-
1
-
-
56349150992
-
Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations
-
Multiple Sclerosis Therapy Consensus Group (mstcg)
-
Multiple Sclerosis Therapy Consensus Group (MSTCG), H. Wiendl, K.V. Toyka, P. Rieckmann, R. Gold, and H.P. Hartung Basic and escalating immunomodulatory treatments in multiple sclerosis: current therapeutic recommendations J Neurol 255 10 2008 1449 1463
-
(2008)
J Neurol
, vol.255
, Issue.10
, pp. 1449-1463
-
-
Wiendl, H.1
Toyka, K.V.2
Rieckmann, P.3
Gold, R.4
Hartung, H.P.5
-
2
-
-
34250779802
-
Natalizumab for multiple sclerosis
-
R.M. Ransohoff Natalizumab for multiple sclerosis N Engl J Med 356 25 2007 2622 2629
-
(2007)
N Engl J Med
, vol.356
, Issue.25
, pp. 2622-2629
-
-
Ransohoff, R.M.1
-
3
-
-
17644398787
-
Anti-alpha4 integrin therapy for multiple sclerosis: Mechanisms and rationale
-
G.P.A. Rice, H. Hartung, and P.A. Calabresi Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale Neurology 64 8 2005 1336 1342
-
(2005)
Neurology
, vol.64
, Issue.8
, pp. 1336-1342
-
-
Rice, G.P.A.1
Hartung, H.2
Calabresi, P.A.3
-
4
-
-
33644584352
-
A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
-
C.H. Polman, P.W. O'Connor, E. Havrdova, M. Hutchinson, L. Kappos, and D.H. Miller A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis N Engl J Med 354 9 2006 899 910
-
(2006)
N Engl J Med
, vol.354
, Issue.9
, pp. 899-910
-
-
Polman, C.H.1
O'Connor, P.W.2
Havrdova, E.3
Hutchinson, M.4
Kappos, L.5
Miller, D.H.6
-
5
-
-
33644608613
-
Natalizumab plus interferon beta-1a for relapsing multiple sclerosis
-
R.A. Rudick, W.H. Stuart, P.A. Calabresi, C. Confavreux, S.L. Galetta, and E.W. Radue Natalizumab plus interferon beta-1a for relapsing multiple sclerosis N Engl J Med 354 9 2006 911 923
-
(2006)
N Engl J Med
, vol.354
, Issue.9
, pp. 911-923
-
-
Rudick, R.A.1
Stuart, W.H.2
Calabresi, P.A.3
Confavreux, C.4
Galetta, S.L.5
Radue, E.W.6
-
6
-
-
22844439662
-
Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis
-
B.K. Kleinschmidt-DeMasters, and K.L. Tyler Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis N Engl J Med 353 4 2005 369 374
-
(2005)
N Engl J Med
, vol.353
, Issue.4
, pp. 369-374
-
-
Kleinschmidt-Demasters, B.K.1
Tyler, K.L.2
-
7
-
-
22844445230
-
Progressive multifocal leukoencephalopathy in a patient treated with natalizumab
-
A. Langer-Gould, S.W. Atlas, A.J. Green, A.W. Bollen, and D. Pelletier Progressive multifocal leukoencephalopathy in a patient treated with natalizumab N Engl J Med 353 4 2005 375 381
-
(2005)
N Engl J Med
, vol.353
, Issue.4
, pp. 375-381
-
-
Langer-Gould, A.1
Atlas, S.W.2
Green, A.J.3
Bollen, A.W.4
Pelletier, D.5
-
8
-
-
22844445587
-
Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease
-
G. Van Assche, M. Van Ranst, R. Sciot, B. Dubois, S. Vermeire, and M. Noman Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease N Engl J Med 353 4 2005 362 368
-
(2005)
N Engl J Med
, vol.353
, Issue.4
, pp. 362-368
-
-
Van Assche, G.1
Van Ranst, M.2
Sciot, R.3
Dubois, B.4
Vermeire, S.5
Noman, M.6
-
9
-
-
57149117126
-
New cases of progressive multifocal leukoencephalopathy after treatment with natalizumab
-
H. Hartung New cases of progressive multifocal leukoencephalopathy after treatment with natalizumab Lancet Neurol 8 1 2009 28 31
-
(2009)
Lancet Neurol
, vol.8
, Issue.1
, pp. 28-31
-
-
Hartung, H.1
-
10
-
-
84890073146
-
-
D96A171A-3815-4766-940D- BE6E2DAD8F0A-biibTysabri13Mar09.pdf (application/pdf Object). [Accessed March 17, 2009]
-
D96A171A-3815-4766-940D-BE6E2DAD8F0A-biibTysabri13Mar09.pdf (application/pdf Object). Available at: http://library.corporate-ir.net/library/ 14/148/148682/items/328677/D96A171A-3815-4766-940D-BE6E2DAD8F0A- biibTysabri13Mar09.pdf [Accessed March 17, 2009].
