Editorial commentary: Community-associated Clostridium difficile infection in children

Clinical Infectious Diseases

Volumn 57, Issue 12, 2013, Pages 1673-1675

  Toltzis, Philip ^a   Zaoutis, Theoklis ^b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Clostridium difficile; pediatrics; public health; surveillance

Indexed keywords

METRONIDAZOLE; VANCOMYCIN;

AMBULATORY SURGERY; CHILDHOOD DISEASE; CLOSTRIDIUM DIFFICILE INFECTION; COHORT ANALYSIS; COMMUNICABLE DISEASE; COMORBIDITY; EMERGENCY CARE; ENVIRONMENTAL EXPOSURE; GASTROENTERITIS; GASTROINTESTINAL SYMPTOM; HEALTH CARE FACILITY; HIGH RISK POPULATION; HOSPITALIZATION; HUMAN; INCUBATION TIME; NOTE; OUTPATIENT CARE; PRIORITY JOURNAL; SEPSIS; STUDY DESIGN; TOXIC MEGACOLON;

CLOSTRIDIUM DIFFICILE; PEDIATRICS; PUBLIC HEALTH; SURVEILLANCE;

CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; FEMALE; HUMANS; MALE;

EID: 84890038200     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cit589     Document Type: Note

References (26)

1. Pepin J, Valiquette L, Alary ME, et al. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: A changing pattern of disease severity. CMAJ 2004; 171:466-72
2. Loo VG, Poirier L, Miller MA, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005; 353:2442-9
3. Kim J, Smathers SA, Prasad P, Leckerman KH, Coffin S, Zaoutis T. Epidemiological features of Clostridium difficile-associated disease among inpatients at children's hospitals in the United States, 2001-2006. Pediatrics 2008; 122:1266-70
4. Nylund CM, Goudie A, Garza JM, Fairbrother G, Cohen MB. Clostridium difficile infection in hospitalized children in the United States. Arch Pediatr Adolesc Med 2011; 165:451-7
5. Kim J, Shaklee JF, Smathers S, et al. Risk factors and outcomes associated with severe Clostridium difficile infection in children. Pediatr Infect Dis J 2012; 31:134-8
6. Sammons JS, Localio R, Xiao R, Coffin SE, Zaoutis T. Clostridium difficile infection is associated with increased risk of death and prolonged hospitalization in children. Clin Infect Dis 2013; 57:1-8
7. Toltzis P, Kim J, Dul M, Zoltanski J, Smathers S, Zaoutis T. Presence of the epidemic North American pulsed field type 1 Clostridium difficile strain in hospitalized children. J Pediatr 2009; 154:607-8
8. Centers for Disease Control and Prevention. Severe Clostridium difficile-associated disease in populations previously at low risk - four states, 2005. MMWR Morb Mortal Wkly Rep 2005; 54:1201-5
9. Chitnis AS, Holzbauer SM, Belflower RM, et al. Epidemiology of community-associated Clostridium difficile infection, 2009 through 2011. JAMA Int Med 2013; 173:1359-67
10. Hirshon JM, Thompson AD, Limbago B, et al. Clostridium difficile infection in outpatients, Maryland and Connecticut, USA, 2002-2007. Emerg Infect Dis 2011; 17: 1946-9
11. Khanna S, Pardi DS, Aronson SL, et al. The epidemiology of community-acquired Clostridium difficile infection: A populationbased study. Am J Gastroenterol 2012; 107: 89-95
12. Kuntz JL, Chrischilles EA, Pendergast JF, Herwaldt LA, Polgreen PM. Incidence of and risk factors for community-associated Clostridium difficile infection: A nested casecontrol study. BMC Infect Dis 2011; 11:194
13. Kutty PK, Woods CW, Sena AC, et al. Risk factors for and estimated incidence of community- Associated Clostridium difficile infection, North Carolina, USA. Emerg Infect Dis 2008; 16:197-204
14. Naggie S, Miller BA, Zuzak KB, et al. A casecontrol study of community-associated Clostridium difficile infection: No role for proton pump inhibitors. Am J Med 2011; 124:276 e1-7
15. Wilcox MH, Mooney L, Bendall R, Settle CD, Fawley WN. A case-control study of community-associated Clostridium difficile infection. J Antimicrob Chemother 2008; 62:388-96
16. Surveillance for community-associated Clostridium difficile - Connecticut, 2006. Morb Mort Wkly Rep 2008; 57:340-3
17. Khanna S, Baddour LM, Huskins WC, et al. The epidemiology of Clostridium difficile infection in children: A population-based study. Clin Infect Dis 2013; 56:1401-6
18. Benson L, Song X, Campos J, Singh N. Changing epidemiology of Clostridium difficile-associated disease in children. Infect Control Hosp Epidemiol 2007; 28:1233-5
19. Baker SS, Faden H, Sayej W, Patel R, Baker RD. Increasing incidence of communityassociated atypical Clostridium difficile disease in children. Clinical Pediatr 2010; 49: 644-7
20. Donta ST, Myers MG. Clostridium difficile toxin in asymptomatic neonates. J Pediatr 1982; 100:431-4
21. Sherertz RJ, Sarubbi FA. The prevalence of Clostridium difficile and toxin in a nursery population: A comparison between patients with necrotizing enterocolitis and an asymptomatic group. J Pediatr 1982; 100:435-9
22. Klein EJ, Boster DR, Stapp JR, et al. Diarrhea etiology in a children's hospital emergency department: A prospective cohort study. Clin Infect Dis 2006; 43:807-13
23. Denno DM, Shaikh N, Stapp JR, et al. Diarrhea etiology in a pediatric emergency department: A case control study. Clin Infect Dis 2012; 55:897-904
24. Tschudin-Sutter S, Tamma PD, Naegli AN, Speck KA, Milstone AM, Perl TM. Distinguishing community-associated from hospital- Associated Clostridium difficile infections in children: Implications for public health surveillance. Clin Infect Dis 2013; 57: 1665-72
25. McDonald LC, Coignard B, Dubberke E, Song X, Horan T, Kutty PK. Recommendations for surveillance of Clostridium difficileassociated disease. Infect Control Hosp Epidemiol 2007; 28:140-5
26. Jury LA, Sitzlar B, Kundrapu S, et al. Outpatient healthcare settings and transmission of Clostridium difficile. PLoS One 2013; 8: E70175