello Tissue injury in neutrophilic inflammation Inflamm Res 46 1997 382 391 (Pubitemid 27478595)
13. N. Borregaard, and J.B. Cowland Granules of the human neutrophilic polymorphonuclear leukocyte Blood 89 1997 3503 3521 (Pubitemid 27227073)
14. B. Bottazzi, A. Doni, C. Garlanda, and A. Mantovani An integrated view of humoral innate immunity: pentraxins as a paradigm Annu Rev Immunol 28 2010 157 183
15. M.A. Cassatella Neutrophil-derived proteins: selling cytokines by the pound Adv Immunol 73 1999 369 509 (Pubitemid 29300434)
16. C.N. Serhan, N. Chiang, and T.E. Van Dyke Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators Nat Rev Immunol 8 2008 349 361 (Pubitemid 351595216)
17. A. Ariel, G. Fredman, Y.P. Sun, A. Kantarci, T.E. Van Dyke, and A.D. Luster Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression Nat Immunol 7 2006 1209 1216 (Pubitemid 44594317)
18. S.D. Kobayashi, J.M. Voyich, C. Burlak, and F.R. DeLeo Neutrophils in the innate immune response Arch Immunol Ther Exp (Warsz) 53 2005 505 517 (Pubitemid 43035779)
19. F. Colotta, F. Re, N. Polentarutti, S. Sozzani, and A. Mantovani Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products Blood 80 1992 2012 2020
20. O. Soehnlein, and L. Lindbom Phagocyte partnership during the onset and resolution of inflammation Nat Rev Immunol 10 2010 427 439
21. S. Fox, A.E. Leitch, R. Duffin, C. Haslett, and A.G. Rossi Neutrophil apoptosis: relevance to the innate immune response and inflammatory disease J Innate Immun 2 2010 216 227
22. A.A. Filardy, D.R. Pires, M.P. Nunes, C.M. Takiya, C.G. Freire-de-Lima, and F.L. Ribeiro-Gomes Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages J Immunol 185 2010 2044 2050
23. S. Bennouna, and E.Y. Denkers Microbial antigen triggers rapid mobilization of TNF-alpha to the surface of mouse neutrophils transforming them into inducers of high-level dendritic cell TNF-alpha production J Immunol 174 2005 4845 4851
24. M. Pelletier, L. Maggi, A. Micheletti, E. Lazzeri, N. Tamassia, and C. Costantini Evidence for a cross-talk between human neutrophils and Th17 cells Blood 115 2010 335 343
25. P. Scapini, F. Bazzoni, and M.A. Cassatella Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils Immunol Lett 116 2008 1 6
26. M.A. Cassatella, F. Mosna, A. Micheletti, V. Lisi, N. Tamassia, and C. Cont Toll-like receptor-3-activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophils Stem Cells 29 2011 1001 1011
27. G.J. del Zoppo, G.W. Schmid-Schonbein, E. Mori, B.R. Copeland, and C.M. Chang Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons Stroke 22 1991 1276 1283
28. R.K. Clark, E.V. Lee, R.F. White, Z.L. Jonak, G.Z. Feuerstein, and F.C. Barone Reperfusion following focal stroke hastens inflammation and resolution of ischemic injured tissue Brain Res Bull 35 1994 387 392 (Pubitemid 24332684)
29. R.L. Zhang, M. Chopp, H. Chen, and J.H. Garcia Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat J Neurol Sci 125 1994 3 10 (Pubitemid 24240180)
30. A.J. Dutka, P.M. Kochanek, and J.M. Hallenbeck Influence of granulocytopenia on canine cerebral ischemia induced by air embolism Stroke 20 1989 390 395 (Pubitemid 19080098)
31. B. Grogaard, L. Schurer, B. Gerdin, and K.E. Arfors Delayed hypoperfusion after incomplete forebrain ischemia in the rat. The role of polymorphonuclear leukocytes J Cereb Blood Flow Metab 9 1989 500 505 (Pubitemid 19183296)
32. M.M. Bednar, S. Raymond, T. McAuliffe, P.A. Lodge, and C.E. Gross The role of neutrophils and platelets in a rabbit model of thromboembolic stroke Stroke 22 1991 44 50
33. Y. Matsuo, H. Onodera, Y. Shiga, M. Nakamura, M. Ninomiya, and T. Kihara Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion Stroke 25 1994 1469 1475 (Pubitemid 24198597)
34. C.J. Prestigiacomo, S.C. Kim, E.S. Connolly Jr., H. Liao, S.F. Yan, and D.J. Pinsky CD18-mediated neutrophil recruitment contributes to the pathogenesis of reperfused but not nonreperfused stroke Stroke 30 1999 1110 1117 (Pubitemid 29211635)
35. E.S. Connolly Jr., C.J. Winfree, T.A. Springer, Y. Naka, H. Liao, and S.D. Yan Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke J Clin Invest 97 1996 209 216 (Pubitemid 26021710)
