Epithelial mesenchymal transition-like phenomenon in trabecular meshwork cells

Experimental Eye Research

Volumn 118, Issue , 2014, Pages 72-79

  Takahashi, Eri ^a   Inoue, Toshihiro ^a   Fujimoto, Tomokazu ^a   Kojima, Sachi ^a   Tanihara, Hidenobu ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

SMA; ECM; EMT; Integrin ligands; JNK; Migration; Paxillin; TGF ; TM; Trabecular meshwork cell

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; COLLAGEN TYPE 1; FIBRONECTIN; LAMININ; PAXILLIN; SMAD2 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL CONTACT; CELL CULTURE; CELL ISOLATION; CELL MIGRATION; CELL MOTILITY; CELL STIMULATION; CELL STRUCTURE; CHEMOTAXIS; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; GENETIC TRANSFECTION; IMMUNOCYTOCHEMISTRY; MACACA FASCICULARIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRABECULAR MESHWORK; WESTERN BLOTTING; WOUND HEALING;

EID: 84890107817     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2013.11.014     Document Type: Article

References (41)

1. Acott T.S., Kelley M.J. Extracellular matrix in the trabecular meshwork. Exp. Eye Res. 2008, 86:543-561.
2. Ahrens T., Sleeman J.P., Schempp C.M., Howells N., Hofmann M., Ponta H., Herrlich P., Simon J.C. Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid. Oncogene 2001, 20:3399-3408.
3. Bill A. Editorial: the drainage of aqueous humor. Invest. Ophthalmol. 1975, 14:1-3.
4. Burk U., Schubert J., Wellner U., Schmalhofer O., Vincan E., Spaderna S., Brabletz T. Areciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 2008, 9:582-589.
5. Cano A., Perez-Moreno M.A., Rodrigo I., Locascio A., Blanco M.J., del Barrio M.G., Portillo F., Nieto M.A. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2000, 2:76-83.
6. Chen G.C., Turano B., Ruest P.J., Hagel M., Settleman J., Thomas S.M. Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development. Mol. Cell. Biol. 2005, 25:979-987.
7. Deakin N.O., Turner C.E. Paxillin comes of age. J.Cell Sci. 2008, 121:2435-2444.
8. Fautsch M.P., Johnson D.H. Aqueous humor outflow: what do we know? Where will it lead us?. Invest. Ophthalmol. Vis. Sci. 2006, 47:4181-4187.
9. Ferrer E. Trabecular meshwork as a new target for the treatment of glaucoma. Drug News Perspect. 2006, 19:151-158.
10. Fujimoto T., Inoue T., Kameda T., Kasaoka N., Inoue-Mochita M., Tsuboi N., Tanihara H. Involvement of RhoA/Rho-associated kinase signal transduction pathway in dexamethasone-induced alterations in aqueous outflow. Invest. Ophthalmol. Vis. Sci. 2012, 53:7097-7108.
11. Garibaldi F., Cicchini C., Conigliaro A., Santangelo L., Cozzolino A.M., Grassi G., Marchetti A., Tripodi M., Amicone L. An epistatic mini-circuitry between the transcription factors Snail and HNF4alpha controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs. Cell Death Differ. 2012, 19:937-946.
12. Greenburg G., Hay E.D. Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J.Cell Biol. 1982, 95:333-339.
13. Hagel M., George E.L., Kim A., Tamimi R., Opitz S.L., Turner C.E., Imamoto A., Thomas S.M. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol. Cell Biol. 2002, 22:901-915.
14. Hann C.R., Springett M.J., Wang X., Johnson D.H. Ultrastructural localization of collagen IV, fibronectin, and laminin in the trabecular meshwork of normal and glaucomatous eyes. Ophthalmic Res. 2001, 33:314-324.
15. Hashimoto N., Phan S.H., Imaizumi K., Matsuo M., Nakashima H., Kawabe T., Shimokata K., Hasegawa Y. Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 2010, 43:161-172.
16. Huang C., Borchers C.H., Schaller M.D., Jacobson K. Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells. J.Cell Biol. 2004, 164:593-602.
17. Huang C., Rajfur Z., Borchers C., Schaller M.D., Jacobson K. JNK phosphorylates paxillin and regulates cell migration. Nature 2003, 424:219-223.