-
-
-
-
11
-
-
34547892636
-
Progressive multifocal leukoencephalopathy after rituximab in a case of non-Hodgkin lymphoma
-
S.M. Kranick, E.M. Mowry, and M.R. Rosenfeld Progressive multifocal leukoencephalopathy after rituximab in a case of non-Hodgkin lymphoma Neurology 69 7 2007 704 706
-
(2007)
Neurology
, vol.69
, Issue.7
, pp. 704-706
-
-
Kranick, S.M.1
Mowry, E.M.2
Rosenfeld, M.R.3
-
12
-
-
33745299246
-
Infectious complications associated with alemtuzumab use for lymphoproliferative disorders
-
S.I. Martin, F.M. Marty, K. Fiumara, S.P. Treon, J.G. Gribben, and L.R. Baden Infectious complications associated with alemtuzumab use for lymphoproliferative disorders Clin Infect Dis 43 1 2006 16 24
-
(2006)
Clin Infect Dis
, vol.43
, Issue.1
, pp. 16-24
-
-
Martin, S.I.1
Marty, F.M.2
Fiumara, K.3
Treon, S.P.4
Gribben, J.G.5
Baden, L.R.6
-
13
-
-
54949143968
-
Alemtuzumab vs interferon beta-1a in early multiple sclerosis
-
CAMMS223 Trial Investigators, A.J. Coles, D.A. Compston, K.W. Selmaj, S.L. Lake, and S. Moran Alemtuzumab vs. interferon beta-1a in early multiple sclerosis N Engl J Med 359 17 2008 1786 1801
-
(2008)
N Engl J Med
, vol.359
, Issue.17
, pp. 1786-1801
-
-
Coles, A.J.1
Compston, D.A.2
Selmaj, K.W.3
Lake, S.L.4
Moran, S.5
-
14
-
-
34249818493
-
Oral disease-modifying treatments for multiple sclerosis: The story so far
-
B.C. Kieseier, and H. Wiendl Oral disease-modifying treatments for multiple sclerosis: the story so far CNS Drugs 21 6 2007 483 502
-
(2007)
CNS Drugs
, vol.21
, Issue.6
, pp. 483-502
-
-
Kieseier, B.C.1
Wiendl, H.2
-
15
-
-
23044442340
-
Adherence to medication
-
L. Osterberg, and T. Blaschke Adherence to medication N Engl J Med 353 5 2005 487 497
-
(2005)
N Engl J Med
, vol.353
, Issue.5
, pp. 487-497
-
-
Osterberg, L.1
Blaschke, T.2
-
17
-
-
2342627946
-
Leflunomide in the treatment of rheumatoid arthritis
-
E.K. Li, L. Tam, and B. Tomlinson Leflunomide in the treatment of rheumatoid arthritis Clin Ther 26 4 2004 447 459
-
(2004)
Clin Ther
, vol.26
, Issue.4
, pp. 447-459
-
-
Li, E.K.1
Tam, L.2
Tomlinson, B.3
-
18
-
-
20144378736
-
Leflunomide in rheumatoid arthritis: Recommendations through a process of consensus
-
P. Maddison, P. Kiely, B. Kirkham, T. Lawson, R. Moots, and D. Proudfoot Leflunomide in rheumatoid arthritis: recommendations through a process of consensus Rheumatology (Oxford) 44 3 2005 280 286
-
(2005)
Rheumatology (Oxford)
, vol.44
, Issue.3
, pp. 280-286
-
-
Maddison, P.1
Kiely, P.2
Kirkham, B.3
Lawson, T.4
Moots, R.5
Proudfoot, D.6
-
19
-
-
0042649980
-
Leflunomide for treating rheumatoid arthritis
-
M. Osiri, B. Shea, V. Robinson, M. Suarez-Almazor, V. Strand, and P. Tugwell Leflunomide for treating rheumatoid arthritis CDS Rev 1 2003 CD002047
-
(2003)
CDS Rev
, Issue.1
, pp. 002047
-
-
Osiri, M.1
Shea, B.2
Robinson, V.3
Suarez-Almazor, M.4
Strand, V.5
Tugwell, P.6
-
20
-
-
0031838192
