Lack of evidence for neutrophil participation during infarct formation following focal cerebral ischemia in the rat

Experimental Neurology

Volumn 139, Issue 2, 1996, Pages 188-202

  Hayward, Neil J ^a   Elliott, Peter J ^a   Sawyer, Sean D ^a   Bronson, Roderick T ^b   Bartus, Raymond T ^a,c  

^a ALKERMES INC   (United States)

^b TUFTS UNIVERSITY   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; HISTOLOGY; MALE; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030157567     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1996.0093     Document Type: Article

References (53)

1. 1. BARONE, F. C., L. M. HILLEGASS, W. J. PRICE, R. F. WHITE, E. V. LEE, G. Z. FEUERSTEIN, H. M. SARAU, R. K. CLARK, AND L. GRISWOLD. 1991. Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: Myeloperoxidase activity assay and histologic verification. J. Neurosci. Res. 29: 336-345.
2. 2. BARONE, F. C., D. B. SCHMIDT, AND L. M. HILLEGASS. 1992. Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia. Stroke 23: 1337-1348.
3. 3. BARTUS, R. T., K. L. BAKER, A. D. HEISER, S. D. SAWYER, R. L. DEAN, P. J. ELLIOTT, AND J. A. STRAUB. 1994. Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage. J. Cereb. Blood Flow Metab. 14: 537-544.
4. 4. BARTUS, R. T., N. J. HAYWARD, P. J. ELLIOTT, S. D. SAWYER, K. L. BAKER, R. L. DEAN, A. D. AKIYAMA, J. A. STRAUB, S. L. HARBESON, AND J. POWERS. 1994. The calpain inhibitor, AK295, protects neurons from focal brain ischemia: Effects of post-occlusion, intra-arterial administration. Stroke 25: 2265-2270.
5. 5. BARTUS, R. T., R. L. DEAN, K. CAVANAUGH, D. EVELETH, D. L. CARRIERO, AND G. LYNCH. 1995. Time-related neuronal changes following middle cerebral artery occlusion: Implications for therapeutic intervention and the role of calpain. J. Cereb. Blood Flow Metab. 15: 969-979.
6. 6. BARTUS, R. T., P. J. ELLIOTT, N. J. HAYWARD, R. L. DEAN, S. HARBESON, J. A. STRAUB, Z. LI, AND J. C. POWERS. 1995. Calpain as a novel target for treating acute neurodegenerative disorders. Neurol. Res. 17: 249-258.
7. 7. BEDERSON, J. B., L. H. PITTS, S. M. GERMANO, M. C. NISHIMURA, R. L. DAVIS, AND H. M. BARTOWSKI. 1986. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17: 1304-1308.
8. 8. BEDNAR, M. M., S. RAYMOND, T. MCAULIFFE, P. A. LODGE, AND C. E. GROSS. 1991. The role of neutrophils and platelets in a rabbit model of thomboembolic stroke. Stroke 22: 44-50.
9. 9. BUCHAN, A. M., D. XUE, AND A. SLIVKA. 1992. A new model of temporary focal neocortical ischemia in the rat. Stroke 23: 273-279.
10. 10. CHEN, H., M. CHOPP, AND G. BODZIN. 1992. Neutropenia reduces the volume of cerebral infarct after transient middle cerebral artery occlusion in the rat. Neurosci. Res. Commun. 11: 93-99.
11. 11. CHEN, H., M. CHOPP, R. L. ZHANG, G. BODZIN, Q. CHEN, J. R. RUSCHE, AND R. F. TODD. 1994. Anti-CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rat. Ann. Neurol. 35: 458-463.
12. 12. CHEN, S. T., C. Y. HSU, E. L. HOGAN, H. MARICQ, AND J. D. BALENTINE. 1986. A model of focal ischemic stroke in the rat: Reproducible extensive cortical infarction. Stroke 17: 738-743.
13. 13. CHOPP, M., R. L. ZHANG, H. CHEN, Y. LI, N. JIANG, AND J. R. RUSCHE. 1994. Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats. Stroke 25: 869-876.
14. 14. CLARK, R. K., E. V. LEE, C. J. FISH, R. F. WHITE, W. J. PRICE, Z. L. JONAK, G. Z. FEUERSTEIN, AND F. C. BARONE. 1993. Development of tissue damage, inflammation and resolution following stroke: An immunohistochemical and quantitative planimetric study. Brain Res. Bull. 31: 565-572.