36. R.L. Zhang, M. Chopp, Y. Li, C. Zaloga, N. Jiang, and M.L. Jones Anti-ICAM-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat Neurology 44 1994 1747 1751 (Pubitemid 24286659)
37. R.L. Zhang, M. Chopp, N. Jiang, W.X. Tang, J. Prostak, and A.M. Manning Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat Stroke 26 1995 1438 1442 [discussion 1443]
38. B.S. Aspey, C. Jessimer, S. Pereira, and M.J. Harrison Do leukocytes have a role in the cerebral no-reflow phenomenon? J Neurol Neurosurg Psychiatry 52 1989 526 528 (Pubitemid 19104515)
39. R.J. Schott, J.E. Natale, S.W. Ressler, R.E. Burney, and L.G. D'Alecy Neutrophil depletion fails to improve neurologic outcome after cardiac arrest in dogs Ann Emerg Med 18 1989 517 522 (Pubitemid 19127690)
40. L. Schurer, B. Grogaard, B. Gerdin, O. Kempski, and K.E. Arfors Leucocyte depletion does not affect post-ischaemic nerve cell damage in the rat Acta Neurochir (Wien) 111 1991 54 60
41. R. Takeshima, J.R. Kirsch, R.C. Koehler, A.W. Gomoll, and R.J. Traystman Monoclonal leukocyte antibody does not decrease the injury of transient focal cerebral ischemia in cats Stroke 23 1992 247 252
42. N.J. Hayward, P.J. Elliott, S.D. Sawyer, R.T. Bronson, and R.T. Bartus Lack of evidence for neutrophil participation during infarct formation following focal cerebral ischemia in the rat Exp Neurol 139 1996 188 202 (Pubitemid 26228088)
43. K. Kitagawa, M. Matsumoto, T. Mabuchi, Y. Yagita, T. Ohtsuki, and M. Hori Deficiency of intercellular adhesion molecule 1 attenuates microcirculatory disturbance and infarction size in focal cerebral ischemia J Cereb Blood Flow Metab 18 1998 1336 1345 (Pubitemid 28559681)
44. S.H. Ahmed, Y.Y. He, A. Nassief, J. Xu, X.M. Xu, and C.Y. Hsu Effects of lipopolysaccharide priming on acute ischemic brain injury Stroke 31 2000 193 199 (Pubitemid 30035774)
45. V. Beray-Berthat, N. Croci, M. Plotkine, and I. Margaill Polymorphonuclear neutrophils contribute to infarction and oxidative stress in the cortex but not in the striatum after ischemia-reperfusion in rats Brain Res 987 2003 32 38 (Pubitemid 37267884)
46. R.M. Weston, N.M. Jones, B. Jarrott, and J.K. Callaway Inflammatory cell infiltration after endothelin-1-induced cerebral ischemia: histochemical and myeloperoxidase correlation with temporal changes in brain injury J Cereb Blood Flow Metab 27 2006 100 114 (Pubitemid 46006588)
47. H. Chen, M. Chopp, and G. Bodzin Neutropenia reduces the volume of cerebral infarct after transient middle cerebral artery occlusion in the rat Neurosci Res Commun 11 1992 93 99
48. O. Lopez, and T. Lanthorn Anti-neutrophil antiserum reduces infarct volume after mouse permanent middle cerebral artery occlusion without producing neutropenia Neurosci Res Commun 13 1993 45 53 (Pubitemid 23239727)
49. D.F. Emerich, R.L. Dean III, and R.T. Bartus The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct? Exp Neurol 173 2002 168 181 (Pubitemid 34081736)
50. J.H. Garcia, K.F. Liu, and M.P. Bree Effects of CD11b/18 monoclonal antibody on rats with permanent middle cerebral artery occlusion Am J Pathol 148 1996 241 248 (Pubitemid 26019658)
51. A. Meretoja, and T. Tatlisumak Thrombolytic therapy in acute ischemic stroke - basic concepts Curr Vasc Pharmacol 4 2006 31 44 (Pubitemid 46785180)
52. K.J. Becker Anti-leukocyte antibodies: LeukArrest (Hu23F2G) and Enlimomab (R6.5) in acute stroke Curr Med Res Opin 18 Suppl. 2 2002 s18 s22
53. R.F. Keep, G. Xi, Y. Hua, and J.T. Hoff The deleterious or beneficial effects of different agents in intracerebral hemorrhage: think big, think small, or is hematoma size important? Stroke 36 2005 1594 1596 (Pubitemid 40967538)
54. W.D. Lo, R. Chen, D.R. Boue, and B.T. Stokes Effect of neutrophil depletion in acute cerebritis Brain Res 802 1998 175 183 (Pubitemid 28392169)
55. C. Villmann, and C.M. Becker On the hypes and falls in neuroprotection: targeting the NMDA receptor Neuroscientist 13 2007 594 615 (Pubitemid 350077310)
56. X. Zhang, Y. Kluger, Y. Nakayama, R. Poddar, C. Whitney, and A. DeTora Gene expression in mature neutrophils: early responses to inflammatory stimuli J Leukoc Biol 75 2004 358 372 (Pubitemid 38174594)