18. Islam S., Carey T.E., Wolf G.T., Wheelock M.J., Johnson K.R. Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion. J.Cell Biol. 1996, 135:1643-1654.
19. Kalluri R., Neilson E.G. Epithelial-mesenchymal transition and its implications for fibrosis. J.Clin. Invest. 2003, 112:1776-1784.
20. Knepper P.A., Goossens W., Mayanil C.S. CD44H localization in primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 1998, 39:673-680.
21. Knepper P.A., Miller A.M., Choi J., Wertz R.D., Nolan M.J., Goossens W., Whitmer S., Yue B.Y., Ritch R., Liebmann J.M., Allingham R.R., Samples J.R. Hypophosphorylation of aqueous humor sCD44 and primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2005, 46:2829-2837.
22. Li B.J., Tang Q., Cheng D., Qin C., Xie F.Y., Wei Q., Xu J., Liu Y., Zheng B.J., Woodle M.C., Zhong N., Lu P.Y. Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. Nat. Med. 2005, 11:944-951.
23. Li G., Luna C., Qiu J., Epstein D.L., Gonzalez P. Alterations in microRNA expression in stress-induced cellular senescence. Mech. Ageing Dev. 2009, 130:731-741.
24. Luna C., Li G., Huang J., Qiu J., Wu J., Yuan F., Epstein D.L., Gonzalez P. Regulation of trabecular meshwork cell contraction and intraocular pressure by miR-200c. PloS One 2012, 7:e51688.
25. Navarro P., Gomez M., Pizarro A., Gamallo C., Quintanilla M., Cano A. Arole for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis. J.Cell Biol. 1991, 115:517-533.
26. Oft M., Akhurst R.J., Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat. Cell Biol. 2002, 4:487-494.
27. Pattabiraman P.P., Rao P.V. Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. Am. J. Physiol. Cell Physiol. 2010, 298:C749-C763.
28. Picht G., Welge-Luessen U., Grehn F., Lutjen-Drecoll E. Transforming growth factor beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development. Graefes Arch. Clin. Exp. Ophthalmol. 2001, 239:199-207.
29. Piera-Velazquez S., Li Z., Jimenez S.A. Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders. Am. J. Pathol. 2011, 179:1074-1080.
30. Pilcher B.K., Dumin J.A., Sudbeck B.D., Krane S.M., Welgus H.G., Parks W.C. The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix. J.Cell Biol. 1997, 137:1445-1457.
31. Plow E.F., Haas T.A., Zhang L., Loftus J., Smith J.W. Ligand binding to integrins. J.Biol. Chem. 2000, 275:21785-21788.
32. Schaller M.D. Paxillin: a focal adhesion-associated adaptor protein. Oncogene 2001, 20:6459-6472.
33. Schaller M.D., Parsons J.T. pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol. Cell. Biol. 1995, 15:2635-2645.
34. Stefani G., Slack F.J. Small non-coding RNAs in animal development. Nat. Rev. Mol. Cell Biol. 2008, 9:219-230.
35. Takahashi E., Nagano O., Ishimoto T., Yae T., Suzuki Y., Shinoda T., Nakamura S., Niwa S., Ikeda S., Koga H., Tanihara H., Saya H. Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction. J.Biol. Chem. 2010, 285:4060-4073.
36. Tektas O.Y., Lutjen-Drecoll E. Structural changes of the trabecular meshwork in different kinds of glaucoma. Exp. Eye Res. 2009, 88:769-775.
37. Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
38. Toole B.P., Zoltan-Jones A., Misra S., Ghatak S. Hyaluronan: a critical component of epithelial-mesenchymal and epithelial-carcinoma transitions. Cells Tissues Organs 2005, 179:66-72.
39. Tripathi R.C., Li J., Chan W.F., Tripathi B.J. Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2. Exp. Eye Res. 1994, 59:723-727.
40. Zeisberg E.M., Potenta S.E., Sugimoto H., Zeisberg M., Kalluri R. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J.Am. Soc. Nephrol. 2008, 19:2282-2287.
41. Zeisberg M., Yang C., Martino M., Duncan M.B., Rieder F., Tanjore H., Kalluri R. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J.Biol. Chem. 2007, 282:23337-23347.