Adverse biventricular remodeling in isolated right ventricular hypertension is mediated by increased transforming growth factor-β1 signaling and is abrogated by angiotensin receptor blockade

American Journal of Respiratory Cell and Molecular Biology

Volumn 49, Issue 6, 2013, Pages 1019-1028

  Friedberg, Mark K ^a   Cho, Mi Young ^a   Li, Jing ^a   Assad, Renato S ^d   Sun, Mei ^a   Rohailla, Sagar ^a   Honjo, Osami ^b   Apitz, Christian ^c   Redington, Andrew N ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HOSPITAL GIESSEN   (Germany)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Angiotensin receptor blocker; Apoptosis; Fibrosis; Right ventricular afterload; Ventricular ventricular interactions

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; GELATINASE A; GELATINASE B; LOSARTAN; PLACEBO; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOPPLER ECHOCARDIOGRAPHY; DOWN REGULATION; EXPERIMENTAL RABBIT; HEART AFTERLOAD; HEART BIVENTRICULAR FIBROSIS; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART RIGHT VENTRICLE FUNCTION; HEART RIGHT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE PRESSURE; HEART SURGERY; HYPERTENSION; LUNG ARTERY BANDING; M MODE ECHOCARDIOGRAPHY; MALE; NONHUMAN; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; APOPTOSIS; CONNECTIVE TISSUE GROWTH FACTOR; ENDOTHELIN-1; FIBROSIS; HYPERTENSION; HYPERTENSION, PULMONARY; LOSARTAN; MALE; MATRIX METALLOPROTEINASE 2; RABBITS; RECEPTOR, ENDOTHELIN B; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1; VENTRICULAR DYSFUNCTION, RIGHT; VENTRICULAR REMODELING;

EID: 84890094499     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0149OC     Document Type: Article

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