-
Clinical experience with leflunomide in rheumatoid arthritis. Leflunomide Investigators' Group
-
B. Rozman Clinical experience with leflunomide in rheumatoid arthritis. Leflunomide Investigators' Group J Rheumatol Suppl 53 1998 27 32
-
(1998)
J Rheumatol Suppl
, vol.53
, pp. 27-32
-
-
Rozman, B.1
-
21
-
-
0032374063
-
Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide
-
J.M. Bruneau, C.M. Yea, S. Spinella-Jaegle, C. Fudali, K. Woodward, and P.A. Robson Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide Biochem J 336 Pt 2 1998 299 303
-
(1998)
Biochem J
, vol.336
, Issue.PART 2
, pp. 299-303
-
-
Bruneau, J.M.1
Yea, C.M.2
Spinella-Jaegle, S.3
Fudali, C.4
Woodward, K.5
Robson, P.A.6
-
22
-
-
0031865023
-
Mechanism of action of leflunomide in rheumatoid arthritis
-
R.I. Fox Mechanism of action of leflunomide in rheumatoid arthritis J Rheumatol Suppl 53 1998 20 26
-
(1998)
J Rheumatol Suppl
, vol.53
, pp. 20-26
-
-
Fox, R.I.1
-
23
-
-
0032692178
-
Mycophenolic acid and matrix metalloproteinase inhibitors
-
D.E. Furst, and Leflunomide mycophenolic acid and matrix metalloproteinase inhibitors Rheumatology (Oxford) 38 Suppl. 2 1999 14 18
-
(1999)
Rheumatology (Oxford)
, vol.38
, Issue.SUPPL. 2
, pp. 14-18
-
-
Furst, D.E.1
Leflunomide2
-
24
-
-
0029050136
-
Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide
-
S. Greene, K. Watanabe, J. Braatz-Trulson, and L. Lou Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide Biochem Pharmacol 50 6 1995 861 867
-
(1995)
Biochem Pharmacol
, vol.50
, Issue.6
, pp. 861-867
-
-
Greene, S.1
Watanabe, K.2
Braatz-Trulson, J.3
Lou, L.4
-
25
-
-
0028985102
-
The immunosuppressant leflunomide inhibits lymphocyte progression through cell cycle by a novel mechanism
-
H.M. Cherwinski, D. McCarley, R. Schatzman, B. Devens, and J.T. Ransom The immunosuppressant leflunomide inhibits lymphocyte progression through cell cycle by a novel mechanism J Pharmacol Exp Ther 272 1 1995 460 468
-
(1995)
J Pharmacol Exp Ther
, vol.272
, Issue.1
, pp. 460-468
-
-
Cherwinski, H.M.1
McCarley, D.2
Schatzman, R.3
Devens, B.4
Ransom, J.T.5
-
26
-
-
0032804664
-
Mechanism of action for leflunomide in rheumatoid arthritis
-
R.I. Fox, M.L. Herrmann, C.G. Frangou, G.M. Wahl, R.E. Morris, and V. Strand Mechanism of action for leflunomide in rheumatoid arthritis Clin Immunol 93 3 1999 198 208
-
(1999)
Clin Immunol
, vol.93
, Issue.3
, pp. 198-208
-
-
Fox, R.I.1
Herrmann, M.L.2
Frangou, C.G.3
Wahl, G.M.4
Morris, R.E.5
Strand, V.6
-
27
-
-
0029052321
-
Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide
-
X. Xu, J.W. Williams, E.G. Bremer, A. Finnegan, and A.S. Chong Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide J Biol Chem 270 21 1995 12398 12403
-
(1995)
J Biol Chem
, vol.270
, Issue.21
, pp. 12398-12403
-
-
Xu, X.1
Williams, J.W.2
Bremer, E.G.3
Finnegan, A.4
Chong, A.S.5
-
28
-
-
0031180972
-
