N-3 polyunsaturated fatty acids and atrial fibrillation in patients with chronic heart failure: The GISSI-HF trial

European Journal of Heart Failure

Volumn 15, Issue 11, 2013, Pages 1289-1295

  Aleksova, Aneta ^a   Masson, Serge ^b   Maggioni, Aldo P ^b   Lucci, Donata ^c   Fabbri, Gianna ^c   Beretta, Luciano ^d   Mos, Lucio ^e   Paino, Anna Maria ^e   Nicolosi, Gian Luigi ^f   Marchioli, Roberto ^g   Tognoni, Gianni ^g   Tavazzi, Luigi ^h   Sinagra, Gianfranco ^a   Latini, Roberto ^b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c ANMCO RESEARCH CENTER   (Italy)

^d OSPEDALE NIGUARDA CA GRANDA   (Italy)

^e Cardiovascular Department   (Italy)

^f Cardiology Unit   (Italy)

^g Santa Maria Imbaro ^*  (Italy)

^h Ettore Sansavini Health Science Foundation   (Italy)

Author keywords

Atrial fibrillation; Chronic heart failure; Fish consumption; N 3 PUFAs

Indexed keywords

DIURETIC AGENT; OLIVE OIL; OMEGA 3 FATTY ACID; PLACEBO;

AGE DISTRIBUTION; AGED; ANTICOAGULANT THERAPY; ARTICLE; BODY MASS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ELECTROCARDIOGRAM; FEMALE; FISH; FOLLOW UP; FOOD INTAKE; HEART ATRIUM FIBRILLATION; HEART FAILURE; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; POST HOC ANALYSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL;

ATRIAL FIBRILLATION; CHRONIC HEART FAILURE; FISH CONSUMPTION; N-3 PUFAS;

AGED; ATRIAL FIBRILLATION; CHRONIC DISEASE; DOUBLE-BLIND METHOD; FATTY ACIDS, OMEGA-3; FEMALE; HEART FAILURE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; TREATMENT OUTCOME;

EID: 84890068806     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1093/eurjhf/hft103     Document Type: Article

References (34)

