Transforming growth factor β 1 oppositely regulates the hypertrophic and contractile response to β-Adrenergic stimulation in the heart

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Huntgeburth, Michael ^a   Tiemann, Klaus ^b   Shahverdyan, Robert ^a   Schlüter, Klaus Dieter ^c   Schreckenberg, Rolf ^c   Gross, Marie Luise ^d   Mödersheim, Sonja ^d   Caglayan, Evren ^a   Müller Ehmsen, Jochen ^a   Ghanem, Alexander ^e   Vantler, Marius ^a   Zimmermann, Wolfram H ^f   Böhm, Michael ^g   Rosenkranz, Stephan ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e UNIVERSITY HOSPITAL BONN   (Germany)

^f UNIVERSITY OF GÖTTINGEN   (Germany)

^g SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; DOBUTAMINE; ISOPRENALINE; METOPROLOL; TELMISARTAN; TRANSFORMING GROWTH FACTOR BETA1; UNCOUPLING PROTEIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BENZIMIDAZOLE DERIVATIVE; BENZOIC ACID DERIVATIVE; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 3;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC STIMULATION; BODY WEIGHT; CONTROLLED STUDY; ENERGY METABOLISM; HEART CONTRACTION; HEART FAILURE; HEART HYPERTROPHY; HEART LEFT VENTRICLE; HEART MITOCHONDRION; HEART MUSCLE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART WEIGHT; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INOTROPISM; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STRESS ECHOCARDIOGRAPHY; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; CARDIOMEGALY; CELL CULTURE; DRUG EFFECT; ECHOGRAPHY; GENE EXPRESSION REGULATION; GENETICS; HEART; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

MUS; MUS MUSCULUS;

ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BENZIMIDAZOLES; BENZOATES; CARDIOMEGALY; CELLS, CULTURED; ECHOCARDIOGRAPHY, STRESS; GENE EXPRESSION REGULATION; HEART; HUMANS; ION CHANNELS; ISOPROTERENOL; METOPROLOL; MICE; MICE, TRANSGENIC; MITOCHONDRIAL PROTEINS; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 81255143238     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026628     Document Type: Article

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