In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice
-
X. Xu, L. Blinder, J. Shen, H. Gong, A. Finnegan, and J.W. Williams In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice J Immunol 159 1 1997 167 174
-
(1997)
J Immunol
, vol.159
, Issue.1
, pp. 167-174
-
-
Xu, X.1
Blinder, L.2
Shen, J.3
Gong, H.4
Finnegan, A.5
Williams, J.W.6
-
29
-
-
25444448197
-
Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: Involvement of impaired integrin activation and immunologic synapse formation
-
M. Zeyda, M. Poglitsch, R. Geyeregger, J.S. Smolen, G.J. Zlabinger, and W.H. Hörl Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation Arthritis Rheum 52 9 2005 2730 2739
-
(2005)
Arthritis Rheum
, vol.52
, Issue.9
, pp. 2730-2739
-
-
Zeyda, M.1
Poglitsch, M.2
Geyeregger, R.3
Smolen, J.S.4
Zlabinger, G.J.5
Hörl, W.H.6
-
30
-
-
0033557695
-
Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression
-
S.K. Manna, and B.B. Aggarwal Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression J Immunol 162 4 1999 2095 2102
-
(1999)
J Immunol
, vol.162
, Issue.4
, pp. 2095-2102
-
-
Manna, S.K.1
Aggarwal, B.B.2
-
31
-
-
0345491507
-
Exposure of T lymphocytes to leflunomide but not to dexamethasone favors the production by monocytic cells of interleukin-1 receptor antagonist and the tissue-inhibitor of metalloproteinases-1 over that of interleukin-1beta and metalloproteinases
-
V. Déage, D. Burger, and J.M. Dayer Exposure of T lymphocytes to leflunomide but not to dexamethasone favors the production by monocytic cells of interleukin-1 receptor antagonist and the tissue-inhibitor of metalloproteinases-1 over that of interleukin-1beta and metalloproteinases Eur Cytokine Netw 9 4 1998 663 668
-
(1998)
Eur Cytokine Netw
, vol.9
, Issue.4
, pp. 663-668
-
-
Déage, V.1
Burger, D.2
Dayer, J.M.3
-
32
-
-
0033884087
-
Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine patients at two centers
-
M.C. Kraan, R.J. Reece, E.C. Barg, T.J. Smeets, J. Farnell, and R. Rosenburg Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine patients at two centers Arthritis Rheum 43 8 2000 1820 1830
-
(2000)
Arthritis Rheum
, vol.43
, Issue.8
, pp. 1820-1830
-
-
Kraan, M.C.1
Reece, R.J.2
Barg, E.C.3
Smeets, T.J.4
Farnell, J.5
Rosenburg, R.6
-
33
-
-
0037238591
-
The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E(2), matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes
-
D. Burger, N. Begué-Pastor, and S. Benavent The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E(2), matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes Rheumatology (Oxford) 42 1 2003 89 96
-
(2003)
Rheumatology (Oxford)
, vol.42
, Issue.1
, pp. 89-96
-
-
Burger, D.1
Begué-Pastor, N.2
Benavent, S.3
-
34
-
-
0029847123
-
A novel mechanism of action of the immunomodulatory drug, leflunomide: Augmentation of the immunosuppressive cytokine, TGF-beta 1, and suppression of the immunostimulatory cytokine, IL-2
