The effects of tranexamic acid and prothrombin complex concentrate on the coagulopathy of trauma: An in vitro analysis of the impact of severe acidosis

Journal of Trauma and Acute Care Surgery

Volumn 75, Issue 5, 2013, Pages 954-960

  Porta, Christopher Rees ^a   Nelson, Daniel ^a   McVay, Derek ^a   Salgar, Shashikumar ^a   Eckert, Matthew ^a   Izenberg, Seth ^b   Martin, Matthew J ^a,b  

^a MADIGAN ARMY MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Metabolic acidosis; Prothrombin complex concentrate; Swine; Tranexamic acid; Traumatic coagulopathy

Indexed keywords

FRESH FROZEN PLASMA; PROTHROMBIN COMPLEX; TISSUE PLASMINOGEN ACTIVATOR; TRANEXAMIC ACID; BLOOD CLOTTING FACTOR 9 COMPLEX; LACTIC ACID;

AORTA CLAMPING; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD PH; BLOOD SAMPLING; CONTROLLED STUDY; DRUG EFFECT; FIBRINOGEN BLOOD LEVEL; FIBRINOLYSIS; HEMATOCRIT; HEMORRHAGIC SHOCK; HYPOFIBRINOGENEMIA; IN VITRO STUDY; INJURY; INTERNATIONAL NORMALIZED RATIO; LACTATE BLOOD LEVEL; METABOLIC ACIDOSIS; NONHUMAN; PRIORITY JOURNAL; PROTHROMBIN TIME; REPERFUSION INJURY; RESUSCITATION; SINGLE DRUG DOSE; ANIMAL EXPERIMENT; CONFERENCE PAPER; DISEASE SEVERITY; DRUG EFFICACY; PH;

ACIDOSIS; ANIMALS; ANTIFIBRINOLYTIC AGENTS; BLOOD COAGULATION DISORDERS; BLOOD COAGULATION FACTORS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; HEMORRHAGE; LACTIC ACID; PLASMA; PROTHROMBIN; PROTHROMBIN TIME; RESUSCITATION; SWINE; TRANEXAMIC ACID; WOUNDS AND INJURIES;

EID: 84890041281     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e31829e20bf     Document Type: Article

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