15. 15. CLARK, W. M., K. P. MADDEN, R. ROTHLEIN, AND J. A. ZIVIN. 1991. Reduction of central nervous system ischemic injury by monoclonal antibody to intracellular adhesion molecule. J. Neurosurg. 75: 623-627.
16. 16. DELZOPPO, G. J., G. W. SCHMID-SCHONBEIN, E. MORI, B. R. COPELAND, AND C-M. CHANG. 1991. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 22: 1276-1283.
17. 17. DERESKI, M. O., M. CHOPP, R. A. KNIGHT, H. CHEN, AND J. H. GARCIA. 1992. Focal cerebral ischemia in the rat: Temporal profile of neutrophil responses. Neurosci. Res. Commun. 11: 179-186.
18. 18. DERESKI, M. O., M. CHOPP, R. A. KNIGHT, L. C. RODOLOSI, AND J. H. GARCIA. 1993. The heterogeneous temporal evolution of focal ischemic neuronal damage in the rat. Acta Neurol. 85: 327-333.
19. 19. DUTKA, A. J., P. M. KOCHANEK, AND J. M. HALLENBECK. 1989. Influence of granulocytopenia on canine cerebral ischemia induced by air embolism. Stroke 20: 390-395.
20. 20. ENGLER, R. L., G. W. SCHMID-SCHONBEIN, AND R. S. PAVELEC. 1983. Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog. Am. J. Pathol. 111: 98-111.
21. 21. GARCIA, J. H., AND Y. KAMIJYO. 1974. Cerebral infarction: Evolution of histopathological changes after occlusion of a middle cerebral artery in primates. J. Neuropathol. Exp. Neurol. 33: 408-421.
22. 22. GARCIA, J. H., Y. YOSHIDA, H. CHEN, Y. LUI, Z. G. ZHANG, J. LIAN, S. CHEN, AND M. CHOPP. 1993. Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am. J. Pathol. 142: 623-635.
23. 23. GARCIA, J. H., K. F. LIU, Y. YOSHIDA, J. LIAN, S. CHEN, AND G. J. DELZOPPA. 1994. Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat). Am. J. Pathol. 144: 188-199.
24. 24. GINSBERG, M. D. 1995. Neuroprotection in brain ischemia: An update (part I). Neuroscientist 1: 95-103.
25. 25. GINSBERG, M. D., AND R. BUSTO. 1989. Rodent models of cerebral ischemia. Stroke 20: 1627-1642.
26. 26. GROGAARD, B., L. SCHURER, B. GERDIN, AND K. E. ARFORS. 1989. Delayed hypoperfusion after incomplete forebrain ischemia in the rat: The role of polymorphonuclear leukocytes. J. Cereb. Blood Flow Metab. 9: 500-505.
27. 27. HALLENBECK, J. M., A. J. DUTKA, T. TANISHIMA, P. M. KOCHANEK, K. K. KUMAROO, C. B. THOMPSON, T. P. OBRENOVITCH, AND T. J. CONTRERAS. 1986. Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period. Stroke 17: 246-253.
28. 28. HATFIELD, R. H., A. D. MENDELOW, R. H. PERRY, L. M. ALVAREZ, AND P. MODHA. 1991. Triphenyltetrazolium chloride (TTC) as a marker for ischaemic changes in rat brain following permanent middle cerebral artery occlusion. Neuropathol. Appl. Neurobiol. 17: 61-67.
29. 29. HEINEL, L. A., S. RUBIB, R. H. ROSENWASSER, U. S. VASTHARE, AND R. F. TUME. 1994. Leukocyte involvement in cerebral infarct generation after ischemia and reperfusion. Brain Res. Bull. 34: 137-141.
30. 30. JIANG, N., R. L. ZHANG, H. CHEN, AND M. CHOPP. 1994. Anti-Cd11B monoclonal antibody reduces ischemic cell damage after transient (2h) but not after permanent MCA occlusion in the rat. Neurosci. Res. Commun. 15: 85-93.
31. 31. KAPLAN, B., S. BRINT, J. TANABE, M. MACEWICZ, AND X-J. WANG. 1991. Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia. Stroke 22: 1032-1038.
32. 32. KARIBE, H., J. CHEN, G. J. ZAROW, S. H. GRAHAM, AND P. R. WEINSTEIN. 1994. Delayed induction of mild hypothermia to reduce infarct volume after temporary middle cerebral artery occlusion in rats. J. Neurosurg. 80: 112-119.
33. 33. KOCHANEK, P. M., A. J. DUTKA, AND J. M. HALLENBECK. 1987. Indomethacin, prostacyclin, and heparin improve postischemic cerebral blood flow without affecting early postischemic granulocyte accumulation. Stroke 18: 634-637.