-
W.W. Cao, P.N. Kao, Y. Aoki, J.C. Xu, R.A. Shorthouse, and R.E. Morris A novel mechanism of action of the immunomodulatory drug, leflunomide: augmentation of the immunosuppressive cytokine, TGF-beta 1, and suppression of the immunostimulatory cytokine, IL-2 Transplant Proc 28 6 1996 3079 3080
-
(1996)
Transplant Proc
, vol.28
, Issue.6
, pp. 3079-3080
-
-
Cao, W.W.1
Kao, P.N.2
Aoki, Y.3
Xu, J.C.4
Shorthouse, R.A.5
Morris, R.E.6
-
35
-
-
0032773737
-
A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner
-
L.C. Hamilton, I. Vojnovic, and T.D. Warner A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner Br J Pharmacol 127 7 1999 1589 1596
-
(1999)
Br J Pharmacol
, vol.127
, Issue.7
, pp. 1589-1596
-
-
Hamilton, L.C.1
Vojnovic, I.2
Warner, T.D.3
-
36
-
-
84890044614
-
-
arava.pdf (application/pdf Object). [Accessed March 18, 2009]
-
arava.pdf (application/pdf Object). Available at: http://products.sanofi- aventis.us/arava/arava.pdf [Accessed March 18, 2009].
-
-
-
-
37
-
-
0036143623
-
Effect of hemodialysis on leflunomide plasma concentrations
-
J.M. Beaman, L.P. Hackett, G. Luxton, and K.F. Illett Effect of hemodialysis on leflunomide plasma concentrations Ann Pharmacother 36 1 2002 75 77
-
(2002)
Ann Pharmacother
, vol.36
, Issue.1
, pp. 75-77
-
-
Beaman, J.M.1
Hackett, L.P.2
Luxton, G.3
Illett, K.F.4
-
38
-
-
7644223637
-
Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide - Mechanisms independent of pyrimidine depletion
-
T. Korn, T. Magnus, K. Toyka, and S. Jung Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide - mechanisms independent of pyrimidine depletion J Leukoc Biol 76 5 2004 950 960
-
(2004)
J Leukoc Biol
, vol.76
, Issue.5
, pp. 950-960
-
-
Korn, T.1
Magnus, T.2
Toyka, K.3
Jung, S.4
-
39
-
-
62149096116
-
Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis
-
J.E. Merrill, S. Hanak, S.F. Pu, J. Liang, C. Dang, and D. Iglesias-Bregna Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis J Neurol 256 1 2009 89 103
-
(2009)
J Neurol
, vol.256
, Issue.1
, pp. 89-103
-
-
Merrill, J.E.1
Hanak, S.2
Pu, S.F.3
Liang, J.4
Dang, C.5
Iglesias-Bregna, D.6
-
40
-
-
34548133584
-
Multiple sclerosis: A complicated picture of autoimmunity
-
H.F. McFarland, and R. Martin Multiple sclerosis: a complicated picture of autoimmunity Nat Immunol 8 9 2007 913 919
-
(2007)
Nat Immunol
, vol.8
, Issue.9
, pp. 913-919
-
-
McFarland, H.F.1
Martin, R.2
-
41
-
-
33645799680
-
A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses
-
P.W. O'Connor, D. Li, M.S. Freedman, A. Bar-Or, G.P. Rice, and C. Confavreux A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses Neurology 66 6 2006 894 900
-
(2006)
Neurology
, vol.66
, Issue.6
, pp. 894-900
-
-
O'Connor, P.W.1
Li, D.2
Freedman, M.S.3
Bar-Or, A.4
Rice, G.P.5
Confavreux, C.6
-
42
-
-
0021035886
-
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
-