1. Naccarelli GV, Varker H, Lin J, Schulman KL. Increasing prevalence of atrial fibrillation and flutter in the United States. Am J Cardiol 2009;104:1534-1539
2. European Heart Rhythm Association; European Association for Cardio-Thoracic Surgery, Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S, Van Gelder IC, Al-Attar N, Hindricks G, Prendergast B, Heidbuchel H, Alfieri O, Angelini A, Atar D, Colonna P, De Caterina R, De Sutter J, Goette A, Gorenek B, Heldal M, Hohloser SH, Kolh P, Le Heuzey JY, Ponikowski P, Rutten FH. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J 2010;31: 2369-2429
3. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Køber L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Rønnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A; Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology, Bax JJ, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Torbicki A, Vahanian A, Windecker S, McDonagh T, Sechtem U, Bonet LA, Avraamides P, Ben L, amin HA, Brignole M, Coca A, Cowburn P, Dargie H, Elliott P, Flachskampf FA, Guida GF, Hardman S, Iung B, Merkely B, Mueller C, Nanas JN, Nielsen OW, Orn S, Parissis JT, Ponikowski P; ESC Committee for Practice Guidelines. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2012;14:803-869
4. Benjamin EJ, Levy D, Vaziri SM, D'Agostino RB, Belanger AJ,Wolf PA. Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA 1994;271:840-844
5. Schnabel RB, Sullivan LM, Levy D, Pencina MJ, Massaro JM, D'Agostino RB Sr, Newton-Cheh C, Yamamoto JF, Magnani JW, Tadros TM, Kannel WB, Wang TJ, Ellinor PT, Wolf PA, Vasan RS, Benjamin EJ. Development of a risk score for atrial fibrillation (Framingham Heart Study): A community-based cohort study. Lancet 2009,373:739-745
6. Dries DL, Exner DV, Gersh BJ, Domanski MJ,Waclawiw MA, Stevenson LW. Atrial fibrillation is associated with an increased risk for mortality and heart failure progression in patients with asymptomatic and symptomatic left ventricular systolic dysfunction: A retrospective analysis of the SOLVD trials. Studies of Left Ventricular Dysfunction. J Am Coll Cardiol 1998;32:695-703
7. Aleksova A, Merlo M, Zecchin M, Sabbadini G, Barbati G, Vitrella G, Di Lenarda A, Sinagra G. Impact of atrial fibrillation on outcome of patients with idiopathic dilated cardiomyopathy: Data from the Heart Muscle Disease Registry of Trieste. Clin Med Res 2010;8:142-149
8. Swedberg K, OlssonLG, Charlesworth A, Cleland J, Hanrath P, Komajda M, Metra M, Torp-Pedersen C, Poole-Wilson P. Prognostic relevance of atrial fibrillation in patients with chronic heart failure on long-term treatment with beta-blockers: Results from COMET. Eur Heart J 2005;26:1303-1308
9. Olsson LG, Swedberg K, Ducharme A, Granger CB, Michelson EL, McMurray JJ, Puu M, Yusuf S, PfefferMA;CHARMInvestigators. Atrial fibrillation and risk of clinical events in chronic heart failure with and without left ventricular systolic dysfunction: Results from the Candesartan in Heart failure-Assessment of Reduction in Mortality and morbidity (CHARM) program. J Am Coll Cardiol 2006;47:1997-2004
10. Mahoney P, Kimmel S, DeNofrio D,Wahl P, Loh E. Prognostic significance of atrial fibrillation in patients at a tertiary medical center referred for heart transplantation because of severe heart failure. Am J Cardiol 1999;83:1544-1547
11. Savelieva I, Kakouros N, Kourliouros A, Camm AJ. Upstream therapies for management of atrial fibrillation: Review of clinical evidence and implications for European Society of Cardiology guidelines. Part I: Primary prevention. Europace 2011;13: 308-328
12. Nodari S, Triggiani M, Campia U, Manerba A, Milesi G, Cesana BM, Gheorghiade M, Dei Cas L. n-3 polyunsaturated fatty acids in the prevention of atrial fibrillation recurrences after electrical cardioversion: A prospective, randomized study. Circulation 2011;124:1100-1106
13. Kumar S, Sutherland F, Morton JB, Lee G, Morgan J, Wong J, Eccleston DE, Voukelatos J, Garg ML, Sparks PB. Long-term omega-3 polyunsaturated fatty acid supplementation reduces the recurrence of persistent atrial fibrillation after electrical cardioversion. Heart Rhythm 2012;9:483-491
14. Kowey PR, Reiffel JA, Ellenbogen KA, Naccarelli GV, Pratt CM. Efficacy and safety of prescription omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation: A randomized controlled trial. JAMA 2010;304:2363-2372
15. Mozaffarian D, Marchioli R, Macchia A, Silletta MG, Ferrazzi P, Gardner TJ, Latini R, Libby P, Lombardi F, O'Gara PT, Page RL, Tavazzi L, Tognoni G; for theOPERAInvestigators. Fish oil and postoperative atrial fibrillation: The Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial. JAMA 2012; 308:2001-2011