34. 34. KOCHANEK, P. M., AND J. M. HALLENBECK. 1992. Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke. Stroke 23: 1367-1379.
35. 35. LIN, T. N., Y. HE, G. WU, M. KHAN, AND C. Y. HSU. 1993. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke 24: 117-121.
36. 36. LINSBERG, P. J., A-L. SIREN, G. Z. FEUERSTEIN, AND J. H. HALLENBECK. 1995. Antagonism of neutrophil adherence in the deteriorating stroke model in rabbits. J. Neurosurg. 82: 269-277.
37. 37. LIU, T., R. K. CLARK, P. C. MCDONNELL, P. R. YOUNG, R. F. WHITE, F. C. BARONE, AND G. Z. FEUERSTEIN. 1994. Tumor necrosis factor-α expression in ischemic neurons. Stroke 25: 1481-1488.
38. 38. LOPEZ, O. T., AND T. H. LANTHORN. 1993. Anti-neutrophil antiserum reduces infarct volume after mouse permanent middle cerebral artery occlusion without producing neutropenia. Neurosci. Res. Commun. 13: 45-53.
39. 39. LUNDY, E. F., B. S. SOLIK, R. S. FRANK, P. S. LACY, D. J. COMBS, G. B. ZELENOCK, AND L. G. D'ALECY. 1986. Morphometric evaluation of brain infarcts in rats and gerbils. J. Pharmacol. Methods 16: 201-214.
40. 40. MATSUO, Y. M., H. ONODERA, Y. SHIGA, M. NAKAMURA, M. NINOMIYA, T. KIHARA, AND K. KOGURE. 1994. Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion. Stroke 25: 1469-1475.
41. 41. MATSUO, Y. M., H. ONODERA, Y. SHIGA, H. SHOZUHARA, M. NIMOMIYA, T. KIHARA, T. TAMATANI, M. MIYASAKA, AND K. KOGURE. 1994. Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat. Brain Res. 656: 344-352.
42. 42. MORI, E., G. J. DELZOPPO, J. D. CHAMBERS, B. R. COPELAND, AND K. E. ARFORS. 1992. Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia. Stroke 23: 712-718.
43. 43. NISHIGAYA, K., Y. YOSHIDA, M. SASUGA, H. NUKUI, AND G. OONEDA. 1991. Effect of recirculation on exacerbation of ischemic vascular lesions in rat brain. Stroke 22: 635-642.
44. 44. PATARROYO, M. 1991. Leukocyte adhesion in host defense and tissue injury. Clin. Immunol. Immunopathol. 60: 333-348.
45. 45. PAXINOS, G., AND C. WATSON. 1986. The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
46. 46. RIDENOUR, T. R., D. WARNER, M. M. TODD, AND A. C. MCALLISTER. 1992. Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats. Stroke 23: 733-738.
47. 47. SHIGA, Y., H. ONODERA, K. KOGURE, Y. YAMASAKI, Y. YASHIMA, H. SYOZUHARA, AND F. SENDO. 1991. Neutrophil as a mediator of ischemic edema formation in the brain. Neurosci. Lett. 125: 110-112.
48. 48. TAKESHIMA, R., J. R. KIRSCH, R. C. KOEHLER, A. W. GOMOLL, AND R. J. TRAYSTMAN. 1992. Monoclonal leukocyte antibody does not decrease the injury of transient focal cerebral ischemia in cats. Stroke 23: 247-252.
49. 49. TAMURA, A., D. I. GRAHAM, J. MCCULLOCH, AND G. M. TEASDALE. 1981. Focal cerebral ischemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 1: 53-60.
50. 50. UHL, M. W., K. V. BIAGAS, P. D. GRUNDL, M. A. BARMADA, J. K. SCHIDING, E. M. NEMOTO, AND P. M. KOCHANEK. 1994. Effects of neutropenia on edema, histology, and cerebral blood flow after traumatic brain injury in rats. J. Neurotrauma 11: 303-315.
51. 51. XUE, D., Z-G. HUANG, K. E. SMITH, AND A. M. BUCHAN. 1992. Immediate or delayed mild hypothermia prevents focal cerebral infarction. Brain Res. 587: 66-72.
52. 52. ZHANG, R-L., M. CHOPP, H. CHEN, AND J. H. GARCIA. 1994. Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat. J. Neurol. Sci. 125: 3-10.
53. 53. ZHANG, R-L., M. CHOPP, H. CHEN, J. H. GARCIA, AND Z. G. ZHANG. 1993. Postischemic (1 hour) hypothermia significantly reduces ischemic cell damage in rats subjected to 2 hours of middle cerebral artery occlusion. Stroke 24: 1235-1240.