J.F. Kurtzke Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS) Neurology 33 11 1983 1444 1452
-
(1983)
Neurology
, vol.33
, Issue.11
, pp. 1444-1452
-
-
Kurtzke, J.F.1
-
43
-
-
0023853487
-
MRI in the diagnosis of MS: A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
-
D.W. Paty, J.J. Oger, L.F. Kastrukoff, S.A. Hashimoto, J.P. Hooge, and A.A. Eisen MRI in the diagnosis of MS: a prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT Neurology 38 2 1988 180 185
-
(1988)
Neurology
, vol.38
, Issue.2
, pp. 180-185
-
-
Paty, D.W.1
Oger, J.J.2
Kastrukoff, L.F.3
Hashimoto, S.A.4
Hooge, J.P.5
Eisen, A.A.6
-
44
-
-
0020686503
-
New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
-
C.M. Poser, D.W. Paty, L. Scheinberg, W.I. McDonald, F.A. Davis, and G.C. Ebers New diagnostic criteria for multiple sclerosis: guidelines for research protocols Ann Neurol 13 3 1983 227 231
-
(1983)
Ann Neurol
, vol.13
, Issue.3
, pp. 227-231
-
-
Poser, C.M.1
Paty, D.W.2
Scheinberg, L.3
McDonald, W.I.4
Davis, F.A.5
Ebers, G.C.6
-
45
-
-
0028792355
-
Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study
-
V. Mladenovic, Z. Domljan, B. Rozman, I. Jajic, D. Mihajlovic, and J. Dordevic Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study Arthritis Rheum 38 11 1995 1595 1603
-
(1995)
Arthritis Rheum
, vol.38
, Issue.11
, pp. 1595-1603
-
-
Mladenovic, V.1
Domljan, Z.2
Rozman, B.3
Jajic, I.4
Mihajlovic, D.5
Dordevic, J.6
-
46
-
-
0033053835
-
Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: A double-blind, randomised, multicentre trial. European Leflunomide Study Group
-
J.S. Smolen, J.R. Kalden, D.L. Scott, B. Rozman, T.K. Kvien, and A. Larsen Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. European Leflunomide Study Group Lancet 353 9149 1999 259 266
-
(1999)
Lancet
, vol.353
, Issue.9149
, pp. 259-266
-
-
Smolen, J.S.1
Kalden, J.R.2
Scott, D.L.3
Rozman, B.4
Kvien, T.K.5
Larsen, A.6
-
47
-
-
0033596065
-
Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group
-
V. Strand, S. Cohen, M. Schiff, A. Weaver, R. Fleischmann, and G. Cannon Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group Arch Intern Med 159 21 1999 2542 2550
-
(1999)
Arch Intern Med
, vol.159
, Issue.21
, pp. 2542-2550
-
-
Strand, V.1
Cohen, S.2
Schiff, M.3
Weaver, A.4
Fleischmann, R.5
Cannon, G.6
-
48
-
-
2542613661
-
Leflunomide: A manageable safety profile
-
P.L. van Riel, J.S. Smolen, P. Emery, J.R. Kalden, M. Dougados, and C.V. Strand Leflunomide: a manageable safety profile J Rheumatol Suppl 71 2004 21 24
-
(2004)
J Rheumatol Suppl
, vol.71
, pp. 21-24
-
-
Van Riel, P.L.1
Smolen, J.S.2
Emery, P.3
Kalden, J.R.4
Dougados, M.5
Strand, C.V.6
-
49
-
-
84890018886
-
-
arava-deardoc.pdf (application/pdf Object). [Accessed March 18, 2009]
-
arava-deardoc.pdf (application/pdf Object). Available at: http://www.fda.gov/medwatch/SAFETY/2003/arava-deardoc.pdf [Accessed March 18, 2009].