57. K.T. Kotz, W. Xiao, C. Miller-Graziano, W.J. Qian, A. Russom, and E.A. Warner Clinical microfluidics for neutrophil genomics and proteomics Nat Med 16 2010 1042 1047
58. Z.G. Fridlender, J. Sun, S. Kim, V. Kapoor, G. Cheng, and L. Ling Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN Cancer Cell 16 2009 183 194
59. M.R. DiStasi, and K. Ley Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability Trends Immunol 30 2009 547 556
60. J.M. Simard, T.A. Kent, M. Chen, K.V. Tarasov, and V. Gerzanich Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications Lancet Neurol 6 2007 258 268 (Pubitemid 46228081)
61. D.C. Anthony, S.J. Bolton, S. Fearn, and V.H. Perry Age-related effects of interleukin-1 beta on polymorphonuclear neutrophil-dependent increases in blood-brain barrier permeability in rats Brain 120 Pt 3 1997 435 444 (Pubitemid 27153636)
62. S.J. Bolton, D.C. Anthony, and V.H. Perry Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo Neuroscience 86 1998 1245 1257 (Pubitemid 28318549)
63. D. Anthony, R. Dempster, S. Fearn, J. Clements, G. Wells, and V.H. Perry CXC chemokines generate age-related increases in neutrophil-mediated brain inflammation and blood-brain barrier breakdown Curr Biol 8 1998 923 926 (Pubitemid 28371758)
64. W.B. Veldhuis, S. Floris, P.H. van der Meide, I.M. Vos, H.E. de Vries, and C.D. Dijkstra Interferon-beta prevents cytokine-induced neutrophil infiltration and attenuates blood-brain barrier disruption J Cereb Blood Flow Metab 23 2003 1060 1069 (Pubitemid 37082431)
65. W.B. Veldhuis, J.W. Derksen, S. Floris, P.H. Van Der Meide, H.E. De Vries, and J. Schepers Interferon-beta blocks infiltration of inflammatory cells and reduces infarct volume after ischemic stroke in the rat J Cereb Blood Flow Metab 23 2003 1029 1039 (Pubitemid 37082428)
66. S.L. Joice, F. Mydeen, P.O. Couraud, B.B. Weksler, I.A. Romero, and P.A. Fraser Modulation of blood-brain barrier permeability by neutrophils: in vitro and in vivo studies Brain Res 1298 2009 13 23
67. V.I. Inglis, M.P. Jones, A.D. Tse, and A.S. Easton Neutrophils both reduce and increase permeability in a cell culture model of the blood-brain barrier Brain Res 998 2004 218 229 (Pubitemid 38125063)
68. D. Wong, R. Prameya, and K. Dorovini-Zis Adhesion and migration of polymorphonuclear leukocytes across human brain microvessel endothelial cells are differentially regulated by endothelial cell adhesion molecules and modulate monolayer permeability J Neuroimmunol 184 2007 136 148 (Pubitemid 46389416)
69. P.F. Lennon, C.T. Taylor, G.L. Stahl, and S.P. Colgan Neutrophil-derived 5′-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activation J Exp Med 188 1998 1433 1443 (Pubitemid 28489580)
70. C.D. Collard, K.A. Park, M.C. Montalto, S. Alapati, J.A. Buras, and G.L. Stahl Neutrophil-derived glutamate regulates vascular endothelial barrier function J Biol Chem 277 2002 14801 14811 (Pubitemid 34952552)
71. K.M. Cowan, and A.S. Easton Neutrophils block permeability increases induced by oxygen glucose deprivation in a culture model of the human blood-brain barrier Brain Res 1332 2010 20 31
72. S. Love, D.N. Louis, and D.W. Ellison Greenfield's neuropathology 8th ed. 2008 Hodder Arnold
73. Z.G. Zhang, L. Zhang, W. Tsang, H. Soltanian-Zadeh, D. Morris, and R. Zhang Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia J Cereb Blood Flow Metab 22 2002 379 392 (Pubitemid 34273594)
74. S.L. Kirk, and S.J. Karlik VEGF and vascular changes in chronic neuroinflammation J Autoimmun 21 2003 353 363 (Pubitemid 37420080)
75. C.J. Macmillan, R.J. Starkey, and A.S. Easton Angiogenesis is regulated by angiopoietins during experimental autoimmune encephalomyelitis and is indirectly related to vascular permeability J Neuropathol Exp Neurol 70 2011 1107 1123
76. S. Jain, V. Mishra, P. Singh, P.K. Dubey, D.K. Saraf, and S.P. Vyas RGD-anchored magnetic liposomes for monocytes/neutrophils-mediated brain targeting Int J Pharm 261 2003 43 55 (Pubitemid 36962744)
77. J. Qin, D. Chen, H. Hu, Q. Cui, M. Qiao, and B. Chen Surface modification of RGD-liposomes for selective drug delivery to monocytes/neutrophils in brain Chem Pharm Bull (Tokyo) 55 2007 1192 1197 (Pubitemid 47344972)