16. Macchia A,GrancelliH, Varini S,Nul D, Laffaye N,Mariani J, Ferrante D, Badra R, Figal J, Ramos S, Tognoni G, Doval HC; GESICA Investigators. Omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation: Results of the FORWARD (Randomized Trial to Assess Efficacy of PUFA for the Maintenance of Sinus Rhythm in Persistent Atrial Fibrillation) trial. J Am Coll Cardiol 2013;61:463-468
17. GISSI-HF Investigators, Tavazzi L, Maggioni AP, Marchioli R, Barlera S, Franzosi MG, Latini R, Lucci D, Nicolosi GL, Porcu M, Tognoni G. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): A randomised, double-blind, placebo-controlled trial. Lancet 2008;372:1223-1230
18. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 1999;354:447-455
19. Barzi F,Woodward M, Marfisi RM, Tavazzi L, Valagussa F, Marchioli R Mediterranean diet and all-causes mortality after myocardial infarction: Results from the GISSIPrevenzione trial. Eur J Clin Nutr 2003; 57:604-611
20. Masson S, Marchioli R, Mozaffarian D, Bernasconi R, Milani V, Dragani L, Tacconi M, Marfisi RM, Borgese L, Cirrincione V, Febo O, Nicolis E, Maggioni AP, Tognoni G, Tavazzi L, Latini R, on behalf of the GISSI-HF Investigators. Plasma n-3 polyunsaturated fatty acids in chronic heart failure in the GISSI-Heart Failure Trial: Relation with fish intake, circulating biomarkers and mortality. Am Heart J 2013;165:208-215
21. Laurent G,MoeG,HuX, Holub B, Leong-Poi H, Trogadis J, Connelly K, Courtman D, Strauss BH, Dorian P. Long chain n-3 polyunsaturated fatty acids reduce atrial vulnerability in a novel canine pacing model. Cardiovasc Res 2008;77:89-97
22. Lau DH, Mackenzie L, Kelly DJ, Psaltis PJ, Brooks AG,Worthington M, Rajendram A, Kelly DR, Zhang Y, Kuklik P, Nelson AJ, Wong CX, Worthley SG, Rao M, Faull RJ, Edwards J, Saint DA, Sanders P. Hypertension and atrial fibrillation: Evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model. Heart Rhythm 2010;7:1282-1290
23. Sakabe M, Shiroshita-Takeshita A, Maguy A, Dumesnil C, Nigam A, Leung TK, Nattel S. Omega-3 polyunsaturated fatty acids prevent atrial fibrillation associated with heart failure but not atrial tachycardia remodeling. Circulation 2007;116: 2101-2109
24. Wu JH, Lemaitre RN, King IB, Song X, Sacks FM, Rimm EB, Heckbert SR, Siscovick DS, Mozaffarian D. Association of plasma phospholipid long-chain v-3 fatty acids with incident atrial fibrillation in older adults: The cardiovascular health study. Circulation 2012;125:1084-1093
25. He Z, Yang L, Tian J, Yang K,WuJ, YaoY. Efficacy and safety of omega-3 fatty acids for the prevention of atrial fibrillation: A meta-analysis. Can J Cardiol 2013;29:196-203
26. Liu T, Korantzopoulos P, Shehata M, Li G,Wang X, Kaul S. Prevention of atrial fibrillation with omega-3 fatty acids: A meta-analysis of randomised clinical trials. Heart 2011;97:1034-1040
27. Benedetto U, Angeloni E, Melina G, Danesi TH, Di Bartolomeo R, Lechiancole A, Refice S, Roscitano A, Comito C, Sinatra R. n-3 Polyunsaturated fatty acids for the prevention of postoperative atrial fibrillation: A meta-analysis of randomized controlled trials. J Cardiovasc Med 2013;14:104-109
28. Ramadeen A, Connelly KA, Leong-Poi H, Hu X, Fujii H, Laurent G, Domenichiello AF, Bazinet RP, Dorian P. Docosahexaenoic acid, but not eicosapentaenoic acid, supplementation reduces vulnerability to atrial fibrillation. Circ Arrhythm Electrophysiol 2012;5:978-983
29. Virtanen JK, Mursu J, Voutilainen S, Tuomainen TP. Serum long-chain n-3 polyunsaturated fatty acids and risk of hospital diagnosis of atrial fibrillation in men. Circulation 2009;120:2315-2321
30. Shinagawa K, Shi YF, Tardif JC, Leung TK, Nattel S. Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs. Circulation 2002; 105:2672-2678
31. Cha YM, Dzeja PP, ShenWK,Jahangir A, HartCY,Terzic A, RedfieldMM.Failing atrial myocardium: Energetic deficits accompany structural remodelling and electrical instability. Am J Physiol Heart Circ Physiol 2003;284:H1313-H1320
32. Brouwer IA, Heeringa J, Geleijnse JM, Zock PL, Witteman JC. Intake of very longchain n-3 fatty acids from fish and incidence of atrial fibrillation. The Rotterdam Study. Am Heart J 2006;151:857-862
33. Berry JD, Prineas RJ, van Horn L, Passman R, Larson J, Goldberger J, Snetselaar L, Tinker L, Liu K, Lloyd-Jones DM. Dietary fish intake and incident atrial fibrillation (from the Women's Health Initiative). Am J Cardiol 2010;105: 844-848
34. Shen J, Johnson VM, SullivanLM, Jacques PF, MagnaniJW, Lubitz SA, Pandey S, Levy D, Vasan RS, Quatromoni PA, Junyent M, Ordovas JM, Benjamin EJ. Dietary factors and incident atrial fibrillation: The Framingham Heart Study. Am J Clin Nutr 2011;93: 261-266