-
-
-
-
50
-
-
6744262231
-
A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis
-
P. Emery, F.C. Breedveld, E.M. Lemmel, J.P. Kaltwasser, P.T. Dawes, and B. Gömör A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis Rheumatology (Oxford) 39 6 2000 655 665
-
(2000)
Rheumatology (Oxford)
, vol.39
, Issue.6
, pp. 655-665
-
-
Emery, P.1
Breedveld, F.C.2
Lemmel, E.M.3
Kaltwasser, J.P.4
Dawes, P.T.5
Gömör, B.6
-
51
-
-
0033695542
-
Severe pancytopenia after leflunomide in rheumatoid arthritis
-
J. Auer, M. Hinterreiter, S. Allinger, A. Kirchgatterer, and P. Knoflach Severe pancytopenia after leflunomide in rheumatoid arthritis Acta Med Austriaca 27 4 2000 131 132
-
(2000)
Acta Med Austriaca
, vol.27
, Issue.4
, pp. 131-132
-
-
Auer, J.1
Hinterreiter, M.2
Allinger, S.3
Kirchgatterer, A.4
Knoflach, P.5
-
52
-
-
0037224358
-
Pancytopenia associated with leflunomide and methotrexate
-
R.L. Hill, D.J. Topliss, and P.M. Purcell Pancytopenia associated with leflunomide and methotrexate Ann Pharmacother 37 1 2003 149
-
(2003)
Ann Pharmacother
, vol.37
, Issue.1
, pp. 149
-
-
Hill, R.L.1
Topliss, D.J.2
Purcell, P.M.3
-
53
-
-
0038653142
-
The efficacy and safety of leflunomide in patients with active rheumatoid arthritis: A five-year followup study
-
J.R. Kalden, M. Schattenkirchner, and H. Sörensen The efficacy and safety of leflunomide in patients with active rheumatoid arthritis: a five-year followup study Arthritis Rheum 48 6 2003 1513 1520
-
(2003)
Arthritis Rheum
, vol.48
, Issue.6
, pp. 1513-1520
-
-
Kalden, J.R.1
Schattenkirchner, M.2
Sörensen, H.3
-
54
-
-
35949002068
-
Leflunomide-associated infections in rheumatoid arthritis
-
K.A. Jenks, L.K. Stamp, J.L. O'Donnell, R.L. Savage, and P.T. Chapman Leflunomide-associated infections in rheumatoid arthritis J Rheumatol 34 11 2007 2201 2203
-
(2007)
J Rheumatol
, vol.34
, Issue.11
, pp. 2201-2203
-
-
Jenks, K.A.1
Stamp, L.K.2
O'Donnell, J.L.3
Savage, R.L.4
Chapman, P.T.5
-
55
-
-
0037214085
-
Infectious CNS disease as a differential diagnosis in systemic rheumatic diseases: Three case reports and a review of the literature
-
K. Warnatz, H.H. Peter, M. Schumacher, L. Wiese, A. Prasse, and F. Petschner Infectious CNS disease as a differential diagnosis in systemic rheumatic diseases: three case reports and a review of the literature Ann Rheum Dis 62 1 2003 50 57
-
(2003)
Ann Rheum Dis
, vol.62
, Issue.1
, pp. 50-57
-
-
Warnatz, K.1
Peter, H.H.2
Schumacher, M.3
Wiese, L.4
Prasse, A.5
Petschner, F.6
-
56
-
-
0036000248
-
Leflunomide and hypertension
-
B. Rozman, S. Praprotnik, D. Logar, M. Tomsic, M. Hojnik, and M. Kos-Golja Leflunomide and hypertension Ann Rheum Dis 61 6 2002 567 569
-
(2002)
Ann Rheum Dis
, vol.61
, Issue.6
, pp. 567-569
-
-
Rozman, B.1
Praprotnik, S.2
Logar, D.3
Tomsic, M.4
Hojnik, M.5
Kos-Golja, M.6
-
57
-
-
64349093750
-
Inhibiting the teratogenicity of the immuno-suppressant leflunomide in mice by supplementation of exogenous uridine
-
