Curcumin inhibits tumor growth and angiogenesis in an orthotopic mouse model of human pancreatic cancer

BioMed Research International

Volumn 2013, Issue , 2013, Pages

  Bimonte, Sabrina ^a   Barbieri, Antonio ^a   Palma, Giuseppe ^a,b   Luciano, Antonio ^a   Rea, Domenica ^a   Arra, Claudio ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CURCUMIN; GEMCITABINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; DEOXYCYTIDINE; DRUG DERIVATIVE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOLUMINESCENCE; CANCER INHIBITION; CELL ASSAY; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; DNA BINDING; FEMALE; FLOW CYTOMETRY; MOUSE; NONHUMAN; PANCREAS CANCER; TUMOR VOLUME; WESTERN BLOTTING; WOUND HEALING; ANIMAL; BIOSYNTHESIS; DIET THERAPY; DISEASE MODEL; DRUG EFFECT; HUMAN; NEOVASCULARIZATION (PATHOLOGY); NUDE MOUSE; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CURCUMIN; DEOXYCYTIDINE; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; PANCREATIC NEOPLASMS;

EID: 84890082601     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/810423     Document Type: Article

References (20)

1. Jemal A., Siegel R., Ward E., Murray T., Xu J., Smigal C., Thun M. J., Cancer statistics, 2006. Ca: A Cancer Journal for Clinicians 2006 56 2 106 130 2-s2.0-33645526144 10.3322/canjclin.56.2.106
2. Duffy J. P., Eibl G., Reber H. A., Hines O. J., Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer. Molecular Cancer 2003 2, article no. 12 2-s2.0-2942615346 10.1186/1476-4598-2-12 (Pubitemid 38751485)
3. Burris H. A. III, Moore M. J., Andersen J., Green M. R., Rothenberg M. L., Modiano M. R., Cripps M. C., Portenoy R. K., Storniolo A. M., Tarassoff P., Nelson R., Dorr F. A., Stephens C. D., Von Hoff D. D., Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. Journal of Clinical Oncology 1997 15 6 2403 2413 2-s2.0-8244254377 (Pubitemid 27251144)
4. Lao C. D., Ruffin M. T. IV, Normolle D., Heath D. D., Murray S. I., Bailey J. M., Boggs M. E., Crowell J., Rock C. L., Brenner D. E., Dose escalation of a curcuminoid formulation. BMC Complementary and Alternative Medicine 2006 6, article 10 2-s2.0-33645648062 10.1186/1472-6882-6-10
5. Aggarwal B. B., Nuclear factor- B: the enemy within. Cancer Cell 2004 6 3 203 208 2-s2.0-4544342570 10.1016/j.ccr.2004.09.003 (Pubitemid 39222032)
6. Arlt A., Gehrz A., Müerköster S., Vorndamm J., Kruse M.-L., Fölsch U. R., Schäfer H., Role of NF- B and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 2003 22 21 3243 3251 2-s2.0-0038621384 10.1038/sj.onc.1206390 (Pubitemid 36712936)
7. Liptay S., Weber C. K., Ludwig L., Wagner M., Adler G., Schmid R. M., Mitogenic and antiapoptotic role of constitutive NF- B/Rel activity in pancreatic cancer. International Journal of Cancer 2003 105 6 735 746 2-s2.0-0037780982 10.1002/ijc.11081 (Pubitemid 36706095)
8. Fujioka S., Sclabas G. M., Schmidt C., Frederick W. A., Dong Q. G., Abbruzzese J. L., Evans D. B., Baker C., Chiao P. J., Function of nuclear factor B in pancreatic cancer metastasis. Clinical Cancer Research 2003 9 1 346 354 (Pubitemid 36109751)
9. Greten F. R., Weber C. K., Greten T. F., Schneider G., Wagner M., Adler G., Schmid R. M., Stat3 and NF- B activation prevents apoptosis in pancreatic carcinogenesis. Gastroenterology 2002 123 6 2052 2063 2-s2.0-0036884187 10.1053/gast.2002.37075 (Pubitemid 35408327)
10. Xiong H. Q., Abbruzzese J. L., Lin E., Wang L., Zheng L., Xie K., NF- B activity blockade impairs the angiogenic potential of human pancreatic cancer cells. International Journal of Cancer 2004 108 2 181 188 2-s2.0-0348012946 10.1002/ijc.11562 (Pubitemid 37541768)
11. Yebra M., Filardo E. J., Bayna E. M., Kawahara E., Becker J. C., Cheresh D. A., Induction of carcinoma cell migration on vitronectin by NF- B-dependent gene expression. Molecular Biology of the Cell 1995 6 7 841 850 2-s2.0-0029044627
12. Arbiser J. L., Klauber N., Rohan R., Van Leeuwen R., Huang M.-T., Fisher C., Flynn E., Byers H. R., Curcumin is an in vivo inhibitor of angiogenesis. Molecular Medicine 1998 4 6 376 383 2-s2.0-0031840433 (Pubitemid 28387896)
13. Thaloor D., Singh A. K., Sidhu G. S., Prasad P. V., Kleinman H. K., Maheshwari R. K., Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcumin. Cell Growth and Differentiation 1998 9 4 305 312 2-s2.0-0031816432 (Pubitemid 28345884)
14. Mohan R., Sivak J., Ashton P., Russo L. A., Pham B. Q., Kasahara N., Raizman M. B., Fini M. E., Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B. Journal of Biological Chemistry 2000 275 14 10405 10412 2-s2.0-0034615942 10.1074/jbc.275.14.10405 (Pubitemid 30202100)
15. Li L., Aggarwal B. B., Shishodia S., Abbruzzese J., Kurzrock R., Nuclear factor- B and I B are constitutively active in human pancreatic cells, and their down-regulation by curcumin (Diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 2004 101 10 2351 2362 2-s2.0-7644223910 10.1002/cncr.20605 (Pubitemid 39458693)
16. Li L., Braiteh F. S., Kurzrock R., Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer 2005 104 6 1322 1331 2-s2.0-24644508916 10.1002/cncr.21300 (Pubitemid 41282806)
17. Kunnumakkara A. B., Guha S., Krishnan S., Diagaradjane P., Gelovani J., Aggarwal B. B., Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor- B-regulated gene products. Cancer Research 2007 67 8 3853 3861 2-s2.0-34248573808 10.1158/0008-5472.CAN-06- 4257 (Pubitemid 46762173)
18. Chaturvedi M. M., Mukhopadhyay A., Aggarwal B. B., Assay for redox-sensitive transcription factor. Methods in Enzymology 2000 319 585 602 2-s2.0-0033919150 (Pubitemid 30448077)
19. Mukhopadhyay A., Banerjee S., Stafford L. J., Xia C., Liu M., Aggarwal B. B., Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene 2002 21 57 8852 8861 2-s2.0-0037069939 10.1038/sj.onc.1206048 (Pubitemid 36132405)
20. Aggarwal B. B., Kumar A., Bharti A. C., Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Research 2003 23 1A 363 398 2-s2.0-0037236792 (Pubitemid 36361976)