R. Fukushima, S. Kanamori, M. Hirashiba, A. Hishikawa, R. Muranaka, and M. Kaneto Inhibiting the teratogenicity of the immuno-suppressant leflunomide in mice by supplementation of exogenous uridine Toxicol Sci 108 2 2009 419 426
-
(2009)
Toxicol Sci
, vol.108
, Issue.2
, pp. 419-426
-
-
Fukushima, R.1
Kanamori, S.2
Hirashiba, M.3
Hishikawa, A.4
Muranaka, R.5
Kaneto, M.6
-
58
-
-
60349119455
-
Critical periods for the teratogenicity of immune-suppressant Leflunomide in mice
-
R. Fukushima, S. Kanamori, M. Hirashiba, A. Hishikawa, R. Muranaka, and M. Kaneto Critical periods for the teratogenicity of immune-suppressant Leflunomide in mice Congenit Anom (Kyoto) 49 1 2009 20 26
-
(2009)
Congenit Anom (Kyoto)
, vol.49
, Issue.1
, pp. 20-26
-
-
Fukushima, R.1
Kanamori, S.2
Hirashiba, M.3
Hishikawa, A.4
Muranaka, R.5
Kaneto, M.6
-
59
-
-
35548953841
-
Teratogenicity study of the dihydroorotate-dehydrogenase inhibitor and protein tyrosine kinase inhibitor Leflunomide in mice
-
R. Fukushima, S. Kanamori, M. Hirashiba, A. Hishikawa, R.I. Muranaka, and M. Kaneto Teratogenicity study of the dihydroorotate-dehydrogenase inhibitor and protein tyrosine kinase inhibitor Leflunomide in mice Reprod Toxicol 24 3-4 2007 310 316
-
(2007)
Reprod Toxicol
, vol.24
, Issue.34
, pp. 310-316
-
-
Fukushima, R.1
Kanamori, S.2
Hirashiba, M.3
Hishikawa, A.4
Muranaka, R.I.5
Kaneto, M.6
-
60
-
-
80053533877
-
Randomized trial of oral teriflunomide for relapsing multiple sclerosis
-
P. O'Connor, J.S. Wolinsky, C. Confavreux, G. Comi, L. Kappos, and T.P. Olsson Randomized trial of oral teriflunomide for relapsing multiple sclerosis N Engl J Med 365 2011 1293 1303
-
(2011)
N Engl J Med
, vol.365
, pp. 1293-1303
-
-
O'Connor, P.1
Wolinsky, J.S.2
Confavreux, C.3
Comi, G.4
Kappos, L.5
Olsson, T.P.6
-
61
-
-
84883410242
-
Magnetic resonance imaging outcomes from a phase III trial of teriflunomide
-
J.S. Wolinsky, P.A. Narayana, F. Nelson, S. Datta, P. O'Connor, and C. Confavreux Magnetic resonance imaging outcomes from a phase III trial of teriflunomide Mult Scler. 19 10 2013 1310 1319
-
(2013)
Mult Scler.
, vol.19
, Issue.10
, pp. 1310-1319
-
-
Wolinsky, J.S.1
Narayana, P.A.2
Nelson, F.3
Datta, S.4
O'Connor, P.5
Confavreux, C.6
-
62
-
-
70449717876
-
Review of teriflunomide and its potential in the treatment of multiple sclerosis
-
C. Warnke, G. Meyer zu Hörste, H.P. Hartung, O. Stüve, and B.C. Kieseier Review of teriflunomide and its potential in the treatment of multiple sclerosis Neuropsych Dis Treat 5 2009 333 340
-
(2009)
Neuropsych Dis Treat
, vol.5
, pp. 333-340
-
-
Warnke, C.1
Meyer Zu Hörste, G.2
Hartung, H.P.3
Stüve, O.4
Kieseier, B.C.5
-
63
-
-
84879506535
-
-
C. Warnke, G. Meyer Zu Hörste, T. Menge, O. Stüve, H.P. Hartung, and H. Wiendl Nervenarzt 84 2013 724 731
-
(2013)
Nervenarzt
, vol.84
, pp. 724-731
-
-
Warnke, C.1
Meyer Zu Hörste, G.2
Menge, T.3
Stüve, O.4
Hartung, H.P.5
Wiendl, H.6
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